Associations of catechol-O-methyltransferase (rs4680) single nucleotide polymorphisms with opioid use and dose among adults with chronic pain

Pain ◽  
2019 ◽  
Vol 160 (1) ◽  
pp. 263-268 ◽  
Author(s):  
W. Michael Hooten ◽  
Joanna M. Biernacka ◽  
Travis G. OʼBrien ◽  
Julie M. Cunningham ◽  
John L. Black
Keyword(s):  
Chronic Pain ◽  
Single Nucleotide Polymorphisms ◽  
Nucleotide Polymorphisms ◽  
Opioid Use ◽  
Single Nucleotide

scholarly journals THE INFLUENCE OF SINGLE-NUCLEOTIDE POLYMORPHISMS OF CATECHOL-O-METHYLTRANSFERASE GENE ON THE FORMATION OF PAIN SYNDROME AND EFFECTIVENESS OF ANALGESIA IN ONCOLOGICAL PATIENTS

2017 ◽  
Vol 11 (2) ◽  
pp. 112-127
Author(s):  
Arina P. Spasova ◽  
I. V Kurbatova ◽  
O. Yu Barysheva ◽  
G. P Tikhova
Keyword(s):  
Chronic Pain ◽  
Single Nucleotide Polymorphisms ◽  
Pain Intensity ◽  
Rating Scale ◽  
Pain Syndrome ◽  
Comt Gene ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Oncological Patients ◽  
One Year

The objective is to study the effect of single-nucleotide polymorphisms (SNPs) of COMT gene on the formation and characteristics of chronic pain, level of anxiety and depression, effectiveness of analgesia in oncological patients. Material and Methods. The study includes 196 patients with oncological pathology. The formation of chronic pain syndrome was estimated in all patients one year after surgery using the assessment of pain intensity by numeric rating scale, pain questionnaire of McGill, PainDetect. Basing on the patients genotyping data the genotypes and haplotypes frequency distribution on SNPs of rs4680, rs740603, rs2097603=rs2070577, rs4633 of COMT gene was estimated. The relationship between different genotypes, haplotypes and chronic pain intensity, severity of ranking index of pain for sensor and affective characteristics on McGill scale, presence of neuropathic component of pain and anxiety was studied in all patients sample. The same analysis was carried out in order to clarify difference in morphine consumption (mg/24h) and severity of adverse side effects such as drowsiness, confusion and hallucinations. Results. It is found that after one year the pain syndrome was developed in 134 patients. It was showed that there is direct relationship between chronic pain intensity, anxiety level and presence of mutant allele on polymorphisms of rs4680 in exon and rs740603 in intron of COMT gene. There was also revealed inverse relationship between morphine requirement and presence of pointed polymorphisms in comparison with the patients who have GG genotype of these markers. Conclusion. The determination of pointed SNPs may be useful for choosing the optimal tactics of analgesia in patients with chronic oncological pain syndrome.

scholarly journals Four single nucleotide polymorphisms in genes involved in neuronal signaling are associated with opioid use disorder in West Virginia

2019 ◽  
Vol 15 (2) ◽  
pp. 103-109 ◽  
Author(s):  
Shane W. Kaski, BS, MD/PhD ◽  
Stephan Brooks, MPH ◽  
Sijin Wen, PhD ◽  
Marc W. Haut, PhD ◽  
David P. Siderovski, PhD ◽  
...  
Keyword(s):  
Substance Use ◽  
Pilot Study ◽  
General Population ◽  
Single Nucleotide Polymorphisms ◽  
West Virginia ◽  
Addiction Treatment ◽  
Opioid Use Disorder ◽  
Nucleotide Polymorphisms ◽  
Opioid Use ◽  
Single Nucleotide

Objective: Pilot study to assess utility in opioid use disorder (OUD) of a panel of single nucleotide polymorphisms (SNPs) in genes previously related to substance use disorder (SUD) and/or phenotypes that predispose individuals to OUD/SUD. Design: Genetic association study.Setting: West Virginia University’s Chestnut Ridge Center Comprehensive Opioid Addiction Treatment (COAT) clinic for individuals diagnosed with OUD. Patients: Sixty patients 18 years of age or older with OUD undergoing medication (buprenorphine/naloxone)-assisted treatment; all 60 patients recruited contributed samples for genetic analysis.Outcome measure(s): Minor allele frequencies for SNPs.Results: Four of the 14 SNPs examined were present at frequencies that are statistically significantly different than in a demographically matched general population. Conclusions: For the purposes of testing WV individuals via genetic means for predisposition to OUD, at least four SNPs in three genes are likely to have utility in predicting susceptibility. Additional studies with larger populations will need to be conducted to confirm these results before use in a clinical setting.

Development of a simple method for the determination of single nucleotide polymorphisms

2010 ◽  
Vol 34 (8) ◽  
pp. S75-S75
Author(s):  
Weifeng Zhu ◽  
Zhuoqi Liu ◽  
Daya Luo ◽  
Xinyao Wu ◽  
Fusheng Wan
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Nucleotide Polymorphisms ◽  
Simple Method ◽  
Single Nucleotide

Sex Differences in Childhood Associations between DNA Markers and General Cognitive Ability

2007 ◽  
Vol 28 (3) ◽  
pp. 161-164 ◽  
Author(s):  
Rosalind Arden ◽  
Nicole Harlaar ◽  
Robert Plomin
Keyword(s):  
Sex Differences ◽  
Single Nucleotide Polymorphisms ◽  
Cognitive Ability ◽  
Dna Markers ◽  
Community Sample ◽  
Nucleotide Polymorphisms ◽  
General Cognitive Ability ◽  
Single Nucleotide ◽  
The Difference

Abstract. An association between intelligence at age 7 and a set of five single-nucleotide polymorphisms (SNPs) has been identified and replicated. We used this composite SNP set to investigate whether the associations differ between boys and girls for general cognitive ability at ages 2, 3, 4, 7, 9, and 10 years. In a longitudinal community sample of British twins aged 2-10 (n > 4,000 individuals), we found that the SNP set is more strongly associated with intelligence in males than in females at ages 7, 9, and 10 and the difference is significant at 10. If this finding replicates in other studies, these results will constitute the first evidence of the same autosomal genes acting differently on intelligence in the two sexes.

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