Application Effect of Comprehensive Nursing in Clinical Nursing of Rheumatic Immune System Diseases

2021 ◽  
Keyword(s):  
Immune System ◽  
Immune System Diseases ◽  
Clinical Nursing

scholarly journals The Role of Nitric Oxide in Stem/Progenitor Cells

2018 ◽  
Vol 2 (1) ◽  
Keyword(s):  
Nitric Oxide ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Immune System ◽  
Progenitor Cells ◽  
Embryonic Stem ◽  
Clinical Value ◽  
Immune System Diseases ◽  
Function Mechanism

The research on nitric Oxide (NO) and stem cells are the focus in recent years. However, seldom do people conclude the function, mechanism and clinical value of NO in various stem cells including embryonic stem cells (ESCs), endothelial progenitor cells (EPCs), mesenchymal stem cells (MSCs) and neural stem cells (NSCs). In the present review, we evaluate the recent studies on NO in different stem cells and display the latest progresses of NO therapy for tumor, cardiovascular, neurologic and immune system diseases by stem cells.

scholarly journals Therapeutic Interventions into Innate Immune Diseases by Means of Aptamers

Pharmaceutics ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 955
Author(s):  
Farzana Yasmeen ◽  
Hana Seo ◽  
Nasir Javaid ◽  
Moon Suk Kim ◽  
Sangdun Choi
Keyword(s):  
Pattern Recognition ◽  
Immune System ◽  
Crucial Role ◽  
Innate Immune System ◽  
Innate Immune ◽  
Therapeutic Interventions ◽  
Immune System Diseases ◽  
Target Molecules ◽  
Molecular Patterns ◽  
Recognition Receptor

The immune system plays a crucial role in the body’s defense system against various pathogens, such as bacteria, viruses, and parasites, as well as recognizes non-self- and self-molecules. The innate immune system is composed of special receptors known as pattern recognition receptors, which play a crucial role in the identification of pathogen-associated molecular patterns from diverse microorganisms. Any disequilibrium in the activation of a particular pattern recognition receptor leads to various inflammatory, autoimmune, or immunodeficiency diseases. Aptamers are short single-stranded deoxyribonucleic acid or ribonucleic acid molecules, also termed “chemical antibodies,” which have tremendous specificity and affinity for their target molecules. Their features, such as stability, low immunogenicity, ease of manufacturing, and facile screening against a target, make them preferable as therapeutics. Immune-system–targeting aptamers have a great potential as a targeted therapeutic strategy against immune diseases. This review summarizes components of the innate immune system, aptamer production, pharmacokinetic characteristics of aptamers, and aptamers related to innate-immune-system diseases.

Immune system diseases

2001 ◽  
pp. 61-72
Author(s):  
Jennifer Torr ◽  
Lynette Lee
Keyword(s):  
Immune System ◽  
Immune System Diseases

Development of Computer-Assisted Instruction Lesson on Immune System Organs and Immune System Diseases

2018 ◽  
Vol 879 ◽  
pp. 276-283
Author(s):  
Monamorn Precharattana
Keyword(s):  
Immune System ◽  
Qualitative Data ◽  
T Test ◽  
Assessment Tools ◽  
Computer Assisted Instruction ◽  
Computer Assisted ◽  
School Students ◽  
Immune System Diseases ◽  
Assessment Techniques ◽  
Assisted Instruction

Recent advances in computer technology have led to the creation and development of computer-assisted instruction (CAI), which are rapidly assuming a prominent role in many fields of education. The development process includes analyzing lesson and users, designing computing lesson and assessment techniques, constructing computing lesson and assessment tools, and evaluating the lesson through users feedback. In this work, we aim to (i) Develop computer-assisted instruction of immune system organs and immune system diseases, and (ii) Examine efficiency of the developed CAI. A total of 142 secondary school students was involved in the study. Pretest-Posttest and Satisfaction questionnaire for the students towards the CAI were used as research instruments. The quantitative data was analyzed by t-test, and the qualitative data was analyzed by content analysis. The paired-sample t-test indicated a significant enhancement of students’ understanding after the using of developed instruction at .05 significant level. Moreover, the students were very satisfied with the developed CAI.

Functional variants in hematopoietic transcription factor footprints and their roles in the risk of immune system diseases

2021 ◽  
Author(s):  
Naoto Kubota ◽  
Mikita Suyama
Keyword(s):  
Transcription Factor ◽  
Immune System ◽  
Human Genome ◽  
Disease Risk ◽  
Regulatory Elements ◽  
Molecular Pathogenesis ◽  
Protein Coding ◽  
Immune System Diseases ◽  
Regulatory Variants ◽  
Functional Variants

AbstractGenome-wide association studies (GWAS) have been performed to identify thousands of variants in the human genome as disease risk markers, but functional variants that actually affect gene regulation and their genomic features remain largely unknown. Here we performed a comprehensive survey of functional variants in the regulatory elements of the human genome. We integrated hematopoietic transcription factor (TF) footprints datasets generated by ENCODE project with multiple quantitative trait locus (QTL) datasets (eQTL, caQTL, bQTL, and hQTL) and investigated the associations of functional variants and immune system disease risk. We identified candidate regulatory variants highly linked with GWAS lead variants and found that they were strongly enriched in active enhancers in hematopoietic cells, emphasizing the clinical relevance of enhancers in disease risk. Moreover, we found some strong relationships between traits and hematopoietic cell types or TFs. We highlighted some credible regulatory variants and found that a variant, rs2291668, which potentially functions in the molecular pathogenesis of multiple sclerosis, is located within a TF footprint present in a protein-coding exon of the TNFSF14 gene, indicating that protein-coding exons as well as noncoding regions can possess clinically relevant regulatory elements. Collectively, our results shed light on the molecular pathogenesis of immune system diseases. The methods described in this study can readily be applied to the study of the risk factors of other diseases.

scholarly journals Attention-Deficit/Hyperactivity Disorder in Offspring of Mothers With Inflammatory and Immune System Diseases

2017 ◽  
Vol 81 (5) ◽  
pp. 452-459 ◽  
Author(s):  
Johanne T. Instanes ◽  
Anne Halmøy ◽  
Anders Engeland ◽  
Jan Haavik ◽  
Kari Furu ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Immune System ◽  
Attention Deficit ◽  
Immune System Diseases ◽  
Hyperactivity Disorder

scholarly journals Gender Variations in the Oral Microbiomes of Elderly Patients with Initial Periodontitis

2021 ◽  
Vol 2021 ◽  
pp. 1-16
Author(s):  
Jie Zhao ◽  
Ying-Hui Zhou ◽  
Ya-Qiong Zhao ◽  
Yao Feng ◽  
Fei Yan ◽  
...  
Keyword(s):  
Immune System ◽  
Elderly Patients ◽  
16S Rrna Gene Sequencing ◽  
Oral Microbiome ◽  
Rrna Gene ◽  
Oral Microbiota ◽  
Microbial Composition ◽  
Linear Discriminant ◽  
Immune System Diseases ◽  
Analytical Approaches

Periodontitis is a globally prevalent disease that imposes a functional and aesthetic burden on patients. The oral microbiome influences human health. The aim of this study was at assessing gender variation in the subgingival bacterial microbiome of elderly patients with initial periodontitis and to determine the causes of this variation. Twelve males and twenty females (range 50–68 years old) with initial periodontitis provided subgingival plaque samples. 16S rRNA gene sequencing, QIIME-based data processing, and statistical analyses were carried out using several different analytical approaches to detect differences in the oral microbiome between the two groups. Males had higher Chao1 index, observed species, and phylogenetic diversity whole tree values than females. Analysis of β-diversity indicated that the samples were reasonably divided by the gender. The linear discriminant analysis effect size showed that the most representative biomarkers were the genus Haemophilus in males, whereas the dominant bacteria in females were Campylobacter. Kyoto Encyclopedia of Genes and Genomes analysis showed that predicting changes in the female oral microbiota may be related to the immune system and immune system diseases are the main factor in males. These data suggest that gender may be a differentiating factor in the microbial composition of subgingival plaques in elderly patients with initial periodontitis. These results could deepen our understanding of the role of gender in the oral microbiota present during initial periodontitis.

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