MANAGEMENT OF ORAL LICHEN PLANUS TRIGGERED BY STRESS

Introduction: Oral lichen planus (OLP) is a mucocutaneous disorder that rarely occurs around us and only involves the layer of the stratified squamous epithelium. Oral lichen planus is more common in women aged 30-65 years. The etiology of this disorder is not yet known, but there are several predisposing factors that play a role, such as hepatitis C virus infection, food, drugs, malignancy, and psychological factors. Purpose: This case report aims to describe the treatment of stress-induced OLP. Case Report: A 46-year-old man presented with complaints of stinging on the inner right and left cheeks for one month ago. The patient admits that he has a lot of thoughts related to family problems. It is found that the lesion resembles a white streak with redness that forms in the intraoral area. Case management: The patient was given therapy in the form of topical corticosteroids and consulted to psychiatry and got improvement after 1 week of treatment. Discussion: The treatment of OLP lesions is a treatment that requires collaboration between the dentist, the patient and the patient's family. Corticosteroid therapy is the gold standard treatment given to people with OLP. Corticosteroids are widely used in medicine because of their strong effect and fast anti-inflammatory reaction. Corticosteroids are widely used for the management of inflammatory diseases. Besides supporting therapy in consultation with a psychologist or psychiatrist to deal with stress disorders. Conclusion: Treatment of OLP lesions is a complex treatment. Corticosteroid therapy, both topical and systemic, is the most appropriate therapy and the role of a psychologist or psychiatrist is needed in managing patient stress to increase the percentage of patient recovery.

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Squamous cell carcinoma arising in oral lichen planus – case report and literature review

ORL ro ◽

10.26416/orl.48.3.2020.3748 ◽

2020 ◽

Vol 3 (48) ◽

pp. 15

Author(s):

Corina I. Cucu ◽

Liliana Gabriela Popa ◽

Călin Giurcăneanu ◽

Vladimir S. Ibric Cioran ◽

Cristina Beiu ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Case Report ◽

Literature Review ◽

Cell Carcinoma ◽

Lichen Planus ◽

Squamous Cell ◽

Oral Lichen Planus ◽

Oral Lichen

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Salivary mir-27b Expression in Oral Lichen Planus Patients: A Series of Cases and a Narrative Review of Literature

Current Topics in Medicinal Chemistry ◽

10.2174/1568026619666191121144407 ◽

2020 ◽

Vol 19 (31) ◽

pp. 2816-2823 ◽

Cited By ~ 3

Author(s):

Dario Di Stasio ◽

Laura Mosca ◽

Alberta Lucchese ◽

Donatella Delle Cave ◽

Hiromichi Kawasaki ◽

...

Keyword(s):

Lichen Planus ◽

Oral Lichen Planus ◽

Inflammatory Diseases ◽

Biological Fluids ◽

Critical Role ◽

Invasive Procedure ◽

Control Group ◽

Study Group ◽

Immune Functions ◽

Oral Lichen

Background: microRNAs play a critical role in auto-immunity, cell proliferation, differentiation and cell death. miRNAs are present in all biological fluids, and their expression is essential in maintaining regular immune functions and preventing autoimmunity, whereas miRNA dysregulation may be associated with the pathogenesis of autoimmune and inflammatory diseases. Oral lichen planus (OLP) is an inflammatory disease mediated by cytotoxic T cells attack against epithelial cells. The present study aims to perform a specific microRNA expression profile through the analysis of saliva in this disease. Methods: The study group was formed by five patients (mean age 62.8±1.98 years; 3 females/2 males) affected by oral lichen planus and control group by five healthy subjects (mean age 59.8 years±2.3; 3 females/ 2 males); using a low-density microarray analysis, we recorded a total of 98 differentially expressed miRNAs in the saliva of patients with oral lichen planus compared to the control group. The validation was performed for miR-27b with qRT-PCR in all saliva samples of oral lichen planus group. Results: 89 miRNAs were up-regulated and nine down-regulated. In details, levels of miR-21, miR- 125b, miR-203 and miR15b were increased (p<0.001) in study group while levels of miR-27b were about 3.0-fold decreased compared to controls (p<0.001) of miR-27b expression in OLP saliva. QRTPCR validation confirmed the down regulation of miR-27b in all saliva samples. Conclusions: Collecting saliva samples is a non-invasive procedure and is well accepted by all patients. microRNAs can be readily isolated and identified and can represent useful biomarkers of OLP.

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