Review of Cervical Carcinoma Screening Program in Tamil Nadu – Current Trend and Recommendations from a Histopathologist’s Viewpoint

2017 ◽  
Vol 5 (1) ◽  
pp. 1-7
Author(s):  
Shifa S Ibrahim ◽  
Kamaleshwari Kesavaraj ◽  
Muthumani Arun ◽  
SA Mohamed Ameen ◽  
Raasi Sankar
Keyword(s):  
Cervical Carcinoma ◽  
Hpv Vaccine ◽  
Tamil Nadu ◽  
Visual Inspection ◽  
Screening Program ◽  
Current Trend ◽  
High Grade Dysplasia ◽  
High Grade ◽  
Cervical Biopsy ◽  
Biopsy Specimens

ABSTRACT Objectives Cervical carcinoma, the commonest carcinoma affecting Indian females, is caused by human papilloma virus (HPV) infection. Primordial prevention and primary prevention with HPV vaccine and cancer screening respectively, can go a long way in preventing this carcinoma. The health system project in Tamil Nadu has done a commendable job in reducing the disease burden by introducing screening programs for cervical carcinoma at the grassroots level, way back in 2005. This study was done to evaluate the cervical biopsy specimens received as a part of this program to compute its incidence, compare the incidence among various districts, and suggest future directions based on our observations. Materials and methods From visual inspection with acetic acid/visual inspection with Lugol’s iodine positive cervical biopsy specimens, 506 were chosen randomly from various districts. Based on histopathological examination, incidence of individual lesions and district-wise incidence were calculated. Predictive factors that determine the progression of these lesions were analyzed based on the literature. Results Out of the 506 cervical biopsy specimens, 34 were unsatisfactory. The incidence of high-grade dysplasia peaked around 31 to 40 years, and squamous cell carcinoma peaked among 51 to 60 years. Madurai ranked high in the incidence of both high-grade dysplasia and carcinoma. Conclusion Incidence of dysplasia and carcinoma in our study was comparable to those seen in the literature. Integration of HPV deoxyribonucleic acid studies into the program can increase the detection rate, detect the progressors, help to identify the HPV species prevalent in an area, and aid in formulating cost-effective HPV vaccine cocktail. How to cite this article Ibrahim SS, Kesavaraj K, Arun M, Ameen SAM, Sankar R. Review of Cervical Carcinoma Screening Program in Tamil Nadu – Current Trend and Recommendations from a Histopathologist’s Viewpoint. J South Asian Feder Menopause Soc 2017;5(1):1-7.

scholarly journals Review of Cervical Carcinoma Screening Program in Tamil Nadu, the Current Trend and Recommendations from a Histopathologist’s Viewpoint

2019 ◽  
Vol 11 (6) ◽  
pp. 356-362
Author(s):  
Kamaleshwari Kesavaraj ◽  
Muthumani Arun ◽  
Raasi Sankar ◽  
Shifa S Ibrahim ◽  
Syed AM Ameen
Keyword(s):  
Cervical Carcinoma ◽  
Tamil Nadu ◽  
Screening Program ◽  
Current Trend

Controversies in the Diagnosis of Barrett Esophagus and Barrett-Related Dysplasia: One Pathologist's Perspective

2010 ◽  
Vol 134 (10) ◽  
pp. 1479-1484 ◽  
Author(s):  
John R. Goldblum
Keyword(s):  
English Literature ◽  
Goblet Cells ◽  
High Grade Dysplasia ◽  
Barrett Esophagus ◽  
Low Grade ◽  
High Grade ◽  
Biopsy Specimens ◽  
Columnar Lined Esophagus ◽  
Intramucosal Adenocarcinoma ◽  
Rule Out

Abstract Context.—Pathologists frequently assess esophageal biopsy specimens to “rule out Barrett esophagus,” as well as to assess for the presence or absence of dysplasia. Objective.—To review some of the recent controversies in the diagnosis of Barrett esophagus and Barrett-related dysplasia. Data Sources.—Sources were the author's experience and review of the English literature from 1978 to 2009. Conclusions.—Although goblet cells are required by the American College of Gastroenterology to confirm a diagnosis of Barrett esophagus, this definition might expand to include columnar-lined esophagus without goblet cells. The recognition of dysplasia in Barrett esophagus remains a difficult task for the surgical pathologist, with difficulties in distinguishing reactive epithelium from dysplasia, low-grade dysplasia from high-grade dysplasia, and even high-grade dysplasia from intramucosal adenocarcinoma.

scholarly journals HPV status in women with high-grade dysplasia on cervical biopsy and preceding negative HPV tests

2019 ◽  
Vol 8 (3) ◽  
pp. 149-156 ◽  
Author(s):  
Yimin Ge ◽  
Roxanne R. Mody ◽  
Randall J. Olsen ◽  
Haijun Zhou ◽  
Eric Luna ◽  
...  
Keyword(s):  
High Grade Dysplasia ◽  
High Grade ◽  
Cervical Biopsy ◽  
Hpv Status

Risk factors of colorectal cancer after screening colonoscopy

2021 ◽  
Vol 8 ◽  
pp. 25-29
Author(s):  
Paulina Wieszczy ◽  
Michał F. Kamiński ◽  
Jarosław Reguła
Keyword(s):  
Colorectal Cancer ◽  
High Risk ◽  
Screening Program ◽  
Risk Group ◽  
High Risk Group ◽  
High Grade Dysplasia ◽  
Screening Colonoscopy ◽  
High Grade ◽  
Screening Programs

In the era of populational screening programs for colorectal cancer, evaluation of their quality and efficacy becomes an important issue. One of the main criteria taken into account when assessing the quality of a screening program is related to the risk of colorectal cancer developing in the period between the screening colonoscopy and the control examination. The objective of this article consists in presenting the results of the doctoral research carried out by dr. Paulina Wieszcza, a beneficient of the Polpharma Scientific Foundation scholarship. The objective of the doctoral dissertation was to investigate and discuss the relationship between the definition of risk groups as well as the quality of the study and the risk of colorectal cancer developing after the screening colonoscopy. The risk of colorectal cancer developing following adenomas being removed during the screening colonoscopy procedure was assessed using data obtained from the Colorectal Cancer Screening Program and the National Cancer Registry databases. The quality of the study was assessed on the basis of literature evidence regarding the adenoma detection rates (ADR). A total of 236.089 patients were included in colorectal cancer risk analyses, with at least one adenoma being detected in a screening study in 17.7% of cases. Over the follow-up period (median of 7 years, maximum duration of 14 years), colorectal cancer was detected in 439 patients. It was demonstrated that when the high-risk group was defined as patients presenting with adenomas ≥ 20 mm in diameter or high grade dysplasia rather than patients with ≥ 3 adenomas or adenomas ≥10 mm in diameter with high grade dysplasia or villous component (current definition), the number of patients requiring intensive surveillance can be reduced by 74% without any impact on the risk in the low-risk group. The literature review revealed a total of three studies which clearly showed that the risk of colorectal cancer significantly decreased with the increase in the endoscopist’s ADR. Restricting the high-risk group to patients with adenomas ≥ 20 mm in diameter or high-grade dysplasia facilitates optimized care being delivered to patients with a significantly increased risk of colorectal cancer. Scientific evidence is available for the important role of endoscopist’s ADR as the key parameter of the quality of colonoscopic examination.

scholarly journals Prevalence of human papillomavirus in Mazandaran Province, Islamic Republic of Iran

2002 ◽  
Vol 08 (06) ◽  
pp. 805-811
Author(s):  
R. Hamkar
Keyword(s):  
Human Papillomavirus ◽  
Cervical Carcinoma ◽  
Islamic Republic ◽  
Mazandaran Province ◽  
Hpv Dna ◽  
Cervical Biopsy ◽  
Biopsy Specimens ◽  
Islamic Republic Of Iran ◽  
Hpv Types

We report the prevalence of human papillomavirus [HPV] types in 100 cervical biopsy specimens in Mazandaran province. HPV DNA was detected in 78.6% of cervical carcinoma cases, 64.3% of dys/ metaplasia and 9% of normal cases. Significant correlation was found between the presence of HPV DNA and development of cervical carcinoma. HPV types 16 and 18 were detected in 60.6% of HPV-positive cervical carcinoma cases, whereas HPV31 and 33 were found in 21.2%, and HPV6 and 11 in 18.2%. Among HPV-positive dys/metaplasia cases, 55.6% were positive for HPV16 and 18, 22.3% for HPV6 and 11, and 11.1% for HPV31 and 33. Only HPV6 and 11 were detected in 4 [100%] normal biopsy specimens.

Argon beam plasma coagulation as therapy for high-grade dysplasia in Barrett's esophagus

2003 ◽  
Vol 1 (4) ◽  
pp. 258-263 ◽  
Author(s):  
Stephen E. A. Attwood ◽  
Christopher J. Lewis ◽  
Scott Caplin ◽  
Karla Hemming ◽  
Gordon Armstrong
Keyword(s):  
Barrett’S Esophagus ◽  
Barrett's Esophagus ◽  
High Grade Dysplasia ◽  
High Grade ◽  
Plasma Coagulation ◽  
Beam Plasma
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