scholarly journals Survival analysis of recurrent events on prostate cancer: facts from cancer genome

2018 ◽  
Vol 51 (2) ◽  
pp. 145-164
Author(s):  
Farhin Rahman ◽  
Munni Begum
Keyword(s):  
Prostate Cancer ◽  
Risk Factors ◽  
Cancer Patients ◽  
Genetic Risk ◽  
Recurrent Events ◽  
Genetic Risk Factors ◽  
Cancer Genome ◽  
The Cancer Genome Atlas ◽  
Time To Event ◽  
Cancer Genome Atlas

Many diseases and clinical outcomes may recur to the same patient. These events are termed as recurrent events. Several statistical models have been proposed in the literature to analyze recurrent events. In this study, we identify the clinical and the genetic risk factors for recurring tumors among prostate cancer patients from The Cancer Genome Atlas (TCGA). Five statistical approaches for modeling recurrent time-to-event are implemented to identify and to determine the effects of the clinical and the genetic risk factors of tumor recurrence. In particular, we consider Andersen-Gill (A-G), Wei-Lin-Weissfeld (WLW), Prentice-Williams-Peterson Total Time (PWP-TT), Prentice-Williams-Peterson Gap Time (PWPGT) and Frailty models. We present and discuss the risk factors influencing the recurrence of tumors and their impacts in prostate cancer patients obtained from five commonly used models in this paper.

scholarly journals Japanese version of The Cancer Genome Atlas, JCGA, established using fresh frozen tumors obtained from 5143 cancer patients

2020 ◽  
Vol 111 (2) ◽  
pp. 687-699 ◽  
Author(s):  
Takeshi Nagashima ◽  
Ken Yamaguchi ◽  
Kenichi Urakami ◽  
Yuji Shimoda ◽  
Sumiko Ohnami ◽  
...  
Keyword(s):  
Cancer Patients ◽  
Japanese Version ◽  
Cancer Genome ◽  
The Cancer Genome Atlas ◽  
Fresh Frozen ◽  
Cancer Genome Atlas ◽  
Genome Atlas

Association of genetic and non-genetic risk factors with the development of prostate cancer in Malaysian men

2014 ◽  
Vol 41 (4) ◽  
pp. 2501-2508 ◽  
Author(s):  
Khamsigan Munretnam ◽  
Livy Alex ◽  
Nurul Hanis Ramzi ◽  
Jagdish Kaur Chahil ◽  
I. S. Kavitha ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Risk Factors ◽  
Genetic Risk ◽  
Genetic Risk Factors

Clinical and genetic risk factors for epirubicin-induced cardiac toxicity in early breast cancer patients

2015 ◽  
Vol 152 (1) ◽  
pp. 67-76 ◽  
Author(s):  
Christof Vulsteke ◽  
Alena M. Pfeil ◽  
Charlotte Maggen ◽  
Matthias Schwenkglenks ◽  
Ruth Pettengell ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Cancer Patients ◽  
Early Breast Cancer ◽  
Genetic Risk ◽  
Cardiac Toxicity ◽  
Genetic Risk Factors ◽  
Breast Cancer Patients

Using machine learning method to identify MYLK as a novel marker to predict biochemical recurrence in prostate cancer

2021 ◽  
Vol 15 (1) ◽  
pp. 29-41
Author(s):  
Peng Qiao ◽  
Di Zhang ◽  
Song Zeng ◽  
Yicun Wang ◽  
Biao Wang ◽  
...  
Keyword(s):  
Gene Expression ◽  
Prostate Cancer ◽  
Biochemical Recurrence ◽  
Surgical Margin ◽  
Gene Expression Omnibus ◽  
Cancer Genome ◽  
The Cancer Genome Atlas ◽  
Support Vector ◽  
Cancer Genome Atlas ◽  
Genome Atlas

Aim: This study aims to identify novel marker to predict biochemical recurrence (BCR) in prostate cancer patients after radical prostatectomy with negative surgical margin. Materials & methods: The Cancer Genome Atlas database, Gene Expression Omnibus database and Cancer Cell Line Encyclopedia database were employed. The ensemble support vector machine-recursive feature elimination method was performed to select crucial gene for BCR. Results: We identified MYLK as a novel and independent biomarker for BCR in The Cancer Genome Atlas training cohort and confirmed in four independent Gene Expression Omnibus validation cohorts. Multi-omic analysis suggested that MYLK was a DNA methylation-driven gene. Additionally, MYLK had significant positive correlations with immune infiltrations. Conclusion: MYLK was identified and validated as a novel, robust and independent biomarker for BCR in prostate cancer.

scholarly journals Assessing the Cumulative Contribution of New and Established Common Genetic Risk Factors to Early-Onset Prostate Cancer

2015 ◽  
Vol 25 (5) ◽  
pp. 766-772 ◽  
Author(s):  
Ethan M. Lange ◽  
Jessica V. Ribado ◽  
Kimberly A. Zuhlke ◽  
Anna M. Johnson ◽  
Gregory R. Keele ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Risk Factors ◽  
Genetic Risk ◽  
Early Onset ◽  
Genetic Risk Factors

scholarly journals Identification of new genetic risk factors for prostate cancer

2008 ◽  
Vol 11 (1) ◽  
pp. 49-55 ◽  
Author(s):  
Michelle Guy ◽  
Zsofia Kote-Jarai ◽  
Graham G. Giles ◽  
Ali Amin Al Olama ◽  
Sarah K. Jugurnauth ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Risk Factors ◽  
Genetic Risk ◽  
Genetic Risk Factors
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