scholarly journals Consideration of late complications of the annulo aortic ectasia and DeBakey type 1 dissections had Marfan syndrome.

1989 ◽  
Vol 18 (6) ◽  
pp. 864-866
Author(s):  
H. Akashi
Keyword(s):  
Marfan Syndrome ◽  
Late Complications ◽  
Aortic Ectasia

scholarly journals General Principles for Rehabilitation of Patients With Type 1 Diabetes and Diabetic Nephropathy

2021 ◽  
Vol 7 (12) ◽  
pp. 97-103
Author(s):  
O. Terekhova ◽  
Furtikova
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Diabetic Nephropathy ◽  
Insulin Therapy ◽  
Type 1 Diabetes Mellitus ◽  
Diabetic Complications ◽  
Late Complications ◽  
Genetically Engineered ◽  
Self Control

All over the world, an increase in type 1 diabetes mellitus is noted annually, along with its late complications. In recent years, more and more information has appeared aimed at the prevention and rehabilitation of children with diabetes. Type 1 diabetes mellitus is a genetically determined disease, in the development of which the main component is an autoimmune process that triggers the destruction of β-cells, which leads to a decrease in insulin production, and subsequently to its absolute insufficiency, the main method of treatment is insulin replacement therapy. To select an adequate dose of insulin, it is necessary to take into account HbA1c, glycemic and glucosuric profiles. Children are advised to use semi-synthetic or genetically engineered insulins. In children, intensified insulin therapy is more often used in the form of a combination of short and medium-acting insulins or ultra-short with prolonged ones. This article presents an analysis of insulin therapy and self-control in children and adolescents with type 1 diabetes mellitus and diabetic nephropathy. It was found that children with diabetic nephropathy approached their illness less responsibly, did not always count bread units and kept records in self-control diaries. Also, this group of children were more likely to receive human insulin with the use of syringe pens. The nutrition of children with diabetes should not be inferior in calories to that of healthy adolescents, while the energy value of the daily diet should be calculated taking into account age, gender, body weight, and energy expenditures. Taking into account the possibility of regression of the initial diabetic complications when the compensation of carbohydrate metabolism is achieved, therapy for type 1 diabetes is a means of preventing the development of severe diabetic complications.

The 20210 G to A Prothrombin Polymorphism and Late Complications in Type 1 Diabetes Mellitus

1999 ◽  
Vol 81 (01) ◽  
pp. 164-164 ◽  
Author(s):  
Per Humpert ◽  
Berend Isermann ◽  
Gottfried Rudofsky ◽  
Reinhard Ziegler ◽  
Angelika Bierhaus ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Late Complications

scholarly journals The borohydride-reducible compounds of human aortic elastin. Demonstration of a new cyclic amino acid in alkali hydrolysate, and changes with age and in patients with annulo-aortic ectasia including one with Marfan syndrome

1985 ◽  
Vol 232 (1) ◽  
pp. 169-175 ◽  
Author(s):  
T Halme ◽  
M Jutila ◽  
T Vihersaari ◽  
P Oksman ◽  
N D Light ◽  
...  
Keyword(s):  
Acid Hydrolysis ◽  
Marfan Syndrome ◽  
Aldol Condensation ◽  
Condensation Product ◽  
Hydrolysis Product ◽  
Exchange Chromatography ◽  
Spectrometric Analysis ◽  
Cross Link ◽  
Aortic Ectasia ◽  
And Control

Human aortic elastin reduced with [3H]borohydride was analysed by ion-exchange chromatography after alkali or acid hydrolysis. Alkali hydrolysates of elastins contained a radioactive peak that was eluted between proline and leucine. This peak was not present in foetal elastin, but its proportion increased steadily during aging. Aortic samples from patients with annulo-aortic ectasia (aneurysm of the ascending aorta), including one with classical Marfan syndrome, contained less elastin (CNBr-insoluble material) than did the age-matched controls. The proportion of radioactivity in the new peak of all these aortas was low when compared with age-matched controls. Gas-chromatographic/mass-spectrometric analysis suggested that it contained a cyclic derivative of a hydrated aldol-condensation product. The concentration of the cross-link precursors, lysine aldehyde and aldol-condensation product (estimated from the acid-hydrolysis product 6-chloronorleucine and the acid-degradation product of reduced aldol-condensation product) was high in very young aortas but remained quite stable after childhood. No differences were observed in cross-link profiles of acid hydrolysates between pathological and control aortas. A low proportion of radioactivity in the new peak may indicate the presence of young or immature elastin in the pathological aortas.

scholarly journals Soluble EMMPRIN levels discriminate aortic ectasia in Marfan syndrome patients

Theranostics ◽  
2019 ◽  
Vol 9 (8) ◽  
pp. 2224-2234 ◽  
Author(s):  
Erica Rurali ◽  
Gianluca L. Perrucci ◽  
Raffaella Gaetano ◽  
Alessandro Pini ◽  
Donato Moschetta ◽  
...  
Keyword(s):  
Marfan Syndrome ◽  
Aortic Ectasia

scholarly journals Functional and Structural Outcomes of Temporal Zone II-Sparing Laser Photocoagulation Combined with Intravitreal Bevacizumab in Retinopathy of Prematurity

2018 ◽  
Vol 2018 ◽  
pp. 1-8
Author(s):  
Eoi Jong Seo ◽  
Joo Yong Lee
Keyword(s):  
Treatment Group ◽  
Retinopathy Of Prematurity ◽  
Laser Photocoagulation ◽  
Combined Treatment ◽  
Intravitreal Bevacizumab ◽  
Late Complications ◽  
Refractive Errors ◽  
Retinal Vessels ◽  
Zone Ii

Background/Aim. The aim of the study was to investigate the outcomes of temporal Zone II-sparing laser photocoagulation combined with intravitreal bevacizumab (IVB) in patients with Type 1 retinopathy of prematurity (ROP) in Zone I.Methods. Medical records of 74 eyes of 37 infants were analysed. Only infants with Type 1 ROP in Zone I were included. Thirty-two eyes were treated with temporal-sparing laser + IVB. Both Zone I and temporal Zone II were spared to minimise potential visual field loss. Forty-two eyes were treated with laser alone conventionally. Early treatment outcomes, late complications, and refractive errors were analysed.Results. The mean gestational age and birth weight of the enrolled patients were 25.7 ± 2.5 weeks and 798.8 ± 440.2 g, respectively. In the combined treatment group, plus sign regression was achieved faster (12.1 ± 6.2 days vs. 25.6 ± 21.3 days,p=0.011) and retreatment was required less (0% vs. 23.8%,p=0.004) than in the laser-alone group. Retinal/preretinal haemorrhages occurred more often in the laser-alone group (42.9% vs. 9.4%,p=0.002). Normal development of temporal retinal vessels was also observed in twelve eyes in the combined treatment group. No differences in late complications or refractive errors were observed between the groups.Conclusion. Temporal Zone II-sparing laser treatment combined with IVB showed good early treatment outcome and temporal retinal vessels development.

Аlcohol and diabetes: a double-edged stick

2021 ◽  
Author(s):  
Л.Ю. Моргунов
Keyword(s):  
Diabetes Mellitus ◽  
Alcohol Consumption ◽  
Alcoholic Beverage ◽  
Late Complications ◽  
Self Control ◽  
Alcohol Abusers ◽  
Increased Risk ◽  
Patients With Diabetes

В данной работе изучены и обобщены исследования, посвященные эпидемиологии, риску развития сахарного диабета и влиянию на сердечно-сосудистую систему пациентов с диабетом и разным уровнем потребления алкоголя. Продемонстрированы высокие затраты на лечение злоупотребляющих алкогольными напитками. Описано влияние этанола на метаболизм глюкозы и механизмы, вызывающие гипергликемию и гипогликемию, роль грелина и лептина у употребляющих алкоголь пациентов с сахарным диабетом. Уделено внимание вопросам гипокоагуляции и системного воспаления у диабетиков, употребляющих этанол. Отдельно показано влияние алкоголя на пациентов с сахарным диабетом 1 типа. Описано влияние алкоголя на развитие атеросклероза, а также поздних осложнений сахарного диабета, таких как диабетическая ангиопатия нижних конечностей. Продемонстрировано влияние предпочтений алкогольных напитков на риски развития сахарного диабета. Подчеркнута низкая приверженность к самоконтролю у употребляющих этанол пациентов с сахарным диабетом. Показано, что употребление небольшого или среднего количества алкоголя снижает заболеваемость сахарным диабетом в большинстве исследований, в то время как сильно пьющие пациенты подвергаются повышенному риску развития этого заболевания. У людей с сахарным диабетом употребление алкоголя от легкого до умеренного снижает риск сердечно-сосудистых заболеваний и смертности от всех причин. Тип алкогольного напитка, пол и, вероятно, индекс массы тела – факторы, влияющие на эти результаты. This article examines and summarizes studies on the epidemiology, risk of developing diabetes, and the influence on the cardiovascular system of patients with diabetes and different levels of alcohol consumption. High costs for the treatment of alcohol abusers have been demonstrated. The article describes the effect of ethanol on glucose metabolism and the mechanisms that cause hyperglycemia and hypoglycemia, the role of ghrelin and leptin in alcohol-consuming patients with diabetes mellitus. Attention is paid to the issues of hypocoagulation and systemic inflammation in diabetics who use ethanol. The effect of alcohol on patients with type 1 diabetes mellitus is shown separately. The influence of alcohol on the development of atherosclerosis, as well as late complications of diabetes mellitus, such as diabetic angiopathy of the lower extremities, is described. The influence of alcoholic beverage preferences on the risk of developing diabetes mellitus has been demonstrated. Low adherence to self-control in ethanol-consuming patients with diabetes mellitus is emphasized.Drinking small or medium amounts of alcohol has been shown to reduce the incidence of diabetes in most studies, while heavy drinkers are at an increased risk of developing the disease. In people with diabetes, light to moderate alcohol consumption reduces the risk of cardiovascular disease and all-cause mortality. The type of alcoholic drink, gender, and probably body mass index are factors that influence these results.

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