scholarly journals Four single nucleotide polymorphisms in genes involved in neuronal signaling are associated with opioid use disorder in West Virginia

2019 ◽  
Vol 15 (2) ◽  
pp. 103-109 ◽  
Author(s):  
Shane W. Kaski, BS, MD/PhD ◽  
Stephan Brooks, MPH ◽  
Sijin Wen, PhD ◽  
Marc W. Haut, PhD ◽  
David P. Siderovski, PhD ◽  
...  
Keyword(s):  
Substance Use ◽  
Pilot Study ◽  
General Population ◽  
Single Nucleotide Polymorphisms ◽  
West Virginia ◽  
Addiction Treatment ◽  
Opioid Use Disorder ◽  
Nucleotide Polymorphisms ◽  
Opioid Use ◽  
Single Nucleotide

Objective: Pilot study to assess utility in opioid use disorder (OUD) of a panel of single nucleotide polymorphisms (SNPs) in genes previously related to substance use disorder (SUD) and/or phenotypes that predispose individuals to OUD/SUD. Design: Genetic association study.Setting: West Virginia University’s Chestnut Ridge Center Comprehensive Opioid Addiction Treatment (COAT) clinic for individuals diagnosed with OUD. Patients: Sixty patients 18 years of age or older with OUD undergoing medication (buprenorphine/naloxone)-assisted treatment; all 60 patients recruited contributed samples for genetic analysis.Outcome measure(s): Minor allele frequencies for SNPs.Results: Four of the 14 SNPs examined were present at frequencies that are statistically significantly different than in a demographically matched general population. Conclusions: For the purposes of testing WV individuals via genetic means for predisposition to OUD, at least four SNPs in three genes are likely to have utility in predicting susceptibility. Additional studies with larger populations will need to be conducted to confirm these results before use in a clinical setting.

Associations of catechol-O-methyltransferase (rs4680) single nucleotide polymorphisms with opioid use and dose among adults with chronic pain

Pain ◽  
2019 ◽  
Vol 160 (1) ◽  
pp. 263-268 ◽  
Author(s):  
W. Michael Hooten ◽  
Joanna M. Biernacka ◽  
Travis G. OʼBrien ◽  
Julie M. Cunningham ◽  
John L. Black
Keyword(s):  
Chronic Pain ◽  
Single Nucleotide Polymorphisms ◽  
Nucleotide Polymorphisms ◽  
Opioid Use ◽  
Single Nucleotide

Intron-specific Single Nucleotide Polymorphisms of Fat Mass and Obesity- Associated Gene in Obese and Overweight Individuals of the Indian Adult Population- A Pilot Study

2019 ◽  
Vol 16 (1) ◽  
pp. 84-94
Author(s):  
Aakash Reddy ◽  
Katari Venkatesh ◽  
Sayani Sahu ◽  
Pallavi Sinha Roy ◽  
Konkona Datta ◽  
...  
Keyword(s):  
Pilot Study ◽  
Single Nucleotide Polymorphisms ◽  
Fat Mass ◽  
Indian Population ◽  
Detection System ◽  
Adult Population ◽  
Genotypic Frequency ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Increased Risk

Background: The Fat mass and obesity-associated gene (FTO) and its involvement in weight gain and obesity is well-known. However, no reports have been published on the Indian population regarding the relationship between single nucleotide polymorphisms (SNPs) in its intronic region and obesity. The aim of this pilot study was to evaluate the frequency and association of SNPs in intron-1 of the FTO gene in obese and overweight Indian adults. Methods: This study group consisted of 80 adults, aged 23.5 ± 8.9 yr, with a mean BMI of 28.8 ± 6.2 kg/m2. Genomic DNA was isolated, exons1-3 & intron1 of FTO were amplified using polymerase chain reaction and sequenced by ABI sequencing detection system. The reported SNPs rs1420185, rs8050136, rs1121980 and rs55872725 were checked for their presence or absence in this group of the adult Indian population. Results: No mutations were found in the exonic sequence of FTO, however, the association of rs1420185, rs8050136, rs1121980 and rs55872725 SNPs was identified in this population. The genotypic frequency at FTO rs8050136 was 32.2% for C>A, at rs55872725 it was 45.7% for C>T, at rs1420185 it was 27.1% for T>C and at rs1121980 it was 30.5% for G>A. All four SNPs in combination were observed in 6 participants (10.2%), all of whom were found to be either obese or overweight. Conclusion: These findings indicate that Indians with these SNPs are most likely to be at increased risk of obesity.

scholarly journals T1 and T2 ADAM33 single nucleotide polymorphisms and the risk of childhood asthma in a Saudi Arabian population: a pilot study

2012 ◽  
Vol 32 (5) ◽  
pp. 479-486 ◽  
Author(s):  
Arwa Ishaq Al-Khayyat ◽  
Mohammed Al-Anazi ◽  
Arjumand Warsy ◽  
Alejandro Vazquez-Tello ◽  
Abdullah Mohammed Alamri ◽  
...  
Keyword(s):  
Pilot Study ◽  
Single Nucleotide Polymorphisms ◽  
Childhood Asthma ◽  
Saudi Arabian ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
T1 And T2 ◽  
Arabian Population
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