scholarly journals Salivary Biomarker Levels and Oral Health Status of Children with Cerebral Palsy and Their Healthy Siblings: A Comparative Study

2021 ◽  
Vol 12 (2) ◽  
pp. e0015
Author(s):  
Palanichamy Anjugam ◽  
◽  
Veerabadhran Mahesh Mathian ◽  
Murugesan Gawthaman ◽  
Selvaraj Vinod ◽  
...  

Background: The dental needs of cerebral palsy children are an area of study much in need of attention. The neglect of this aspect should be rectified, and simpler diagnostic methodologies should be established and used to serve this purpose. Aim: This study aimed to determine oral health status and salivary biomarkers (salivary flow rate, pH, buffering capacity) among children with cerebral palsy (CP), to compare their data with that of their healthy siblings, and to evaluate the relationship between salivary biomarkers and dental caries. Methods: A total of 30 CP children (study group) and 30 normal healthy siblings (controls) were selected between the ages of 5 and 12 years. Salivary biomarkers were assessed, and oral health status was examined. Statistical Analysis: Chi-square test was used for comparison of oral health status. “Unpaired t test was used to compare caries indexes (decay/filled teeth–primary dentition [dft] and decay/missing/filled teeth–permanent dentition [DMFT]) and salivary biomarkers between the groups. Pearson correlation was used to find the correlation between salivary biomarkers and caries. Results: The dft scores were significantly higher in the study group (P<0.05). The pH values and salivary flow rates were significantly lower in the study group (P<0.05 and P<0.001, respectively). There was a significant correlation between DMFT scores and salivary flow rate in the study group (P<0.05). Conclusion: Low pH and low salivary flow rate might be risk factors for dental caries in CP populations; moreover, the significant correlation between DMFT score and salivary flow rate suggests that salivary flow rate could be used as a screening tool for assessing at-risk subjects in such populations.

2011 ◽  
Vol 56 (10) ◽  
pp. 1137-1141 ◽  
Author(s):  
Ariela Hidas ◽  
Avia Fux Noy ◽  
Noam Birman ◽  
Joseph Shapira ◽  
Israel Matot ◽  
...  

2017 ◽  
Vol 59 (1) ◽  
pp. 55-62 ◽  
Author(s):  
Yoshihiro Shimazaki ◽  
Bohan Fu ◽  
Koji Yonemoto ◽  
Sumio Akifusa ◽  
Yukie Shibata ◽  
...  

2011 ◽  
Vol 35 (3) ◽  
pp. 319-323 ◽  
Author(s):  
AM Hegde ◽  
S Joshi ◽  
K Rai ◽  
S Shetty

Leukemia constitutes approximately 30% of all childhood cancers and Acute Lymphoblastic Leukemia(ALL) is the most common type of malignancy. Oral dryness, ulceration, increased dental decay seen is due to altered salivary flow rate and buffering capacity in these children. Oxidative stress may play an important role in the malignancies resulting in onset of inflammatory oral pathologies. Saliva constitutes first line of defense against free radical-mediated oxidative stress. The present study attempted to relate the oral health status, salivary flow rate, salivary pH, gingival health status, dental caries experience and total salivary antioxidant levels in ALL children. A total of 120 children aged 4-10 years (90 leukemic children, study group and 30 normal healthy siblings, control group) were divided into 4 groups of 30 each. Oral health status, gingival status and dental caries experience was recorded followed by un-stimulated saliva collection. Total antioxidant capacity of un-stimulated saliva was evaluated. The results depicted deterioration in oral health status, gingival status and increased dental caries experience in leukemic children. Salivary flow rate, salivary pH and total salivary antioxidant levels were lowered in leukemic children when compared with control group.


2017 ◽  
Vol 11 (03) ◽  
pp. 357-363 ◽  
Author(s):  
Abla Arafa ◽  
Salwa Aldahlawi ◽  
Adel Fathi

ABSTRACT Objectives: To assess the oral health status and salivary composition in a group of children suffering from bronchial asthma. Materials and Methods: The sample consisted of sixty asthmatic children, sixty healthy negative controls, and sixty healthy positive controls of both sexes with age ranging from 4 to 12 years old. The asthmatics were grouped according to disease severity into mild, moderate, or severe asthmatic. All the children were clinically examined to assess their dental caries experience (decayed, indicated for extraction, and filled primary tooth [def] and decayed-missing-filled permanent tooth [DMF]), dental erosion condition (tooth wear index), and gingival health condition (gingival index [GI]). Salivary samples were collected and assessed for salivary flow rate, salivary pH, and the level of calcium, sodium, and potassium. Results: The results of this study revealed that asthmatic children presented significantly higher def, DMF score, and GI mean values compared to the control groups. Severe asthmatics significantly presented the highest def and GI score. Salivary analysis revealed reduced stimulated salivary flow rate and altered salivary pH. In addition, significantly elevated mean salivary calcium level found to be associated with higher GI mean score. Conclusions: Children suffering from bronchial asthma should receive special dental preventive attention as presented with greater risk for oral and dental diseases as compared to the healthy controls.


2020 ◽  
Vol 67 (1) ◽  
pp. 7-14
Author(s):  
Ana Cicmil ◽  
Olivera Govedarica ◽  
Jelena Lecic ◽  
Dragana Puhalo-Sladoje ◽  
Ruzica Lukic ◽  
...  

Introduction. Decreased salivary flow is frequently associated with numerous diseases such as diabetes mellitus and may lead to numerous oral diseases. The aim of this study was to compare salivary flow rate and oral health status in type 2 diabetics and healthy controls. Material and methods. The study involved 90 patients, divided into the three groups: 30 with well controlled (HbA1c<9%), 30 will poorly controlled (HbA1c?9%) diabetes and 30 healthy subjects. The following clinical parameters were determined: decayed, missing and filled teeth (DMFT); plaque index (PI), sulcus bleeding index (SBI), probing pocket depth (PPD) and clinical attachment level (CAL). Culture of Candida spp. specimens were obtained from tongue dorsum and inoculated into Sabouraud Dextrose Agar. Saliva was collected using ?a spit technique?. Results. Highest mean of unstimulated salivary flow was in healthy subjects; however significant difference between groups was not observed. Stimulated salivary flow results indicate significant reduction in diabetics as well as significant relation between metabolic control and salivary flow. Unstimulated and stimulated salivary flows were negatively and significantly correlated with periodontal parameters and DMFT. Conclusion. The present findings indicate that decreased salivary flow rate could have a significant impact on oral health status in type 2 diabetics.


2018 ◽  
Vol 11 (4) ◽  
pp. 2085-2089
Author(s):  
Ali Hadi Fahad ◽  
Raed Faisal Al-Huwaizi ◽  
Yamama A. Al-Rubbaey ◽  
Abbas F. Alhuwaizi

Differences in susceptibility to dental caries occurs even under the similar, controlled conditions because of genetic variations, certain environmental factors are potentially more cariogenic for some individuals than for others. Salivary constituents differences may cause variation in caries susceptibility. This study was conducted to assess the salivary pH, flow rate and streptococcus mutans count in relation to oral health status among colored eyes adolescents. The study group included all 85 colored eyes adolescents from 6 secondary schools, while control group contained 85 brown eyes adolescents selected randomly from the same schools (12-15 for both groups, only males). Decayed, missing and filled teeth (DMFT), plaque (PlI), Gingival (GI) and calculus (CI) indices were used to measure oral health status for both groups. Salivary samples collection was done in the morning at least one hour after breakfast, then normal saline was added to have tenfold dilutions, to assess the total colony counting of the caries related microorganisms (streptococcus mutans), after that inoculation was done in the special selective media (Mitis-Salivarius-Bacitracin agar). Counting of bacterial colonies were estimated by the aid of dissection microscope. Salivary pH and flow rate were measured directly. The data of present study was analyzed using SPSS version 21. The median and mean rank values for DMFT, PlI, GI and CI indices were higher in study group than control group with high significant differences with regard to DMFT and PlI. A strong positive correlation was recorded between DMFT and PlI, GI, CI in both groups. Salivary pH and flow rate were lower in study compared to the control group (statistically significant difference with salivary flow rate). Higher mean value of salivary streptococcus mutans count among study group compared to control group with statistical significant difference. Dental caries experience and streptococcus mutans count were higher in colored eyes adolescents than brown eyes adolescents. Oral hygiene and salivary flow rate were lower in study group than control group.


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