scholarly journals In-vivo hypoglycemic and hypolipidemic properties of Tagetes lucida alcoholic extract in streptozotocin-induced hyperglycemic Wistar albino rats

2017 ◽  
Vol 62 (2) ◽  
pp. 169-181 ◽  
Author(s):  
Samah A. Abdel-Haleem ◽  
Abeer Y. Ibrahim ◽  
Rasha F. Ismail ◽  
Nermeen M. Shaffie ◽  
S.F. Hendawy ◽  
...  
Keyword(s):  
Albino Rats ◽  
Alcoholic Extract ◽  
Wistar Albino Rats

Anti-Hypertensive Activity of Hydro Alcoholic Extract of Cìraka Cūraṇam on High Salt Loaded Wistar Albino Rats

2021 ◽  
Vol 8 (5) ◽  
pp. 110-115
Author(s):  
Sujeethasai K ◽  
Manoharan A ◽  
Santhanakumar M
Keyword(s):  
Heart Diseases ◽  
Premature Death ◽  
Antihypertensive Activity ◽  
Albino Rats ◽  
Alcoholic Extract ◽  
Deoxycorticosterone Acetate ◽  
Wistar Albino Rats ◽  
Animal House ◽  
Hypertensive Activity

Background: Hypertension is called as Silent killer. The most important risk factor for heart diseases and stroke and it may leads to premature death. Several medicinal plants have high effective in anti-hypertensive and anti-thrombotic activity without any side effects. Aim: To evaluate the anti-hypertensive activity of hydro alcoholic extract of Cìraka cūraṇam on deoxycorticosterone acetate (DOCA) salt induced wistar albino rats. Study design: Observational in-vivo study Place and duration of study: Animal house, Dept. of Pharmacology, Arulmigu Kalasalingam College of Pharmacy, Krishnankoil, Srivilliputtur,Tamilnadu. Materials and methods: Antihypertensive activity was conducted on wistar albino rats by determining serum Sodium and Potassium levels by using semi auto analyzer (RA-50, Bayer Diagnostics), using specific kits (Auto span, India) at 500 and 550 nm respectively and left carotid artery (for recording BP) was cannulated under aseptic conditions with polyethylene cannula filled with 1% heparin in normal saline. Rest procedure, which was stated under the 2K1C-model was followed and BP was observed in terms of mm of Hg. Results: The Cìraka cūraṇam possesses strong antihypertensive effect against DOCA-salt hypertensive rats, which is evidenced by a considerable decrease in blood pressures. Keywords: Anti-hypertensive activity, Cìraka cūraṇam, Wistar albino rats, Deoxycorticosterone acetate.

Hepatoprotective Activity of Calotropis gigantea Root Bark Experimental Liver Damage Induced by D-Galactosamine in Rats

1970 ◽  
Vol 1 (3) ◽  
pp. 281-286
Author(s):  
Pradeep Deshmukh ◽  
Tanaji Nandgude ◽  
Mahendra Singh Rathode ◽  
Anil Midha ◽  
Nitin Jaiswal
Keyword(s):  
Methyl Cellulose ◽  
Hepatoprotective Activity ◽  
Albino Rats ◽  
Root Bark ◽  
Significant Activity ◽  
Alcoholic Extract ◽  
Calotropis Gigantea ◽  
Wistar Albino Rats ◽  
Experimental Liver ◽  
Hepatoprotective Drug

The suspensions of alcoholic extract of root bark of the plant Calotropis gigantea in 0.6% carboxy methyl cellulose (CMC) were evaluated for hepatoprotective activity in Wistar albino rats by inducing hepatic injury with D-galactosamine (400 mg/kg). Alcoholic extract of root bark of the plant Calotropis gigantea at an oral dose of 200 mg/kg and 400 mg/kg exhibited a significant (P<0.001, P<0.01 and P<0.05) protection effect by normalizing the levels of aspartate amino transferase (ASAT/ GOT), alanine amino transferase (ALAT/GPT), alkaline phosphatase (ALP), total bilirubin (TB), lactate dehydrogenase (LDH), which were significantly (P<0.001) increased in rats by treatment with 400 mg/kg i.p. of D-galactosamine. Silymarin (25 mg/kg), a known hepatoprotective drug used for comparison exhibited significant activity (P<0.001).

Secondary metabolites from Lantana camara L. flowers extract exhibit in vivo anti-urolithiatic activity in adult Wistar albino rats

2020 ◽  
pp. 1-4
Author(s):  
Marwa I. Ezzat ◽  
Salsabeel N. El Gendy ◽  
Ahmed S. Saad ◽  
Walied S. Abdo ◽  
Aly M. EL Sayed ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Lantana Camara ◽  
Albino Rats ◽  
Wistar Albino Rats

scholarly journals Ameliorative effect of Aerva lanata against nephrolithiasis following chronic administration of Ethylene glycol in male wistar Albino rats

2021 ◽  
Author(s):  
Ankul Singh S ◽  
Gowri K ◽  
Chitra V
Keyword(s):  
Ethylene Glycol ◽  
Urine Volume ◽  
Chronic Administration ◽  
Negative Control ◽  
Albino Rats ◽  
Standard Group ◽  
Alcoholic Extract ◽  
Health Crisis ◽  
Group I ◽  
Wistar Albino Rats

Abstract Nephrolithiasis appear to be a major health crisis among the population with serious medical related consequences throughout the lifetime of patient. The aim of the study was to evaluate the preventive effect of the hydro-alcoholic extract of A. lanata roots on Urolithiasis rats. Thirty adults male wistar Albino rats weighing 200 – 250 g were divided into five groups comprising 6 rats in each. Group I Served as positive control with water ad libitum. Group II as negative control which is disease treated group receiving 0.75% ethylene glycol mixed with drinking water for 28 days. Group III chosen as standard group receiving ethylene glycol for first 14 days and Cystone 750 mg/Kg from day 15 till day 28. Group IV and V received ethylene glycol for first 14 days and treatment regimen of LD (400 mg/Kg) and HD 800 mg/Kg orally from day 15 till day 28. Invitro studies like Nucleation, Aggregation and Growth assays were performed. Urine volume and pH was collected and observed for change in appearance, pH, odour and turbidity. Extract was given by preparing suspension and stability was observed by measuring its parameters. On Day 29, the kidneys were dissected and histopathology was done to check tubular injury. There was Increase in urine volume, enhanced excretion of urinary constituents like citrate, oxalate etc. and improving clearance rate. Improvement in pH and antioxidant activity was observed in treated groups. The extract showed that it has prominent effect on nephrolithiasis and has better safety profile in the dose given.

EVALUATION OF HEPATOPROTECTIVE EFFECTS OF SELECTED FRUIT PEEL EXTRACTS AND THEIR POLY HERBAL MIXTURE ON CCL4 INDUCED HEPATOTOXICITY: AN IN VIVO STUDY

INDIAN DRUGS ◽  
2020 ◽  
Vol 57 (09) ◽  
pp. 67-74
Author(s):  
Gana Manjusha Kondepudi ◽  
Battu Ganga Rao ◽  
P Balakrishnaiah
Keyword(s):  
Hepatoprotective Activity ◽  
Serum Markers ◽  
Albino Rats ◽  
Dependent Manner ◽  
Fruit Peel ◽  
Herbal Mixture ◽  
Wistar Albino Rats ◽  
Dose Dependent ◽  
Peel Extract

The main aim of this study was to screen the selected fruit peel extracts and their polyherbal mixture (PHM) for hepatoprotective activity. Male wistar albino rats (180-200 g), divided into 12 groups after induction of hepatotoxicity, were treated with selected fruit peel extracts and PHM and at the end of 14th day blood and liver samples were collected and analysed. The aqueous peel extract of Malus pumila was a better hepatoprotective among the selected peel extracts. The activities might be due to the conditioning of hepatocytes by protecting the integrity of the membrane from CCl4 induced leakage of serum markers into circulation. All the selected plant extracts and PHM were shown to revert back the liver enzymes to the normal values in diseased rats in a dose dependent manner. In conclusion, the selected fruit peel extracts and poly herbal mixture can be a potent hepatoprotective agent due to their antioxidant and anti-inflammatory actions.

scholarly journals Radiolabeling of methanol extracts of yarrow (Achillea millefolium l) in rats

2012 ◽  
Vol 27 (5) ◽  
pp. 294-300 ◽  
Author(s):  
Betul Cekic ◽  
Ayfer Yurt Kilcar ◽  
Fazilet Zumrut Biber Muftuler ◽  
Perihan Unak ◽  
Emin Ilker Medine
Keyword(s):  
High Performance ◽  
Imaging System ◽  
New Drugs ◽  
High Yield ◽  
Albino Rats ◽  
Imaging Studies ◽  
Biodistribution Studies ◽  
In Vivo Imaging System ◽  
Wistar Albino Rats

PURPOSE: Current study is focused on extraction with methanol, purification, labeling with 131I using iodogen method of the yarrow plant and investigating in vivo biological activity using biodistribution and imaging studies on healthy animal models. The aim of the study is to contribute plant extracts to discover new drugs in the diagnosis and treatment of several diseases. METHODS: Nine female and nine male healthy Wistar albino rats, which were approximately 100-150 g in weight, were used for biodistribution studies. For imaging studies four healthy male Balb-C mice were used. Quality control studies were done utilizing thin layer radio chromatography (TLRC) and high performance liquid chromatography (HPLC) methods. For biodistribution studies, 131I radiolabeled Peak 7 (131I-Peak 7) was sterilized and injected into the tail veil of rats and imaging studies were obtained using Kodak FX PRO in vivo Imaging System. RESULTS: The radiolabeling yield of each purified the bioactive extracts of the yarrow plant, seven peaks was between 79 and 92%. The highest radiolabeling yield was calculated for 131I radiolabeled seventh peak (131I-Peak 7) (92.78±5.04, n=5). For this reason the biodistribution and imaging studies were done for 131I-Peak 7. That's why; these studies with Peak 7 were carried out. CONCLUSION: Peak 7 was radiolabeled with 131I in high yield for using imaging and therapeutic studies in nuclear medical applications.

scholarly journals HIBISCUS ROSA SINENSIS LOADED SOLID LIPID NANOPARTICLES AND IN VIVO WOUND HEALING ACTIVITY IN WISTAR ALBINO RATS

2020 ◽  
pp. 78-83
Author(s):  
VIJAYANAND P. ◽  
JYOTHI V. ◽  
MOUNIKA A.
Keyword(s):  
Wound Healing ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Albino Rats ◽  
Herbal Extracts ◽  
Solid Lipid ◽  
Hibiscus Rosa Sinensis ◽  
Wistar Albino Rats ◽  
Wound Healing Activity

Objective: The objective of the present research was to investigate the wound-healing potency of solid lipid nano particles of Hibiscus rosa sinensis extract. Crude herbal extracts and rudimentary formulations containing herbal extracts are good for demonstrating the feasibility of the concept; however, such formulations suffer with poor oral bioavailability and variability within groups of subjects. Converting herbal extracts into novel drug delivery systems may prove effective in addressing some of these problems. Methods: In the present study an attempt was made to develop Hibiscus rosa sinensis extract loaded solid lipid nanoparticles (HSLNs) using lipids glycerol monostearate (GMS) or beeswax. The prepared HSLNs were characterised for their size, surface charge and morphology. The optimized HSLNs were incorporated into Carbopol gel and tested for wound healing activity in male Wistar albino rats using excision wound model. Results: HSLNs of ~175 nm in size carrying negative charge were obtained with the optimised procedure using beeswax. The shape of the HSLNs was nearly spherical. The HSLNs (10 mg/ml) treated wounds healed much faster compared to raw crude extract and healing was comparable to marketed preparation. Conclusion: It is concluded that converting crude herbal extracts into SLNs can be an effective way to enhance the effectiveness of herbal extracts and their in vivo activity.

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