scholarly journals A Comparative Review of Preclinical Infertility Models

2021 ◽  
Vol 71 (2) ◽  
Author(s):  
Kavitha Andugula ◽  
Narendra Babu Ankem
Keyword(s):  
Quality Of Life ◽  
Animal Models ◽  
Neurological Complications ◽  
Rodent Model ◽  
Female Rats ◽  
Hormonal Changes ◽  
Health Consequences ◽  
High Quality ◽  
Comparative Review

Current animal models of infertility in female rats fail to adequately recapitulate transitions like fluctuations in hormonal changes and other complications. androgen-induced infertility rodent model is cause PCO and a new rodent model of Accelerated ovarian failure (AOF) successfully replicate the human perimenopause and postmenopause also it including estrus acyclicity and undetectable estrogen levels .This models not only for menopause it is also useful method for various other infertility models, to develop this model various chemicals are used but in that all models 4- Vinyl cyclohexene diepoxide (VCD) novel chemical which is used for induction of menopause in female rodents. Along with menopause it can also used for other infertility and gynecological complications. In this study other infertility models were compared with androgen induced infertility rodent model, VCD model and our aim to use this animal models to elucidate novel perspective and interventions for maintaining a high quality of life in women and to potentially decrease the negative health consequences associated with these changes during age and other gynecological, neurological complications.

scholarly journals Health-Related Quality of Life of Elderly Women with Fall Experiences

2021 ◽  
Vol 18 (15) ◽  
pp. 7804
Author(s):  
Jiyoung Song ◽  
Eunwon Lee
Keyword(s):  
Quality Of Life ◽  
Elderly Women ◽  
The Elderly ◽  
Basic Data ◽  
Health Related Quality ◽  
High Quality ◽  
Related Quality ◽  
Health Related ◽  
The Impact

This study aimed to describe the health-related quality of life of elderly women with experience in fall treatment as well as to prepare basic data for the development of interventions to improve the quality of life for this group. The study was based on raw data from the 2019 Korea Community Health Survey. Using the SPSS program, the characteristics of the subjects were tested by frequency, percentage, and chi-square test. To establish the impact of fall experience on the health-related quality of life of elderly women, the OR and 95% CI were calculated using multiple logistic regression analysis. Of the 4260 people surveyed, 44.7% of the elderly women said they had a high quality of life, whereas 55.3% of the elderly women said they had a low quality of life. A younger age was associated with a better-rated health-related quality of life. Those who lived in a city and had a high level of education tended to describe a high quality of life. The quality of life was considered high by those who exercised, but low by those who were obese or diabetic. The results of this study can lead to a better understanding of the experiences of elderly women who have experienced falls, and they can be used as basic data for the development of related health programs.

scholarly journals Determining the psychometric properties of a novel questionnaire to measure “preparedness for the future” (Prep FQ)

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Daren K. Heyland ◽  
J. Paige Pope ◽  
Xuran Jiang ◽  
Andrew G. Day
Keyword(s):  
Quality Of Life ◽  
Construct Validity ◽  
Health Behaviors ◽  
Psychometric Properties ◽  
Well Being ◽  
High Quality ◽  
The Future ◽  
Quality Of Death ◽  
Test Retest Reliability

Abstract Background People are living longer than ever before. However, with living longer comes increased problems that negatively impact on quality of life and the quality of death. Tools are needed to help individuals assess whether they are practicing the best attitudes and behaviors that are associated with a future long life, high quality of life, high quality of death and a satisfying post-death legacy. The purpose of paper is to describe the process we used to develop a novel questionnaire (“Preparedness for the Future Questionnaire™ or Prep FQ”) and to define its psychometric properties. Methods Using a multi-step development procedure, items were generated, for the new questionnaire after which the psychometric properties were tested with a heterogeneous sample of 502 Canadians. Using an online polling panel, respondents were asked to complete demographic questions as well as the Prep-FQ, Global Rating of Life Satisfaction, the Keyes Psychological Well-Being scale and the Short-Form 12. Results The final version of the questionnaire contains 34 items in 8 distinct domains (“Medico-legal”, “Social”, “Psychological Well-being”, “Planning”, “Enrichment”, “Positive Health Behaviors”, “Negative Health Behaviors”, and “Late-life Planning”). We observed minimum missing data and good usage of all response options. The average overall Prep FQ score is 51.2 (SD = 13.3). The Cronbach alphas assessing internal reliability for the Prep FQ domains ranged from 0.33 to 0.88. The intra-class correlation coefficient (ICC) used to assess the test–retest reliability had an overall score of 0.87. For the purposes of establishing construct validity, all the pre-specified relationships between Prep FQ and the other questionnaires were met. Conclusion Analyses of this novel measure offered support for its face validity, construct validity, test–retest reliability, and internal consistency. With the development of this useful and valid scale, future research can utilize this measure to engage people in the process of comprehensively assessing and improving their state of preparedness for the future, tracking their progress along the way. Ultimately, this program of research aims to improve the quality and quantity of peoples live by helping them ‘think ahead’ and ‘plan ahead’ on the aspects of their daily life that matter to their future.

scholarly journals Affordable Homeownership: Solutions For Alleviating Mississauga's Affordable Housing Issue

2021 ◽  
Author(s):  
Jennifer Lynn Ormiston
Keyword(s):  
Quality Of Life ◽  
Affordable Housing ◽  
Vital Role ◽  
High Quality ◽  
Local Economies ◽  
Housing Issue ◽  
Market Trends ◽  
Policies And Programs

This research looks at literature, market trends, and policies and programs pertaining to affordable homeownership. The literature suggests that homeownership contributes to local economies and quality of life and is an important part of creating vibrant societies. This research is important as planning plays a vital role in representing those who cannot represent themselves and ensuring that a high quality of life is accessible to everyone. It explores the affordable housing issue in Mississauga and identifies the programs that currently exist to alleviate affordable housing issues. The recommendations are intended to guide Mississauga in the next steps of alleviating affordable homeownership issues. The recommendations provided are transient and can be used as a template for other municipalities in the Greater Golden Horseshoe Area alleviate similar issues.

scholarly journals Systematic Review of Radiofrequency Ablation and Pulsed Radiofrequency for Management of Cervicogenic Headache

2015 ◽  
Vol 2;18 (2;3) ◽  
pp. E109-E130
Author(s):  
Amit Asopa
Keyword(s):  
Quality Of Life ◽  
Systematic Review ◽  
Randomized Trials ◽  
Primary Outcome ◽  
Cervicogenic Headache ◽  
Pulsed Radiofrequency ◽  
Rf Ablation ◽  
High Quality ◽  
Level Of Evidence

Background: Cervicogenic headache is a secondary headache that has a source in the upper cervical spine. There is a small but growing body of evidence to establish effectiveness of radiofrequency (RF) neurotomy, and the pulsed RF (PRF) procedure for management of cervicogenic headache. Objective: To investigate the clinical utility of RF neurotomy, and PRF ablation for the management of cervicogenic headache. Study Design: Systematic review. Methods: The review included relevant literature identified through searches of PubMed, Cochrane, Clinical trials, U.S. National Guideline Clearinghouse and EMBASE from 1960 to January 2014.The quality assessment and clinical relevance criteria utilized were the Cochrane Musculoskeletal Review Group criteria for randomized control trials and the Newcastle-Ottawa Scale criteria for observational studies. The level of evidence was classified as good, fair, and poor based on the quality of evidence. Outcomes Measured: The primary outcome measures were reduction in pain scores and improvement in quality of life. Results: The primary outcome measures were headache relief and improved quality of life. Twenty five studies were identified for full text review of these, 9 studies met inclusion criteria. There were 5 non-randomized, among them 4/5 were of moderate quality, 3/5 showed RF ablation and 1/5 showed PRF as an effective intervention for cervicogenic headache. There were 4 randomized trials among them 2/4 were of high quality, 3/4 investigated RF ablation as an intervention for CHA, 1/4 investigated PRF ablation as an intervention for CHA and none of the randomized studies showed strong evidence for RF and PRF ablation as an effective intervention for CHA. Limitations: In the selected studies there were inconsistencies between randomized trials, flaws in trial design, and gaps in the chain of evidence. Conclusion: There is limited evidence to support RF ablation for management of CHA as there are no high quality RCTs and/ or multiple consistent non-RCTs without methodological flaws. There is poor evidence to support PRF for CHA as there are no high quality RCTs or Non-RCTs. Key Words: Chronic pain, cervicogenic headache, radiofrequency (rf) neurotomy, pulsed radiofrequency (PRF) ablation, reduction in pain, improvement in quality of life, level of evidence

scholarly journals Coping Behavior of Persons with Disabilities as a Factor of Quality of Life and Subjective Well-Being

2018 ◽  
Vol 26 (4) ◽  
pp. 101-118 ◽  
Author(s):  
S.A. Khazova ◽  
N. Shipova ◽  
T.N. Adeeva ◽  
I.V. Tikhonova
Keyword(s):  
Quality Of Life ◽  
Coping Strategies ◽  
Coping Behavior ◽  
Well Being ◽  
Separate Analysis ◽  
Subjective Well Being ◽  
High Quality ◽  
Persons With Disabilities ◽  
Rehabilitation Programs

The article presents an analysis of the problem of determining disabled-since-childhood adults’ quality of life. We suggested that coping behavior was a factor of high quality of life and subjective well-being. The sample (N=102) included disabled-since-childhood adults’ (N=51) with visual (N=16), hearing (N=18) and mobility disabilities (N=17) and adults with typical development (N=51). The respondents` average age is 37 years. Methods: the brief questionnaire WHOQOL-BREF in the adaptation of the V.M. Bechterev Research Institute; M.V. Sokolova’s Subjective Well-Being Scale; The Ways of Coping Questionnaire (Folkman, Lazarus, adapted by Kryukova T.L., Kuftyak E.V.). The results indicate a sufficiently high quality of life of adults with disabilities regardless of the type of disorders. The links between coping strategies, indicators of quality of life and subjective well-being are described. Distancing, avoidance and positive revaluation strategies make the greatest contribution to the quality of life. We conducted a separate analysis of the determination of the quality of life by coping strategies in groups of people with various disabilities. The results of the study can be used to develop rehabilitation programs and help people with disabilities.

Why We Ought to Accept the Repugnant Conclusion

Utilitas ◽  
2002 ◽  
Vol 14 (3) ◽  
pp. 339-359 ◽  
Author(s):  
Torbjorn Tannsjo
Keyword(s):  
Quality Of Life ◽  
Well Being ◽  
Derek Parfit ◽  
Worth Living ◽  
Repugnant Conclusion ◽  
High Quality ◽  
Hedonistic Utilitarianism ◽  
Sentient Beings ◽  
Very High

Derek Parfit has famously pointed out that ‘total’ utilitarian views, such as classical hedonistic utilitarianism, lead to the conclusion that, to each population of quite happy persons there corresponds a more extensive population with people living lives just worth living, which is (on the whole) better. In particular, for any possible population of at least ten billion people, all with a very high quality of life, there must be some much larger imaginable population whose existence, if other things are equal, would be better, even though its members have lives that are barely worth living. This world is better if the sum total of well-being is great enough, and it is great enough if only enough sentient beings inhabit it. This conclusion has been considered by Parfit and others to be ‘repugnant’.

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