scholarly journals Evaluation of the efficacy of levocarnitine in supporting therapy in multiple myeloma

2021 ◽  
Vol 2 (1) ◽  
pp. 56-61
Author(s):  
Ozoda Achilova ◽  
Gulchekhra Makhamadalieva ◽  
Eldor Iskhakov
Keyword(s):  
Biochemical Parameters ◽  
Medical Center ◽  
Chemotherapy Toxicity ◽  
Blood Biochemical ◽  
Significant Positive Change ◽  
Stem Cell Treatment ◽  
Scientific Practical ◽  
Metabolic Correction ◽  
Toxic Drugs ◽  
Cytochemical Parameters

The accompanying therapy prescribed during the use of toxic drugs helps patients to complete the treatment to the end, and the doctor adheres to the treatment of the chosen line The aim of the study was to study the effect of levocarnitine on blood biochemical parameters and on chemotherapy tolerance. Materials and methods. The study was conducted in the stem cell treatment department at Republican Specialized Scientific Practical Medical Center of Hematology . Chemotherapy toxicity was assessed according to WHO and NCIC standards. Results. In a comparative study, 30 patients receiving chemotherapy for myeloma with varying degrees of toxicity when fortecarnite (100 mg / kg / day) was added to standard therapy for 2 months or more showed a significant positive change in cytochemical parameters (Alanin transferase (ALT), aspartat transferase (AST)), which allowed the authors recommend metabolic correction to all patients receiving chemotherapy, especially with 2nd and 3rd degree of toxicity.

scholarly journals Pathogenicity of novel goose-origin astrovirus causing gout in goslings

2021 ◽  
Vol 17 (1) ◽  
Author(s):  
Dan Yin ◽  
Jiajun Tian ◽  
Jing Yang ◽  
Yi Tang ◽  
Youxiang Diao
Keyword(s):  
Biochemical Parameters ◽  
Clinical Symptoms ◽  
Future Research ◽  
Tissue Tropism ◽  
Virus Shedding ◽  
Viral Loads ◽  
Blood Biochemical ◽  
Copy Numbers ◽  
Viral Copy ◽  
Kidney Liver

Abstract Background A novel goose-origin astrovirus (GoAstV) has broken out across China in recent years, causing gout in goslings with a mortality rate of around 50%. However, our understanding of the dynamic distribution, tissue tropism and pathogenesis of GoAstV is incomplete. In order to assess its pathogenicity, one-day-old goslings were inoculated separately with GoAstV via oral and subcutaneous injection routes. Results Clinical symptoms, gross and microscopic lesions, blood biochemical parameters and viral loads were detected and recorded for 20 days after infection. Typical gout was observed in experimental goslings. GoAstV can be replicated in tissues and cause pathological damage, especially in the kidney, liver, heart and spleen. Virus-specific genomic RNA was detected in blood, cloacal swabs and all representative tissues, and virus shedding was detected up to 20 days after inoculation, suggesting that GoAstV has a wide tissue tropism and spread systematically after inoculation. The viral copy numbers examined in kidney were the highest, followed by spleen and liver. Conclusion This experiment determined the accurate value of viral loads and biochemical indicators of GoAstV-induced goslings. These findings increase our understanding of the pathogenicity of GoAstV in goslings and provide more reference for future research.

scholarly journals Multi-Approach Assessment for Stress Evaluation in Rainbow Trout Females, Oncorhynchus mykiss (Walbaum, 1792) from Three Different Farms during the Summer Season

Animals ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 1810
Author(s):  
Paul Uiuiu ◽  
Călin Lațiu ◽  
Tudor Păpuc ◽  
Cristina Craioveanu ◽  
Andrada Ihuț ◽  
...  
Keyword(s):  
Rainbow Trout ◽  
Oncorhynchus Mykiss ◽  
Biochemical Parameters ◽  
Principal Component ◽  
Environmental Parameters ◽  
Blood Parameters ◽  
Summer Season ◽  
Farmed Fish ◽  
Blood Profile ◽  
Blood Biochemical

Blood biochemistry parameters are valuable tools for monitoring fish health. Their baseline values are still undefined for a multitude of farmed fish species. In this study, changes in the blood profile of rainbow trout females (Oncorhynchus mykiss) from three farms were investigated using different biomarkers during the summer season. In the given context, the main water physicochemical parameters were investigated and twelve biochemical parameters were measured from blood samples of rainbow trout reared in the Fiad, Șoimul de Jos, and Strâmba farms. We selected these farms because the genetic background of the rainbow trout is the same, with all studied specimens coming from the Fiad farm, which has an incubation station. Forty-five samples were collected monthly (May to August) throughout summer to observe the changes in the blood profile of rainbow trout. Principal component analysis showed a clear separation both among the studied farms and months. Furthermore, significant correlations (p < 0.05) between the majority of the biochemical parameters were found, indicating that the environmental parameters can influence several blood parameters at the same time. The present study provides several useful norms for assessing the welfare of rainbow trout, indicating that the relationships among different parameters are important factors in interpreting the blood biochemical profiles.

Insights Into The Effect of Shelter Modification On Key Biochemical Aspects vis-a-vis the Performance of Sahiwal Zebu Cows Reared in Hot Arid Ambience

2021 ◽  
Author(s):  
R. Arora ◽  
R. Maan ◽  
G. Gujar
Keyword(s):  
Heat Stress ◽  
Biochemical Parameters ◽  
Milk Composition ◽  
Productive Performance ◽  
Stress Amelioration ◽  
Blood Biochemical ◽  
Cooling Fans ◽  
Sahiwal Cows ◽  
Rubber Mat ◽  
Zebu Cows

Abstract This study was undertaken to evaluate the effect of shelter modifications in the form of floor alteration and heat stress amelioration aids on the biochemical aspects and productive performance of Sahiwal zebu cows. 24 healthy Sahiwal cows in their second or third parity were randomly assigned to four groups (G1, G2, G3, and G4) having 6 cows each and were studied for duration of 150 days from June to November. G1 acted as control without any shelter modification, while G2 cows were housed in stalls with rubber mat covered floors, G3 cows were provided with cooling fans along with water sprinkling twice a day, and G4 cows were housed in stalls combining rubber mat floors with cooling fans and water sprinkling twice a day. This study revealed a significant (p<0.05) effect of shelter modification on milk yield, though no significant effect on milk composition was found. Among blood biochemical parameters, serum cholesterol and cortisol levels registered a significant (p<0.05) effect of shelter modification. The use of heat amelioration aids with, and without rubber mat floors positively influenced the productive and biochemical aspects of Sahiwal cows. Such strategies can be utilized to reduce stress on animals and help in maintaining their production.

EVALUATING THE EFFICIENCY OF FEEDING BROILER CHICKENS OF THE ARBOR ACRES CROSS IN HOT CLIMATIC CONDITIONS OF THE REPUBLIC OF CHAD

2020 ◽  
pp. 72-82
Author(s):  
M.V. LAZKO ◽  
◽  
ADAM A. ABDERAKHIM
Keyword(s):  
Environmental Factors ◽  
Biochemical Parameters ◽  
Broiler Chickens ◽  
Central Africa ◽  
Live Weight ◽  
Climatic Conditions ◽  
Geochemical Conditions ◽  
Blood Biochemical ◽  
The Republic ◽  
The University

The paper presents the results of evaluating the efficiency of feed rations offered to broilers of the Arbor Acres cross, formed taking into account the climatic, geochemical conditions of Central Africa and its native food flora. The study was conducted on the basis of an experimental farm at the University of N’Djamena, the Republic of Chad. In the experiment, the authors used five formulas of feed rations, which are currently used by farms in the Republic of Chad for growing broiler chickens. They mainly contain locally availble ingredients. To increase the resistance of the poultry organism to unfavorable environmental factors, the chickens of the control and experimental groups were given “TETRACOLIVIT” and “AMIN’TOTAL” vitamins. The efficiency of feed rations was evaluated by determining the age dynamics of live weight, average weekly gains in live weight and blood biochemical parameters of broiler chickens of the Arbor Acres cross from 1 to 42 days of life. The formula of feed ration No. 1 proved to be the most effective in terms of the cross productivity.

Reproductive traits and blood biochemical parameters of sows when using a vitamin feed additive “LipoCar”

2020 ◽  
pp. 25-31
Author(s):  
I. A. Pushkaryev ◽  
N. M. Kostomakhin ◽  
S. V. Burtseva ◽  
N. A. Novikov
Keyword(s):  
Blood Serum ◽  
Biochemical Parameters ◽  
Total Duration ◽  
Reproductive Traits ◽  
Feed Additive ◽  
Control Group ◽  
Large White ◽  
Basic Diet ◽  
Blood Biochemical ◽  
Experimental Group

The reproductive traits of sows are of paramount importance in the production of high-quality pork. The world experience of pig farming shows the need to solve first of all the feed problem. Diets unbalanced in the content of vitamins restrain the manifestation of genetically inherent high prolificacy of sows. The purpose of the research was to study the influence of feeding the vitamin feed additive “LipoCar” on the reproductive traits of sows and the biochemical parameters of blood serum. The results of research on the introduction of vitamin feed additive “LipoCar” into the diet of pregnant sows have been presented in the article. The experiment has been carried out in the production conditions in JSC “Linevsky pedigree farm” on sows of Large White breed. Pregnant sows have received a basic diet, balanced for all the normalized elements of nutrition. Sows of the experimental group in the composition of the basic diet fed the feed additive “LipoCar”. The dosage of the drug “Lipocar” was 2,1 g/head/day. “Lipocar” has been fed for 20 days. The total duration of the experiment was 3 months. When introducing the vitamin feed additive “LipoCar” into the main diet of sows in the second half of pregnancy the increase in the number of piglets in the litter by 1,6-6,8 % and the weight of the litter – by 5,6-56,2 % (P ≤ 0,001) have been revealed in comparison with the control group of animals. There was a higher content of carotene in the blood serum of sows of the experimental group by 50,0 % (P ≤ 0,01), vitamin A - by 48,7 % (P ≤ 0,05), and total protein – by 4,9 % (P ≤ 0,05).

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