scholarly journals PHYSICOCHEMICAL CHARACTERIZATION OF QUERCETIN-LOADED LIPOSOMES PREPARED BY SONICATION FOR FUNCTIONAL FOOD APPLICATION

2020 ◽  
Vol 15 (6) ◽  
pp. 15-27
Author(s):  
NUR AMALINA RAMLI ◽  
◽  
NORA’AINI ALI ◽  
SOFIAH HAMZAH
Keyword(s):  
Functional Food ◽  
Encapsulation Efficiency ◽  
High Stability ◽  
Physicochemical Characterization ◽  
Phospholipid Bilayer ◽  
Loading Capacity ◽  
High Magnitude ◽  
Average Size ◽  
Probe Sonication

This research was intended to synthesize liposome as a nanocarrier to encapsulate quercetin, which is prone to degradation and susceptible to low bioavailability upon oral administration. The liposomes were synthesized by thin-film hydration method and followed by probe sonication for downsizing. Soy phosphatidylcholine (SPC) and cholesterol (CHOL) were employed as the composition of the phospholipid bilayer. Results indicated a dependence of sonication amplitude and time in the formation of free liposomes (FL). The average size of quercetin-loaded liposomes (QL) prepared was 346.4 nm with a narrow polydispersity index (0.22) and a high magnitude of zeta potential (-49.6 mV). These characterizations depict that a homogenous nanovesicle suspension with high stability was successfully synthesized. Quercetin was incorporated into the liposomes with a high encapsulation efficiency of 90.7% and loading capacity of 9.3%. This viable nanocarrier perhaps will provide ingenious protection for a wider spectrum of active agents in food and biopharmaceutical products.

Preparation and Characterization of Folate-Decorated Chitosan Microspheres as a Sustained-Release Drugs Carrier

2013 ◽  
Vol 684 ◽  
pp. 57-62 ◽  
Author(s):  
Zhi Hua Xing
Keyword(s):  
Encapsulation Efficiency ◽  
Average Particle Size ◽  
Morphological Characteristics ◽  
Average Particle ◽  
Loading Capacity ◽  
Chitosan Microspheres ◽  
Ionic Crosslinking ◽  
Artificial Gastric Juice

Folic acid-chitosan (FA-CTS) and 10-hydroxycamptothecin (HCPT)-loaded folate-conjugated chitosan (FA-CTS/HCPT) microspheres were prepared by the ionic crosslinking method.The morphological characteristics of microspheres were examined using a scanning electron microscope (SEM). The average particle size and size distribution were determined by dynamic light scattering. The drug encapsulation efficiency (EE) , loading capacity (LC)and release characteristics in vitro were determined using ultraviolet spectrophotometer.The results shown that the microspheres are uniform spherical and regular with a size between 19.79 and81.40μm.Optimized preparation parameters lead to the successful preparation of hydroxycamptothecin-loaded folate-conjugated chitosan microspheres characterized with encapsulation efficiency and loading capacity up to (86.8±0.1)% and 20.6±0.3 % respectively. More then 90% of 10-hydroxycamptothecin was released from microspheres in 4 h at artificial gastric juice, 8h at artificial small intestinal fluid with a good delayed release effect.

Optimization and Physicochemical Characterization of Chitosan and Chitosan Nanoparticles Extracted from the Crayfish Procambarus clarkii Wastes

2019 ◽  
Vol 38 (2) ◽  
pp. 385 ◽  
Author(s):  
Marwa M. El-Naggar ◽  
Wael S. I. Abou-Elmagd ◽  
Ashraf Suloma ◽  
Hamza A. El-Shabaka ◽  
Magdy T. Khalil ◽  
...  
Keyword(s):  
Procambarus Clarkii ◽  
Chitosan Nanoparticles ◽  
Physicochemical Characterization

Physicochemical Characterization of Solid Dispersions of Cefdinir with PVP K-30 and PEG 4000

2010 ◽  
Vol 3 (2) ◽  
pp. 948-956
Author(s):  
Kumar P ◽  
S Kumar ◽  
A Kumar ◽  
M Chander
Keyword(s):  
Solid Dispersions ◽  
Physicochemical Characterization ◽  
Drug Carriers ◽  
Dissolution Properties ◽  
Rate Of Dissolution ◽  
Peg 4000 ◽  
Release Studies ◽  
Crystalline Nature ◽  
Physical Mixtures

The purpose of this study was to prepare and characterize solid dispersions of the antibacterial agent Cefdinir with PEG 4000 and PVP K-30 with a view to improve its dissolution properties. Investigations of the properties of the dispersions were performed using release studies, X-ray powder diffraction (XRD) and Fourier transform infrared (FTIR). The results obtained showed that the rate of dissolution of Cefdinir was considerably improved when formulated in solid dispersions with PVP K-30 and PEG 4000 as compared with pure drug and physical mixtures. The results from XRD studies showed the transition of crystalline nature of drug to amorphous form, while FTIR studies demonstrated the absence of drug-carriers interaction.

Purification and Physicochemical Characterization of a Trypsin Inhibitor from Cassia absus Linn

2013 ◽  
Vol 21 (2) ◽  
pp. 108-114 ◽  
Author(s):  
Girijesh Patel ◽  
Amit Gupta ◽  
Akshita Gupta ◽  
Manisha Mishra ◽  
Pradhyumna Singh ◽  
...  
Keyword(s):  
Trypsin Inhibitor ◽  
Physicochemical Characterization

Physicochemical characterization of peptides and proteins by capillary electromigration methods

2005 ◽  
Author(s):  
Václav Kašička ◽  
Dušan Koval ◽  
Veronika Šolínová ◽  
Petra Sázelová ◽  
Zdeněk Prusík
Keyword(s):  
Physicochemical Characterization

scholarly journals Microscopic Image Segmentation and Morphological Characterization of Novel Chitosan/Silica Nanoparticle/Nisin Films Using Antimicrobial Technique for Blueberry Preservation

Membranes ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 303
Author(s):  
Rokayya Sami ◽  
Schahrazad Soltane ◽  
Mahmoud Helal
Keyword(s):  
Ph Value ◽  
Silica Nanoparticle ◽  
Morphological Characterization ◽  
Aerobic Bacteria ◽  
Nano Materials ◽  
Elongation At Break ◽  
Stable Suspension ◽  
Average Size ◽  
Material Ductility

In the current work, the characterization of novel chitosan/silica nanoparticle/nisin films with the addition of nisin as an antimicrobial technique for blueberry preservation during storage is investigated. Chitosan/Silica Nanoparticle/N (CH-SN-N) films presented a stable suspension as the surface loads (45.9 mV) and the distribution was considered broad (0.62). The result shows that the pH value was increased gradually with the addition of nisin to 4.12, while the turbidity was the highest at 0.39. The content of the insoluble matter and contact angle were the highest for the Chitosan/Silica Nanoparticle (CH-SN) film at 5.68%. The use of nano-materials in chitosan films decreased the material ductility, reduced the tensile strength and elongation-at-break of the membrane. The coated blueberries with Chitosan/Silica Nanoparticle/N films reported the lowest microbial contamination counts at 2.82 log CFU/g followed by Chitosan/Silica Nanoparticle at 3.73 and 3.58 log CFU/g for the aerobic bacteria, molds, and yeasts population, respectively. It was observed that (CH) film extracted 94 regions with an average size of 449.10, at the same time (CH-SN) film extracted 169 regions with an average size of 130.53. The (CH-SN-N) film presented the best result at 5.19%. It could be observed that the size of the total region of the fruit for the (CH) case was the smallest (1663 pixels), which implied that the fruit lost moisture content. As a conclusion, (CH-SN-N) film is recommended for blueberry preservation to prolong the shelf-life during storage.

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