scholarly journals Kangaroo Mother Care versus Incubator in Transporting Stable Preterm Neonates: A Randomized Controlled Trial

2021 ◽  
Vol 55 (9) ◽  
Author(s):  
Renelyn P. Ignacio ◽  
Maria Esterlita T. Villanueva-Uy
Keyword(s):  
Heart Rate ◽  
Randomized Controlled Trial ◽  
Blood Glucose ◽  
Oxygen Saturation ◽  
Respiratory Rate ◽  
Controlled Trial ◽  
Kangaroo Mother Care ◽  
Preterm Neonates ◽  
Control Group ◽  
Randomized Controlled

Background. Transporting preterm neonates soon after birth entails risks. Only one study among many about the beneficial effects of Kangaroo Mother Care (KMC) had cited it as a safe and effective alternative to transport incubators. Objective. To determine if KMC transport could be an alternative to transport incubators by comparing the physiological outcomes of the two transport methods. Methods. This is a parallel non-blinded randomized-controlled trial funded by KMC Foundation, Philippines, Inc, of physiologically stable preterm neonates weighing ≤ 2200 grams delivered at a tertiary government hospital from September 10, 2011, to April 18, 2012. After obtaining written consent from their mothers, participants were randomly assigned to either the intervention or control group. The intervention groups were transported from the delivery room to the NICU while on skin-to-skin contact with the caregiver. In contrast, those in the control group were placed in a transport incubator. Vital signs, oxygen saturation, and blood glucose were measured before transport and upon NICU arrival. Adverse effects were monitored. Data were recorded using a standard database. Results. Ninety-two participants were recruited, forty-six in each arm. Two dropped out. The mean change in heart rate in the KMC transport decreased by 1.6 beats per minute; respiratory rate decreased by 0.18 breaths per minute, the temperature increased by 0.01°C, oxygen saturation decreased by 0.07%, blood glucose decreased by 5.07 mg/dL. The measured physiological parameters were not statistically significant between the two groups. In the KMC transport, there was a decreasing trend in the incidence of hypothermia, hypoglycemia, tachypnea, and tachycardia. Conclusion. There are no significant differences in the heart rate, respiratory rate, temperature, oxygen saturation, and blood glucose levels among preterm neonates on KMC transport compared with preterm neonates on transport incubators, which is the current standard of care. The study showed that KMC transport is equally effective as a transport incubator. Hence, in low-resource settings, KMC transport may be used as a safe and effective neonatal transport.

scholarly journals Effectiveness of Kangaroo Mother Care in Intubated Preterm Neonates 28 to 36 Weeks Gestational Age, Weighing 600 to 2000 Grams at Birth: A Randomized Controlled Trial

2021 ◽  
Vol 55 (9) ◽  
Author(s):  
Shary May M. Baton ◽  
Maria Esterlita T. Villanueva-Uy ◽  
Socorro De Leon-Mendoza
Keyword(s):  
Randomized Controlled Trial ◽  
Hospital Stay ◽  
Late Onset ◽  
Controlled Trial ◽  
Intervention Group ◽  
Kangaroo Mother Care ◽  
Preterm Neonates ◽  
Control Group ◽  
Low Birth Weight Infants ◽  
Randomized Controlled

Background. Kangaroo Mother Care (KMC) is the standard of care for stable low birth weight infants. Provision of KMC to intubated preterm infants may also be beneficial, but strong evidence is still lacking. Objective. To determine the effectiveness of KMC in decreasing mortality among intubated preterm neonates. Study Design. This is a non-blinded, parallel, non-inferiority randomized controlled trial. Methodology. All intubated, preterm admissions, 28-36 weeks gestation, weighing 600-2000 grams, with respiratory distress were included. They were randomized to the intervention group who received KMC for 2-4 hours daily while intubated and the control group who received care inside an incubator. Participants’ physiologic status – before, during, and after the intervention – was recorded. The primary outcome was mortality. Secondary outcomes included comorbidities, days intubated, and hospital stay. Results. There was a total of 32 patients. The risk of dying in the KMC group (n=16) was significantly reduced by 78% (RR 0.22; 95% CI 0.06 - 0.87 p=0.009). The KMC patients were also less likely to have hypothermia, nosocomial pneumonia, NEC, and late-onset neonatal sepsis (p<0.05). The KMC group had higher blood sugar levels (110 vs. 58, p=0.001) and required fewer days of intubation (3.5 vs.1.5 days, p<0.000) compared to the control group. There was no difference in the duration of the hospital stay. Conclusion. KMC is effective in decreasing mortality among intubated preterm neonates. Other comorbidities and days of intubation were also reduced.

scholarly journals The effect of therapeutic listening on anxiety and fear among surgical patients: randomized controlled trial

2018 ◽  
Vol 26 (0) ◽  
Author(s):  
Ana Cláudia Mesquita Garcia ◽  
Talita Prado Simão-Miranda ◽  
Ana Maria Pimenta Carvalho ◽  
Paula Condé Lamparelli Elias ◽  
Maria da Graça Pereira ◽  
...  
Keyword(s):  
Heart Rate ◽  
Randomized Controlled Trial ◽  
State Anxiety ◽  
Controlled Trial ◽  
Intervention Group ◽  
Control Group ◽  
Clinical Trial Registration ◽  
Physiological Variables ◽  
Randomized Controlled ◽  
Therapeutic Listening

ABSTRACT Objective: To investigate the effect of therapeutic listening on state anxiety and surgical fears in preoperative colorectal cancer patients. Method: A randomized controlled trial with 50 patients randomly allocated in the intervention group (therapeutic listening) (n = 25) or in the control group (n = 25). The study evaluated the changes in the variables state anxiety, surgical fears and physiological variables (salivary alpha-amylase, salivary cortisol, heart rate, respiratory rate and blood pressure). Results: In the comparison of the variables in the control and intervention groups in pre- and post-intervention, differences between the two periods for the variables cortisol (p=0.043), heart rate (p=0.034) and surgical fears (p=0.030) were found in the control group, which presented reduction in the values of these variables. Conclusion: There was no reduction in the levels of the variables state anxiety and surgical fears resulting from the therapeutic listening intervention, either through the physiological or psychological indicators. However, the contact with the researcher during data collection, without stimulus to reflect on the situation, may have generated the results of the control group. Clinical Trial Registration: NCT02455128.

scholarly journals The effect of dexmedetomidine on intraoperative blood glucose homeostasis: secondary analysis of a randomized controlled trial

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Chun-Jing Li ◽  
Bo-Jie Wang ◽  
Dong-Liang Mu ◽  
Dong-Xin Wang
Keyword(s):  
Randomized Controlled Trial ◽  
Blood Glucose ◽  
Elderly Patients ◽  
Controlled Trial ◽  
Statistical Significance ◽  
Secondary Analysis ◽  
Major Surgery ◽  
Control Group ◽  
Time Interval ◽  
Randomized Controlled

Abstract Purpose To investigate the effect of dexmedetomidine on intraoperative blood glucose hemostasis in elderly patients undergoing non-cardiac major surgery. Methods This was secondary analysis of a randomized controlled trial. Patients in dexmedetomidine group received a loading dose dexmedetomidine (0.6 μg/kg in 10 min before anaesthesia induction) followed by a continuous infusion (0.5 μg/kg/hr) till 1 h before the end of surgery. Patients in control group received volume-matched normal saline at the same time interval. Primary outcome was the incidence of intraoperative hyperglycemia (blood glucose higher than 10 mmol/L). Results 303 patients in dexmedetomidine group and 306 patients in control group were analysed. The incidence of intraoperative hyperglycemia showed no statistical significance between dexmedetomidine group and control group (27.4% vs. 22.5%, RR = 1.22, 95%CI 0.92–1.60, P = 0.167). Median value of glycemic variation in dexmedetomidine group (2.5, IQR 1.4–3.7, mmol) was slightly lower than that in control group (2.6, IQR 1.5–4.0, mmol), P = 0.034. In multivariable logistic analysis, history of diabetes (OR 3.007, 95%CI 1.826–4.950, P < 0.001), higher baseline blood glucose (OR 1.353, 95%CI 1.174–1.560, P < 0.001) and prolonged surgery time (OR 1.197, 95%CI 1.083–1.324, P < 0.001) were independent risk factors of hyperglycaemia. Conclusions Dexmedetomidine presented no effect on intraoperative hyperglycemia in elderly patients undergoing major non-cardiac surgery. Trial registration Present study was registered at Chinese Clinical Trial Registry on December 1, 2015 (www.chictr.org.cn, registration number ChiCTR-IPR-15007654).

scholarly journals Effectiveness of Kangaroo Mother Care in Reducing Morbidity and Mortality among Preterm Neonates on Nasal Continuous Positive Airway Pressure: A Randomized Controlled Trial

2021 ◽  
Vol 55 (9) ◽  
Author(s):  
Catherine P. Ricero-Luistro ◽  
Maria Esterlita T. Villanueva-Uy ◽  
Aurora Gloria I. Libadia ◽  
Socorro De Leon-Mendoza
Keyword(s):  
Randomized Controlled Trial ◽  
Continuous Positive Airway Pressure ◽  
Hospital Stay ◽  
Airway Pressure ◽  
Positive Airway Pressure ◽  
Controlled Trial ◽  
Length Of Hospital Stay ◽  
Kangaroo Mother Care ◽  
Preterm Neonates ◽  
Randomized Controlled

Background. Prematurity is a major cause of neonatal death. Continuous positive airway pressure (CPAP) is the recognized initial intervention among preterm neonates in respiratory distress. Kangaroo mother care (KMC) may help improve neonatal outcomes. Objective. To determine the effectiveness of KMC in reducing morbidity and mortality among preterm neonates on CPAP via RAM nasal cannula (nCPAP). Methods. A prospective, non-blinded, randomized controlled trial was conducted on eligible preterm neonates requiring nCPAP due to respiratory distress. They were randomly allocated to either KMC (n=35) or conventional care groups (n=35). Outcome measures included duration of nCPAP and oxygen support, physiologic parameters, morbidity, mortality, and length of hospital stay. Results. The durations of nCPAP and oxygen support were both significantly shorter in the KMC group. Morbidities (air leak syndrome, necrotizing enterocolitis, and late-onset sepsis) were also significantly lower in the KMC group. Although the mortality rate and the hospital stay were lower in the KMC group, these were not statistically significant. Conclusion. KMC effectively decreased the duration of nCPAP and oxygen support, as well as the incidence of neonatal morbidities. There were trends towards reduced mortality and length of hospital stay in the neonates who received KMC.

scholarly journals Breast Feeding as Analgesia in Neonates: A Randomized Controlled Trial

2017 ◽  
Vol 36 (3) ◽  
pp. 238-242 ◽  
Author(s):  
Rajesh Kumar Singh ◽  
Ashish Kumar Simalti ◽  
Daljit Singh
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Randomized Controlled Trial ◽  
Oxygen Saturation ◽  
Breast Feeding ◽  
Controlled Trial ◽  
Randomized Controlled ◽  
Group I ◽  
Heel Prick ◽  
Breast Fed

Introduction: Major myth regarding neonatal pain suggests that neonates because of their neurological immaturity do not experience pain. Although exact mechanism is not known, it is proposed that breast feeding through combination of various senses and the closeness of the infant’s mother, saturates the senses thus reducing perception of noxious stimuli. The objective of this study was to investigate the analgesic effect of breastfeeding during blood sampling through heel lance in healthy term neonates.Material and Methods: This was a Randomized controlled trial done in a Tertiary level Neonatal Intensive Care Unit. Sixty healthy term newborns, undergoing heel prick were included in study. Neonates were randomly assigned to two groups: Group I (breastfed) with; Group II (not breast fed). Babies were given heel prick and crying time, Heart rate, SpO2 and BP monitored. Changes in various physiological parameters following a heel prick were studied in two groups.Results: Neonates in both groups expressed pain by crying, increase in heart rate, fall in transcutaneous oxygen saturation and rise in blood pressure. Compared to control group, the babies who were breast fed were found to have lesser crying time (40.04 sec and 69.09 sec respectively, p<0.05) and lesser rise in heart rate (rise of 21.78 and 34.46 bpm respectively, p<0.03). In the breast fed group there was a trend to a lesser decrease in oxygen saturation and lesser rise in blood pressure though this was not statistically significant.Conclusion: Breast feeding offers a quick and effective means of reducing pain in neonates during routine neonatal procedures.J Nepal Paediatr Soc 2016;36(3):238-242

scholarly journals Transcutaneous electrical acupoint stimulation before induction of anesthesia reduces sufentanil-induced cough: a randomized, controlled trial

2021 ◽  
Keyword(s):  
Heart Rate ◽  
Randomized Controlled Trial ◽  
General Anesthesia ◽  
Controlled Trial ◽  
Inhibitory Effect ◽  
Common Side Effect ◽  
Control Group ◽  
Randomized Controlled ◽  
The Mean ◽  
Acupoint Stimulation

Background: Sufentanil-induced cough is a common side effect during the induction of general anesthesia. This study sought to determine the inhibitory effect of TEAS (transcutaneous electrical acupoint stimulation) on the incidence of sufentanil-induced cough. Methods: A total of 339 patients were recruited of which 300 patients were enrolled and randomly allocated into five groups (n = 60): Patients did not receive TEAS in the control group (C group); patients received 2 Hz TEAS at LI4/PC6 (Hegu/Neiguan) in the 2A group; patients received 100 Hz TEAS at LI4/PC6 in the 100A group; patients received 2 Hz TEAS at ST36/SP6 (Zusanli/sanyinjiao) in the 2B group; and patients received 100 Hz TEAS at ST36/SP6 in the 100B group. With the exception of the C group, all groups received TEAS for 30 minutes before induction. 0.5 µg/kg of IV sufentanil was given over 2 seconds, and the occurrence of cough was observed and recorded for 1 minute. The severity of cough was graded as mild (1-2 coughs), moderate (3-5 coughs), and severe (> 5 coughs). The mean arterial pressure (MAP) and heart rate (HR) before (T0) and 1 minute after (T1) sufentanil injection were recorded. Results: The incidence of sufentanil-induced cough in C group, 2A group, 2B group, 100A group and 100B group were 37%, 27%, 27%, 12% and 13%, respectively. Compared with the C group, the incidence of cough in the 100A group and the 100B group were significantly lower (P < 0.05). The MAP and HR between the five groups were not statistically different. Conclusion: The administration of 100 Hz TEAS for 30 minutes before sufentanil injection can effectively reduce the incidence of sufentanil-induced cough during the induction of general anesthesia.

Is Matching Exercise Intensity to Heart Rate Variability a Key to Effective Conditioning for Dancers? A Prospective Randomized Controlled Trial

2021 ◽  
Author(s):  
Meredith N. Butulis ◽  
Brittany J. Fedor ◽  
Rebecca Stone McGaver ◽  
M. Russell Giveans
Keyword(s):  
Heart Rate ◽  
Randomized Controlled Trial ◽  
Lower Extremity ◽  
Mobile Technology ◽  
Controlled Trial ◽  
Muscle Endurance ◽  
Control Group ◽  
Randomized Controlled ◽  
Intensity Control ◽  
Prospective Randomized Controlled Trial

Dancers seek studio-based conditioning methods that improve fitness to help them meet the demands of their discipline. Heart rate variability (HRV) mobile technology offers one such potential method. The purpose of this prospective randomized controlled trial was to investigate how HRV impacted fitness outcomes over a 4 to 6 week period of supplemental training. The study’s cohort, 134 competitive female dancers ages 12 to 35, were randomly assigned to one of three groups: the HRV study group, the Tabata high-intensity control group, or the Vinyasa yoga low-intensity control group. Fitness assessments conducted in the pre- and post-training period included cardiovascular endurance, muscular endurance, and lower extremity power. These assessments were evaluated with ANOVA between group and within group comparisons. Results revealed lower extremity power improvement in the HRV group at a statistically significant level (p < 0.05) and overall trends toward greater muscle endurance. Additional unanticipated findings surfaced in the yoga control group that demonstrated cardiovascular improvements and normalization of right versus left lower extremity power discrepancies. Conclusions support the use of HRV mobile technology to individualize daily conditioning intensity, thereby efficiently improving lower extremity power and overall muscle endurance for dancers while monitoring for signs of overtraining.

scholarly journals Physiological and Psychological Effects of Parental Traditional Thai Massage on Children with Autism: A Protocol for a Randomized Controlled Trial

2021 ◽  
Author(s):  
Hui Ruan ◽  
Wichai Eungpinichpong ◽  
Hua Wu ◽  
Chanada Aonsri
Keyword(s):  
Heart Rate ◽  
Randomized Controlled Trial ◽  
Heart Rate Variability ◽  
Controlled Trial ◽  
Children With Autism ◽  
Complementary Therapy ◽  
Psychological Effects ◽  
Stress Index ◽  
Control Group ◽  
Randomized Controlled

Introduction Although many autistic children receive massage as a complementary therapy, it is not included in evidence-based practices for autism since evidence of its efficacy is lacking. Further, prior studies have failed to identify objective indicators of core symptoms or elucidate their mechanisms. We developed a parent-delivered traditional Thai massage (TTM) on children intervention with autism, aim is to access the physiological (gait and heart rate variability) and psychological effects of intervention. Methods and analysis A two-armed, parallel randomized controlled trial study will recruit forty-eight children with autism from the XX Special Education School at the beginning of Febuary2022. They will be randomly assigned to either a parental TTM or control group with a ratio of 1:1. Individuals in the parental TTM group will receive 16 parent-delivered TTM sessions over 8 weeks. The outcome will be assessed on admission, after 8 weeks, and as well as at 2-month follow-up, including the Autism Treatment Evaluation Checklist score, heart rate variability, gait, and parenting stress index. Ethics and dissemination Ethical approved by the Khon Kaen University Ethics Committee for Human Research (XXXX). Result will be published in a peer-reviewed journal and give presentations in domestic and international academic conferences to further promote communication. Trial registration number: XXXXXX

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