Ultra-rapid opiate detoxification using dexmedetomidine under general anesthesia

2011 ◽  
Vol 7 (5) ◽  
pp. 337-344 ◽  
Author(s):  
Dalia Abdelhamid Mohamed Nasr, MD ◽  
Hani Abdelfattah Said Ahmed Omran, MD ◽  
Sameh Michel Hakim, MD ◽  
Waleed Ahmed Abdelrahman Mansour, MD
Keyword(s):  
Patient Satisfaction ◽  
General Anesthesia ◽  
Withdrawal Symptoms ◽  
Opiate Withdrawal ◽  
Control Group ◽  
Anesthesia Group ◽  
Male Patients ◽  
Recovery From Anesthesia ◽  
Group Control Group ◽  
Group D

Background: In this study, ultra-rapid detoxification using dexmedetomidine under general anesthesia (GA) has been evaluated in preventing the withdrawal symptoms in patients addicted to opioids.Methods: Sixty male patients who were addicted to opioids were assigned to one of the two groups, in which anesthesia was induced and maintained using propofol infusion: group D = treated with dexmedetomidine during anesthesia and for 6 days after recovery from anesthesia; group C = control group treated after recovery from anesthesia with oral dose of lefoxidine 0.2 mg three times daily. Hemodynamic changes and withdrawal symptoms were assessed using Objective Opiate Withdrawal Scale (OOWS) during anesthesia and both the Objective Opiate Withdrawal Scale (OOWS) and Subjective Opiate Withdrawal Scale (SOWS) after recovery from anesthesia. Patient satisfaction was assessed using 101-point verbal rating scale.Results: Hemodynamic data showed that there were statistically significant increases in heart rate and systolic blood pressure during anesthesia in control group. Control group had significantly higher OOWS score on the following 3 days than the dexmedetomidine group, with no significant changes between the two groups from the fourth day till the sixth day except for muscle twitches in the control group on the sixth day (Cd6). Control group had significantly higher SOWS score on the following 4 days than the dexmedetomidine group, with no significant changes between the two groups on the fifth and sixth days except for yawning, nausea, and muscle twitches in control group on the fifth and sixth days (Cd5, Cd6). Patient satisfaction was significantly greater in dexmedetomidine group than in control group.Conclusions: Dexmedetomidine had shown to decrease markedly the withdrawal symptoms when used during ultra-rapid opiate detoxification under GA, and the patients in this group were more satisfied.

scholarly journals Intravesical dexmedetomidine instillation reduces postoperative catheter-related bladder discomfort in male patients under general anesthesia: a randomized controlled study

2020 ◽  
Author(s):  
Hong Chen ◽  
Bin Wang ◽  
Qin Li ◽  
Juan Zhou ◽  
Rui Li ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Patient Satisfaction ◽  
General Anesthesia ◽  
Normal Saline ◽  
Rating Scale ◽  
Intravesical Instillation ◽  
Controlled Study ◽  
Control Group ◽  
Post Operation ◽  
Male Patients

Abstract Background: The catheter-related bladder discomfort (CRBD) of male patients is a common clinical problem, albeit lacking effective solutions. The present study aimed to investigate whether intravesical dexmedetomidine instillation alleviates the postoperative urinary discomfort in male patients with catheter under general anesthesia.Methods: This single-blinded, prospective, randomized study included a total of 167 male patients American Society of Anesthesiologists (ASA) physical status I-II scheduled for surgery under general anesthesia were allocated to two groups: 84 in the dexmedetomidine group and 83 in the control group. Dexmedetomidine group patients received intravesical instillation of the drug 0.5 μg/kg and normal saline 20 mL, while the control group received intravesical instillation of 20 mL normal saline. The catheter was clamped for 30 min after intravesical instillation for all patients. CRBD scores and urethra pain numerical rating scale (NRS) scores were measured at admittance to post-anesthesia care unit (PACU) (T0), intravesical instillation (T1), 30 min (T2), 60 min (T3), 2 h (T4) after intravesical instillation, discharged from PACU (T5), and 6 h (T6) and 24 h (T7) after the operation. Patient satisfaction at discharge from PACU and 24 h post-operation were compared between the two groups. Results: CRBD scores and urethra pain NRS scores after 30 min of intravesical dexmedetomidine instillation to 24 h post-operation were significantly lower than the control group (p<0.001), and patient satisfaction was higher at discharge from PACU and 24 h post-operation (p<0.001). No differences were detected in Steward score out of PACU (p=0.213) and from the time of the end of operation to fully awake (p=0.417).Conclusion: Intravesical dexmedetomidine instillation reduces postoperative urinary discomfort and urethra pain and improves satisfaction in male patients under general anesthesia.Clinical Trial Registration: Chinese Clinical Trial Registry (No. ChiCTR1800016429), date of registration 1st June 2018

scholarly journals Intravesical dexmedetomidine instillation reduces postoperative catheter-related bladder discomfort in male patients under general anesthesia: a randomized controlled study

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Hong Chen ◽  
Bin Wang ◽  
Qin Li ◽  
Juan Zhou ◽  
Rui Li ◽  
...  
Keyword(s):  
Patient Satisfaction ◽  
General Anesthesia ◽  
Normal Saline ◽  
Rating Scale ◽  
Numerical Rating Scale ◽  
Intravesical Instillation ◽  
Controlled Study ◽  
Control Group ◽  
Post Operation ◽  
Male Patients

Abstract Background The catheter-related bladder discomfort (CRBD) of male patients is a common clinical problem, albeit lacking effective solutions. The present study aimed to investigate whether intravesical dexmedetomidine instillation alleviates the postoperative urinary discomfort in male patients with catheter under general anesthesia. Methods This single-blinded, prospective, randomized study included a total of 167 male patients American Society of Anesthesiologists (ASA) physical status I-II scheduled for surgery under general anesthesia were allocated to two groups: 84 in the dexmedetomidine group and 83 in the control group. Dexmedetomidine group patients received intravesical instillation of the drug 0.5 μg/kg and normal saline 20 mL, while the control group received intravesical instillation of 20 mL normal saline. The catheter was clamped for 30 min after intravesical instillation for all patients. CRBD scores and urethra pain numerical rating scale (NRS) scores were measured at admittance to post-anesthesia care unit (PACU) (T0), intravesical instillation (T1), 30 min (T2), 60 min (T3), 2 h (T4) after intravesical instillation, discharged from PACU (T5), and 6 h (T6) and 24 h (T7) after the operation. Patient satisfaction at discharge from PACU and 24 h post-operation were compared between the two groups. Results CRBD scores and urethra pain NRS scores after 30 min of intravesical dexmedetomidine instillation to 24 h post-operation were significantly lower than the control group (p < 0.001), and patient satisfaction was higher at discharge from PACU and 24 h post-operation (p < 0.001). No differences were detected in Steward score out of PACU (p = 0.213) and from the time of the end of operation to fully awake (p = 0.417). Conclusion Intravesical dexmedetomidine instillation reduces postoperative urinary discomfort and urethra pain and improves satisfaction in male patients under general anesthesia. Trial registration Chinese Clinical Trial Registry (No. ChiCTR1800016429), date of registration 1st June 2018.

scholarly journals Intravesical dexmedetomidine instillation reduces postoperative catheter-related bladder discomfort in male patients under general anesthesia: a randomized controlled study

2020 ◽  
Author(s):  
Hong Chen ◽  
Bin Wang ◽  
Qin Li ◽  
Juan Zhou ◽  
Rui Li ◽  
...  
Keyword(s):  
Patient Satisfaction ◽  
General Anesthesia ◽  
Normal Saline ◽  
Rating Scale ◽  
Numerical Rating Scale ◽  
Intravesical Instillation ◽  
Controlled Study ◽  
Control Group ◽  
Post Operation ◽  
Male Patients

Abstract Background: The catheter-related bladder discomfort (CRBD) of male patients is a common clinical problem, albeit lacking effective solutions. The present study aimed to investigate whether intravesical dexmedetomidine instillation alleviates the postoperative urinary discomfort in male patients with catheter under general anesthesia. Methods: This single-blinded, prospective, randomized study included a total of 167 male patients American Society of Anesthesiologists (ASA) physical status I-II scheduled for surgery under general anesthesia were allocated to two groups: 84 in the dexmedetomidine group and 83 in the control group. Dexmedetomidine group patients received intravesical instillation of the drug 0.5 μg/kg and normal saline 20 mL, while the control group received intravesical instillation of 20 mL normal saline. The catheter was clamped for 30 min after intravesical instillation for all patients. Bladder stimulation scales and urethra pain numerical rating scale (NRS) scores were measured at admittance to post-anesthesia care unit (PACU) (T0), intravesical instillation (T1), 30 min (T2), 60 min (T3), 2 h (T4) after intravesical instillation, discharged from PACU (T5), and 6 h (T6) and 24 h (T7) after the operation. Patient satisfaction at discharge from PACU and 24 h post-operation were compared between the two groups. Results: Bladder stimulation scales and urethra pain NRS scores after 30 min of intravesical dexmedetomidine instillation to 24 h post-operation were significantly lower than the control group (p<0.001), and patient satisfaction was higher at discharge from PACU and 24 h post-operation (p<0.001). No differences were detected in Steward score out of PACU (p=0.213) and from the time of the end of operation to fully awake (p=0.417). Conclusion: Intravesical dexmedetomidine instillation reduces postoperative urinary discomfort and urethra pain and improves satisfaction in male patients under general anesthesia.

scholarly journals Dexmedetomidine intravesical instillation reduces postoperative catheter-related bladder discomfort in male patients under general anesthesia: a randomized controlled study

2020 ◽  
Author(s):  
Hong Chen ◽  
Bin Wang ◽  
Qin Li ◽  
Juan Zhou ◽  
Rui Li ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Patient Satisfaction ◽  
General Anesthesia ◽  
Normal Saline ◽  
Rating Scale ◽  
Intravesical Instillation ◽  
Controlled Study ◽  
Control Group ◽  
Post Operation ◽  
Male Patients

Abstract Background The catheter-related bladder discomfort (CRBD) of male patients is a common clinical problem, albeit lacking effective solutions. The present study aimed to investigate whether dexmedetomidine intravesical instillation alleviates the postoperative urinary discomfort in male patients with catheter under general anesthesia.Methods This single-blinded, prospective, randomized study included a total of 167 male patients American Society of Anesthesiologists (ASA) physical status I-II scheduled for surgery under general anesthesia were allocated to two groups: 84 in the dexmedetomidine (Dex) group and 83 in the control group. Dex group patients received intravesical instillation of the drug 0.5 µg/kg and normal saline 20 mL, while the control group received intravesical instillation of 20 mL normal saline. The catheter was clamped for 30 min after intravesical instillation for all patients. Bladder stimulation scales and urethra pain numerical rating scale (NRS) scores were measured at admittance to post-anesthesia care unit (PACU) (T0), intravesical instillation (T1), 30 min (T2), 60 min (T3), 2 h (T4) after intravesical instillation, discharged from PACU (T5), and 6 h (T6) and 24 h (T7) after the operation. Patient satisfaction at discharge from PACU and 24 h post-operation were compared between the two groups.Results Bladder stimulation scales and urethra pain NRS scores after 30 min of dexmedetomidine intravesical instillation to 24 h post-operation were significantly lower than the control group (p < 0.001), and patient satisfaction was higher at discharge from PACU and 24 h post-operation (p < 0.001). No differences were detected in Steward score out of PACU (p = 0.213) and from the time of the end of operation to fully awake (p = 0.417).Conclusion Dex intravesical instillation reduces postoperative urinary discomfort and urethra pain and improves satisfaction in male patients under general anesthesia.Clinical Trial Registration: Chinese Clinical Trial Registry (No. ChiCTR1800016429), date of registration 1st June 2018

scholarly journals Dexmedetomidine intravesical instillation reduces postoperative catheter-related bladder discomfort in male patients under general anesthesia: a randomized controlled study

2020 ◽  
Author(s):  
Hong Chen ◽  
Bin Wang ◽  
Qin Li ◽  
Juan Zhou ◽  
Rui Li ◽  
...  
Keyword(s):  
Patient Satisfaction ◽  
General Anesthesia ◽  
Normal Saline ◽  
Rating Scale ◽  
Numerical Rating Scale ◽  
Intravesical Instillation ◽  
Controlled Study ◽  
Control Group ◽  
Post Operation ◽  
Male Patients

Abstract Background The catheter-related bladder discomfort (CRBD) of male patients is a common clinical problem, albeit lacking effective solutions. The present study aimed to investigate whether dexmedetomidine intravesical instillation alleviates the postoperative urinary discomfort in male patients with catheter under general anesthesia. Methods This single-blinded, prospective, randomized study included a total of 167 male patients American Society of Anesthesiologists (ASA) physical status I-II scheduled for surgery under general anesthesia were allocated to two groups: 84 in the dexmedetomidine (Dex) group and 83 in the control group. Dex group patients received intravesical instillation of the drug 0.5 μg/kg and normal saline 20 mL, while the control group received intravesical instillation of 20 mL normal saline. The catheter was clamped for 30 min after intravesical instillation for all patients. Bladder stimulation scales and urethra pain numerical rating scale (NRS) scores were measured at admittance to post-anesthesia care unit (PACU) (T0), intravesical instillation (T1), 30 min (T2), 60 min (T3), 2 h (T4) after intravesical instillation, discharged from PACU (T5), and 6 h (T6) and 24 h (T7) after the operation. Patient satisfaction at discharge from PACU and 24 h post-operation were compared between the two groups. Results Bladder stimulation scales and urethra pain NRS scores after 30 min of dexmedetomidine intravesical instillation to 24 h post-operation were significantly lower than the control group (p<0.001), and patient satisfaction was higher at discharge from PACU and 24 h post-operation (p<0.001). No differences were detected in Steward score out of PACU (p=0.213) and from the time of the end of operation to fully awake (p=0.417). Conclusion Dex intravesical instillation reduces postoperative urinary discomfort and urethra pain and improves satisfaction in male patients under general anesthesia.

scholarly journals STRESS-LIMITING ANESTHESIA IN OPHTHALMOSURGERY

World Science ◽  
2021 ◽  
Author(s):  
Mynka N. V. ◽  
Kobelyatskyy Yu. Yu.
Keyword(s):  
Blood Glucose ◽  
Stress Response ◽  
General Anesthesia ◽  
Surgical Stress ◽  
Pain Syndrome ◽  
Control Group ◽  
Surgical Trauma ◽  
Complete Protection ◽  
Surgical Stress Response ◽  
Anesthesia Group

Despite the significant advances made by modern anesthesiology in the perioperative management of patients, surgical interventions are still accompanied by a high proportion of complications and even deaths. At the same time, it is known that in 50% of cases mortality and serious postoperative complications could be prevented. After performing a thorough study of the factors affecting the increase in hospitalization and postoperative recovery (Kehlet H., 1997; Kehlet H., Wilmore D., 2002), it was determined that the surgical stress response is the most significant inducer of dysfunction of various organs. and systems. To date, it has been established that general anesthesia in its classical sense does not allow achieving complete protection of the patient from surgical trauma. More complete protection can be achieved by combining general anesthesia with regional blockages and adjuvant drugs with stress-protective properties. In the present study, we compared the severity of the surgical stress response and pain syndrome in patients operated on under conditions of multicomponent balanced general anesthesia (group K) with patients who received a stress-limiting anesthesia regimen (group DB). In both groups, multicomponent anesthesia was performed, in group K, sibazone was used for sedation, in group DB, dexmedetomidine was used. Also, patients of the DB group underwent regional blockade (blockade of the pterygo-palatine fossa) before surgery. The main criteria for evaluating the results were: hemodynamic stability, blood glucose, the level of venous blood leukocytes and the severity of pain according to the VAS in the postoperative period. Both schemes made it possible to avoid pronounced fluctuations in hemodynamic and gas exchange parameters at all stages of the study. When analyzing blood glucose and leukocyte counts, it was found that patients in the control group had a more significant deviation of both indicators from the preoperative level than in the stress-limiting anesthesia group. In the study of pain syndrome, it was determined that in the control group the level of pain according to the VAS was higher at all stages of the study compared to patients in the group of stress-limiting anesthesia.

scholarly journals Artificial Bee Colony Algorithm-Based Ultrasound Image Features in the Analysis of the Influence of Different Anesthesia Methods on Lung Air Volume in Orthopedic Surgery Patients

2021 ◽  
Vol 2021 ◽  
pp. 1-12
Author(s):  
Yufang Li ◽  
Manyun Bai ◽  
Xin Wang ◽  
Di Wu ◽  
Qian Zhao
Keyword(s):  
General Anesthesia ◽  
Orthopedic Surgery ◽  
Artificial Bee Colony Algorithm ◽  
Artificial Bee Colony ◽  
Ultrasound Image ◽  
Control Group ◽  
General Anesthesia Group ◽  
Bee Colony ◽  
Anesthesia Group ◽  
Fitness Value

This study aimed to provide a quantitative evaluation of the lung gas content in orthopedic surgery patients under different anesthesia using ultrasound images based on the artificial bee colony algorithm. The ultrasound image features based on an artificial bee colony algorithm were applied to analyze segmentation images to investigate the influence of different anesthesia methods on the lung air content of patients undergoing orthopedic surgery and the clinical features of such patients. They were also adopted for the anesthesia in orthopedic surgery to assist clinicians in the diagnosis of diseases. 160 orthopedic surgery patients who were hospitalized were treated with different anesthesia methods. The first group (traditional general anesthesia group) received general anesthesia and traditional ultrasound; the second group (ABC general anesthesia group) was used for ultrasound image analysis based on the artificial bee colony algorithm; the third group (traditional sclerosis group) was anesthetized with combined sclerosis block; ultrasound images of patients from the fourth group (ABC sclerosis group) were analyzed based on the artificial bee colony algorithm. Analysis was conducted at three time points. The LUS score of the traditional sclerosis group and ABC sclerosis group was hugely higher than the score of the traditional general anesthesia group and ABC general anesthesia group at T2 time, with statistical significance ( P < 0.005 ). At time point T3, the score of the traditional sclerosis group rose greatly compared with the general anesthesia group, and that of the ABC group was generally higher than that of the traditional ultrasound group ( P < 0.005 ). When the threshold value was 4, the fitness value of ABC algorithm was 2680.4461, and the fitness value of the control group was 1736.815. The difference between the two groups was 943.6311 ( P < 0.05 ). The operation time of ABC algorithm was 1.83, while that of the control group was 1.05, and the difference between the two groups was 0.78 ( P < 0.05 ). In conclusion, the feature analysis of ultrasonic images based on the artificial bee colony algorithm could effectively improve the accuracy of ultrasonic images and the accuracy of focus recognition. It can promote medical efficiency and accurately identify the lung air content of patients in future clinical case measurement and auxiliary treatment of fracture, which has great application potential in improving surgical anesthesia effect.

scholarly journals Brain Natriuretic Peptide and the Severity of Aortic Regurgitation: Is There Any Correlation?

2005 ◽  
Vol 33 (4) ◽  
pp. 454-459 ◽  
Author(s):  
M Ozkan ◽  
O Baysan ◽  
K Erinc ◽  
C Koz ◽  
M Yokusoglu ◽  
...  
Keyword(s):  
Aortic Regurgitation ◽  
Ventricular Dysfunction ◽  
Left Ventricular ◽  
Control Group ◽  
Vena Contracta ◽  
Group A ◽  
Male Patients ◽  
Group B ◽  
Chronic Aortic Regurgitation ◽  
Group D

We aimed to evaluate the correlation between aortic regurgitation severity and brain natriuretic (BNP) levels as a marker for left ventricular dysfunction. Sixty consecutive male patients (mean age 22 ± 3 years) with isolated chronic aortic regurgitation were enrolled in the study together with a control group of 30 age-matched healthy volunteers (group A). Patients were classified with regard to aortic regurgitation vena contracta width as follows: group B, < 3 mm, mild ( n = 16); group C, ≥ 3 and < 6 mm, moderate ( n = 26); group D, ≥ 6 mm, severe ( n = 18). BNP measurements were performed with a fluorescence immunoassay kit. BNP levels were increased in patients with aortic regurgitation, and severity of regurgitation had a significant influence on BNP levels. This effect can be explained by the volume loading effect of aortic regurgitation.

scholarly journals The Impact of Zinc Supplementation on Oxidative Stress and Inflammatory Biomarkers in Opioid Addicts-Withdrawal Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial

2021 ◽  
Author(s):  
Amir Keshavarzi ◽  
Ali Hassanalizade ◽  
Akram Ranjbar ◽  
Ali Ghaleiha ◽  
Seyed Yaser Vafaei ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Treatment Group ◽  
Withdrawal Syndrome ◽  
Zinc Supplementation ◽  
Opioid Withdrawal ◽  
Withdrawal Symptoms ◽  
Opiate Withdrawal ◽  
Control Group ◽  
Opioid Withdrawal Syndrome ◽  
The Impact

Abstract Background Opioid withdrawal can induce oxidative stress in opioid addicts. This interventional study aimed to investigate the effect of zinc supplementation on the oxidative profile of patients with an opioid withdrawal syndrome. Methods In the current study, 40 patients aged 18 to 65 years with opioid withdrawal syndrome were randomly assigned to intervention and control groups, each with 20 subjects. In addition to standard treatment, the intervention group received 30 mg of zinc daily, while the control group was given a placebo for one month. They were evaluated using Beck Depression Inventory (BDI), Clinical Opiate Withdrawal Scale (COWS), and Young Mania Rating Scale (YMRS) for withdrawal symptoms. Moreover, other parameters included catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) and levels of total antioxidant capacity (TAC), total thiol groups (TTG), tumor necrosis factor-α (TNF-α), and malondialdehyde (MDA). Results The rate of withdrawal symptoms (COWS) was statistically significantly lower in the treated group in comparison to the control group (P < 0.05). In the treatment group, the levels of TAC, CAT, SOD, and GPx increased significantly compared to the control group (P < 0.05). In the treatment group compared to the control group, there was a statistically significant decrease in hs-CRP, MDA, and TNFα (P < 0.05). Conclusions The results revealed that zinc supplementation could effectively reduce withdrawal symptoms by increasing antioxidant activity and reducing the lipid peroxidation index.

scholarly journals GAMBARAN HISTOPATOLOGIS LAMBUNG TIKUS WISTAR (RATTUS NOVERGICUS) YANG DIBERIKAN ALKOHOL

2014 ◽  
Vol 2 (2) ◽  
Author(s):  
Dewi Febry Kololu ◽  
Poppy M. Lintong ◽  
Lily Loho
Keyword(s):  
Intestinal Metaplasia ◽  
Blood Vessels ◽  
Inflammatory Cells ◽  
Control Group ◽  
Alcohol Content ◽  
Alcohol Group ◽  
Group B ◽  
Group Control Group ◽  
Group D ◽  
Metaplasia Intestinal

Abstract: Alcohol has become aglobal problem. When it is consumed alcohol can disrupt the structure and function of the digestive tract. Objective: To reveal the histopathological features of the gastric of Wistar rats that are administered with bir, wine, whisky and cap tikus. Method: Experimental research using 15 rats that ware fasted and divided into 5 groups those are group control group which was treated by water, group A which was treated by beer (4.9% alcohol),group B which was treated by wine (14% alcohol), group C which was treated by whiskey (43% alcohol),and group D rats which wastreated by cap tikus(70% alcohol). The treatment of the test animals is done in 5 days. Results:In the control group on mucosa, submucosa, muscularis and serosa layers,inflammatory cells are also seen.In group Ainflammatory cells found on submucosal layer, intestinal metaplasia, and dilation of blood vessels. In group B inflammatory cell, intestinal metaplasia and dilation of blood vessels are found.In group C erosion, inflammatory cells, intestinal metaplasia and dilation of blood vessels are found.In group D submucosal necrosis, inflammatory cells, intestinal metaplasia and hyperemia are found. Conclusions: The provision of alcoholic drinks (beer, wine, whiskey, and cap tikus) in wistar can cause acute gastritis and of the high alcohol content (70% alcohol content)will be accompanied by gastric necrosis. Keywords: Beer, wine, whisky, cap tikus, gastritis.   Abstrak: Alkohol telah menjadi masalah global. Ketika dikonsumsi, alkohol dapat mengganggu struktur dan fungsi dari saluran pencernaan. Tujuan: Untuk mengetahui gambaran histopatologi lambung tikus wistar yang diberikan bir, minuman anggur, whisky, dan cap tikus. Metode: Penelitian eksperimental menggunakan 15 ekor wistar yang dipuasakan kemudian dibagi menjadi 5 kelompok yaitu kelompok kontrol diberi minum air, kelompok A diberi perlakuan bir (kadar alkohol 4,9%), kelompok B diberi perlakuan anggur (kadar alkohol 14%), kelompok C diberi perlakuan whisky (kadar alkohol 43%), kelompok D diberi perlakuan cap tikus (kadar alkohol 70%). Perlakuan hewan uji selama 5 hari. Hasil: Pada kelompok kontrol tampak lapisan mukosa, submukosa, muskularis dan serosa, terlihat juga sel radang. Pada kelompok A didapatkan sel radangpada lapisan submukosa, metaplasia intestinal, dan pelebaran pembuluh darah. Pada kelompok B didapatkan sel radang, metaplasia intestinal dan pelebaran pembuluh darah.Pada kelompok C didapatkan erosi, sel radang, dan metaplasia intestinal dan pelebaran pembuluh darah.Pada kelompok D didapatkan nekrosis pada submukosa, sel radang, metaplasia intestinal dan hiperemi. Simpulan: Pemberian minuman beralkohol (bir, anggur, whisky, dan cap tikus) pada wistar dapat menyebabkan gastritis akut dan pada kadar alkohol yang tinggi (kadar alkohol 70%) disertai dengan nekrosis lambung. Kata Kunci: Bir, anggur, whisky, cap tikus, gastritis.

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