Abstract. Water resources are essential to the ecosystem and social economy in the desert and oasis of the arid Tarim River Basin, Northwest China, and expected to be vulnerable to climate change. Regional Climate Models (RCM) have been proved to provide more reliable results for regional impact study of climate change (e.g. on water resources) than GCM models. However, it is still necessary to apply bias correction before they are used for water resources research due to often considerable biases. In this paper, after a sensitivity analysis on input meteorological variables based on Sobol' method, we compared five precipitation correction methods and three temperature correction methods to the output of a RCM model with its application to the Kaidu River Basin, one of the headwaters of the Tarim River Basin. Precipitation correction methods include Linear Scaling (LS), LOCal Intensity scaling (LOCI), Power Transformation (PT), Distribution Mapping (DM) and Quantile Mapping (QM); and temperature correction methods include LS, VARIance scaling (VARI) and DM. These corrected precipitation and temperature were compared to the observed meteorological data, and then their impacts on streamflow were also compared by driving a distributed hydrologic model. The results show: (1) precipitation, temperature, solar radiation are sensitivity to streamflow while relative humidity and wind speed are not, (2) raw RCM simulations are heavily biased from observed meteorological data, which results in biases in the simulated streamflows, and all bias correction methods effectively improved theses simulations, (3) for precipitation, PT and QM methods performed equally best in correcting the frequency-based indices (e.g. SD, percentile values) while LOCI method performed best in terms of the time series based indices (e.g. Nash–Sutcliffe coefficient, R2), (4) for temperature, all bias correction methods performed equally well in correcting raw temperature. (5) For simulated streamflow, precipitation correction methods have more significant influence than temperature correction methods and the performances of streamflow simulations are consistent with these of corrected precipitation, i.e. PT and QM methods performed equally best in correcting flow duration curve and peak flow while LOCI method performed best in terms of the time series based indices. The case study is for an arid area in China based on a specific RCM and hydrologic model, but the methodology and some results can be applied to other area and other models.