scholarly journals Protective effect of grifolin against brain injury in an acute cerebral ischemia rat model

2017 ◽  
Vol 16 (6) ◽  
pp. 1299 ◽  
Author(s):  
Shan Jing ◽  
Piaopiao Ying ◽  
Xiaohua Hu ◽  
Ze Yu ◽  
Jianwei Sun ◽  
...  
Keyword(s):  
Brain Injury ◽  
Cerebral Ischemia ◽  
Protective Effect ◽  
Rat Model ◽  
Acute Cerebral Ischemia

Protective effect of Ginkgolids (A+B) is associated with inhibition of NIK/IKK/IκB/NF-κB signaling pathway in a rat model of permanent focal cerebral ischemia

2008 ◽  
Vol 1234 ◽  
pp. 8-15 ◽  
Author(s):  
Xuan Wang ◽  
Zheng-Hong Qin ◽  
Hong Shi ◽  
Sean Isaac Savitz ◽  
Ai-Ping Qin ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Protective Effect ◽  
Signaling Pathway ◽  
Rat Model ◽  
Focal Cerebral Ischemia

Protective Effect of Paeoniflorin on Acute Cerebral Infarction in Rats

2020 ◽  
Vol 21 (8) ◽  
pp. 702-709
Author(s):  
Weilin Wu ◽  
Chenfeng Qiu ◽  
Xuewen Feng ◽  
Xiaoxiao Tao ◽  
Qian Zhu ◽  
...  
Keyword(s):  
Lactate Dehydrogenase ◽  
Cerebral Ischemia ◽  
Cerebral Infarction ◽  
Protective Effect ◽  
Brain Tissue ◽  
Cell Damage ◽  
Acute Cerebral Infarction ◽  
Neurological Deficits ◽  
Sod Activity ◽  
Acute Cerebral Ischemia

Objective: The purpose of this paper was to study the protective effect of paeoniflorin on acute cerebral ischemia. The animal model of cerebral infarction induced by Middle Cerebral Artery Occlusion (MCAO) was blocked by the suture method. Sixty SD rats were randomly divided into the shame group, MCAO group, paeoniflorin (60, 120, 240 mg/kg, respectively) and Nimodipine (NMDP) group (n = 10 per group). Methods: The rats were intragastrically administered immediately after the operation. After 7 days of gavage, the brains were decapitated at 24 h. Hematoxylin and Eosin (HE) staining was used to observe the degree of cell damage in the cerebral cortex of rats. Immunohistochemistry was used to detect silver plating and to observe changes in nerve cells. Rats in the model group showed obvious symptoms of neurological deficits, such as the ischemic morphological changed, the Malondialdehyde (MDA), Lactate Dehydrogenase (LD) content and lactate dehydrogenase (LDH) activity were significantly increased in the ischemic brain tissue, while the Superoxide Dismutase (SOD) activity was decreased. Results: The decrease in Na+-K+-ATPase activity was significantly lower than that in the sham group. The neurological symptoms and signs of MCAO in the different doses of paeoniflorin group were improved, and the neuronal edema in the cortical area was alleviated. The activities of SOD, LDH and Na+-K+-ATPase were significantly increased, and the contents of MDA and LD were decreased. Conclusion: Therefore, paeoniflorin could alleviate the degree of tissue damage in rats with acute cerebral infarction, inhabit the formation of free radicals in the brain tissue after ischemia, and reduce the degree of lipid peroxidation. Thus, the degree of cell damage was reduced greatly and a protective effect was showed on cerebral ischemia.

Protective Effect of Buflomedil in a Rat Model of Moderate Cerebral Ischemia

2011 ◽  
Vol 55 (08) ◽  
pp. 437-442
Author(s):  
Francesco Briguglio ◽  
Maria Mondello ◽  
Mariangela Galluzzo ◽  
Eugenio Raneri ◽  
Anna Pasquale ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Protective Effect ◽  
Rat Model

scholarly journals Protective effect of Fluosol-DA in acute cerebral ischemia.

Stroke ◽  
1981 ◽  
Vol 12 (5) ◽  
pp. 558-563 ◽  
Author(s):  
S J Peerless ◽  
R Ishikawa ◽  
I G Hunter ◽  
M J Peerless
Keyword(s):  
Cerebral Ischemia ◽  
Protective Effect ◽  
Acute Cerebral Ischemia
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