scholarly journals A Study of Management of Benign Lesions of the Larynx

2011 ◽  
Vol 1 (2) ◽  
pp. 61-64 ◽  
Author(s):  
Pankaj Kumar Doloi ◽  
Swagata Khanna
Keyword(s):  
Cost Effective ◽  
Clinical Findings ◽  
Benign Tumors ◽  
Complete Relief ◽  
Vocal Rehabilitation ◽  
Body Sensation ◽  
Laryngeal Lesions ◽  
Endolaryngeal Surgery ◽  
Microlaryngeal Surgery ◽  
Benign Laryngeal Lesions

ABSTRACT A two-year prospective study was conducted from June 2008 to May 2010. A total of 80 patients with benign laryngeal lesions were included in the study based on symptoms, such as hoarseness of voice, foreign body sensation, vocal fatigue, dyspnea and cough and with positive clinical findings on indirect laryngoscopy. Diagnostic and therapeutic laryngoscopic and microlarygoscopic procedures were employed. Vocal cord polyps were observed to be the commonest type of lesions. Out of the 80 patients in the study group, 40% patients got complete relief with voice rest and vocal rehabilitation; 60% patients required surgery, which included endoscopic/microlarygoscopic endolaryngeal surgery and external approaches. There was no recurrence in cases of vocal polyps and nodules during the period of observation. Endolaryngeal surgery and voice rest offer a cost-effective, useful and safe method for the management of benign laryngeal lesions. With the inclusion of lasers, they can be more precisely operated. As such, the standard treatment of choice in all types of benign tumors of the larynx should consist of a triad of approach by microlaryngeal surgery (either microscopic or endoscopic, with or without use of lasers), voice rest and vocal rehabilitation.

Benign Laryngeal Lesions

2022 ◽  
Author(s):  
Jeffrey Straub ◽  
Brandon Kim
Keyword(s):  
Laser Therapy ◽  
Vocal Fold ◽  
Clinical Presentation ◽  
Benign Tumors ◽  
Vocal Hygiene ◽  
Laryngeal Lesions ◽  
Benign Laryngeal Lesions ◽  
Vocal Fold Nodules

Benign laryngeal lesions represent a diverse set of pathologies whose clinical presentation may range from no symptoms to dyspnea and/or dysphonia. Flexible fiberoptic laryngoscopy and videolaryngostroboscopy are important in distinguishingdifferent types of lesions, and management and treatment are dependent on the identification of these lesions, as they have different etiologies. Some lesions such as vocal fold nodules and polyps are primarily phonotraumatic and may benefit fromspeech therapy and vocal hygiene as initial approaches. Vocal fold cysts and benign tumors may benefit from microlaryngeal approaches, while capillary ectasias, polypoid corditis, laryngoceles, saccular cysts, and papilloma may benefit from laser therapy. Vocal fold granulomas may arise from various etiologies such as intubation, traumatic behaviors, or reflux. Polypoid corditis arises from smoking. This review is intended to provide an overview of the variety of lesions that encompass non-malignant laryngeal lesions that is both suitable for junior and senior residents. This review contains 12 figures, 5 tables, and 64 references Keywords: Benign laryngeal lesions, Laryngocele, Polyp, Cyst, Polypoid Corditis, Papilloma

scholarly journals Study of laryngeal lesions undergoing microlaryngeal surgery in a tertiary health centre

2020 ◽  
Vol 6 (6) ◽  
pp. 1167
Author(s):  
Gangadhara K. S. ◽  
Chaitanya Vadva ◽  
Sridhara S.
Keyword(s):  
Vocal Cord ◽  
Health Centre ◽  
Cost Effective ◽  
Ratio Analysis ◽  
Good Tool ◽  
Laryngeal Lesions ◽  
Malignant Lesions ◽  
Microlaryngeal Surgery

<p class="abstract"><strong>Background:</strong> Patients with laryngeal lesions were evaluated for age and sex ratio, analysis of clinical features, videolaryngoscopic findings and histopathological features. Assessment of therapeutic role of microlaryngeal surgery (MLS) by telescopic method and also prognosis after surgery and voice therapy were evaluated.</p><p class="abstract"><strong>Methods:</strong> A prospective institutional based study. A total of 18 patients with vocal cord lesions the chief complaint being hoarseness of voice were subjected to surgery in a tertiary health centre. After thorough evaluation patients underwent MLS by telescopic method.  </p><p class="abstract"><strong>Results:</strong> In our study 6 patients stand out to be benign lesions and 12 patients stand out to be pre malignant and malignant lesions. Improvement in voice after surgery was reported in all patients. No recurrence was reported after 6-8 months of follow-up.</p><p class="abstract"><strong>Conclusions:</strong> MLS is a good tool as it is precise and cost effective. MLS by telescopic method is a good therapeutic tool in both benign and malignant vocal cord lesions.</p>

scholarly journals A clinicopathological study of non-malignant lesions of the larynx

2021 ◽  
Vol 7 (2) ◽  
pp. 369
Author(s):  
Visweswara Rao Suraneni ◽  
Parveen Sulthana ◽  
Sanjusha Panchumarthi
Keyword(s):  
Foreign Body ◽  
Tertiary Care ◽  
Foreign Body Sensation ◽  
Histopathological Analysis ◽  
Tertiary Care Centre ◽  
Radiological Investigation ◽  
Throat Pain ◽  
Body Sensation ◽  
Laryngeal Lesions ◽  
Benign Laryngeal Lesions

<p class="abstract">The study was undertaken to identify the type of laryngeal lesions, the age, sex distribution, symptomatology, sites of involvement, conservative and surgical management, histopathological analysis and outcome of the same. This is a prospective study conducted at a tertiary care centre for one and a half years. A total of 20 patients were included based on symptomatology such as hoarseness of voice, foreign body sensation, throat pain, and respiratory distress. All malignant cases were excluded. Hematological and radiological investigations, along with microlaryngoscopic procedures followed by histopathology, were employed. A male preponderance with an M: F ratio of 3:2 was observed. The majority of the patients were in the age group of 30 to 45 years. Vocal cord polyps were observed to be the commonest type of the lesion. A case of a bilobed concomitant tonsillar cyst of the larynx was the rarest encountered. In this study, hoarseness of voice, cough, foreign body sensation, and throat pain proved to be the commonest symptoms. Early diagnosis with routine clinical examination aided by radiological investigation such as contrast enhanced computed tomography (CECT) has proven to be useful in suspicious lesions of the larynx. Micro laryngeal surgery, voice rest, and postoperative speech therapy together offer a cost-effective and safe method for the management of benign laryngeal lesions.</p>

scholarly journals A Few Unusual Cases of Benign Laryngeal Lesions - Our Experience

2015 ◽  
Vol 23 (1) ◽  
pp. 26-30
Author(s):  
Sebananda Halder ◽  
Debangshu Ghosh ◽  
Jayanta Saha ◽  
Sumit Kumar Basu
Keyword(s):  
Respiratory Distress ◽  
Vocal Cord ◽  
Vocal Cord Paralysis ◽  
Clinical Findings ◽  
Diagnostic Tools ◽  
Benign Lesions ◽  
Laryngeal Lesions ◽  
Benign Laryngeal Lesions ◽  
Careful History

Introduction: Benign laryngeal lesions may have some uncommon presentations.  Aims: The aim was to identify unusual benign vocal cord lesions and review their management and follow up.  Material and methods: The records of the patients presenting with different benign vocal cord lesions were reviewed retrospectively. Confirmed cases of vocal cord paralysis and malignancy were excluded from the study. Nine cases were imcluded in this study. Clinical findings, investigation reports, treatment and outcome were analysed.  Results: Most of the patients were from 18 years to 52 years (66%). Most common presenting feature was hoarseness of voice (89%) followed by respiratory distress (33%) . Microlaryngeal surgeries were done in 7 patients (78%) and 2 patients (22%) were  managed conservatively.  Conclusion: Diagnosis of benign vocal cord lesions may sometimes be difficult. Careful history, attention to the anatomy and the probable variations in presentation of the benign lesions of larynx, thorough clinical examination and different diagnostic tools are essential for satisfactory management.

scholarly journals Genetic Analysis of a Cohort of 275 Patients with Hyper-IgE Syndromes and/or Chronic Mucocutaneous Candidiasis

2021 ◽  
Author(s):  
Natalie Frede ◽  
Jessica Rojas-Restrepo ◽  
Andrés Caballero Garcia de Oteyza ◽  
Mary Buchta ◽  
Katrin Hübscher ◽  
...  
Keyword(s):  
Screening Method ◽  
Cost Effective ◽  
Illumina Miseq ◽  
Clinical Findings ◽  
Genetic Defects ◽  
Chronic Mucocutaneous Candidiasis ◽  
Mucocutaneous Candidiasis ◽  
Serious Infections ◽  
History Of ◽  
Panel Sequencing

AbstractHyper-IgE syndromes and chronic mucocutaneous candidiasis constitute rare primary immunodeficiency syndromes with an overlapping clinical phenotype. In recent years, a growing number of underlying genetic defects have been identified. To characterize the underlying genetic defects in a large international cohort of 275 patients, of whom 211 had been clinically diagnosed with hyper-IgE syndrome and 64 with chronic mucocutaneous candidiasis, targeted panel sequencing was performed, relying on Agilent HaloPlex and Illumina MiSeq technologies. The targeted panel sequencing approach allowed us to identify 87 (32 novel and 55 previously described) mutations in 78 patients, which generated a diagnostic success rate of 28.4%. Specifically, mutations in DOCK8 (26 patients), STAT3 (21), STAT1 (15), CARD9 (6), AIRE (3), IL17RA (2), SPINK5 (3), ZNF341 (2), CARMIL2/RLTPR (1), IL12RB1 (1), and WAS (1) have been detected. The most common clinical findings in this cohort were elevated IgE (81.5%), eczema (71.7%), and eosinophilia (62.9%). Regarding infections, 54.7% of patients had a history of radiologically proven pneumonia, and 28.3% have had other serious infections. History of fungal infection was noted in 53% of cases and skin abscesses in 52.9%. Skeletal or dental abnormalities were observed in 46.2% of patients with a characteristic face being the most commonly reported feature (23.1%), followed by retained primary teeth in 18.9% of patients. Targeted panel sequencing provides a cost-effective first-line genetic screening method which allows for the identification of mutations also in patients with atypical clinical presentations and should be routinely implemented in referral centers.

Thoracolumbar Fascia Enthesopathy as a Cause of Low Back Pain: A Retrospective and Follow-up Study

2021 ◽  
Author(s):  
Ouidade A. Tabesh ◽  
Roba Ghossan ◽  
Soha H Zebouni ◽  
Rafic Faddoul ◽  
Michel Revel ◽  
...  
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Iliac Crest ◽  
Pain Syndrome ◽  
Clinical Findings ◽  
Complete Relief ◽  
Low Back ◽  
Thoracolumbar Fascia ◽  
The Mean

Abstract Aim. To evaluate ultrasonography findings of Thoracolumbar Fascia (TLF) enthesis in patients with low back pain (LBP) due to iliac crest pain syndrome (ICPS). Method. The ultrasonographic and clinical findings of 60 patients with LBP due to ICPS were compared to those of 30 healthy volunteers with no LBP. Thickness of the TLF was measured with ultrasound (US) at its insertion on the iliac crest. Results. Forty-eight women and 12 men with a mean age of 42.1±11.3 years were diagnosed with ICPS. In patients, the mean thickness of the TLF was 2.51±0.70mm in affected sides compared to 1.81±0.44mm in the contralateral unaffected sides. The mean thickness difference of 0.82mm between the affected and non-affected sides was statistically significant (95%CI, 0.64-0.99, P<0.0001). In volunteers, the mean thickness of the TLF was 1.6±0.2mm. The mean thickness difference of 0.89mm between the affected sides of patients and volunteers was statistically significant (95%CI, 0.73-1.06, P<0.0001). Forty-two patients who didn’t improve with conservative therapy, received injections of methylprednisolone acetate and 1% lidocaine around the TLF enthesis. All patients reported complete relief of their LBP within 20 minutes of the injections thanks to the lidocaine anesthetic effect. Fifty-six (93.3%) patients were reached by phone for a long-term follow-up. Among them, 33 (58.9%) patients experienced a sustained complete pain relief after a mean follow-up of 45±19.3 months (range, 3-74 months). Conclusion. our findings suggest that TLF enthesopathy is a potential cause of nonspecific LBP that can be diagnosed using US.

scholarly journals AniScan Using Extracellular Cyclic AMP-Dependent Protein Kinase A as a Serum Biomarker Assay for the Diagnosis of Malignant Tumors in Dogs

Sensors ◽  
2020 ◽  
Vol 20 (15) ◽  
pp. 4075
Author(s):  
Ji-Eun Lee ◽  
Woo-Jin Song ◽  
Hunjoo Lee ◽  
Byung-Gak Kim ◽  
Taeho Kim ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Protein Kinase A ◽  
Cancer Detection ◽  
Malignant Tumors ◽  
Cost Effective ◽  
Benign Tumors ◽  
Dependent Protein Kinase ◽  
Diagnostic Significance ◽  
Dependent Protein ◽  
Kinase A

The early detection of tumors improves chances of decreased morbidity and prolonged survival. Serum biomarkers are convenient to use and have several advantages over other approaches, such as accuracy and straightforward protocols. Reliable biomarkers from easily accessible sources are warranted for the development of cost-effective assays for routine screening, particularly in veterinary medicine. Extracellular c-AMP-dependent protein kinase A (ECPKA) is a cytosolic leakage enzyme. The diagnostic accuracy of detecting autoantibodies against ECPKA was found to be higher than that of ECPKA activity from enzymatic assays, which use a complicated method. Here, we investigated the diagnostic significance of measuring serum ECPKA autoantibody levels using an in-house kit (AniScan cancer detection kit; Biattic, Anyang, Korea). We used sera from 550 dogs, including healthy dogs and those with malignant and benign tumors. Serum ECPKA and immunoglobulin G were determined using the AniScan cancer detection kit. ECPKA autoantibody levels were significantly higher (p < 0.01) in malignant tumors than in benign tumors, non-tumor diseases, and healthy controls. On the basis of sensitivity and specificity values, AniScan ECPKA is a rapid and easy-to-use assay that can be applied to screen malignant tumors from benign tumors or other diseases in dogs.

scholarly journals Applications of Office-Based 445 nm Blue Laser Transnasal Flexible Laser Surgery: A Case Series and Review of Practice

2020 ◽  
Vol 100 (1_suppl) ◽  
pp. 105S-112S
Author(s):  
Benjamin John Miller ◽  
Amr Abdelhamid ◽  
Yakubu Karagama
Keyword(s):  
Laser Surgery ◽  
Case Reports ◽  
Case Series ◽  
Primary Outcome Measure ◽  
Blue Laser ◽  
Current Evidence ◽  
Future Research ◽  
Retrospective Case ◽  
Laryngeal Lesions ◽  
Benign Laryngeal Lesions

Background: The recent introduction of 445 nm blue laser to office-based laryngology presents potential advantages. These include a desirable combination of cutting and photoangiolytic qualities and a lightweight, shock-resistant design. Despite its increasing use, current evidence is limited to experimental data and case reports. Objectives: The authors present a case series and overview of office blue laser transnasal flexible laser surgery (TNFLS), considering indications, patient selection, safety, technique, and surgical outcomes. We also review the safety and relevance of TNFLS to the ongoing coronavirus pandemic. Methods: Retrospective case series and narrative review. Our primary outcome measure was preoperative and postoperative Voice Handicap Index (VHI-10) score. Complications were documented by nature and severity. Results: Thirty-six cases of office blue laser TNFLS were performed. A statistically significant improvement in VHI-10 score was demonstrated in cases of recurrent respiratory papillomatosis (RRP) and benign laryngeal lesions causing dysphonia ( P < 0.01 and 0.045). Blue laser also proved effective in assisting office biopsy procedures. A minor and self-limiting complication was reported. Conclusions: Office blue laser TNFLS is safe and effective in the treatment of RRP and a range of benign laryngeal lesions. Future research should compare the efficacy and safety of blue laser with potassium titanyl phosphate laser in office-based treatment of these conditions. Further assessment of the cutting qualities of blue laser, initially in the theater environment, is necessary to refine our understanding of future applications.

scholarly journals Desarda Versus Lichtenstein Repair for Primary Inguinal Hernia in Men: Results of A Randomized Control Trial

2020 ◽  
Vol 14 (1) ◽  
pp. 20-26
Author(s):  
ASM Tanjilur Rahman ◽  
Swapan Kumar Biswas ◽  
Ratan Kumar Saha ◽  
ASM Zahidur Rahman ◽  
Tanvir Ahmed ◽  
...  
Keyword(s):  
Inguinal Hernia ◽  
Low Cost ◽  
Cost Effective ◽  
Lichtenstein Repair ◽  
Primary Inguinal Hernia ◽  
Body Sensation ◽  
Mesh Hernia Repair ◽  
Male Patients ◽  
The One

Inguinal hernia is a very common surgical problem for which mesh based technique particularly Lichtenstein repair is considered as standard. However, it is not free from some major and bothersome complications. Desarda technique of non-mesh hernia repair invented by the Indian surgeon is claimed as low cost tension free procedure with promising results. The objective of the study is to evaluate the feasibility of Desarda procedure in country like Bangladesh as a treatment of primary inguinal hernia in men by comparing with Lichtenstein repair in terms of various parameters. One hundred and sixty male patients between ages of 18-70 years with uncomplicated primary inguinal hernia were initially randomized to perform the one of the two procedures in every alternate patient. Outcome were measured and analyzed. A total of 100 patients were finally studied with a follow up of 2 years. Operative time and immediate postoperative pain were significantly less in Desarda arm. Cost and foreign body sensation were also in favour of Desarda group. There was no recurrence in either group. Desarda repair is easy to perform and takes less time. It is cost effective with a comparable clinical outcome to standard Lichtenstein repair at least in short term. Faridpur Med. Coll. J. Jan 2019;14(1): 20-26

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