scholarly journals The Effect of Captopril on the Decrease of Systolic and Diastolic Blood Pressure in Hypertension Rat with Kidney Dysfunction Complications

2021 ◽  
Vol 6 (5) ◽  
pp. 21-31
Author(s):  
Aisa Dinda Mitra ◽  
Helmi Arifin ◽  
Harrizul Rivai
Keyword(s):  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Renal Dysfunction ◽  
Diastolic Blood Pressure ◽  
Enzyme Inhibitor ◽  
Age Groups ◽  
Channel Blockers ◽  
Non Invasive ◽  
Lower Blood ◽  
Histopathologic Findings

The most commonly used antihypertensives in Indonesia vary according to the age of the patient. At the age of 40-60 years, angiotensin-converting enzyme inhibitor (ACEi) and calcium channel blockers (CCBs) are usually given to older patients. All age groups were treated with a combination of CCB and angiotensin receptor blocker (ARB). Captopril is one of the ACE inhibitor classes, and captopril can lower blood pressure, improve renal impairment, and suppress kidney inflammation through the inactivation of NF-κB in hypertensive mice. Hypertension is closely related to renal dysfunction, requiring blood pressure to be lowered to the normotensive range to prevent progressive kidney damage. In the acute reperfusion stage, captopril prevents excessive angiotensin II synthesis, improves renal dysfunction, inhibited intrarenal inflammation, and better histopathologic findings. Most of the renoprotective effects of captopril occur in the acute reperfusion stage. At the same time, captopril significantly reduces NO availability, exacerbates intrarenal hypoxia, and exacerbates oxidative stress. This study aims to determine the effect of captopril on systolic blood pressure and diastolic blood pressure. In this study, all experimental animals were made hypertensive first by inducing 8% NaCl for 21 days given orally. Then the group with renal complications was induced by administering gentamicin for seven days provided intraperitoneally. Blood creatinine levels were measured using a Photometer5010V5 +. Measurement of systolic blood pressure and diastolic blood pressure using the Non-Invasive Blood Pressure (NIBP) instrument. The data from this study were analyzed using two-way ANOVA. The results showed that complications of renal dysfunction in hypertensive rats had a significant effect on reducing systolic blood pressure and diastolic blood pressure (p ˂ 0.05). The administration of captopril at doses of 1.25 mg, 2.5 mg, and 5 mg significantly affected decreased systolic blood pressure and diastolic blood pressure (p ˂ 0.05). Captopril 5 mg dose was the most effective in lowering systolic blood pressure and diastolic blood pressure.

A comparison of CAT Doppler and oscillometric Memoprint machines for non-invasive blood pressure measurement in conscious cats

2005 ◽  
Vol 7 (3) ◽  
pp. 147-152 ◽  
Author(s):  
Rosanne E. Jepson ◽  
Vivien Hartley ◽  
Michael Mendl ◽  
Sarah ME Caney ◽  
David J Gould
Keyword(s):  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Blood Pressure Measurement ◽  
Systemic Hypertension ◽  
Pressure Measurements ◽  
Non Invasive ◽  
Measuring Devices ◽  
Oscillometric Device ◽  
Significant Difference

Indirect blood pressure measurements were compared in 28 conscious cats using Doppler and oscillometric blood pressure-measuring devices. Ten cats were used to compare Doppler measurements between two examiners and 18 cats were used to compare Doppler and oscillometric measurements. The Doppler machine obtained systolic and diastolic blood pressure readings in 100% and 51% of attempts, respectively. With the oscillometric machine, systolic and diastolic blood pressure readings were obtained in 52% of the attempts. With the Doppler, measures of mean systolic blood pressure between two examiners were positively correlated, but there was no correlation for diastolic blood pressure measures. When comparing the results obtained by Doppler and oscillometric machines there was no significant difference between mean systolic blood pressure readings, but the oscillometric machine produced significantly higher estimates of diastolic blood pressure. In both cases, the standard deviations for the oscillometric machine were considerably larger than those for the Doppler machine. The first reading of systolic blood pressure obtained with the Doppler machine was an excellent predictor of the mean of five readings, but this was not so for the oscillometric machine. It took less than 5 min to obtain five readings in 37.5% of cases with the Doppler machine but this was true for only 5% of cases with the oscillometric machine. Two cats with ophthalmological lesions consistent with systemic hypertension were identified. In these two patients, systolic blood pressure measurements were between 200 and 225 mmHg when measured by Doppler, and between 140 and 150 mmHg when measured by the oscillometric machine. This suggests that a lower reference range for normal systolic blood pressure values should be used for the oscillometric device.

scholarly journals Peculiarities of 24 hour ambulatory blood pressure monitoring indices in patients with essential hypertension, stage II of different age groups

2018 ◽  
Vol 1 (4) ◽  
pp. 63-70
Author(s):  
V. S. Pasko
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Arterial Pressure ◽  
Systolic Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Ambulatory Blood Pressure Monitoring ◽  
Ambulatory Blood Pressure ◽  
Blood Pressure Monitoring ◽  
Age Groups ◽  
Pressure Monitoring

The aim of the study was to determine peculiarities of 24 hour ambulatory blood pressure monitoring indices of patients with essential hypertension, stage II of different age groups. Material and methods. Indices of ambulatory blood pressure monitoring were identified in 57 middle-aged patients (45-59 years) (group I) and 43 elderly patients (60-74 years) (group II), who underwent two-week in-patient treatment. The control group consisted of 15 patients for every of the surveyed categories (group III - middle-aged and group IV – elderly respectively) matched with basic by age and gender. Results. We have shown that one of the factors that determines the change in hemodynamics in patients with essential hypertension is age, with the age patients experience the decrease in diastolic blood pressure with steadily increased systolic blood pressure, that should be considered in the prescription of antihypertensive treatment. With age, a gradual increase in systolic blood pressure is associated with the increased aortic stiffness, partially with the increase in collagen and the decrease in elastic fibrils and the formation of isolated systolic hypertension. Thus, it is proved that in the formation of isolated hypertension the growth of pulse blood pressure for more than 60 mm Hg is unfavorable in a development of cerebrovascular events. Pulse arterial blood pressure was stronger risk factor than systolic blood pressure and diastolic blood pressure or average arterial pressure in the elderly. Recently, taking into account age characteristics, all three indices were recognized as comparable predictors at the age of 50-59 years as the transitional period, and at the age of 60-79 years diastolic blood pressure adversely affecting the cardiovascular risk, increased pulse blood pressure prognostically above the level of systolic arterial pressure.

scholarly journals PELATIHAN DAN EDUKASI POLA HIDUP SEHAT DALAM PENCEGAHAN HIPERTENSI WARGA DI SEKITAR JAKARTA BARAT MELALUI SENAM DAN PENGUKURAN TEKANAN DARAH

2021 ◽  
Vol 3 (2) ◽  
Author(s):  
Alexander Halim Santoso ◽  
Novendy Novendy ◽  
Susy Olivia Lontoh
Keyword(s):  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Salt Intake ◽  
Healthy Lifestyle ◽  
Health Condition ◽  
Risk Of Death ◽  
Lower Blood ◽  
Quitting Smoking ◽  
Service Activity

Hypertension can cause serious health condition such as heart attack, kidney failure and stroke. A person's blood pressure is considered hypertensive if it is 140/90 mmHg, and 139/89 mmHg is called pre-hypertension. An increase of 20 mmHg systolic blood pressure or 10 mmHg diastolic blood pressure can increase the risk of death from ischemic heart disease and stroke. Living a healthy lifestyle for at least 4-6 months has been shown to lower blood pressure and can lower the risk of cardiovascular problems. The recommended healthy lifestyles include weight loss, reducing salt intake, exercise, reducing alcohol consumption, and quitting smoking. Lifestyle is an important risk factor for hypertension in young adult. The team leader visited the cadres at the village office to convey the objectives of the service activities. The distribution of invitations was carried out by cadres from Kelurahan Tomang and Kelurahan Grogol. Participants registered and then filled out a questionnaire. Then they were directed to check blood pressure. After that, participants filled out the questionnaire and watch the exercise demo. This service activity involves Medical students of the Tarumanagara University. The number of residents who participated in this event were in total of 181 residents from Tomang and Grogol, West Jakarta. The results of blood pressure measurements, found that 88.4% of residents had blood pressure classified as normal. The mean systolic blood pressure was 130.82 mmHg, and the diastolic blood pressure 77.69 mmHg. Continuous efforts are needed in the form of counseling to continue to increase hypertension awareness.ABSTRAK:Hipertensi adalah faktor penyebab timbulnya penyakit berat seperti serangan jantung, gagal ginjal dan stoke. Tekanan darah orang dikatakan hipertensi apabila 140/90 mmHg dan 139/89 mmHg disebut prahipertensi. Peningkatan 20 mmHg tekanan darah sistolik atau 10 mmHg tekanan darah diastolik dapat meningkatkan risiko kematian akibat penyakit jantung iskemik dan stroke. Menjalankan pola hidup sehat setidaknya selama 4–6 bulan terbukti dapat menurunkan tekanan darah dan secara umum dapat menurunkan risiko permasalahan kardiovaskular. Beberapa pola hidup sehat yang dianjurkan di antaranya penurunan berat badan, mengurangi asupan garam, olahraga, mengurangi konsumsi alkohol, dan berhenti merokok. Gaya hidup merupakan faktor risiko penting timbulnya hipertensi pada seseorang di usia dewasa muda. Pada hari yang telah disepakati, ketua tim melakukan kunjungan kepada para kader di kantor kelurahan untuk menyampaikan tujuan kegiatan pengabdian. Selanjutnya, penyebaran undangan dilakukan oleh para kader dari Kelurahan Tomang dan Kelurahan Grogol. Pada hari pelaksanaan, peserta melakukan registrasi dan kemudian mengisi kuesioner. Selanjutnya peserta diarahkan untuk pemeriksaan tekanan darah. Setelah pengukuran tekanan darah, peserta dikumpulkan kembali untuk melanjutkan pengisian kuesioner dan melihat demo senam melalui video. Kegiatan pengabdian ini melibatkan mahasiswa Fakultas Kedokteran Universitas Tarumanagara. Jumlah warga yang harid sebanyak 181 warga dari Kelurahan Tomang dan Grogol Jakarta Barat, Hasil pengukuran tekanan darah, didapatkan 88,4% warga tekanan darahnya tergolong normal. Rata-rata tekanan darah sistolik adalah 130,82 mmHg, dan tekanan darah diastolik 77.69 mmHg. Diperlukan upaya berkelanjutan dalam bentuk penyuluhan untuk tetap meningkatkan kewaspadaan dan pengetahun masyarakat akan Hipertensi.

Continuous non-invasive remote automated blood pressure monitoring with novel wearable technology: A Validation Study (Preprint)

2020 ◽  
Author(s):  
Michael McGillion ◽  
Nazari Dvirnik ◽  
Stephen Yang ◽  
Emilie Belley-Côté ◽  
Andre Lamy ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Blood Pressure Monitoring ◽  
Vital Signs ◽  
Standard Of Care ◽  
Non Invasive ◽  
Vital Signs Monitoring ◽  
Measuring Devices ◽  
Cuffless Blood Pressure

BACKGROUND Background: Continuous hemodynamic monitoring is the standard of care for patients intraoperatively, but vital signs monitoring is performed only periodically on post-surgical wards, and patients are routinely discharged home with no surveillance. Wearable continuous monitoring biosensor technologies have the potential to transform postoperative care with early detection of impending clinical deterioration. OBJECTIVE Objective: Our aim was to validate the accuracy of the Cloud DX Vitaliti™ Continuous Vital Signs Monitor (CVSM) continuous non-invasive blood pressure measurements in post-surgical patients. Usability of the Vitaliti™ CVSM was also examined. METHODS Methods: Included patients were recovering from surgery in a cardiac intensive care unit. Validation procedures were according to AAMI - ISO 81060-2 2013 standards for Wearable, Cuffless Blood Pressure Measuring Devices. In static (seated in bed) and supine positons, three 30-second cNIBP measurements were taken for each patient with the Vitaliti™ CVSM and an invasive arterial catheter. The errors of these determinations were calculated. Participants were interviewed about device acceptability RESULTS Results: Data for 21 patients were included in the validation analysis. The overall mean and SD of the errors of determination for the static position were -0.784 mmHg (SD 4.594) for systolic blood pressure and 0.477 mmHg (SD 1.668) for diastolic blood pressure. Errors of determination were slightly higher for the supine position at 3.533 mmHg (SD 6.335) for systolic blood pressure and 3.050 mmHg (SD 3.619) for diastolic blood pressure. The majority rated the Vitaliti™ CVSM as comfortable. CONCLUSIONS Conclusion: The Vitaliti™ CVSM was compliant with AAMI-ISO 81060-2:2013 standards and well-received by patients. CLINICALTRIAL Trial Registration: ClinicalTrials.gov (NCT03493867)

School children systolic and diastolic blood pressure values: YUSAD study

Open Medicine ◽  
2011 ◽  
Vol 6 (5) ◽  
pp. 634-639
Author(s):  
Zeljka Milincic ◽  
Dejan Nikolic ◽  
Slavko Simeunovic ◽  
Ivana Novakovic ◽  
Ivana Petronic ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Pressure Fluctuations ◽  
Age Groups ◽  
Old Patients ◽  
Hypertensive Group ◽  
Group 3 ◽  
Group 2

AbstractThe aim of the study was to analyze changes of systolic and diastolic blood pressure values over five and ten years separately boys and girls and to estimate correlation between them. Three age groups from 8 centers in Serbia were evaluated: Group 1: 10 year old patients, Group 2: 15 year old and Group 3: 20 year old. Group with normal blood pressure values, prehypertensive and hypertensive group were analyzed. Regarding the period of follow-up we analyzed: 10/15 years period-children between 10 and 15 years, 15/20 years period-children between 15 and 20 years, and 10/20 years period-children between 10 and 20 years. Significant increase of diastolic blood pressure was noticed for both genders in 10/15 years period of prehypertensive population, while in hypertensive children, boys showed decline in frequency for systolic and diastolic blood pressure and girls only for diastolic. In 15/20 years period there was significant decrease of prehypertensive and significant increase of hypertensive diastolic blood pressure frequency. In 10/20 years period significant reduction in frequency of prehypertensive systolic blood pressure was noticed, while only hypertensive group of boys showed significant reduction regarding systolic blood pressure frequency. Prehypertensive diastolic and hypertensive systolic blood pressure fluctuations are more related to age.

Effects in Healthy Subjects of a New Non-Thiol-Containing Angiotensin-Converting Enzyme Inhibitor, Enalapril Maleate (MK-421)

1982 ◽  
Vol 63 (s8) ◽  
pp. 183s-185s ◽  
Author(s):  
Mitsuyoshi Nakashima ◽  
Kenji Nishijima
Keyword(s):  
Blood Pressure ◽  
Angiotensin Converting Enzyme ◽  
Systolic Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Enzyme Inhibitor ◽  
Plasma Concentrations ◽  
Maximum Plasma ◽  
Converting Enzyme ◽  
Enalapril Maleate ◽  
Maximum Decrease

1. Single doses of enalapril maleate, ranging from 2.5 to 20 mg, were given orally to 12 normotensive volunteers to determine tolerability, activity on the various components of the renin-angiotensin-aldosterone system and initial pharmacokinetics. 2. Enalapril was rapidly absorbed and maximum plasma concentrations of the diacid, the active metabolite of enalapril, occurred at 3–6 h after dosing. 3. Enalapril significantly decreased systolic blood pressure at 4–6 h after the drug and diastolic blood pressure at 3–6 h after the drug. The maximum decrease of systolic blood pressure was observed at 3–4 h, whereas the maximum decrease of diastolic blood pressure was observed at 6 h. 4. Plasma angiotensin-converting enzyme activity was significantly reduced at all doses. The reduction persisted through 24 h after dosage. Plasma renin activity significantly increased after doses of 5 mg and 20 mg. Aldosterone levels significantly decreased after doses of 10 mg and 20 mg. 5. There were no adverse clinical experiences or abnormal laboratory values noted.

scholarly journals Non-Invasive Estimation of Systolic Blood Pressure and Diastolic Blood Pressure Using Photoplethysmograph Components

2010 ◽  
Vol 51 (3) ◽  
pp. 345 ◽  
Author(s):  
Incheol Jeong ◽  
Sukhwan Jun ◽  
Daeja Um ◽  
Joonghwan Oh ◽  
Hyungro Yoon
Keyword(s):  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Non Invasive

scholarly journals COMPARISON OF EFFECTIVENESS OF A PROGRESSIVE MOBILIZATION AND MOZART MUSIC THERAPY ON NON-INVASIVE HEMODYNAMIC STATUS CHANGES IN PATIENTS WITH HEAD INJURY IN THE INTENSIVE CARE UNIT

2018 ◽  
Vol 4 (2) ◽  
pp. 135-144
Author(s):  
Novi Indriani ◽  
Bedjo Santoso ◽  
Arwani Arwani ◽  
Mardiyono Mardiyono
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Head Injury ◽  
Music Therapy ◽  
Systolic Blood Pressure ◽  
Oxygen Saturation ◽  
Diastolic Blood Pressure ◽  
Non Invasive ◽  
Hemodynamic Status ◽  
Level I

Background: The instability of hemodynamic status in patients with head injury with decreased consciousness has an effect on the increase of intracranial pressure. The recovery of hemodynamic status can be done through nursing intervention either by providing a sensory stimulus (music therapy) or motor stimulus (progressive mobilization).Objective: To compare the effectiveness of progressive mobilization of level I with Mozart's music therapy on non-invasive hemodynamic status changes in patients with head injury with decreased awareness.Methods: This was a quasy-experimental study with pretest-posttest design. There were 34 samples selected using consecutive sampling, which 17 samples assigned in a group of progressive mobilization and group of music therapy. Paired t-test and Wilcoxon test were used for paired group, and Independent t-test and Mann-Whitney test for unpaired group.Results: Progressive mobilization of level I had significant effect on changes in systolic blood pressure (p = 0.0001), diastolic blood pressure (p = 0.002) and MAP (p = 0.019), and no significant effect on heart rate (p = 0.155), respiration (p = 0.895) and oxygen saturation (p = 0.248). Mozart's music therapy had a significant effect on changes in systolic blood pressure (p = 0.0001), diastolic blood pressure (p = 0.0001), respiration (p= 0.032) and oxygen saturation (p = 0.008), but no effect on MAP (p = 0.561). There was a significant difference between the two interventions in the systolic blood pressure and heart rate variables (p <0.05), while the diastolic blood pressure, MAP, respiration and oxygen saturation variables did not show a difference (p> 0.05).Conclusion: The Mozart's music therapy is more effective on non-invasive hemodynamic status changes in patients with head injury with decreased consciousness compared with progressive mobilization of level I. 

scholarly journals Differences in Brain Waves and Blood Pressure by Listening to Quran-e-Kareem and Music

2019 ◽  
Vol 8 (1) ◽  
pp. 40-44
Author(s):  
Noor -ul-Ain Irfan ◽  
Hafsa Atique ◽  
Ayesha Taufiq ◽  
Asma Irfan
Keyword(s):  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Sample Selection ◽  
Age Groups ◽  
Older Age ◽  
P Value ◽  
Common Belief ◽  
Brain Waves ◽  
Group A

Background: Quranic recitation and music do not share any features in terms of content besides the use of melodies, but it is a common belief, that both have positive effect on reducing blood pressure and anxiety level of patients. This research investigates and compares the effects of listening to Quranic recitation and soft music on human brain waves especially Alpha and Beta waves by electroencephalogram (EEG) using Power-Lab.Material and Methods: A clinical trial was carried out in the Physiology Department of Islamabad Medical and Dental College. There were 22 participants, divided into two groups (A and B) with 11 participants in each group. Group A included students with ages 20-25 years and Group B comprised of teaching faculty between 40-60 years. All the study participants were Urdu-speaking, Pakistani Muslims having normal hearing. Sample selection was based on non-random convenient sampling. Paired T-test was used to compare means of Alpha and Beta waves amplitude, with p value < 0.05 considered as statistically significant.Results: Listening to Quranic recitation results in greater amplitude of Alpha waves in both younger and older age groups (p=0.01). The cross comparisons of systolic blood pressure at rest and after music for Group A showed significant results (p=0.04) indicating that soft music increases systolic blood pressure in younger people. Diastolic blood pressure comparison proves that it decreases by Tilawat in older age-groups (p<0.05).Conclusion: EEG showed that Quran generates comparatively higher amplitudes of Alpha than Beta waves, which reflects the calmness and relaxation of the participants while listening to Quranic recitation. Furthermore, there was a mild reduction in diastolic blood pressure in older subjects after listening to Quranic recitation.

EFEKTIVITAS PEMBERIAN HYDROTHERAPI RENDAM KAKI PADA PENDERITA HIPERTENSI DI BANJAR SRI MANDALA, KELURAHAN DAUHWARU KABUPATEN JEMBRANA

2019 ◽  
Vol 10 (01) ◽  
pp. 33-44
Author(s):  
N.L.G. Sudaryati ◽  
I P. Sudiartawan ◽  
Dwi Mertha Adnyana
Keyword(s):  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Pressure Measurement ◽  
Blood Pressure Measurement ◽  
Reduce Blood Pressure ◽  
Second Grade ◽  
Control Group ◽  
Hypertensive Patients ◽  
First Category

The aim of the study was to determine the effectiveness of giving hydrotherapi foot soak in hypertensive patients. The study was conducted with one group pretestposttest design without a control group by measuring blood pressure (pretest) before being given an intervention in the form of foot soak hydrotherm against 15 people with hypertension in Banjar Sri Mandala, Dauhwaru Village, Jembrana Subregency. Then do the blood pressure measurement again (posttest) after finishing the intervention. After the study was completed, the results showed that before the hydrotherapi foot bath intervention, there were 0% of patients classified as normal, 13.32% in prehypertension category, 60.08% in hypertension category I and 26.60% in hypertension category II. After the intervention was given, there were 13.32% of the patients classified as normal, 66.68% in the prehypertension category, 20.00% in the first category of hypertension and no patients belonging to the second grade hypertension category. There is a decrease of 20-30 mmHg for systolic blood pressure and 0-10 mmHg for diastolic blood pressure after intervention. Based on the results of the study it can be concluded that the hydrotherapi foot bath is effectively used to reduce blood pressure in hypertensive patients in the Banjar Sri Mandala, Dauhwaru Village, Jembrana District.

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