scholarly journals Coronary Artery Aneurysm Revealed by an Acute Coronary Syndrome in a Patient with Systemic Lupus Erythematosus: A Case Report

2020 ◽  
Vol 1 (1) ◽  
pp. 20-23
Author(s):  
Adnane Hind ◽  
◽  
Serbout Saousan ◽  
El Ghali Med Benouna ◽  
Abdenasser Drighil ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Coronary Artery ◽  
Lupus Erythematosus ◽  
Artery Aneurysm ◽  
Complete Healing ◽  
Unknown Etiology ◽  
Systemic Lupus ◽  
Coronary Syndrome ◽  
Cardiac Symptoms ◽  
Coronary Aneurysms

Systemic lupus erythematosus is an autoimmune inflammatory disease of unknown etiology, the coronary lesions are extremely rare, and in particular the coronary aneurysms. We report a case of a coronary aneurysm of a patient diagnosed with Systemic lupus erythematosus who showed up at the emergency department suffering from a retro-sternal pain radiating to the jaws which he reported for 4 hours. An electrocardiogram was performed urgently and showed an offset of 2 mm in the inferior, right, basal and low lateral territories with a mirror V1, V2. The patient underwent coronary angiography which revealed an aneurysmal dilatation of the right coronary artery with multiple atheromatous aneurysms of different sizes without thrombi visualized in the lumen of the arteries. Coronary aneurysms are a fatal and has potentially fatal complications that should be considered in the diagnostic of systemic lupus erythematosus patients with cardiac symptoms as early detection may allow complete healing.

Complementary role of cardiovascular imaging and laboratory indices in early detection of cardiovascular disease in systemic lupus erythematosus

Lupus ◽  
2016 ◽  
Vol 26 (3) ◽  
pp. 227-236 ◽  
Author(s):  
S Mavrogeni ◽  
L Koutsogeorgopoulou ◽  
T Dimitroulas ◽  
G Markousis-Mavrogenis ◽  
G Kolovou
Keyword(s):  
Heart Failure ◽  
Systemic Lupus Erythematosus ◽  
Cardiovascular Disease ◽  
Coronary Artery ◽  
Lupus Erythematosus ◽  
Clinical Laboratory ◽  
Systemic Lupus ◽  
Invasive Approach ◽  
Cardiac Symptoms ◽  
Nuclear Techniques

Background Cardiovascular disease (CVD) has been documented in >50% of systemic lupus erythematosus (SLE) patients, due to a complex interplay between traditional risk factors and SLE-related factors. Various processes, such as coronary artery disease, myocarditis, dilated cardiomyopathy, vasculitis, valvular heart disease, pulmonary hypertension and heart failure, account for CVD complications in SLE. Methods Electrocardiogram (ECG), echocardiography (echo), nuclear techniques, cardiac computed tomography (CT), cardiovascular magnetic resonance (CMR) and cardiac catheterization (CCa) can detect CVD in SLE at an early stage. ECG and echo are the cornerstones of CVD evaluation in SLE. The routine use of cardiac CT and nuclear techniques is limited by radiation exposure and use of iodinated contrast agents. Additionally, nuclear techniques are also limited by low spatial resolution that does not allow detection of sub-endocardial and sub-epicardial lesions. CCa gives definitive information about coronary artery anatomy and pulmonary artery pressure and offers the possibility of interventional therapy. However, it carries the risk of invasive instrumentation. Recently, CMR was proved of great value in the evaluation of cardiac function and the detection of myocardial inflammation, stress-rest perfusion defects and fibrosis. Results An algorithm for CVD evaluation in SLE includes clinical, laboratory, ECG and echo assessment as well as CMR evaluation in patients with inconclusive findings, persistent cardiac symptoms despite normal standard evaluation, new onset of life-threatening arrhythmia/heart failure and/or as a tool to select SLE patients for CCa. Conclusions A non-invasive approach including clinical, laboratory and imaging evaluation is key for early CVD detection in SLE.

Right coronary artery aneurysm with fistula into the coronary sinus in patient with systemic lupus erythematosus

2013 ◽  
pp. 1329-1329 ◽  
Author(s):  
Anna Posadzy-Małaczyńska ◽  
Lucyna Woźnicka-Leśkiewicz ◽  
Robert Juszkat ◽  
Maciej Frankiewicz ◽  
Anna Kociemba
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Coronary Artery ◽  
Right Coronary Artery ◽  
Coronary Sinus ◽  
Lupus Erythematosus ◽  
Coronary Artery Aneurysm ◽  
Artery Aneurysm ◽  
Systemic Lupus

Myocardial Infarction in Systemic Lupus Erythematosus – the Sex Specific Risk Profile

2020 ◽  
Vol 26 ◽  
Author(s):  
Marija Vavlukis ◽  
Daniela Pop-Gjorceva ◽  
Lidija Poposka ◽  
Emilija Sandevska ◽  
Sasko Kedev
Keyword(s):  
Myocardial Infarction ◽  
Systemic Lupus Erythematosus ◽  
Cardiovascular Risk ◽  
Coronary Artery ◽  
Young Women ◽  
Lupus Erythematosus ◽  
Molecular Mechanisms ◽  
Clinical Presentation ◽  
Systemic Lupus ◽  
Antiinflammatory Therapy

Background: Accelerated atherosclerosis is widely present in patients with systemic lupus erythematosus. Objective: The aim of this review is to analyze the relationship between systemic lupus erythematosus and cardiovascular diseases, with the emphasis on acute myocardial infarction. Results: Various molecular mechanisms triggered by infection/inflammation are responsible for endothelial dysfunction and development of atherosclerosis at an earlier age. Contributing factor is the cumulative effect of traditional cardiovascular risk factors interaction with disease related characteristics. Myocardial infarction rates are 2- to 10-fold higher compared to the general population. Young women have the highest relative risk, however, men carry at least 3- fold higher risk than women. Coronary involvement varies from normal coronary artery with thrombosis, coronary microartery vasculitis, coronary arteritis, and coronary atherosclerosis. Typical clinical presentation is observed in men and older women, while atypical is more frequent in young women. Treatment is guided by the underlying mechanism, engaging invasive procedures alone, or accompanied with immunosuppressive and/or antiinflammatory therapy. There are significant gender differences in pathophysiology and clinical presentation. However, they receive the same therapeutic treatments. Conclusion: Systemic lupus erythematosus is a major contributor to atherosclerotic and non-atherosclerotic mechanisms involved in the development of myocardial infarction, which should be taken into account during therapeutic treatment. Although Systemic lupus erythematosus per se is a “female” disease, males are at increased cardiovascular risk and worse outcome. Method: We conducted a literature review through PubMed and Cochrane, using key words: SLE, atherosclerosis, atherothrombosis, coronary artery disease, myocardial infarction, prognosis, sex specifics.

Systemic lupus erythematosus and ischemic coronary artery disease

1981 ◽  
Vol 47 ◽  
pp. 446
Author(s):  
Richard R. Liberthson ◽  
Charles Homcy ◽  
Jay Fallon ◽  
Stephen Gross ◽  
Lawrence Miller
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Ischemic Coronary Artery Disease ◽  
Artery Disease
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