scholarly journals Fréquence de l’association artériopathie oblitérante des membres inférieurs et coronaropathie : résultats d’une étude transversale monocentrique à l’est algérien

2020 ◽  
Vol 7 (2) ◽  
pp. 74-78
Author(s):  
Rachid Merghit ◽  
◽  
Mouloud Ait Athmane ◽  
Abdelhak Lakehal
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Peripheral Artery Disease ◽  
Systolic Pressure ◽  
Lower Limbs ◽  
University Hospital ◽  
Peripheral Artery ◽  
Cross Sectional ◽  
Artery Disease ◽  
Brachial Systolic Pressure

Introduction. Patients with both Coronary Artery Disease (CAD) and Peripheral Artery Disease (PAD) have a worse cardiovascular prognosis. It therefore seems interesting to detect this association, in particular by measuring the ankle-brachial systolic pressure index (ABI) which is a simple, inexpensive, and non-invasive way with a significant diagnostic input that can detect silent but threatening lesions. It can also identify a subgroup of patients with coronary artery disease at a higher cardiovascular risk requiring a more specific management. Aims. Estimate the frequency of peripheral artery disease (PAD) in patients with Coronary Artery Disease CAD who were recruited at the department of cardiology at the university hospital of Constantine. This the study also aims to detect the risk factors of this association. Patients and methods. Our study is descriptive, cross-sectional, single-centered in cardiovascular exploration units of the regional military university hospital of Constantine. The included subjects had at least one significant coronary lesion in a major coronary artery using radial Coronary angiography. Guided medical history and a cardiovascular clinical examination preceded the measurement of the ABI for each patient. PAD was defined by an ABI of less than 0.90 in one of the four distal arteries of the two lower limbs. Data were analyzed and processed by Epi-Info Statistics V7. Results. 300 coronary patients, the average age of 61 years, mostly males, took part in the study. The frequency of the combination of PAD and coronary artery disease was 34.7% using the ABI, asymptomatic in 18% of cases. independent factors of the association were : Age≥ 65 [aOR 3,67, P <0,0001], tobacco [aOR 4,10, P<0,002], diabetes [aOR 3,48, P<0,0001] , AHT [aOR 3,30, P<0,0001], dyslipidemia [aOR 2.32, P<0,009], inactivity [aOR 2,14, P<0,015] , stroke [aOR 6,4, P<0,015] and severe coronary impairment [aOR 2,36, P<0,015]. Conclusion. ABI, in addition to being an early detection tool for PAD, its dissemination in medical practice would help in the approach and refinement of vascular risk in coronary heart patients.

scholarly journals DIAGNOSING PERIPHERAL ARTERIAL DISEASE IN PATIENTS WITH KNOWN CORONARY ARTERY DISEASE IN A TERTIARY CARE CENTER IN LAHORE AND ASSESSING DIAGNOSTIC ACCURACY OF ANKLE � BRACHIAL INDEX TAKING DUPLEX ULTRASOUND AS GOLD STANDARD

2016 ◽  
Vol 21 (4) ◽  
pp. 274
Author(s):  
Nauman Naseer ◽  
Ahmed Hassan ◽  
Zeeshan Ghous
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Diagnostic Accuracy ◽  
Peripheral Artery Disease ◽  
Gold Standard ◽  
Ankle Brachial Index ◽  
Systolic Pressure ◽  
Duplex Ultrasound ◽  
Peripheral Artery ◽  
Artery Disease

IntroductionIt is common for patients with PAD to have concomitant CAD because both are caused by atherosclerosis, a systemic process. This has been well established in international studies. The incidence of PAD in patients with known CAD in our population is unknown. The ankle brachial index (ABI) can be calculated by taking the ratio of ankle systolic pressure and brachial systolic pressure. It is a simple, easy and cost effective bedside tool to diagnose peripheral arterial disease (PAD).Objective:The objective of the study was to:Determine the incidence of PAD in patients with known coronary artery disease (CAD) in our population.Determine the diagnostic accuracy of ABI in diagnosing PAD in patients with CAD taking dup-lex ultrasound as gold standard in local population.Study Design: Cross sectional study.Setting:Department of Cardiology (CCU), Jinnah Hospital, Lahore.Study Duration:Six months from 01 June 2014 to 31 December 2014.Subjects and Methods:310 patients who met the inclusion / exclusion criteria were entered in the study. Mercury sphygmomanometer was used to take the systolic blood pressure of all the four limbs, and the ratio of ankle systolic pressure (higher of systolic pressure taken in both left and right limb was taken) to brachial systolic pressure (higher of systolic pressure taken in both left and right limb was taken) was used to calculate the ABI. An abnormal ABI was conside-red if the ratio was < 0.9. All subjects underwent duplex ultrasound as a gold standard to detect the presence or absence of PAD.Results:Out of 310 cases, common age was calcula-ted as 59.21 8.93 years, 53.23% (n = 165) were male while 46.77% (n = 145) were female, frequency of peripheral artery disease (PAD) on gold standard was recorded as 28.71% (n = 89), diagnostic accuracy of Ankle-Brachial Index (ABI) in diagnosing peripheral artery disease (PAD) in patients with coronary artery disease (CAD) was calculated as 93.25%, 94.21%, 86.46%, 97.20% and 93.87% as specificity, sensitivity, negative predictive value, positive predictive value and accuracy rate respectively.Conclusion:There is a 28.7% incidence of PAD in patients with known CAD in our study population. The ABI is a simple, easy low cost and yet underutilized tool that can detect PAD with high diagnostic accuracy in this population.Keywords:Coronary artery disease (CAD), peripheral artery disease (PAD), diagnosis, ankle bra-chial index (ABI), accuracy

scholarly journals Prise en charge de la maladie poly artérielle : résultats d’une étude transversale monocentrique à l’est Algérien

2021 ◽  
Vol 8 (1) ◽  
pp. 19-23
Author(s):  
Rachid Merghit ◽  
◽  
Ikhlas Gueriane ◽  
Mouloud Ait Athmane ◽  
Abdelhak Lakehal ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Abdominal Aortic Aneurysm ◽  
Coronary Artery ◽  
Aortic Aneurysm ◽  
Peripheral Artery Disease ◽  
Atherosclerotic Disease ◽  
University Hospital ◽  
Peripheral Artery ◽  
Abdominal Aortic ◽  
Artery Disease

Introduction. The rates of atherosclerotic disease as well as its multifocal aspects have been increasing significantly. It is important to know these associations to ensure comprehensive management of this category of patients. Aim. To estimate the frequency of the principal peripheral atherosclerotic associations in patients with coronary artery disease referred to cardiology in the University Hospital of Constantine. Methods. Our study is descriptive, cross-sectional, and mono-centric carried out in the unit of cardiovascular investigations of the Regional Military University Hospital of Constantine. The included patients had at least one significant coronary lesion ≥50 in a principal coronary artery. All our patients underwent an ultrasound evaluation (supra-aortic trunk echo-Doppler, Doppler Ultrasound of the aorta and lower limbs). Data were processed using SPSS Statistics V22. Results. The frequency of the association of Peripheral Artery Disease and Coronary Artery Disease was 34.7% representing the most frequent association. A hemodynamic carotid lesion (≥ 50%) and Abdominal Aortic Aneurysm were associated respectively with Coronary Artery Disease in 12% and 4.6% of patients in the current study. The triple association of coronary artery disease, Abdominal Aortic Aneurysm, and hemodynamic carotid disease was observed in 2.67%, whereas the triple association of Peripheral Artery Disease, coronary artery disease, and carotid stenosis≥50% was observed in 6.67%. The frequency of the association of coronary artery disease, Peripheral Artery Disease, and Abdominal Aortic Aneurysm was estimated at 3, 66%. The therapeutic strategy for multi-focal atherosclerotic disease is still discussed, but coronary artery disease dominates the prognosis. Conclusion. Carrying out a comprehensive assessment of patients with coronary artery disease helps significantly in establishing an adapted and pertinent management with an acceptable BenefitCost Ratio. Keywords: coronary artery disease; peripheral atheromatous disease; pan-vascular therapy.

scholarly journals Frequency of Coronary Artery Disease in Patients Undergoing Peripheral Artery Disease Surgery

2012 ◽  
Vol 110 (5) ◽  
pp. 736-740 ◽  
Author(s):  
David J. Hur ◽  
Muhammed Kizilgul ◽  
Wai W. Aung ◽  
Kristin C. Roussillon ◽  
Ellen C. Keeley
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Peripheral Artery Disease ◽  
Peripheral Artery ◽  
Artery Disease

Prognostic value of myeloperoxidase in patients with peripheral artery disease

Vascular ◽  
2020 ◽  
pp. 170853812095749
Author(s):  
Nadjib Schahab ◽  
Seyid Mansuroglu ◽  
Christian Schaefer ◽  
Rolf Fimmers ◽  
Georg Nickenig ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Vascular Disease ◽  
Peripheral Artery Disease ◽  
Prognostic Value ◽  
Target Lesion ◽  
Limb Ischaemia ◽  
Target Lesion Revascularisation ◽  
Peripheral Artery ◽  
Artery Disease

Objectives The involvement of myeloperoxidase in the production of dysfunctional high-density lipoproteins and oxidised biomolecules leads to oxidative stress in the blood vessel endothelium. This prospective cohort study aimed to examine the prognostic value of myeloperoxidase in patients with peripheral artery disease in relation to major adverse cardiac events (MACEs), target lesion revascularisation, and major adverse limb events (MALEs) and its association with multi-bed vascular disease, which is defined as any combination of the following: peripheral artery disease and coronary artery disease. Methods Myeloperoxidase levels were measured in patients with peripheral artery disease and coronary artery disease during angiography. A total of 94 patients were analysed and followed up regarding their MACEs, target lesion revascularisation, and MALEs from August 2016 until February 2019. Results Among patients with peripheral artery disease, the rates of MACE and mortality were higher in patients with high myeloperoxidase levels than in those with low myeloperoxidase levels; the myeloperoxidase levels were 3.68 times higher in these patients ( p < 0.0001). Patients with peripheral artery disease and coronary artery disease (multi-bed vascular disease) had higher myeloperoxidase levels than those with only peripheral artery disease and only coronary artery disease (one-bed vascular disease). Peripheral artery disease patients with higher myeloperoxidase levels had significantly higher rates of limb ischaemia, requiring further revascularisation than those with low myeloperoxidase levels. Conclusions High myeloperoxidase levels suggest poor outcomes and are associated with MACE and limb ischaemia. Our findings indicated that myeloperoxidase levels could become a prognostic marker and may be used in conjunction with other methods for risk stratification in patients with peripheral artery disease and multi-bed vascular disease.

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