scholarly journals AN EXPERIMENTAL EVALUATION OF Andrographis macrobotrys Nees., A FOLK MEDICINAL PLANT FOR ANALGESIC ACTION IN WISTAR ALBINO RATS AND SWISS ALBINO MICE- IN VIVO STUDY

2021 ◽  
Vol 9 (8) ◽  
pp. 1688-1697
Author(s):  
Ranjitha S ◽  
Chandrakanth Bhat
Keyword(s):  
Medicinal Plant ◽  
Research Work ◽  
Albino Rats ◽  
Test Drug ◽  
Analgesic Action ◽  
Swiss Albino Mice ◽  
Wide Range ◽  
Albino Mice ◽  
Wistar Albino Rats

Background and objective: In India Medicinal plants have a wide range of uses in folk medical practice. An- drographis macrobotrys Nees. belongs to Acanthaceae family is found in South India and Srilanka. It is in folk use by tribes in Kerala to treat muscle pain, snakebite, fever, and jaundice. The present research work aims to evaluate test drugs for their analgesic action. Methods: The detailed review of the test drug and disease Pain has been carried out. An animal experimental study has been carried out to assess the analgesic activity of the drug by acetic acid- induced writhing movement in Swiss albino mice and Eddy’s hot plate method in Wistar albino rats. Results and conclusion: The test drug showed analgesic action with Swarasa of leaves and Kashaya of the whole plant. The drug was found to have both peripheral and central analgesic action. Keywords: Andrographis macrobotrys Nees., Acanthaceae, folk medicinal plant, Analgesic action

Secondary metabolites from Lantana camara L. flowers extract exhibit in vivo anti-urolithiatic activity in adult Wistar albino rats

2020 ◽  
pp. 1-4
Author(s):  
Marwa I. Ezzat ◽  
Salsabeel N. El Gendy ◽  
Ahmed S. Saad ◽  
Walied S. Abdo ◽  
Aly M. EL Sayed ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Lantana Camara ◽  
Albino Rats ◽  
Wistar Albino Rats

Phenolic profile, Anti-inflammatory and Diuretic properties of Asplenium ceterach tested on Albino mice and Wistar albino rats

2020 ◽  
Vol 13 (6) ◽  
pp. 449-454
Author(s):  
Rekia Sidhoum ◽  
Mostapha Bachir bey ◽  
Latifa Halli ◽  
Othmane Yalaoui ◽  
Asma Belkadi
Keyword(s):  
Albino Rats ◽  
Phenolic Profile ◽  
Albino Mice ◽  
Anti Inflammatory ◽  
Wistar Albino Rats

scholarly journals In vivo antiplasmodial properties of fractions and flavonoids of Pseudarthria hooheri Wight & Arn. (Fabaceae)

2022 ◽  
Author(s):  
Joseph Tchamgoue ◽  
Amelework N. Eyado ◽  
Boniface P. Kamdem Kamdem ◽  
Yvan Anderson T. Ngandjui Ngandjui ◽  
Jean Claude Tchouankeu ◽  
...  
Keyword(s):  
Acute Toxicity ◽  
Malaria Treatment ◽  
Antiplasmodial Activity ◽  
Swiss Albino Mice ◽  
Treatment Situation ◽  
Healthy Female ◽  
Etoac Fraction ◽  
Albino Mice ◽  
Main Components

Malaria is regarded as one of the most lethal diseases. Resistance to artemisinin and its derivatives jeopardises effective malaria treatment. Finding novel antimalarial chemicals is critical given the existing treatment situation. This work aimed to examine the antiplasmodial capabilities of <i>Pseudarthria hookeri</i> fractions and flavonoids in vivo. The fractions and compounds antiplasmodial activity were evaluated on male Swiss albino mice infected with <i>Plasmodium berghei</i>, and on healthy female Swiss albino mice, the crude extract's acute toxicity was assessed. The EtOAc fraction had significant antiplasmodial activity (32.53 percent suppression at 500 mg/kg BW) and considerably prolonged the survival period of infected mice (9.8 days) compared to control mice (7.8 days). Parasitaemia was dramatically reduced (85.01, 59.41, and 70.39 percent), and the mean survival time extended (11.33, 10.00, and 9.33 days) with 15, 20 and 35 mg/kg of quercetin (<b>1</b>), 7-O-benzyl-6-prenylpinocembrin (<b>6</b>) and 6,8-diprenyleriodictyol (<b>11</b>) (isolates of the EtOAc fraction), respectively. BW loss and PCV reduction were also averted. Moreover, at 2500 mg/kg, the crude extract of <i>P. hookeri</i> showed no acute toxicity in mice. LC-MS analysis of the EtOAc fraction enabled the identification of nine flavonoids, with <b>8</b> and <b>11</b> being the main components. The present investigation confirmed <i>P. hookeri</i>'s antiplasmodial action, substantiating its ethnomedicinal application for malaria treatment.

scholarly journals In-vivo hypoglycemic and hypolipidemic properties of Tagetes lucida alcoholic extract in streptozotocin-induced hyperglycemic Wistar albino rats

2017 ◽  
Vol 62 (2) ◽  
pp. 169-181 ◽  
Author(s):  
Samah A. Abdel-Haleem ◽  
Abeer Y. Ibrahim ◽  
Rasha F. Ismail ◽  
Nermeen M. Shaffie ◽  
S.F. Hendawy ◽  
...  
Keyword(s):  
Albino Rats ◽  
Alcoholic Extract ◽  
Wistar Albino Rats
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