scholarly journals Correlation of Telomere Length and Serotonin Levels with Job Stress and Locus of Control Type among Nurses at a Private Hospital in Gianyar, Indonesia

2021 ◽  
Vol 55 (6) ◽  
Author(s):  
Susy Purnawati ◽  
I Made Krisna Dinata ◽  
Lina Wandira ◽  
I G Kamasan Nyoman Arijana
Keyword(s):  
Locus Of Control ◽  
Telomere Length ◽  
Job Stress ◽  
Shift Work ◽  
Private Hospital ◽  
Health Sector ◽  
Prevalence Ratio ◽  
Serotonin Level ◽  
Cross Sectional ◽  
The Mean

Objectives. Telomere length and its relationship to job stress among workers in the health sector in Indonesia, especially in Bali, have never been studied. The purpose of the study was to analyze the correlation of the telomere length and serotonin levels to job stress and the type of locus of control (LOC) among nurses who were running shift work. Method. This analytical cross-sectional study was conducted from April to November 2018 among 68 nurses who were running shift work at a private hospital in Gianyar. The telomere length was measured with the absolute telomere length (aTL) using quantitative real-time polymerase chain reaction (qPCR) technique. Locus of control (LOC) was assessed using the IPC-LOC questionnaire. Serotonin level was measured by the immunoassay technique. Job stress was measured using the BJSQ. Data analysis was conducted with Chi-squared test, correlation test, and independent sample t-test. Results. There was a significant correlation of job stress with telomere length (p = 0.03). Nurses with job stress faced a 2.9 times risk of short telomere (prevalence ratio, PR = 2.95, 95% CI 1.02, 7.91). The mean telomere length was 17.32 ± 7.80 in nurses who experienced job stress vs. 22.45 ± 8.41 in nurses who did not experience job stress. Comparing with a previous study done by to O’Callaghan et al., in the young group, the mean aTL was 97.2 kb/diploid genome (range 35-260). We also found a significant correlation of job stress score with serotonin level (p = 0.02). The serotonin level among nurses with LOC-e type was lower than LOC-i. Conclusion. There was a significant correlation between job stress and telomere length, where nurses who experienced job stress had a shorter telomere than those who did not experience job stress. There was also a significant correlation between job stress and serotonin levels, where the mean of serotonin levels in nurses with LOC-e type was lower than LOC-i.

Serotonin variations and sleep disorders among shift workers. A cross-sectional study

2021 ◽  
pp. 074823372110331
Author(s):  
Rehab Shehata Abdelhady Shehata ◽  
Zeinab Ahmed Mohamed Nour ◽  
Amul Mohamed Abdelrahim Badr ◽  
Eman Mahmoud Khalifa
Keyword(s):  
Sleep Quality ◽  
Shift Work ◽  
Night Shift ◽  
Cross Sectional Study ◽  
Poor Sleep ◽  
Serotonin Level ◽  
Poor Sleep Quality ◽  
Cross Sectional ◽  
Shift Workers ◽  
Blood Serotonin

Sleep disorders are prevalent occupational health problems among shift workers, especially healthcare workers with long shifts. Serotonin is a neurotransmitter related to circadian variations accompanied by shift work. A cross-sectional study was performed on 73 nurses at a tertiary hospital in Cairo, Egypt, to assess sleep quality among shift work nurses (SWNs), to determine blood serotonin level, and its relation to shift work and sleep quality. A demographic and occupational history questionnaire, Pittsburgh Sleep Quality Index (PSQI) questionnaire, and measurement of blood serotonin were carried out to the studied group. The data were analyzed using SPSS 25, and descriptive statistics, unpaired t-test, ANOVA, Kruskal–Wallis Test, Chi-square, Spearman correlation, and multivariate regression analysis were utilized. The results showed that the mean PSQI global score was significantly higher among SWNs than non-shift work nurses (NSWNs) and was the highest (10.32 ± 3.56 and 10.22 ± 2.4, respectively) among rotatory and fixed night shift nurses. Blood serotonin showed highly significant differences between SWNs over NSWNs ( p = 0.001), and mostly reduced among rotatory and fixed night shift nurses (66.7% and 65%, respectively). Moreover, there were highly significant differences in serotonin levels between poor and good sleep quality nurses ( p < 0.001), and most of the poor sleep quality nurses (62.7%) had low serotonin levels. Abnormal serotonin level (odds = 246.5) and working years (odds = 1.2) were statistically significant predictors of poor sleep quality. In conclusion, SWNs, especially rotating and night shift nurses, suffer from poor sleep quality associated with abnormal levels of blood serotonin.

scholarly journals Breast Cancer in Men: Clinical and Pathological Analysis of 817 Cases

2020 ◽  
Vol 14 (4) ◽  
pp. 155798832090810
Author(s):  
Fernanda Servidoni Spreafico ◽  
Cassio Cardoso-Filho ◽  
Cesar Cabello ◽  
Luis Otávio Sarian ◽  
Luiz Carlos Zeferino ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Ductal Carcinoma ◽  
Prevalence Ratio ◽  
Breast Cancer Diagnosis ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Histological Types ◽  
The Mean ◽  
Breast Cancer In Men

The objective of the current study was to describe breast cancer cases in men according to age, stage, and histology, calculating risks compared to women. It is a retrospective cross-sectional study of all breast cancer cases of the Hospital Cancer Registry of São Paulo state, Brazil, 2000–2015. Variables were age, sex, stage, and histology. Absolute numbers and proportions, Mann–Whitney test and prevalence ratio with 95% confidence interval were used. The study included 93,737 cases, of which 817 were males. The mean age at diagnosis was 60.3 years in men and 56.2 years in women ( p < .001). Stage II was the most common in both sexes (33.9% in men and 36.5% in women). Men had a higher frequency of stage III than women (PR 1.18, 95% CI 1.01–1.37). Stage 0 was significantly more common in women (PR 0.69, 95% CI 0.51–0.94). Ductal carcinoma and its variants were the most common histological types in both sexes (88.7% in men and 89.0% in women). Men had a higher frequency of rarer histological types such as papillary (PR 2.17, 95% CI 1.36–3.44) and sarcomas (PR 4.10, 95% CI 1.86–9.01). In conclusion, in men, breast cancer diagnosis occurred in more advanced ages and stages. Invasive ductal carcinoma was the primary histological type observed, although rarer types were more frequent.

Telomere Length Among the Elderly and Oldest-Old

2005 ◽  
Vol 8 (5) ◽  
pp. 425-432 ◽  
Author(s):  
Claus Bischoff ◽  
Jesper Graakjaer ◽  
Hans Christian Petersen ◽  
Bernard Jeune ◽  
Vilhelm A. Bohr ◽  
...  
Keyword(s):  
Telomere Length ◽  
Oldest Old ◽  
The Elderly ◽  
Specific Difference ◽  
Cross Sectional ◽  
Telomere Shortening ◽  
Telomere Sequence ◽  
Age Dependent ◽  
The Mean ◽  
Telomere Loss

AbstractHuman chromosomes terminate in a number of repeats of the sequence TTAGGG. At birth, each chromosome end is equipped with approximately 15 kb of telomere sequence, but this sequence is shortened during each cell division. In cell cultures telomere shortening is associated with senescence, a phenomenon that has also been observed in normal adult tissues, indicating that telomere loss is associated with organismal ageing. Previous work has established that the rate of telomere loss in humans is age dependent, and recent work shows a sex-specific difference in telomere length and shortening in individuals over the age span of 20 to 75 years. Here, terminal restriction fragment lengths on DNA purified from whole blood were measured to examine the mean telomere length in a cross-sectional cohort of 816 Danish individuals of age 73 to 101 years. In this age group, females show a linear correlation between telomere length and age, whereas the pattern tends to be nonlinear (quadratic in age) for males. This difference in telomere length dynamics between the 2 sexes may be caused by several different mechanisms, including differences in selection by mortality, differences in leukocyte population or different telomerase expression pattern.

scholarly journals Factors Related to the Number of Antral Follicles on InVitro Fertilization (IVF)

2016 ◽  
pp. 75
Author(s):  
Fransiskus C Raharja ◽  
Ketut Suwiyoga ◽  
IPG Wardhiana
Keyword(s):  
Prevalence Ratio ◽  
Cross Sectional Study ◽  
Chi Square ◽  
Cross Sectional ◽  
Vitro Fertilization ◽  
Antral Follicles ◽  
Chi Square Test ◽  
The Mean ◽  
Infertile Patients

Objective: To determine factors which are related to the number of antral follicles on infertile patients. Method: This cross sectional study was conducted in In-Vitro Fertilization (IVF) clinic of Graha Tunjung, Sanglah hospital, Bali. All fertile patients following the IVF program were calculated the number of antral follicles in both ovarian using transgene USG. This sample was recruited by random sampling from April 1st, 2001 to April 30th, 2011. We analyzed the data using Chi square test through SPSS for Windows 17.0 version. Result: Of 102 samples, the mean of patients’ age was 32.9% (SD 4.6) years old. From 72 patients (70.6%) experienced above 3 years of infertile period, the primary infertile was on 69 patients (67.7%). There was a relationship between patients’ age and the number of antral follicles significantly (prevalence ratio (PR) 1.41; 95% CI 1.11- 1.79). Meanwhile, the number of antral follicles and type of infertile (PR 1.02; 95% CI 0.76-1.37) also infertile period (PR 0.95; 95% CI 0.72-1.27) were not associated significantly. Conclusion: Patients’ age has an association with the number of antral follicles on IVF. [Indones J Obstet Gynecol 2016; 4-2: 75-77] Keywords: age, infertile, infertile period, number of antral follicles and type of infertile

scholarly journals Workload Status and Its Relationship with Job Stress in Nurses during the COVID-19 Pandemic

2022 ◽  
Author(s):  
Ali Reza Yusefi ◽  
Parnian Nikmanesh ◽  
Shima Bordbar ◽  
Mohammad Khammarnia ◽  
Zahra Kavosi
Keyword(s):  
Job Stress ◽  
Work Experience ◽  
Emotional Health ◽  
Pearson Correlation ◽  
Cross Sectional Study ◽  
Mental Load ◽  
Cross Sectional ◽  
Significance Level ◽  
Southern Iran ◽  
The Mean

Background and Purpose: Currently, the high prevalence of COVID-19 and increased workload in hospitals has posed a threat to the physical, mental, and emotional health of nurses. The present study was an attempt to investigate the workload and its relationship with job stress of nurses in COVID-19 reference hospitals in southern Iran. Materials and Methods: This descriptive-analytical and cross-sectional study was conducted in 2021 on 431 nurses from COVID-19 reference hospitals in southern Iran. Data collection tools included the NASA workload and OSIPOW job stress standard questionnaires. Data were analyzed using t-test, ANOVA, and Pearson correlation coefficient in SPSS23 Software and at a significance level of 0.05 Results: The mean age and work experience of the nurses participating in the study were 31.03±5.23 and 6.42±4.61, respectively. The mean scores of the workload and job stresses were 83.64 ± 17.24 (of 100) and 236.68 ± 16.54 (of 300), respectively. Mental load dimension (85.81 ±19.31, of 100) among workload dimensions and role workload dimension (43.62 ± 19.14, of 50) among job stress dimensions had the highest mean score. Thus, there was found a statistically significant relationship between workload and job stress of nurses (P= 0.04, r= 0.19). Conclusion: Workload and job stress of the studied nurses were estimated at a high level. There was a significant positive correlation between these two variables, and increasing workload resulted in an increase in job stress.

scholarly journals Profile of Laryngeal Microsurgeries in Patients Over 60 Years Old

2020 ◽  
Vol 24 (01) ◽  
pp. e53-e61
Author(s):  
Caroline Fernandes Rimoli ◽  
Evaldo Dacheux Macedo Filho ◽  
Maria Theresa Costa Ramos Oliveira Patrial ◽  
Cynthia Fontoura Klas ◽  
Giovana Aryane Nascimento
Keyword(s):  
Private Hospital ◽  
The Elderly ◽  
Cross Sectional ◽  
Associated Lesions ◽  
Professional Voice Users ◽  
Male Patients ◽  
The Mean ◽  
Cross Sectional Design ◽  
Reinke Edema ◽  
Professional Voice

Abstract Introduction The increase in life expectancy is an incentive to the development of researches with the elderly population aiming at actions that may ensure healthy and active aging. Objective To analyze the profile of laryngeal microsurgery performed in patients > 60 years old. Methods A retrospective observational study, with a cross-sectional design. A retrospective analysis of the medical records of elderly patients submitted to laryngeal microsurgery was performed at a private hospital in Curitiba, state of Paraná, Brazil, between January 2004 and December 2016. Were included all of the patients > 60 years old that underwent laryngeal microsurgery during this period. Results During the studied period, 213 laryngeal microsurgeries were performed in 181 patients > 60 years old. There was a preponderance of male patients. The mean age was 67.6 years old. Squamous cell carcinoma (SCC) was the most prevalent disorder (26%), followed by Reinke edema (20%), papillomatosis (14%), polyps (11%), leukoplakia (8%), minor structural alterations (8%), associated lesions (9%), and others (4%). Men presented a higher probability of SCC diagnosis, regardless of the age group, while Reinke edema was more frequently observed in women. A directly proportional relation between the frequency of laryngeal cancer and age increase was also observed. No significant differences were observed in professional voice users. Conclusion Further researches are required to properly comprehend the factors associated with laryngeal lesions and determine prevention and treatment approaches.

scholarly journals Occupational Stress in Spanish Police Officers: Validating the Effort-Reward Imbalance Questionnaire

2021 ◽  
Vol 18 (4) ◽  
pp. 1393
Author(s):  
Lourdes Luceño-Moreno ◽  
Beatriz Talavera-Velasco ◽  
Marian Jaén-Díaz ◽  
Jesús Martín-García
Keyword(s):  
Occupational Stress ◽  
Job Stress ◽  
Police Officers ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Confirmatory Factor ◽  
Effort Reward Imbalance ◽  
Valid Instrument ◽  
Reward Imbalance ◽  
The Mean

The Effort-Reward Imbalance Questionnaire (hereinafter, ERIQ) has been largely used worldwide to assess job stress, but it has not yet been applied in Spanish police. The objective of this study was to examine the construct validity and the internal consistency of the ERIQ in police officers. A cross-sectional study was carried out, using a nonprobability sampling (quota). A total of 217 Spanish police officers participated, 192 men (88.47%) and 25 women (11.53%). The mean age was 41 years (SD = 7.51). These police officers completed the ERIQ together with some other questionnaires (DECORE-21, MBI, GHQ and STAI) in order to provide evidence for validity based on the relationships to other constructs. A confirmatory factor analysis was performed and a matrix of correlations with the rest of constructs was created. The results showed an appropriate fit to the original model consisting of three scales. In addition, the scales of the ERIQ presented the expected relationship with the other constructs. The ERIQ is a valid instrument for assessing occupational stress in Spanish police officers and can improve the interventions in this professional group.

scholarly journals GAMBARAN TINGKAT STRESS KERJA ANTAR SHIFT KERJA PADA PETUGAS PENGUMPUL TOL SURABAYA

2017 ◽  
Vol 4 (2) ◽  
pp. 123
Author(s):  
Ayyuda Asyraf Zahra ◽  
Sho'im Hidayat
Keyword(s):  
Job Stress ◽  
Shift Work ◽  
Work Stress ◽  
Sampling Method ◽  
Mild Stress ◽  
Cross Sectional ◽  
Toll Road ◽  
Training Activities ◽  
Moderate Stress ◽  
Morning Shift

PT. (X), Surabaya is one of company that manages toll road or highway that implement the shift system of work. Shift work has the potential for job stress and other health problems. The purpose of this research was to identify descriptive the level of job stress between shift work at the toll collector in PT. (X), Surabaya. This research was an observational analytic study with cross sectional approach. 36 toll collector who work when the morning shift, afternoon, and evening at the toll gate x, toll gate y and toll gate z were chosen as sample by using Proportional Random Sampling method. The results showed when the shift I (morning) there were 15 respondents (41.7%) suffered mild job stress and 21 respondents (58.3%) suffered moderate job stress. At the shift II (evening) there were 12 respondents (33.3%) suffered mild stress of work and 24 respondents (66.7%) suffered moderate job stress, while at the shift III (evening) were 9 respondents (25%) suffered light work stress and 27 respondents (75%) suffered moderate job stress. Based on the research results, it can be concluded the level of job stress between of shift work on the toll collectors suffered mild and moderate stress. The greatest frequency of respondents suffered moderate job stress. Recommendation for the company is review the system of career development and maintaining training activities, while for workers is use the time to rest and regular exercise.Keywords: job stress, shift work, toll collector

Cross-Sectional Study of the Impact of a Natural Disaster on the Delivery of Gynecologic Oncology Care

2015 ◽  
Vol 9 (6) ◽  
pp. 605-608 ◽  
Author(s):  
Gizelka David-West ◽  
Fernanda Musa ◽  
Melissa K. Frey ◽  
Leslie Boyd ◽  
Bhavana Pothuri ◽  
...  
Keyword(s):  
Private Hospital ◽  
Gynecologic Oncology ◽  
Cross Sectional Study ◽  
City Hospital ◽  
Sectional Study ◽  
Cross Sectional ◽  
Mean Delay ◽  
Oncology Care ◽  
The Mean ◽  
The City

AbstractObjectiveWe aimed to compare access to gynecologic oncology care at a private and a city hospital, both of which closed for a period of time because of Hurricane Sandy.MethodsThis was a cross-sectional study of gynecologic oncology chemotherapy, radiotherapy, and surgical patients from October 29, 2012 (the eve of the storm), to February 7, 2013 (the reopening of the city hospital). New referrals during this time were excluded. Delays in chemotherapy, radiotherapy, and surgery were compared.ResultsAnalysis included 113 patients: 59 private patients (52.2%) and 54 city patients (47.8%). Of the private patients, 33/59 received chemotherapy (55.9%), 1/59 received radiotherapy (1.7%), and 28/59 had planned surgery (47.5%). Of the city patients, 40/54 received chemotherapy (74.1%), 7/54 received radiotherapy (12.3%), and 18/54 had planned surgery (33.3%). The mean delay in chemotherapy was 7.6 days at the private hospital and 21.7 days at the city hospital (P=0.0004). The mean delay in scheduled surgery was 14.2 days at the private hospital and 22.7 days at the city hospital (P=0.3979). The mean delay in radiotherapy was 0.0 days at the private hospital and 25.0 days at the city hospital (P=0.0046). Loss to follow-up rates were 3/59 of the private patients (5.1%) and 3/54 of the city patients (5.6%).ConclusionsGynecologic oncology care was maintained during a natural disaster despite temporary closure and relocation of services. Disparity in care was in access to chemotherapy. (Disaster Med Public Health Preparedness. 2015;9:605–608)

scholarly journals Association between carbohydrate consumption with telomere length based on plasma malondialdehyde in Minangkabau male

2019 ◽  
Vol 7 (7) ◽  
pp. 2506
Author(s):  
Weni F. Nazulis ◽  
Delmi Sulastri ◽  
Yuniar Lestari
Keyword(s):  
Telomere Length ◽  
Quantitative Polymerase Chain Reaction ◽  
Health Sector ◽  
Thiobarbituric Acid ◽  
P Value ◽  
Sucrose Consumption ◽  
Cross Sectional ◽  
Carbohydrate Consumption ◽  
Significant Difference ◽  
Plasma Malondialdehyde

Background: Life expectancy was one indicator of human development index in the health sector, one of which was affected by the telomere shortening process. There were many factors that cause shortening of telomere, including an imbalance of carbohydrate consumption then oxidative stress. The study aimed to examine the association between carbohydrate and carbohydrate simplex (sucrose) consumption with telomere length based on plasma malondialdehyde in Minangkabau male.Methods: The study was cross-sectional with 97 samples from male civil servant, Minangkabau ethnic, 40-50 years old in Padang City. Carbohydrate and sucrose consumptions were obtained through semiquantitative food frequency questionnaire, plasma malondialdehyde examination with thiobarbituric acid test and telomere length measured by quantitative polymerase chain reaction using O'Challagan and Fenech method.Results: The result showed mean of telomere length was 550.43±188.47 bp; mean of carbohydrate consumption 1280.97±433.57 kcal or 48.80±16.52%; mean of sucrose consumption 179.40±126.61 kcal or 6.83±4.82% and mean plasma malondialdehyde 66.91±13.93 nmol/ml. The association of carbohydrate consumption with telomere length based on plasma malondialdehyde was obtained p-value = 0.714, 0.908 and 0.903. The relationship of sucrose consumption with telomere length based on malondialdehyde was obtained p-value=0,667 and 1,000. Differences in mean telomere length in various categories of carbohydrate and sucrose consumption obtained p-value = 0.547 and 0.559.Conclusions: There was no significant association between carbohydrate and carbohydrate simplex (sucrose) consumption with telomere length based on plasma malondialdehyde of Minangkabau male; and no significant difference in telomere length in different categories of carbohydrate consumption and different sucrose consumption.

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