Kidney cysts in a capuchin monkey (Sapajus libidinosus) – case report

2017 ◽  
Vol XXII (128) ◽  
pp. 62-68
Author(s):  
Géssica Giselle A. Silva Araújo ◽  
Angélica da Costa F. de Souza ◽  
Vanja de Andrade Gueiros ◽  
Simone Bopp ◽  
Jacinta Eufrásia Brito Leite ◽  
...  
Keyword(s):  
Renal Cysts ◽  
Hepatic Cyst ◽  
Capuchin Monkey ◽  
Cystic Lesions ◽  
Polycystic Kidney ◽  
Sonographic Examination ◽  
Clinical Criteria ◽  
Abdominal Organs ◽  
The Right

Cystic lesions in the renal parenchyma can be attributed to several types of pathologic conditions, such as acquired renal cysts and polycystic kidney disease. Some clinical criteria are used to distinguish between these two diseases. Ultrasonography aids in the characterization of cystic lesions in the abdominal organs, allowing the diagnosis of these diseases. We hereby report the case of a young adult female capuchin monkey (Sapajus libidinosus) submitted to clinical and sonographic examination in order to evaluate its health prior to reintroducing the animal in nature. Physical examination did not reveal any type of alteration. However, the ultrasonogram disclosed the presence of some renal cysts in the right kidney, as well as a hepatic cyst. There are very few reports in the literature of the presence of renal cysts in primates.

scholarly journals Pelvic Kidney Mimicking Skeletal Metastasis on Bone Scan- Interesting Image

2021 ◽  
Vol 22 (2) ◽  
pp. 155-156
Author(s):  
Mohammed Mehedi Al Zahid Bhuiyan ◽  
Azmal Kabir Sarker ◽  
Hongyoon Choi ◽  
Minseok Suh ◽  
Gi Jeong Cheon
Keyword(s):  
Bone Scan ◽  
Left Kidney ◽  
Renal Cysts ◽  
Skeletal Metastasis ◽  
Breast Conserving Surgery ◽  
Left Breast ◽  
Lymph Node Biopsy ◽  
Hepatic Cyst ◽  
Large Area ◽  
The Right

A 57-year-old female patient underwent left breast-conserving surgery with sentinel lymph node biopsy for Left breast carcinoma (stage IIA). The patient had hypertension and diabetes mellitus. Other findings include multiple hepatic cyst, bilateral renal cysts and uterine myoma. She had no significant renal symptoms and her liver &renal function test were normal.She was sent for Technetium-99m-methylene diphosphonate (99mTc-MDP) bone scan. There was a large area of intense tracer concentration in the region of right sacro-iliac (SI) joint which appeared like an osteoblastic metastasis at first glance. However, absence of uptake in the right renal fossa with the left kidney being normal in position contemplated the probability of right-sidedpelvickidneywhich was confirmed later by a contrast enhanced computerized tomography (CT) scan of abdomen that showed a pelvic right kidney overlying the sacrum. Bangladesh J. Nuclear Med. 22(2): 155-156, Jul 2019

scholarly journals Functional Characterization of the mazEF Toxin-Antitoxin System in the Pathogenic Bacterium Agrobacterium tumefaciens

2021 ◽  
Vol 9 (5) ◽  
pp. 1107
Author(s):  
Wonho Choi ◽  
Yoshihiro Yamaguchi ◽  
Ji-Young Park ◽  
Sang-Hyun Park ◽  
Hyeok-Won Lee ◽  
...  
Keyword(s):  
Agrobacterium Tumefaciens ◽  
Physiological Function ◽  
Functional Characterization ◽  
Site Directed Mutagenesis ◽  
In Vitro Assays ◽  
Cell Growth Inhibition ◽  
The Right

Agrobacterium tumefaciens is a pathogen of various plants which transfers its own DNA (T-DNA) to the host plants. It is used for producing genetically modified plants with this ability. To control T-DNA transfer to the right place, toxin-antitoxin (TA) systems of A. tumefaciens were used to control the target site of transfer without any unintentional targeting. Here, we describe a toxin-antitoxin system, Atu0939 (mazE-at) and Atu0940 (mazF-at), in the chromosome of Agrobacterium tumefaciens. The toxin in the TA system has 33.3% identity and 45.5% similarity with MazF in Escherichia coli. The expression of MazF-at caused cell growth inhibition, while cells with MazF-at co-expressed with MazE-at grew normally. In vivo and in vitro assays revealed that MazF-at inhibited protein synthesis by decreasing the cellular mRNA stability. Moreover, the catalytic residue of MazF-at was determined to be the 24th glutamic acid using site-directed mutagenesis. From the results, we concluded that MazF-at is a type II toxin-antitoxin system and a ribosome-independent endoribonuclease. Here, we characterized a TA system in A. tumefaciens whose understanding might help to find its physiological function and to develop further applications.

scholarly journals Evaluation of Cystic and Solid Renal Lesions with Contrast-Enhanced Ultrasound: A Retrospective Study

2021 ◽  
Vol 07 (01) ◽  
pp. E25-E34
Author(s):  
Arash Najafi ◽  
Michael Wildt ◽  
Nicolin Hainc ◽  
Joachim Hohmann
Keyword(s):  
Final Diagnosis ◽  
Cystic Lesions ◽  
Likelihood Ratios ◽  
Renal Lesions ◽  
Contrast Enhanced ◽  
Potentially Malignant ◽  
Sensitivity Specificity ◽  
Solid Lesions ◽  
Conclusive Diagnosis

Abstract Purpose Renal lesions are frequent random findings on CT, MRI, and conventional ultrasound. Since they are usually found accidentally, the respective examinations have not been performed optimally to provide a conclusive diagnosis, making additional multiphase contrast-enhanced examinations necessary. The aim of the study is to correlate CEUS findings with the final diagnosis and to determine whether it is a suitable method for the conclusive characterization of undetermined renal lesions. Materials and Methods All CEUS examinations of focal renal lesions performed at our institute between 2007 and 2014 were retrospectively examined. 437 patients with a total of 491 lesions and 543 examinations were included. 54 patients had bilateral lesions. One patient had three lesions in one kidney. Histology was available in 49 cases and follow-ups in 124 cases. The sensitivity, specificity, positive and negative predictive value as well as positive and negative likelihood ratios were calculated. Results There were 54 malignant and 437 benign lesions. The sensitivity and specificity were 0.981/0.954 overall, 1.000/0.956 for cystic lesions, 0.977/0.906 for solid lesions, and 0.971/0.071 for the histologically confirmed lesions. Bosniak classification was consistent in 289 of 301 lesions (96%). Only 12 lesions (3.9%) were falsely assessed as malignant. Conclusion CEUS is an appropriate method for the clarification of undetermined renal lesions. The characterization of cystic lesions according to Bosniak is adequately possible, especially for potentially malignant lesions (types III and IV).

scholarly journals The orthopedic characterization of cfap298tm304 mutants validate zebrafish to faithfully model human AIS

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Marie-Hardy Laura ◽  
Cantaut-Belarif Yasmine ◽  
Pietton Raphaël ◽  
Slimani Lotfi ◽  
Pascal-Moussellard Hugues
Keyword(s):  
Cerebrospinal Fluid ◽  
Three Dimensional ◽  
Fluid Circulation ◽  
Micro Computed Tomography ◽  
Csf Flow ◽  
Cerebrospinal Fluid Circulation ◽  
Clinical Criteria ◽  
Brain And Spinal Cord ◽  
The Brain

AbstractCerebrospinal fluid (CSF) circulation relies on the beating of motile cilia projecting in the lumen of the brain and spinal cord cavities Mutations in genes involved in cilia motility disturb cerebrospinal fluid circulation and result in scoliosis-like deformities of the spine in juvenile zebrafish. However, these defects in spine alignment have not been validated with clinical criteria used to diagnose adolescent idiopathic scoliosis (AIS). The aim of this study was to describe, using orthopaedic criteria the spinal deformities of a zebrafish mutant model of AIS targeting a gene involved in cilia polarity and motility, cfap298tm304. The zebrafish mutant line cfap298tm304, exhibiting alteration of CSF flow due to defective cilia motility, was raised to the juvenile stage. The analysis of mutant animals was based on micro-computed tomography (micro-CT), which was conducted in a QUANTUM FX CALIPER, with a 59 µm-30 mm protocol. 63% of the cfap298tm304 zebrafish analyzed presented a three-dimensional deformity of the spine, that was evolutive during the juvenile phase, more frequent in females, with a right convexity, a rotational component and involving at least one dislocation. We confirm here that cfap298tm304 scoliotic individuals display a typical AIS phenotype, with orthopedic criteria mirroring patient’s diagnosis.

scholarly journals Characterization of Spatial Planning in Brazil: The Right to the City in Theory and Practice

2019 ◽  
Vol 34 (4) ◽  
pp. 419-437 ◽  
Author(s):  
Roberto Rocco ◽  
Luciana Royer ◽  
Fábio Mariz Gonçalves
Keyword(s):  
Spatial Planning ◽  
Theory And Practice ◽  
Right To The City ◽  
The Right ◽  
The City

Identification and characterization of the centromere from chromosome XIV in Saccharomyces cerevisiae

1985 ◽  
Vol 5 (11) ◽  
pp. 2887-2893
Author(s):  
M Neitz ◽  
J Carbon
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Restriction Fragment ◽  
Dna Sequences ◽  
Yeast Genome ◽  
Ura3 Gene ◽  
Dna Restriction ◽  
Meiotic Analyses ◽  
The Right ◽  
In Cis

A functional centromere located on a small DNA restriction fragment from Saccharomyces cerevisiae was identified as CEN14 by integrating centromere-adjacent DNA plus the URA3 gene by homologous recombination into the yeast genome and then by localizing the URA3 gene to chromosome XIV by standard tetrad analysis. DNA sequence analysis revealed that CEN14 possesses sequences (elements I, II, and III) that are characteristic of other yeast centromeres. Mitotic and meiotic analyses indicated that the CEN14 function resides on a 259-base-pair (bp) RsaI-EcoRV restriction fragment, containing sequences that extend only 27 bp to the right of the element I to III region. In conjunction with previous findings on CEN3 and CEN11, these results indicate that the specific DNA sequences required in cis for yeast centromere function are contained within a region about 150 bp in length.

Role of MRI in Detecting and Characterizing Small Hepatic Focal Lesions

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Rania Ali Maarouf ◽  
Ali Haggag Ali ◽  
Mahmoud Abdelatif Onsy
Keyword(s):  
Tumor Staging ◽  
Left Lobe ◽  
Diagnostic Process ◽  
Liver Imaging ◽  
Focal Lesions ◽  
Focal Hepatic Lesions ◽  
Malignant Lesions ◽  
Hepatic Lesions ◽  
The Right

Abstract Background Despite the recent advances in liver imaging, the detection and characterization of small hepatic focal lesions is still a real challenge. Particularly in cancer patients where the characterization of a small HFL as thus the precise tumor staging is critical for optimal treatment planning. Aim of the Work To explore the effectiveness, and hence the clinical utility, of MRI detection and characterization of small focal hepatic lesions either only discovered on MRI or as a further work up of CT/US-indeterminate lesions. Patients and Methods We reviewed our database for individuals who underwent liver MR imaging between March 2018 and March 2019 for the evaluation of small hepatic lesions that were discovered for the first time or had been previously visualized on routinely performed CT and had been considered indeterminate. Results The present study included 44 patients of which 26 were males (59.1%) and 18 were females (40.9%). The age range of the study group was 19 to 77 years. The mean age for Malignant lesions was 51 years. The right lobe of liver was involved in 23 cases (52.3%), left lobe in 5 cases (11.4%) and both lobes in 16 cases (36.4%). There were 30 (68.18%) benign, 13 (29.54%) malignant lesions and 1 (2.3%) indeterminate, hemangiomas were predominant in benign lesions whereas hepatocellular carcinomas were predominant in malignant lesions. N'TRI could characterize 92% cases. Conclusion The diagnostic process of small hepatic focal lesions, either detection or characterization or both, continues to represent a challenge. Contrast-enhanced MR can accurately detect and characterize majority of small hepatic focal lesions.

scholarly journals Pure laparoscopic unilateral nephrectomy for a patient with a polycystic horseshoe kidney

2014 ◽  
Vol 8 (11-12) ◽  
pp. 881 ◽  
Author(s):  
Shawn Dason ◽  
Christopher B Allard ◽  
Bobby Shayegan ◽  
Kevin Piercey
Keyword(s):  
Renal Transplantation ◽  
Autosomal Dominant ◽  
Iliac Fossa ◽  
Laparoscopic Approach ◽  
Horseshoe Kidney ◽  
Laparoscopic Nephrectomy ◽  
Polycystic Kidney ◽  
Large Size ◽  
Autosomal Dominant Polycystic Kidney ◽  
The Right

A 45-year-old female patient with autosomal dominant polycystic kidney disease (ADPKD) and a horseshoe kidney underwent right laparoscopic nephrectomy. The indication for nephrectomy was to create space within the right iliac fossa for renal transplantation. The operation proceeded as routine for laparoscopic nephrectomy for ADPKD, but was uniquely challenging due to the large size and extensive vasculature of the polycystic horseshoe kidney. In addition to documenting the feasibility of the pure laparoscopic approach for nephrectomy in patients with ADPKD and horseshoe kidney, this case highlights the abnormal location and vasculature encountered when operating on horseshoe kidneys.

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