Screening, Quality Control and Management of Cervical Lesion

Author(s):  
Pranab Dey
Author(s):  
Sean Costelloe ◽  
Natividad Rico Rios ◽  
Nicola Goulding ◽  
Hema Mistry ◽  
Adam Stretton ◽  
...  

Background Haemolysis, icterus and lipaemia (HIL) are common interferants in laboratory medicine, potentially impacting patient care. This survey investigates HIL management in medical laboratories across the UK and ROI. Methods A survey was sent to members of key professional organisations for laboratory medicine in the UK and ROI. Questions related to the detection, monitoring, quality control, and management of HIL. Results In total, responses from 124 laboratories were analysed, predominantly from England (52%) and ROI (36%). Most responses were from public hospitals with biochemistry services (90%), serving primary care (91%), inpatients (91%), and outpatients (89%). Most laboratories monitored H (98%), I (88%), and L (96%) using automated indices (93%), alone or in combination with visual inspection. Manufacturer-stated cut-offs were used by 83% and were applied to general chemistries in 79%, and immunoassays in 50%. Where HIL cut-offs are breached, 64% withheld results, while 96% reported interference to users. HIL were defined using numeric scales (70%) and ordinal scales (26%). HIL targets exist in 35% of laboratories, and 54% have attempted to reduce HIL. Internal Quality Control for HIL was lacking in 62% of laboratories, and just 18% of respondents have participated in External Quality Assurance. Laboratories agree manufacturers should: standardise HIL reporting (94%), ensure comparability between platforms (94%), and provide information on HIL cross-reactivity (99%). Respondents (99%) showed interest in evidence-based, standardised HIL cut-offs. Conclusions Most respondents monitor HIL, although the wide variation in practice may differentially affect clinical care. Laboratories seem receptive to education and advice on HIL management.


2008 ◽  

For the fist time, the WEFTA Annual Meeting takes place in Italy, at Firenze on September 17th to 19th, 2008. The WEFTA 2008 theme is "Seafood from Catch and Aquaculture for a Sustainable Supply". WEFTA 2008 aims the gathering of international researchers, scientists and technicians, as well as professionals from seafood Industry, particularly involved in research and development, quality control and management for a three-day conference involving scientific and technical presentations, discussion and social contacts. The book of abstracts contains the 117 full and short abstracts of the communications presented in this 38th WEFTA Annual Meeting by scientists coming from several European Countries but also from USA, Canada, Brazil and Japan, able to give up-to-date information of great interest, useful for the development of scientific knowledge in much of the seafood issues.


2018 ◽  
Vol 36 (05) ◽  
pp. 280-288 ◽  
Author(s):  
Kimball Pomeroy ◽  
Mark Marcon

AbstractThe recent failure of two liquid nitrogen storage tanks at two separate facilities in the United States has highlighted the need to reexamine our approach to how reproductive laboratories handle the storage of tissue. If we wish to truly understand how we can increase the security and safety of stored reproductive tissue, we really need to understand how often these events (tank failure) occur and what are the ultimate causes of these failures. Are there design flaws in the storage tanks or are these really failures in protocols and following protocols? Unfortunately, because these cases often involve serious litigation, most do not want to or are forbidden to talk about these failures and so we have little data to base recommendations on. Despite the paucity of data, we must come up with protocols and methods to safeguard tissue stored in these tanks. At the same time, we must be careful that we do not introduce potential solutions to these problems that instead of increasing the safety of stored tissue, we exacerbate the problem. Attention should be paid to where tanks are located so that they can be observed throughout the day. Decisions regarding whether tissue will be stored on-site or off-site, whether small- or large-capacity tanks should be used, or whether a patient's specimens should be split among several tanks should not be based on convenience or cost, but on the ability to reduce risks to these precious specimens. Ongoing quality control (QC) must include checking tanks for both visual clues and analyzing evaporation rates of each tank. Finally, each laboratory must have protocols in place that address all the issues involved in maintaining a safe storage system. These protocols must be understood by all those involved in the safeguard of patients' tissue. We may never eliminate all accidents with stored reproductive tissue, but we can reduce the probability of future accidents. In this article, we will discuss how to manage the risks inherent with the storage of reproductive tissue, where to store tissue, how to store them, how to reduce risks through quality control methods, and finally, options available for inventory management.


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