scholarly journals Current classification systems and standardized terminology in cytopathology

2021 ◽  
Vol 61 (3) ◽  
pp. 655-663
Author(s):  
Tibor Mezei ◽  
Keyword(s):  
Classification Systems ◽  
Current Classification ◽  
Standardized Terminology

scholarly journals Detailed Quantification of Glomerular Structural Lesions Associates with Clinical Outcomes and Transcriptomic Profiles in Nephrotic Syndrome

2021 ◽  
Author(s):  
Jeffrey B. Hodgin ◽  
Laura H. Mariani ◽  
Jarcy Zee ◽  
Q Liu ◽  
Abigail R. Smith ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Disease Progression ◽  
Clinical Outcomes ◽  
Messenger Rna ◽  
Structural Changes ◽  
Classification Systems ◽  
Molecular Heterogeneity ◽  
Biologically Relevant ◽  
Current Classification ◽  
Over Time

ABSTRACTThe current classification system for focal segmental glomerulosclerosis (FSGS) and minimal change disease (MCD) does not fully capture the complex structural changes in kidney biopsies, nor the clinical and molecular heterogeneity of these diseases. The Nephrotic Syndrome Study Network (NEPTUNE) Digital Pathology Scoring System (NDPSS) was applied to 221 NEPTUNE FSGS/MCD digital kidney biopsies for glomerular scoring using 37 descriptors. The descriptor-based glomerular profiles were used to cluster patients with similar morphologic characteristics. Glomerular descriptors and patient clusters were assessed for association with time to proteinuria remission and disease progression by using adjusted Cox models, and eGFR measures over time by using linear mixed models. Messenger RNA from glomerular tissue was used to assess differentially expressed genes (DEG) between clusters and identify genes associated with individual descriptors driving cluster membership. Three clusters were identified: X (N=56), Y (N=68), and Z (N=97). Clusters Y and Z had higher probabilities of proteinuria remission (HR [95% CI]= 1.95 [0.99, 3.85] and 3.29 [1.52, 7.13], respectively), lower hazards of disease progression 0.22 [0.08, 0.57] and 0.11 [0.03, 0.45], respectively), and greater loss of eGFR over time compared with X. Cluster X had 1920 DEGs compared to Y+Z, which reflected activation of pathways of immune response and inflammation. Six individual descriptors driving the clusters individually correlated with clinical outcomes and gene expression. The NDPSS allows for characterization of FSGS/MCD patients into clinically and biologically relevant categories and uncovers histologic parameters associated with clinical outcomes and molecular signatures not included in current classification systems.TRANSLATIONAL STATEMENTFSGS and MCD are heterogeneous diseases that manifest with a variety of structural changes often not captured by conventional classification systems. This study shows that a detailed morphologic analysis and quantification of these changes allows for better representation of the structural abnormalities within each patient and for grouping patients with similar morphologic profiles into categories that are clinically and biologically relevant.

scholarly journals How I treat primary cutaneous CD30+ lymphoproliferative disorders

Blood ◽  
2019 ◽  
Vol 134 (6) ◽  
pp. 515-524 ◽  
Author(s):  
Michi M. Shinohara ◽  
Andrei Shustov
Keyword(s):  
Cell Lymphoma ◽  
Large Cell ◽  
Lymphoproliferative Disorders ◽  
Classification Systems ◽  
Team Approach ◽  
Consensus Guidelines ◽  
Lymphomatoid Papulosis ◽  
Current Classification ◽  
Best Disease ◽  
Systemic Therapies

Abstract The primary cutaneous CD30+ lymphoproliferative disorders are a family of extranodal lymphoid neoplasms that arise from mature postthymic T cells and localize to the skin. Current classification systems recognize lymphomatoid papulosis (LyP), primary cutaneous anaplastic large cell lymphoma, and borderline cases. In the majority of patients, the prognosis of primary cutaneous CD30+ lymphoproliferative disorders is excellent; however, relapses are common, and complete cures are rare. Skin-directed and systemic therapies are used as monotherapy or in combination to achieve the best disease control and minimize overall toxicity. We discuss 3 distinct presentations of primary cutaneous CD30+ lymphoproliferative disorder and present recommendations for a multidisciplinary team approach to diagnosis, evaluation, and management of these conditions in keeping with existing consensus guidelines.

DNA barcodes for Cladocera and Copepoda from Mexico and Guatemala, highlights and new discoveries

Zootaxa ◽  
2008 ◽  
Vol 1839 (1) ◽  
pp. 1 ◽  
Author(s):  
MANUEL ELÍAS-GUTIÉRREZ ◽  
FERNANDO MARTÍNEZ JERÓNIMO ◽  
NATALIA V. IVANOVA ◽  
MARTHA VALDEZ-MORENO ◽  
PAUL D. N. HEBERT
Keyword(s):  
Dna Barcoding ◽  
Classification Systems ◽  
Coi Gene ◽  
Aquatic Environments ◽  
Dna Barcodes ◽  
Chydorus Sphaericus ◽  
Mitochondrial Coi ◽  
Mitochondrial Coi Gene ◽  
Current Classification ◽  
Excellent Tool

DNA barcoding, based on sequence diversity in the mitochondrial COI gene, has proven an excellent tool for identifying species in many animal groups. Here, we report the first barcode studies for freshwater zooplankton from Mexico and Guatemala and discuss the taxonomic and biological implications of this work. Our studies examined 61 species of Cladocera and 21 of Copepoda, about 40% of the known fauna in this region. Sequence divergences among conspecific individuals of cladocerans and copepods averaged 0.82% and 0.79%, respectively, while sequence divergences among congeneric taxa were on average 15-20 times as high. Barcodes were successful in discriminating all species in our study, but sequences for Mexican Daphnia exilis overlapped with those of D. spinulata from Argentina. Our barcode data revealed evidence of many species overlooked by current classification systems —for example, based on COI genotypes the Diapahanosoma birgei group appears to include 5 species, while Ceriodaphnia cf. rigaudi, Moina cf. micrura, Mastigodiaptomus albuquerquensis and Mastigodiaptomus reidae all include 2–3 taxa. The barcode results support recent taxonomic revisions, such as recognition of the genus Leberis, and the presence of several species in the D. birgei and Chydorus sphaericus complexes. The present results indicate that DNA barcoding will provide powerful new insights into both the incidence of cryptic species and a better understanding of zooplankton distributions, aiding evaluation of the factors influencing competitive outcomes, and the colonization of aquatic environments.

Issues in the Classification of Motor Disorders

1991 ◽  
Vol 8 (4) ◽  
pp. 280-304 ◽  
Author(s):  
Walter E. Davis ◽  
Terry L. Rizzo
Keyword(s):  
Special Educators ◽  
Traditional Approach ◽  
Negative Attitude ◽  
Classification Systems ◽  
Motor Disorders ◽  
New Classification ◽  
Current Classification ◽  
Per Se ◽  
Labeling System

The detrimental effects of labeling persons as disabled is well known to special educators, many of whom have advocated doing away with labels altogether. However, as a fundamental of science, classification is extremely important. The problem may not be the labeling process per se but one of societal attitudes. Labels are both a product and provocation of attitudes. A review of the current classification systems pinpoints eight characteristics that are problematic in classifying motor disorders. Gibson’s (1977) theory of affordance offers one way of providing a more accurate and useful labeling system, and at the same time addressing, in part, the negative attitude problem. In an affordance approach, the label applies to the behavior as a product of the person/environment system rather than to the person alone, which is the traditional approach. The new classification system offered here, although not complete, differs from the traditional systems in several ways and is seen as useful to researchers and educators alike.

Current classification systems for adult degenerative scoliosis

2013 ◽  
Vol 97 (1) ◽  
pp. 1-8 ◽  
Author(s):  
C. Faldini ◽  
A. Di Martino ◽  
M. De Fine ◽  
M. T. Miscione ◽  
C. Calamelli ◽  
...  
Keyword(s):  
Classification Systems ◽  
Degenerative Scoliosis ◽  
Adult Degenerative Scoliosis ◽  
Current Classification

scholarly journals Culture‑Bound Syndromes and Cultural Concepts of Distress in Psychiatry

2020 ◽  
Vol 6 (3) ◽  
pp. 118-126
Author(s):  
Tomás Teodoro ◽  
Pedro Afonso
Keyword(s):  
Explanatory Models ◽  
Classification Systems ◽  
Idioms Of Distress ◽  
Transcultural Psychiatry ◽  
Cultural Concepts ◽  
Current Classification ◽  
Contextual Characteristics ◽  
Cultural Concepts Of Distress ◽  
Points Of View ◽  
The Relationship

Culture‑bound syndromes (CBS) and cultural concepts of distress include syndromes or disease manifestations whose occurrence is related to particular cultural contexts. The term CBS is controversial, because ultimately all psychiatric and medical conditions are associated with culture. They constitute different points of view on mental health based on alternative explanatory models of mental distress. These idioms of distress have experienced a growing interest in Western countries either by an increase in the number of cases or the influence that transcultural psychiatry has come to conquer. This review describes clinical, epidemiological and contextual characteristics of most commonly reported CBS and briefly discusses the relationship between culture and psychiatric disorders. Modern societies are increasingly multi‑ethnic and multicultural and thus, discussion of these concepts remains relevant, aiming to integrate CBS in current classification systems or establishing criteria that best define them as legitimate nosological entities.

Considering context: lessons from global mental health

2019 ◽  
Vol 28 (2) ◽  
pp. 210-212
Author(s):  
Calina Ouliaris
Keyword(s):  
Mental Health ◽  
Developing Countries ◽  
Global Mental Health ◽  
Models Of Care ◽  
Classification Systems ◽  
Global Model ◽  
Psychiatric Nosology ◽  
Psychiatric Illnesses ◽  
Current Classification ◽  
Value Judgements

Objective: The development of international mental health has been characterised by the globalisation of Western psychiatric nosology that is arguably ill-suited to developing countries. This piece highlights the limitations of our current classification systems and explores how we may seek to overcome these limitations by considering the context in which symptoms present. Conclusion: In developing a global model of psychiatric illnesses, it is important to emphasise contextual value judgements. Doing so welcomes integration of traditional models of care and encourages partnership across nations.

Periprosthetic Femoral Fractures around Hip Arthroplasty: Current Concepts in their Management

2009 ◽  
Vol 19 (2) ◽  
pp. 75-86 ◽  
Author(s):  
Eleftherios Tsiridis ◽  
George Pavlou ◽  
Ram Venkatesh ◽  
Peter Bobak ◽  
Graham Gie
Keyword(s):  
Surgical Techniques ◽  
Femoral Fractures ◽  
Classification Systems ◽  
Anatomical Location ◽  
Bone Allografts ◽  
Current Classification ◽  
Revision Hip Surgery ◽  
Long Stem ◽  
Fracture Stability

Peri-prosthetic fractures (PFF) are complex management problems in orthopaedic surgery. Their treatment has evolved with advances in principles of internal fixation and revision hip surgery. Current classification systems look at anatomical location, prosthesis stability and Bone quality. Recent evidence highlights the importance of fracture stability in treatment planning, the weaknesses of single plating, the increasing role of long stem revision and also the importance of Bone allografts. We present the principles of management of both intra and post-operative PFFs, including surgical techniques and published outcomes.

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