An updated quantitative evaluation of the association between leukaemia risk and XRCC3 Thr241Met polymorphism

IntroductionSeveral analyses have been conducted to assess the association between leukaemia risk and XRCC3 Thr241Met polymorphism. However, their results are conflicting. Hence, this comprehensive study was carried out to obtain a more accurate assessment of the association between leukaemia risk and XRCC3 Thr241Met (rs861539) polymorphismMaterial and methodsWe searched Ovid, Chinese Biomedical Literature Database (CBM), China National Knowledge Infrastructure (CNKI), Google Scholar, PubMed database and Excerpta Medica Database (EMBASE) for potential eligible studies published as of July 2020. Pooled odds ratio (OR) and 95% confidence interval (ci) were used in evaluating the strength of the association between Thr241Met polymorphism of XRCC3 and leukaemia, and the p-value less than 0.05 (p < 0.05) was considered as the level of significance.ResultsA total of 17 studies consisting of 7241 controls and 4198 cases met our inclusion criteria. No significant association was observed between leukaemia risk and Thr241Met polymorphism of XRCC3 across the five genetic variants. In our ethnicity subgroup evaluation, we noted a significant association between leukaemia risk and Thr241Met polymorphism of XRCC3 among Caucasians under four genetic models. Furthermore, SNP (rs861539) of XRCC3 has a protective effect among Asians under four genetic models.ConclusionsThr241Met polymorphism of XRCC3 has a protective effect in the Asian population but has oncogenic potential in the Caucasian population.

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Effects of TNF-α-308G/A Polymorphism on the Risk of Diabetic Nephropathy and Diabetic Retinopathy: An Updated Meta-Analysis

Hormone and Metabolic Research ◽

10.1055/a-1161-0088 ◽

2020 ◽

Vol 52 (10) ◽

pp. 724-731

Author(s):

Mengwei Liu ◽

Mengke Shang ◽

Yue Wang ◽

Qian Li ◽

Xiuping Liu ◽

...

Keyword(s):

Diabetic Retinopathy ◽

Diabetic Nephropathy ◽

Meta Analysis ◽

Asian Population ◽

Recessive Model ◽

China National Knowledge Infrastructure ◽

Knowledge Infrastructure ◽

Tnf Α ◽

Patients With Diabetes ◽

Major Factors

AbstractDiabetic nephropathy (DN) and diabetic retinopathy (DR) are the major factors of morbidity and mortality in the patients with diabetes mellitus (DM). Growing studies have investigated the relationship between the TNF-α-308G/A polymorphism and the susceptibility to DN and DR, without achieving consensus. Thus, we conducted this meta-analysis to reach more comprehensive conclusions for these issues. Eligible studies were retrieved through electronic databases such as PubMed, Embase, Web of Science and China National Knowledge Infrastructure. Summary of odds ratios (OR) and 95% confidence intervals (CIs) were generated to evaluate the intensity of the associations. Statistical analyses were performed by STATA 11.0 and RevMan 5.2. There are fourteen eligible publications involving nineteen studies in this meta-analysis. TNF-α-308G/A polymorphism was significantly related to increasing risk of DN under recessive model (OR=1.37, 95% CI=1.03–1.83) and homozygous model (OR=1.54, 95% CI=1.15–2.06). Moreover, the similar results were also obtained in Asian groups for DN (recessive: OR=1.69, 95% CI=1.18–2.42; homozygous: OR=1.99, 95% CI=1.38–2.86; respectively), and significant association was also detected between TNF-α-308G/A and DN susceptibility in type 2 DM in recessive model (OR=1.39, 95% CI=1.02–1.89). No significant association was observed between TNF-α-308G/A and DR susceptibility in total analyses and subgroup analyses by ethnicity and type of DM. TNF-α-308G/A polymorphism may enhance the susceptibility to diabetic nephropathy, especially in Asian population and in T2DM patients, but not diabetic retinopathy.

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Acupuncture for Obstructive Sleep Apnea (OSA) in Adults: A Systematic Review and Meta-Analysis

BioMed Research International ◽

10.1155/2020/6972327 ◽

2020 ◽

Vol 2020 ◽

pp. 1-10

Author(s):

Liaoyao Wang ◽

Jia Xu ◽

Yijun Zhan ◽

Jian Pei

Keyword(s):

Subgroup Analysis ◽

Assessment Tool ◽

Meta Analysis ◽

Biomedical Literature ◽

Cochrane Library ◽

China National Knowledge Infrastructure ◽

Knowledge Infrastructure ◽

Obstructive Sleep ◽

Clinically Significant

Objective. Our aim was to assess the efficacy and safety of acupuncture for OSA patients with various severities of the disorder. Methods. Eight databases including PubMed, Cochrane Library, EMBASE, Web of Science, China National Knowledge Infrastructure (CNKI), Chongqing VIP (CQVIP), Wanfang Data, and Chinese Biomedical Literature Database (CBM) were comprehensively searched till July 2019. Randomized controlled trials (RCTs) testing acupuncture in the treatment of OSA were eligible for inclusion. Studies were selected for inclusion, and data were extracted by two authors independently. The Cochrane Collaboration’s Risk of Bias Assessment Tool and RevMan software (version 5.3) were used to evaluate the quality of studies and conduct statistical analysis. Results. Nine RCTs with 584 participants were included. The trials covered acupuncture and electropuncture. Acupuncture caused clinically significant reductions in AHI (MD: -6.18; 95% CI: -9.58 to -2.78; Z=3.56, P=0.0004) as well as in ESS (MD: -2.84; 95% CI: -4.80 to -0.16, Z=2.09, P=0.04). AHI was reduced more in the subgroup analysis of moderate OSA patients (MD: -9.44; 95% CI: -12.44 to -6.45; Z=6.18, P<0.00001) and severe OSA patients (MD: -10.09; 95% CI: -12.47 to -7.71; Z=8.31, P<0.00001). ESS was also reduced more in the subgroup analysis of moderate OSA patients (MD: -2.40; 95% CI: -3.63 to -1.17; Z=3.83, P=0.0001) and severe OSA patients (MD: -4.64; 95% CI: -5.35 to -3.92; Z=12.72, P<0.00001). Besides, acupuncture had a beneficial effect on LSaO2 (MD: 5.29; 95% CI: 2.61 to 7.97; Z=3.86, P=0.0001). The outcome of AHI and LSaO2 yielded consistent results after sensitivity analysis, but the direction of the outcome of ESS was reversed. And the quality of evidence was mainly low to very low. Conclusions. Acupuncture therapy is effective for OSA patients in reducing AHI and ESS and in improving the LSaO2 of various severities, especially in moderate and severe OSA patients. High-quality trials are urgently needed.

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ERCC1 rs11615 polymorphism and chemosensitivity to platinum drugs in patients with ovarian cancer: a systematic review and meta-analysis

Journal of Ovarian Research ◽

10.1186/s13048-021-00831-y ◽

2021 ◽

Vol 14 (1) ◽

Author(s):

Yuqiang Zhang ◽

Sufen Cao ◽

Chunyu Zhuang ◽

Jiacheng Chen ◽

Xiaojing Chen ◽

...

Keyword(s):

Ovarian Cancer ◽

Web Of Science ◽

Meta Analysis ◽

Asian Population ◽

Caucasian Population ◽

Cochrane Library ◽

Platinum Drugs ◽

China National Knowledge Infrastructure ◽

Knowledge Infrastructure ◽

The Relationship

Abstract Objective To explore the relationship between ERCC1 rs11615 polymorphism and chemosensitivity to platinum drugs in ovarian cancer by the method of meta-analysis. Methods Pubmed, Web of Science, EMBASE, Cochrane Library, China National Knowledge Infrastructure (CNKI), and China Wanfang databases were comprehensively searched up to September 2020, to identify the relationship between ERCC1 rs11615 polymorphism and chemosensitivity of ovarian cancer. The data was analyzed by Stata 15.0 statistic software. Results A total of 10 published papers were included, including 1866 patients with ovarian cancer. The results showed that compared allele C at ERCC1 rs11615 locus with allele T, the pooled OR was 0.92 (95%CI:0.68 ~ 1.24, P > 0.05). There were no significant differences in recessive, dominant, homozygous, and heterozygous models. In accordance with a subgroup analysis of Ethnicity, all genotypes were statistically significant in the Asian population. In the allelic, dominant, recessive, homozygous and heterozygous models, the OR was 0.70 (95%CI:0.51 ~ 0.95), 0.20 (95%CI:0.07 ~ 0.56), 0.79 (95%CI:0.63 ~ 1.00), 0.21 (95%CI:0.07 ~ 0.59), 0.19 (95%CI:0.07 ~ 0.54), respectively, while in the Caucasian population, no statistically significant genotype was found. Conclusion The ERCC1 rs11615 polymorphism is associated with chemosensitivity in patients with ovarian cancer, especially in the Asian population, but not in the Caucasian population.

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Effectiveness and Safety of Plum - Blossom Needle in the Treatment of Myopia：A Protocol for Systematic Review and Meta-analysis

10.21203/rs.3.rs-73070/v1 ◽

2020 ◽

Author(s):

Siyuan Zhu ◽

Jun Xiong ◽

Jun Chen ◽

Genhua Tang ◽

Lunbin Lu ◽

...

Keyword(s):

Systematic Review ◽

Meta Analysis ◽

Scientific Journal ◽

Biomedical Literature ◽

Systematic Evaluation ◽

Cochrane Library ◽

China National Knowledge Infrastructure ◽

Myopia Progression ◽

Knowledge Infrastructure ◽

The Cochrane Library

Abstract Background: In recent years, the prevalence of myopia has increased significantly, and it has become one of the major eye diseases that cause visual impairment in the world,which is particularly prominent among young people. And uncorrected myopia is the leading cause of blindness.The purpose of this study is to evaluate the efficacy and safety of plum-blossom needle in delaying adolescent myopia progression through systematic evaluation.Methods and analysis:The following electronic databases will be searched from inception to July 2020 regardless of publication status and language: Medline, EMBASE, Web of Science, the Cochrane Library, PubMed, China National Knowledge Infrastructure (CNKI), China Biology Medicine (CBM), Chinese Scientific Journal Database (VIP), Wanfang Database, Chinese Biomedical Literature Database (CBLD), Chinese Science and Technology Periodical Database (CSTPD). RCT registration websites, including http://www.ClinicalTrials.gov and http://www.chictr.org.cn, will also be searched. Review Manager V.5.4 will be used to analysis the statistic. Two reviewers will independently select studies, extract and code the data, assess risk of bias of the included studies, evaluate the quality of evidence for outcomes.Discussion:So far, many studies have been conducted on the treatment of adolescent myopia with plum-blossom needles. However, there is still no clear conclusion on the effectiveness and safety of plum-blossom needles in the treatment of juvenile myopia.In this systematic review and meta-analysis, available data will be pooled together to further inform research and clinical practice.Systematic review registration: Inplasy protocol 202080026

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Ethnicity-stratified analysis of the association between XRCC3 Thr241Met polymorphism and leukemia: an updated meta-analysis

BMC Medical Genomics ◽

10.1186/s12920-021-01076-w ◽

2021 ◽

Vol 14 (1) ◽

Author(s):

Zhengjun Xie ◽

Wei Peng ◽

Qiuhua Li ◽

Wei Cheng ◽

Xin Zhao

Keyword(s):

Genetic Model ◽

Meta Analysis ◽

Search Time ◽

Caucasian Population ◽

Cochrane Library ◽

China National Knowledge Infrastructure ◽

Knowledge Infrastructure ◽

Xrcc3 Thr241met ◽

The Cochrane Library ◽

Stratified Analysis

Abstract Background Presently, whether X-ray repair cross complementing group 3 (XRCC3) Thr241Met polymorphism is correlated to leukemia risk remains controversial. Because of this reason, the objective of current study is to explore whether XRCC3 Thr241Met polymorphism confers risk to leukemia. Methods Two independent authors systematically and comprehensively searched Pubmed, Embase, the Cochrane library, Google academic, China National Knowledge Infrastructure (CNKI). Search time is from database foundation to March 2021. Results Overall, significant associations between leukemia risk and XRCC3 Thr241Met polymorphism were found in Caucasian population by allele contrast (T vs. C: OR 1.20, 95% CI 1.02–1.40), homozygote comparison (TT vs. CC: OR 1.35, 95% CI 1.05–1.73), and recessive genetic model (TT vs. TC/CC: OR 1.31, 95% CI 1.04–1.64). Conclusions The present meta-analysis suggests that the XRCC3 Thr241Met polymorphism may be a risk factor for leukemia in Caucasian population.

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Associations between ADIPOQ rs2241766 SNP and breast cancer risk: a systematic review and a meta-analysis

Genes and Environment ◽

10.1186/s41021-021-00221-2 ◽

2021 ◽

Vol 43 (1) ◽

Author(s):

Xue Hu ◽

Chunguo Cui ◽

Tong Sun ◽

Wan Wang

Keyword(s):

Breast Cancer ◽

Breast Cancer Risk ◽

Cancer Risk ◽

Large Scale ◽

Meta Analysis ◽

Cochrane Library ◽

P Value ◽

China National Knowledge Infrastructure ◽

Knowledge Infrastructure ◽

Potential Association

Abstract Purpose We aimed to conduct a meta-analysis to accurately evaluate the potential association between ADIPOQ rs2241766 gene SNP and breast cancer risk. Methods A systematic literature search on Cochrane Library, PubMed, Embase, Web of Science and China National Knowledge Infrastructure (CNKI) identified 8 articles with 1692 cases and 1890 controls. Strength of association was evaluated by pooled odds ratio (OR), 95 % confidence interval (CI) and p value. Funnel plots and Begger’s regression test were applied for testing the publication bias. Statistical analysis of all data was performed by Stata 12.0. Results The meta-analysis results indicated that the ADIPOQ rs2241766 gene polymorphism did not significantly associated with the risk of breast cancer for these genetic models (TT vs. TG + GG: OR = 1.20, 95 % CI = 0.77–1.89, p=0.417; TT + TG vs. GG: OR = 1.05, 95 % CI = 0.71–1.56, p=0.805; T vs. G: OR =1.17, 95 % CI = 0.79–1.74, p=0.437). Conclusions This study indicated that no significant relationship between the ADIPOQ rs2241766 SNP and breast cancer. Further large-scale and well-designed studies will be indispensable to confirm our result.

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Is Ultrasound an Accurate Alternative for Mammography in Breast Cancer Screening in an Asian Population? A Meta-Analysis

Diagnostics ◽

10.3390/diagnostics10110985 ◽

2020 ◽

Vol 10 (11) ◽

pp. 985

Author(s):

Jing Wang ◽

Senshuang Zheng ◽

Lanjun Ding ◽

Xuan Liang ◽

Yuan Wang ◽

...

Keyword(s):

Breast Cancer ◽

Cancer Screening ◽

Breast Cancer Screening ◽

Data Extraction ◽

Meta Analysis ◽

Asian Population ◽

Asian Women ◽

China National Knowledge Infrastructure ◽

Knowledge Infrastructure ◽

Prisma Statement

In Asian countries, ultrasound has been proposed as a possible alternative for mammography in breast cancer screening because of its superiority in dense breasts, accessibility and low costs. This research aimed to meta-analyze the evidence for the diagnostic performance of ultrasound compared to mammography for breast cancer screening in Asian women. PubMed, Web of Science, and China National Knowledge Infrastructure databases were searched for studies that concurrently compared mammography and ultrasound in 2000–2019. Data extraction and risk of bias were performed according to the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA) statement. The primary outcome was the sensitivity and specificity. Bivariate random models were used to generate pooled estimates of diagnostic parameters and 95% confidence intervals (95% CI). In total, 4424 studies were identified of which six studies met the inclusion criteria with a sample size of 124,425 women. The pooled mean prevalence of the included studies was 3.7‰ (range: 1.2–5.7‰). The pooled sensitivity of mammography was significantly higher than that of ultrasound (0.81 [95% CI 0.71–0.88] versus 0.65 [95% CI 0.58–0.72], p = 0.03), but no significant differences were found in specificity (0.98 [95% CI: 0.94–1.00] versus 0.99 [95% CI: 0.97–1.00], p = 0.65). In conclusion, based on the currently available data on sensitivity alone, there is no indication that ultrasound can replace mammography in breast cancer screening in Asian women.

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Evaluation of the effectiveness and safety of cupping therapy in the treatment of asthma : A protocol for systematic review and meta-analysis

10.37766/inplasy2021.8.0104 ◽

2021 ◽

Author(s):

Lei Guo ◽

◽

Zhongtian Wang ◽

Lina Wei ◽

Lizhong Ding ◽

...

Keyword(s):

Systematic Review ◽

Meta Analysis ◽

Cupping Therapy ◽

Biomedical Literature ◽

China National Knowledge Infrastructure ◽

Aggregated Data ◽

Knowledge Infrastructure ◽

Asthma Patients ◽

Ethical Approval ◽

Review Question

Review question / Objective: “The aim of this systematic review is to compare Cupping therapy and Non cupping therapy in terms of efficacy and acceptability in the asthma to better inform clinical practice. To this end, the proposed systematic review will address the following question: Which is the best choice to reduce PEF, FVC, and FEV1, in asthma patients, Cupping therapy or Non cupping therapy ?”. Information sources: The protocol was prepared based on the preferred reporting project of the systematic review and meta-analysis protocol statement guidelines. Our research does not require ethical approval, as all analyses will be based on aggregated data from previously published studies. We will search the following Chinese and English databases: China National Knowledge Infrastructure, China Science and Periodical Database, Wanfang Database, China Biomedical Literature Database, PubMed, Embase, Cochrane Library.All of the above electronic databases will be searched from inception to August 22, 2021. In addition, we will manually search for conference papers, ongoing experiments and internal reports to supplement the studies retrieved via electronic search.

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The Associations between Interleukin-17 Single Nucleotide Polymorphism and Colorectal Cancer Susceptibility: A Systematic Review and Meta-Analysis

10.21203/rs.3.rs-1152352/v1 ◽

2021 ◽

Author(s):

Gaoming Li ◽

Jingfu Ma ◽

Ning Zhang ◽

Xiaogang Li ◽

Fangfang Li ◽

...

Keyword(s):

Colorectal Cancer ◽

Large Scale ◽

Cancer Susceptibility ◽

Meta Analysis ◽

Caucasian Population ◽

Biomedical Literature ◽

Interleukin 17 ◽

Case Control Studies ◽

China National Knowledge Infrastructure ◽

Knowledge Infrastructure

Abstract Backgrounds: Numerous of case-control studies have reported the associations between Interleukin-17 (IL-17) polymorphisms and colorectal cancer, however, the results were inconsistent. The aim of this meta-analysis was to further clarify the effects of IL-17 polymorphisms on colorectal cancer susceptibility.Materials and method: Relevant Studies were extracted from electronic databases of Pubmed, Embase, Web of science, China National Knowledge Infrastructure (CNKI) and Chinese Biomedical Literature Database (CMB) up to April 2021. The Odds ratio and 95% confidence interval were conducted to estimate the strength of the associations and the Stata 13.0 software was used to perform the meta-analysis.Results: Ten articles including 2599 cases and 2845 controls were enrolled in our research after strictly literature screening. Highly significant associations between IL-17A rs2275913 polymorphism and increased colorectal cancer susceptibility were observed in all the five gene models (allelic, dominant, recessive, homozygous and heterozygous models), subgroup analysis based on ethnicity revealed that these associations existed not only in Asia population, but also in Caucasian population. However, the results showed no significantly elevated colorectal cancer risk correlated to IL-17F rs763780 polymorphism and a slightly lower colorectal cancer susceptibility for Caucasian population was discovered in the recessive and homozygous models of this mutation.Conclusion: IL-17A rs2275913 polymorphism may be an independent risk factor contributed to colorectal cancer susceptibility, while IL-17F rs763780 polymorphism displayed a possible decreased susceptibility to colorectal cancer. Future studies with large-scale samples were warranted to identify these associations.

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Correlation between ABCB1 C3435T gene polymorphism and clopidogrel resistance：a meta analysis

Pharmaceutical Care and Research ◽

10.5428/pcar20200503 ◽

2020 ◽

Vol 20 (5) ◽

pp. 330-335

Author(s):

Jianqin LI ◽

◽

Xingchen YANG ◽

Weiqing SHI

Keyword(s):

Gene Polymorphism ◽

Meta Analysis ◽

Dominant Gene ◽

Recessive Gene ◽

Biomedical Literature ◽

Gene Model ◽

China National Knowledge Infrastructure ◽

Clopidogrel Resistance ◽

Knowledge Infrastructure

Objective： To systematically evaluate the correlation between ABCB1 C3435T gene polymorphism and clopidogrel resistance（CR）.Methods： The databases，such as Wanfang Data，the Chinese Biomedical Literature Database（CBM），the Chinese Journal Fulltext Database in China National Knowledge Infrastructure（CNKI），the China Science and Technology Journal Database（VIP），Science Citation Index（SCI），PubMed and EMBase，were searched from the inception to October 2019.The quality of clinical studies which met the inclusion criteria was evaluated，and meta analysis was performed using Stata 14.0 software.Results： Ten papers were included and 2642 patients were enrolled，including 878 cases in the clopidogrel-resistance group and 1764 cases in the non-clopidogrel resistance group.Results of meta-analysis showed that due to ABCB1 C3435T gene polymorphism，the overall effect of each subgroup was statistically significant（P<0.05）： allele gene model OR=1.39，95% CI（1.07，1.81）， dominant gene model OR=1.37，95% CI（1.13，1.66），recessive gene model OR=1.62，95% CI（1.02，2.57）， homozygous gene model OR=1.92，95% CI（1.14，3.22），and heterozygous gene model OR=1.33，95% CI（1.06，1.66）.Conclusion： Current findings confirmed that ABCB1 C3435T gene polymorphism is associated with clopidogrel resistance.

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