scholarly journals Invasive Squamous Cell Carcinoma of the Cervix in Pregnancy: A Case Report

2020 ◽  
pp. 30-34
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Cervical Carcinoma ◽  
Squamous Cell ◽  
Early Stage ◽  
Cervical Squamous Cell Carcinoma ◽  
Disease Stage ◽  
Invasive Squamous Cell Carcinoma ◽  
Squamous Cell Cervical Carcinoma ◽  
Common Histological Type

Cervical squamous cell carcinoma is the most common histological type of carcinoma in the uterine cervix, but during pregnancy is relativity uncommon, with an incidence of 0.8 to 1.5 cases per 10,000 births. Cervical squamous cell carcinoma is the leading cause of death among women aged 35 to 54 years and the second most common cause among women aged 15 to 34 years after breast carcinoma. Most patients are diagnosed at an early stage of the disease, probably due to routine prenatal screening. The occurrence of invasive cervical carcinoma is relatively uncommon in pregnant women. However, cancer treatment during pregnancy currently remains one of the main and biggest therapeutic challenges in cervical cancer. The therapeutic approach should be customized and depends mainly on histology, disease stage, and gestational age. We present a case concerning a 26-year-old woman with invasive moderately differentiated keratinizing squamous cell cervical carcinoma, stage pT2b, N1, M0/ FIGOIIB, during pregnancy (4th lunar month).

Recurrence during pregnancy of a conservatively treated early-stage cervical squamous cell carcinoma

2011 ◽  
Vol 95 (1) ◽  
pp. 290.e13-290.e16 ◽  
Author(s):  
Pascale Jadoul ◽  
Denis Querleu ◽  
Jean-Luc Squifflet ◽  
Jacques Donnez
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Early Stage ◽  
Cervical Squamous Cell Carcinoma

The Contrast Research of Human Papillomavirus Infection Genotypes in Tissues of Cervical Squamous Cell Carcinoma and Cervical Adenocarcinoma

2019 ◽  
Vol 11 (11) ◽  
pp. 1595-1602
Author(s):  
Qijun Wan ◽  
Xin Chen ◽  
Jianxiang Geng ◽  
Xue Zhao
Keyword(s):  
Squamous Cell Carcinoma ◽  
Human Papillomavirus ◽  
Cell Carcinoma ◽  
Cervical Carcinoma ◽  
Squamous Cell ◽  
Detection Rate ◽  
Cervical Squamous Cell Carcinoma ◽  
Cervical Adenocarcinoma ◽  
Detection Rates ◽  
Hpv Genotypes

The large sample data of HPV genotypes on cervical squamous cell carcinoma (CSCC) and cervical adenocarcinoma (CAC) tissues are rarely reported in China. This study is aimed to investigate the clinical value of distribution of different kinds of genotypes of human papillomavirus (HPV) within regional (mainly in Jiangsu Province in China) patients of both CSCC and CAC. We collected tissue samples of from 1044 women with CSC (826 cases) and CAC (218 cases) in 29 hospitals of 6 Provinces in China from November 1978 to December 2017. HPV DNA was extracted and 23 genotypes of HPV were detected through the combination of gene-chip and polymerase chain reaction (PCR) technology to analyze distribution of HPV infection types among subjects of CSCC and CAC. Among 1044 cases of CSCC and CAC, 901 were found HPV positive making total HPV detection rate of 86.30% (901/1044). Total detection rate of CSCC was 91.53% (756/826) in which 16, 18, 58, 33, 52, 31 were the most common types where detection frequencies of 16 and 18 types were 56.84% (544/957) and 9.93% (95/957), respectively. Total detection rate of CAC was 66.51% (145/218) in which 16, 18, 31, 33, 52, 58 were the most common types where detection frequencies of 16 and 18 types were 35.29% (84/238) and 32.35% (77/238), respectively. The HPV detection rates were different in female CSCC and CAC tissues of region studied. The 16, 18, 31, 33, 52 and 58 types are the most common genotypes found in two sorts of cervical carcinoma tissues. The detection rate of 16 types was higher than 18 types in CSCC and were very close in CAC tissues. Conducting HPV genotypes detection of CSCC and CAC will help doctors evaluating onset risk of cervical carcinoma and tracking HPV infected patients with high cancerogenic risk. The early detection will play important role in prevention and treatment of female CSCC and CAC in our nation.

Stat3 Expression in Oral Squamous Cell Carcinoma: Association with Clinicopathological Parameters and Survival

2006 ◽  
Vol 21 (3) ◽  
pp. 175-183 ◽  
Author(s):  
N.G. Shah ◽  
T.I. Trivedi ◽  
R.A. Tankshali ◽  
J.A. Goswami ◽  
D.H. Jetly ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Early Stage ◽  
Disease Stage ◽  
Clinicopathological Parameters ◽  
Early Event ◽  
Advanced Stage ◽  
Intense Staining

The present study sought to explore the occurrence of signal transducer and activator of transcription 3 (Stat3) in patients with oral squamous cell carcinoma (n=135) and its potential relationship with clinicopathological parameters and survival. Stat3 expression was studied by immunohistochemistry. Cytoplasmic or nuclear localization of Stat3 was observed in 62% of patients, whereas only nuclear Stat3 expression was found in 44%. Stat3 positivity in early-stage patients was 45% compared to 79% in advanced-stage patients. However, early-stage Stat3-positive patients showed a gradual increase in staining intensity, with intense staining seen in 52% of the tumors compared to 18% in Stat3-positive advanced-stage patients, where a gradual decrease in intensity expression was observed (p=0.001). Stat3 showed a significant positive correlation with disease stage (p=0.001), nodal status (p=0.033) and tumor size (p=0.001). Multivariate survival analysis using the Cox proportional hazard regression model showed that nuclear Stat3 was a significant independent prognosticator for both relapse-free survival (p=0.014) and overall survival (p=0.042) in early-stage patients. Our results indicated that Stat3 activation is an early event in oral squamous cell carcinoma and represents a potential risk factor for poor prognosis in early-stage patients.

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