Multiple partners, multiple strategies, multiple causes

Author(s):  
Norman R. Brown ◽  
Oliver Schweickart ◽  
Robert C. Sinclair ◽  
Sean E. Moore
2019 ◽  
Author(s):  
Patricio Mena-Chamorro ◽  
Rodrigo Ferrer

Background: STIs, principally HIV/AIDS, are public health problems that are transmitted by sexual risk behaviours, which have been associated with the sexual sensation seeking (an specific personality factor). In South American context, there are no measurement instruments with psychometric evidence for their use and, in other contexts, only the Sexual sensation seeking scale (Kalichman et al., 1994) is available, which is outdated in content and validity evidence. The purpose of this work is development a scale, in accordance with contemporary psychometric standards, to assess sexual sensation seeking for South Americans young people and adults. Method: instrumental study, with time-space sampling (n=813) of undergraduate students from the two Chilean cities with the highest rates of HIV. Results: Final scale have 8 items to assess two dimensions: 1) sexual emotions seeking; and 2) tendency to sexual boredom. The identified structure provides adequate levels of reliability (ω> .8; α> .7), presents validity evidence, based on the internal structure of the test, using CFA and ESEM (CFI> .95, TLI> .95, RMSEA <. 06), and based on the convergence with other measures (sexual activity with multiple partners, inadequate or insufficient use of protective barriers and sexual activity under the influence of alcohol or drugs). Conclusions: The Multidimensional Scale of Sexual Sensation Seeking evidence adequate psychometric properties to evaluate the search for sexual sensations in equivalents samples.


2006 ◽  
Vol 63 (1) ◽  
pp. 144 ◽  
Author(s):  
Marcel G. M. Olde Rikkert ◽  
Wiesje M. van der Flier ◽  
Frank Erik deLeeuw ◽  
Marcel Verbeek ◽  
René W. M. M. Jansen ◽  
...  

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Nina Kettler ◽  
Manon K. Schweinfurth ◽  
Michael Taborsky

AbstractDirect reciprocity, where individuals apply the decision rule ‘help someone who has helped you’, is believed to be rare in non-human animals due to its high cognitive demands. Especially if previous encounters with several partners need to be correctly remembered, animals might either stop reciprocating favours previously received from an individual, or switch to the simpler generalized reciprocity mechanism. Here we tested the decision rules Norway rats apply when interacting with multiple partners before being able to return received help. In a sequential prisoner’s dilemma situation, focal subjects encountered four different partners that were either helpful or not, on four consecutive days. On the fifth day, the focal subject was paired with one of the previous four partners and given the opportunity to provide it with food. The focal rats returned received help by closely matching the quantity of help their partner had previously provided, independently of the time delay between received and given help, and independently of the ultimate interaction preceding the test. This shows that direct reciprocity is not limited to dyadic situations in Norway rats, suggesting that cognitive demands involved in applying the required decision rules can be met by non-human animals even when they interact with multiple partners differing in helping propensity.


2021 ◽  
Vol 13 (3) ◽  
pp. 1117
Author(s):  
Alessandro Fontana ◽  
Andrea Barni ◽  
Deborah Leone ◽  
Maurizio Spirito ◽  
Agata Tringale ◽  
...  

Even if the economy nowadays is still locked into a linear model of production, tighter environmental standards, resource scarcity and changing consumer expectations are forcing organizations to find alternatives to lighten their impacts. The concept of Circular Economy (CE) is to an increasing extent treated as a solution to this series of challenges. That said, the multitude of approaches and definitions around CE and Life Cycle Extension Strategies (LCES) makes it difficult to provide (Small and Medium Enterprise) SMEs with a consistent understanding of the topic. This paper aims at bridging this gap by providing a systematic literature review of the most prominent papers related to the CE and lifetime extension, with a particular focus on the equipment and machinery sector. A taxonomy was used to define and cluster a subset of selected papers to build a homogeneous approach for understanding the multiple strategies used in the industry, and the standards in maintenance and remanufacturing strategies. As a final research step, we also propose a Strategy Characterization Framework (SCF) to build the ground for the selection of the best strategy to be applied for production equipment life cycle extension on several industrial use cases.


2021 ◽  
Vol 22 (11) ◽  
pp. 5989
Author(s):  
Bilal Ahmad ◽  
Maria Batool ◽  
Moon Suk Kim ◽  
Sangdun Choi

Toll-like receptor (TLR) signaling plays a critical role in the induction and progression of autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematous, experimental autoimmune encephalitis, type 1 diabetes mellitus and neurodegenerative diseases. Deciphering antigen recognition by antibodies provides insights and defines the mechanism of action into the progression of immune responses. Multiple strategies, including phage display and hybridoma technologies, have been used to enhance the affinity of antibodies for their respective epitopes. Here, we investigate the TLR4 antibody-binding epitope by computational-driven approach. We demonstrate that three important residues, i.e., Y328, N329, and K349 of TLR4 antibody binding epitope identified upon in silico mutagenesis, affect not only the interaction and binding affinity of antibody but also influence the structural integrity of TLR4. Furthermore, we predict a novel epitope at the TLR4-MD2 interface which can be targeted and explored for therapeutic antibodies and small molecules. This technique provides an in-depth insight into antibody–antigen interactions at the resolution and will be beneficial for the development of new monoclonal antibodies. Computational techniques, if coupled with experimental methods, will shorten the duration of rational design and development of antibody therapeutics.


2021 ◽  
pp. 138332
Author(s):  
Muhammad Aadil ◽  
Sonia Zulfiqar ◽  
Muhammad Shahid ◽  
Philips O Agboola ◽  
Najeeb Faud Al-Khalli ◽  
...  
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