scholarly journals HISTOPLASMOSIS IN NON-HIV IMMUNOCOMPROMISED PATIENT RESIDING IN A NON-ENDEMIC AREA IN BRAZIL

2021 ◽  
Vol 23 (2) ◽  
pp. 1-9
Author(s):  
Thatyana Siqueira Gonçalves ◽  
Laura Pazinato Ritter ◽  
Taiguara Fraga Guimarães ◽  
Cássia Silva de Miranda Godoy ◽  
Renata De Bastos Ascenço Soares
Keyword(s):  
Case Report ◽  
Cervical Lymph Node ◽  
Endemic Area ◽  
Histoplasma Capsulatum ◽  
Immunocompromised Patient ◽  
Endemic Region ◽  
Drug Induced ◽  
Geographic Expansion ◽  
Continuous Use ◽  
Node Culture

Introduction: Histoplasmosis is a fungal disease, caused by Histoplasma capsulatum. Goal: To report a case of an immunocompromised patient with diagnosis of histoplasmosis in a non-endemic region. Methodology: Case report. Case report: Patient carrier of rheumatoid arthritis, makes continuous use of methotrexate and has reported contact with large amount of bat guano. Result of cervical lymph node culture was positive for H. capsulatum. Discussion: The infection was presented related to drug-induced immunosuppression in a non-endemic area. Conclusion: In view of the location where the infection occurred, the geographic expansion of the disease and the importance of this report for the literature are clear.

scholarly journals Histoplasma capsulatum and Mycobacterium avium co-infection in an immunocompromised patient: Case report and literature review

2020 ◽  
Vol 28 ◽  
pp. 29-32
Author(s):  
Rossana Patricia Basso ◽  
Vanice Rodrigues Poester ◽  
Jussara Maria Silveira ◽  
Roseli Stone Vieira ◽  
Luisa Dias da Mota ◽  
...  
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Mycobacterium Avium ◽  
Histoplasma Capsulatum ◽  
Immunocompromised Patient ◽  
Patient Case

scholarly journals Diffuse leptomeningeal glioneuronal tumor with high-grade features masquerading as tubercular meningitis—a case report

2021 ◽  
Vol 52 (1) ◽  
Author(s):  
Sameer Peer ◽  
Vivek Murumkar ◽  
Karthik Kulanthaivelu ◽  
Chandrajit Prasad ◽  
Shilpa Rao ◽  
...  
Keyword(s):  
Case Report ◽  
Early Diagnosis ◽  
Histopathological Examination ◽  
Glioneuronal Tumor ◽  
Communicating Hydrocephalus ◽  
High Grade ◽  
Endemic Region ◽  
Tubercular Meningitis ◽  
Leptomeningeal Enhancement ◽  
Diffuse Leptomeningeal Glioneuronal Tumor

Abstract Background Diffuse leptomeningeal glioneuronal tumor (DLGNT) has been recently described in the literature. The complete neuroimaging spectrum and histopathological characteristics of this entity are yet to be elucidated. In an endemic region, diffuse leptomeningeal enhancement on neuroimaging with associated communicating hydrocephalus is usually suggestive of infective meningitis and the patients are started on empirical anti-microbial therapy. However, it is important to consider other differential diagnosis of leptomeningeal enhancement in such cases, particularly if the clinical condition does not improve on anti-microbial therapy. An early diagnosis of a neoplastic etiology may be of particular importance as the treatment regimens vary considerably depending on the underlying disease condition. Case presentation In this case report, we describe a case of DLGNT with high-grade histopathological features which was initially managed as tubercular meningitis based on the initial neuroimaging findings. Due to worsening of the clinical course and subsequent imaging findings at follow-up, a diagnosis of DLGNT was considered and subsequently proven to be DLGNT with features of anaplasia on histopathological examination of leptomeningeal biopsy specimen. Conclusion This case highlights the importance of recognizing certain subtle finding on MRI which may help in an early diagnosis of DLGNT which is crucial for appropriate treatment.

scholarly journals Severe Adverse Drug Reactions to Quetiapine in Two Patients Carrying CYP2D6*4 Variants: A Case Report

2021 ◽  
Vol 22 (12) ◽  
pp. 6480
Author(s):  
Céline K. Stäuble ◽  
Markus L. Lampert ◽  
Thorsten Mikoteit ◽  
Martin Hatzinger ◽  
Kurt E. Hersberger ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Case Report ◽  
Adverse Drug Reactions ◽  
Active Metabolite ◽  
Hepatic Metabolism ◽  
Cytochrome P450 3A4 ◽  
Drug Reactions ◽  
Drug Induced ◽  
Potential Impact ◽  
Intermediate Metabolizer

We report two cases of patients who developed severe adverse drug reactions including persistent movement disorders, nausea, and vertigo during treatment with quetiapine at maximum daily doses ranging between 300 and 400 mg. The extensive hepatic metabolism of quetiapine is mainly attributed to cytochrome P450 3A4 (CYP3A4). However, there is recent evidence supporting the idea of CYP2D6 playing a role in the clearance of the quetiapine active metabolite norquetiapine. Interestingly, both patients we are reporting of are carriers of the CYP2D6*4 variant, predicting an intermediate metabolizer phenotype. Additionally, co-medication with a known CYP2D6 inhibitor and renal impairment might have further affected quetiapine pharmacokinetics. The herein reported cases could spark a discussion on the potential impact of a patient’s pharmacogenetic predisposition in the treatment with quetiapine. However, further studies are warranted to promote the adoption of pharmacogenetic testing for the prevention of drug-induced toxicities associated with quetiapine.

Drug‐induced Grover’s disease: a case report and review of the literature

2021 ◽  
Author(s):  
Olufolakemi Awe ◽  
Peter Pavlidakey ◽  
Lauren Kole ◽  
Rebecca Kissel
Keyword(s):  
Case Report ◽  
Review Of The Literature ◽  
Drug Induced ◽  
Grover’S Disease

Omalizumab for the Treatment of Persistent Drug Induced Urticaria Elicited by Thienopyridines: A Case Report

2020 ◽  
Vol 19 (3) ◽  
pp. 335-339 ◽  
Author(s):  
Gianfranco Calogiuri ◽  
Eustachio Nettis ◽  
Alessandro Mandurino-Mirizzi ◽  
Elisabetta Di Leo ◽  
Luigi Macchia ◽  
...  
Keyword(s):  
Case Report ◽  
Stent Placement ◽  
Coronary Stent ◽  
Drug Induced

The anti-IgE Omalizumab may be helpful to treat clopidogrel hypersensitivity without stopping thienopyridine administration in patients requirining continuous antiplatellet therapy after coronary stent placement.

scholarly journals Varicella vaccine strain infection in a non-immunocompromised patient. A case report and review of literature

2020 ◽  
pp. 1-3
Author(s):  
Rana Swed-Tobia ◽  
Imad Kassis ◽  
Suhair Hanna ◽  
Moran Szwarcwort-Cohen ◽  
Sara Dovrat ◽  
...  
Keyword(s):  
Case Report ◽  
Vaccine Strain ◽  
Immunocompromised Patient ◽  
Varicella Vaccine ◽  
Review Of Literature

scholarly journals Case Report: Oxaliplatin-Induced Immune-Mediated Thrombocytopenia

2018 ◽  
Vol 11 (3) ◽  
pp. 880-882 ◽  
Author(s):  
Elizabeth Pan ◽  
Eric Hsieh ◽  
Caroline Piatek
Keyword(s):  
Case Report ◽  
Cancer Therapy ◽  
Cancer Patients ◽  
Immune Thrombocytopenia ◽  
Drug Induced ◽  
Gastrointestinal Malignancies ◽  
Common Cause ◽  
Immune Mediated ◽  
Chemotherapy Agents ◽  
Platinum Derivative

Thrombocytopenia is a frequent complication of cancer may be due to a variety of causes including malignancy itself, acute disease processes, or cancer therapy. Systemic cancer therapy is the most common cause of thrombocytopenia in cancer patients observed nearly two-thirds of patients with solid tumors. Thrombocytopenia with traditional chemotherapy agents is most frequently the result of megakaryocyte cytotoxicity. Oxaliplatin is a platinum derivative commonly used in gastrointestinal malignancies and is associated with drug-induced immune thrombocytopenia.

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