scholarly journals Classification Algorithms for the Detection of the Primary Tumor Based on Microscopic Images of Bone Metastases

2017 ◽  
Author(s):  
Sladan Kantar ◽  
Aleksandar Pluskoski ◽  
Igor Ciganovic ◽  
Jelena Vasiljevic
Keyword(s):  
Bone Metastases ◽  
Primary Tumor ◽  
Classification Algorithms ◽  
Microscopic Images

scholarly journals Surgery for primary tumor benefits survival for breast cancer patients with bone metastases: a large cohort retrospective study

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Zhangheng Huang ◽  
Xin Zhou ◽  
Yuexin Tong ◽  
Lujian Zhu ◽  
Ruhan Zhao ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Prognostic Factors ◽  
Bone Metastases ◽  
Cancer Patients ◽  
Primary Tumor ◽  
Predictive Accuracy ◽  
Rank Test ◽  
Breast Cancer Patients ◽  
Risk Of Death ◽  
The Impact

Abstract Background The role of surgery for the primary tumor in breast cancer patients with bone metastases (BM) remains unclear. The purpose of this study was to determine the impact of surgery for the primary tumor in breast cancer patients with BM and to develop prognostic nomograms to predict the overall survival (OS) of breast cancer patients with BM. Methods A total of 3956 breast cancer patients with BM from the Surveillance, Epidemiology, and End Results database between 2010 and 2016 were included. Propensity score matching (PSM) was used to eliminate the bias between the surgery and non-surgery groups. The Kaplan-Meier analysis and the log-rank test were performed to compare the OS between two groups. Cox proportional risk regression models were used to identify independent prognostic factors. Two nomograms were constructed for predicting the OS of patients in the surgery and non-surgery groups, respectively. In addition, calibration curve, receiver operating characteristic (ROC) curve, and decision curve analysis (DCA) were used to evaluate the performance of nomograms. Result The survival analysis showed that the surgery of the primary tumor significantly improved the OS for breast cancer patients with BM. Based on independent prognostic factors, separate nomograms were constructed for the surgery and non-surgery groups. The calibration and ROC curves of these nomograms indicated that both two models have high predictive accuracy, with the area under the curve values ≥0.700 on both the training and validation cohorts. Moreover, DCA showed that nomograms have strong clinical utility. Based on the results of the X-tile analysis, all patients were classified in the low-risk-of-death subgroup had a better prognosis. Conclusion The surgery of the primary tumor may provide survival benefits for breast cancer patients with BM. Furthermore, these prognostic nomograms we constructed may be used as a tool to accurately assess the long-term prognosis of patients and help clinicians to develop individualized treatment strategies.

MRI-based texture analysis of the primary tumor for pre-treatment prediction of bone metastases in prostate cancer

2019 ◽  
Vol 60 ◽  
pp. 76-84 ◽  
Author(s):  
Yueren Wang ◽  
Bing Yu ◽  
Fei Zhong ◽  
Qiyong Guo ◽  
Kexin Li ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Bone Metastases ◽  
Texture Analysis ◽  
Primary Tumor ◽  
Treatment Prediction ◽  
Pre Treatment

scholarly journals Prognostic factors and a new scoring system for survival of patients irradiated for bone metastases

BMC Cancer ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Dirk Rades ◽  
Rapha Haus ◽  
Steven E. Schild ◽  
Stefan Janssen
Keyword(s):  
Multivariate Analysis ◽  
Bone Metastases ◽  
Primary Tumor ◽  
Scoring System ◽  
Survival Rates ◽  
Karnofsky Performance Score ◽  
Tumor Type ◽  
Factor Scores ◽  
Survival Times ◽  
Primary Tumor Type

Abstract Background Personalized therapy for bone metastases should consider the patients’ remaining lifespan. Estimation of survival can be facilitated with scoring tools. A new tool was developed, specifically designed to estimate 12-month survival. Methods In 445 patients irradiated for bone metastases, radiotherapy regimen plus 13 factors (age, gender, Karnofsky performance score (KPS), primary tumor type, interval between cancer diagnosis and RT of bone metastases, visceral metastases, other (non-irradiated) bone metastases, sites of bone metastases, number of irradiated sites, pathological fracture, fractionation of RT, pre-RT surgery, pre-RT administration of bisphosphonates/denosumab, pre-RT systemic anticancer treatment) were retrospectively analyzed for survival. Factors achieving significance (p < 0.05) or borderline significance (p < 0.055) on multivariate analysis were used for the scoring system. Twelve-month survival rates were divided by 10 (factor scores); factor scores were summed for each patient (patient scores). Results On multivariate analysis, survival was significantly associated with KPS (hazard ratio (HR) 1.91, p < 0.001) and primary tumor type (HR 1.12, p < 0.001); age achieved borderline significance (HR 1.14, p = 0.054). These factors were used for the scoring tool. Patient scores ranged from 8 to 17 points. Three groups were designated: 8–9 (A), 10–14 (B) and 15–17 (C) points. Twelve-month survival rates were 9, 38 and 72% (p < 0.001); median survival times were 3, 8 and 24 months. Conclusions This new tool developed for patients irradiated for bone metastases at any site without spinal cord compression allows one to predict the survival of these patients and can aid physicians when assigning the treatment to individual patients.

Abstract 37: Bone metastases in renal cell carcinoma are predicted by characteristics of the primary tumor

2014 ◽  
Author(s):  
Elke Schneider ◽  
Tobias Haber ◽  
Frederick C. Roos ◽  
Christian Hampel ◽  
Kerstin Junker ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Bone Metastases ◽  
Cell Carcinoma ◽  
Primary Tumor ◽  
Renal Cell

scholarly journals Differential Patterns of Bone Turnover in Relation to Bone Pain and Disease Extent in Bone in Cancer Patients with Skeletal Metastases

1999 ◽  
Vol 45 (8) ◽  
pp. 1240-1247 ◽  
Author(s):  
Alfredo Berruti ◽  
Luigi Dogliotti ◽  
Gabriella Gorzegno ◽  
Mirella Torta ◽  
Marco Tampellini ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Bone Turnover ◽  
Urinary Excretion ◽  
Bone Metastases ◽  
Primary Tumor ◽  
Bone Pain ◽  
Bone Alkaline Phosphatase ◽  
Skeletal Metastases ◽  
Disease Extent ◽  
Tumor Types

Abstract Background: The alteration of the bone microenvironment as a consequence of skeletal metastases is poorly understood. The aim of this study was to search for patterns of bone markers in relation to primary tumor type, bone pain, and number of sites involved in patients with bone metastases. Methods: We studied 323 patients with bone metastases from various primary malignancies. We sequentially measured the serum concentrations of bone alkaline phosphatase [by an electrophoretic technique (BALP)], carboxy-terminal telopeptide of type I collagen (ICTP), calcium (CaS), intact parathyroid hormone (PTH), and the fasting urinary excretion of calcium (Ca:Cr). Immunoradiometric serum bone alkaline phosphatase (I-BALP) and urinary excretion of deoxypyridinoline (DPYD) were also assessed in the 175 cases. Data were analyzed as a function of bone pain (assessed by a validated pain questionnaire), the number of radiographically confirmed sites of bone involvement, and the most frequent primary tumor types: breast cancer (BC; 124 patients), prostate cancer (PC; 90 patients), and non-small cell lung cancer (LC; 49 patients). Results: Serum BALP and I-BALP correlated with the number of radiologically identified blastic bone lesions. BALP and I-BALP were more frequently increased in PC (72% for both measurements) than in BC (50% and 60%, respectively) or LC (3% and 5%, respectively; P &lt;0.001 for BALP and P = 0.001 for I-BALP). ICTP and DPYD values did not differ among PC, BC, and LC, but they did show a direct relationship with the disease extent in bone (P &lt;0.001). CaS and Ca:Cr did not vary significantly according to the bone tumor burden. Bone pain directly correlated with ICTP (P &lt;0.001), DPYD (P = 0.002), CaS (P &lt;0.002), and Ca:Cr (P = 0.001), whereas the relationship was inverse for serum PTH (P = 0.002). When patients were stratified according to the primary tumor, ICTP correlated with the bone pain in all subsets (P &lt;0.005, &lt;0.005, and &lt;0.001 for BC, PC, and LC, respectively), as did CaS and Ca:Cr in LC patients (P = 0.01 and 0.02, respectively) but not in PC and BC patients. Conclusions: The patterns of bone turnover markers differ among the primary tumor types. Both resorption and formation markers reflect the number of radiographically identified sites of bone metastases, whereas resorption markers and serum calcium but not formation markers correlate with bone pain.

scholarly journals Receptor Discordance of Metastatic Breast Cancer Depending on the Molecular Subtype

Breast Care ◽  
2020 ◽  
Vol 15 (6) ◽  
pp. 648-654
Author(s):  
Iris Holzer ◽  
Alex Farr ◽  
Yen Tan ◽  
Christine Deutschmann ◽  
Carmen Leser ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Bone Metastases ◽  
Metastatic Disease ◽  
Primary Tumor ◽  
Molecular Subtype ◽  
Early Stage ◽  
Metastatic Breast ◽  
Her2 Status ◽  
Receptor Status

<b><i>Introduction:</i></b> Almost 30% of all women with early-stage breast cancer develop metastases. Treatment of metastatic disease is often based on the immunohistochemical information of the primary tumor, despite possible discordance of the hormone and Her2 receptor status. <b><i>Objectives:</i></b> The aim of this study was to compare the receptor status of the primary tumor with the metastasis, and to evaluate for receptor discordance with regard to the molecular subtype, receptor status, and the localization of the metastases. <b><i>Methods:</i></b> We retrospectively analyzed the data of all consecutive women with metastatic breast cancer, who underwent treatment at the Medical University Vienna between 2009 and 2016. Associations were calculated using the χ<sup>2</sup>or Fisher’s exact test; years from primary diagnosis to metastatic disease were calculated using the Kaplan-Meier method. <b><i>Results:</i></b> We identified 213 metastatic breast cancer patients, of whom 67 (31.5%) showed a discordant receptor status. Out of 32 patients with luminal A subtype, 14 (43.8%) had a switch of at least one receptor; 27 of 53 patients (50.9%) with luminal B subtype and 21 of 32 patients (65.6%) with Her2+ subtype showed receptor discordance; for triple-negative disease, 5 of 19 patients (36.3%) had a switch of at least one receptor. In 63 samples of bone metastases, 13 (20.6%) had discordant estrogen receptor status (<i>p</i> = 0.04). In 55 samples of bone metastases, 35 (63.3%) had discordant Her2 status (<i>p</i> = 0.002). <b><i>Conclusions:</i></b> Our data show high rates of receptor discordance in metastatic breast cancer. Apart from the primary tumor, the immunohistochemical receptor status of the metastasis needs to be verified. This can lead to a change in treatment and prognosis.

scholarly journals Surgery for Primary Tumor Benefits Survival for Breast Cancer Patients With Bone Metastases: A Large Cohort Retrospective Study

2020 ◽  
Author(s):  
Zhangheng Huang ◽  
Xin Zhou ◽  
Yuexin Tong ◽  
Lujian Zhu ◽  
Ruhan Zhao ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Prognostic Factors ◽  
Bone Metastases ◽  
Cancer Patients ◽  
Primary Tumor ◽  
Predictive Accuracy ◽  
Rank Test ◽  
Breast Cancer Patients ◽  
Risk Of Death ◽  
The Impact

Abstract Background: The role of surgery for the primary tumor in breast cancer patients with bone metastases (BM) remains unclear. The purpose of this study was to determine the impact of surgery for the primary tumor in breast cancer patients with BM and to develop prognostic nomograms to predict the overall survival (OS) of breast cancer patients with BM.Methods: A total of 3,956 breast cancer patients with BM from the Surveillance, Epidemiology, and End Results database between 2010 and 2016 were included. Propensity score matching (PSM) was used to eliminate the bias between the surgery and non-surgery groups. The Kaplan-Meier analysis and the log-rank test were performed to compare the OS between two groups. Cox proportional risk regression models were used to identify independent prognostic factors. Two nomograms were constructed for predicting the OS of patients in the surgery and non-surgery groups, respectively. In addition, calibration curve, receiver operating characteristic (ROC) curve, and decision curve analysis (DCA) were used to evaluate the performance of nomograms.Result: The survival analysis showed that the surgery of the primary tumor significantly improved the OS for breast cancer patients with BM. Based on independent prognostic factors, separate nomograms were constructed for the surgery and non-surgery groups. The calibration and ROC curves of these nomograms indicated that both two models have high predictive accuracy, with the area under the curve values ≥0.700 on both the training and validation cohorts. Moreover, DCA showed that nomograms have strong clinical utility. Based on the results of the X-tile analysis, all patients were classified in the low-risk-of-death subgroup had a better prognosis.Conclusion: The surgery of the primary tumor can provide survival benefits for breast cancer patients with BM. Furthermore, these prognostic nomograms we constructed can be used as a tool to accurately assess the long-term prognosis of patients and help clinicians to develop individualized treatment strategies.

Isolated Bone Metastases as a Manifestation of Primary Tumor of the Liver

1954 ◽  
Vol 27 (3) ◽  
pp. 307-317 ◽  
Author(s):  
Enrico Anglesio
Keyword(s):  
Bone Metastases ◽  
Primary Tumor

The Added Value of [68Ga]Ga-DOTA-FAPI-04 PET/CT in Patients with Head and Neck Cancer of Unknown Primary with [18F]FDG Negative Findings

2021 ◽  
Author(s):  
Bingxin Gu ◽  
Xiaoping Xu ◽  
Ji Zhang ◽  
Xiaomin Ou ◽  
Zuguang Xia ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Lymph Node ◽  
Bone Metastases ◽  
Head And Neck ◽  
Primary Tumor ◽  
Cancer Of Unknown Primary ◽  
Unknown Primary ◽  
Primary Tumors ◽  
Pet Ct ◽  
The Mean

Abstract Purpose [18F]fluorodeoxyglucose ([18F]FDG) positron emission tomography/computed tomography (PET/CT) plays an important role in location of primary tumor for patients with head and neck cancer of unknown primary (HNCUP). But sometimes, [18F]FDG PET/CT still cannot find the primary malignancy. As 68Ga-radiolabeled fibroblast activation protein inhibitor (FAPI) PET/CT has promising results in detecting different tumor entities, our study aimed to evaluate the performance of [68Ga]Ga-DOTA-FAPI-04 PET/CT for detecting the primary tumor in HNCUP patients with negative [18F]FDG findings.Methods A total of eighteen patients (16 males and 2 females; median age, 55 years; range, 24-72 years) with negative [18F]FDG findings were eligible in this study. All patients underwent [18F]FDG and [68Ga]Ga-DOTA-FAPI-04 PET/CT within one week. Biopsy and histopathological examinations were done in the sites with positive [68Ga]Ga-DOTA-FAPI-04 PET/CT findings. Results [68Ga]Ga-DOTA-FAPI-04 PET/CT detected the primary tumor in 7 of 18 patients (38.89%). The primary tumors sites were in nasopharynx (1/7), palatine tonsil (2/7), submandibular gland (2/7), and hypopharynx (2/7). The primary tumors showed mild to intensive uptake of FAPI (mean SUVmax, 8.79; range, 2.60-16.50) and excellent tumor-to-contralateral normal tissue ratio (mean SUVmax ratio, 4.50; range, 2.17-8.21). In lesion-based analysis, a total of 65 lymph nodes and 17 bone metastatic lesions were identified. The mean SUVmax of lymph node metastases were 9.05 ± 5.29 for FDG and 9.08 ± 4.69 for FAPI (p = 0.975); as for bone metastases, the mean SUVmax were 8.11 ± 3.00 for FDG and 6.96 ± 5.87 for FAPI, respectively (p = 0.478). The mean tumor-to-background ratio (TBR) values of lymph node and bone metastases were 10.65 ± 6.59 vs. 12.80 ± 8.11 (p = 0.100) and 9.08 ± 3.35 vs. 9.14 ± 8.40 (p = 0.976), respectively.Conclusion We present first evidence of diagnostic role of [68Ga]Ga-DOTA-FAPI-04 PET/CT in HNCUP, and our study demonstrated that [68Ga]Ga-DOTA-FAPI-04 PET/CT had the potential to improve the detection rate of primary tumor in HNCUP patients with negative FDG findings. Moreover, [68Ga]Ga-DOTA-FAPI-04 had similar performance in assessing metastases with [18F]FDG.

scholarly journals AB1032 CONTRIBUTION OF BONE BIOPSY DURING REVELATORY BONE METASTASES

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1808.3-1808
Author(s):  
S. Jriri ◽  
M. Ben Majdouba ◽  
S. Ben Jemaa ◽  
A. Feki ◽  
R. Akrout ◽  
...  
Keyword(s):  
Bone Metastases ◽  
Primary Tumor ◽  
Pathological Fracture ◽  
Bone Biopsy ◽  
Histological Type ◽  
Diagnostic Strategy ◽  
Primary Neoplasm ◽  
Frequent Reason ◽  
Selection Of

Background:Bone metastases (BM) are tumor cells that originate in a primary malignant tumor and are localized remotely in bone tissue. They more or less faithfully reproduce the morphological and biological characteristics of the primary tumor. Histological analysisis essential to confirm the diagnosis of BM and to identify the primary tumor if possible and sometimes to help in the selection of treatment.Objectives:The aim of this work is to study the contribution of bone biopsy during revealing BM in diagnostic strategy and therapeutic decision.Methods:We retrospectively studied the files of 105 patients hospitalized in a Rheumatology department of for BM revealing from January 2000 until December 2015. For each patient we collected epidemioclinical and anatomopathological data to arrive at the diagnosis of primary neoplasm and histological type.Results:The patients were divided into 86 men (81.9%) and 19 women (18.1%) with a sex ratio (M / F) of 4.52. The average age of our patients was 64.91 ± 13.29 years. Pain was the most frequent reason for consultation found in 97.1%. This pain was either of bone site (61.9%) or of radicular topography (41.9%). Bone swelling or a pathological fracture revealed BM in 4.8% and 8.6% of the cases, respectively. The onset of neurological damage was noted in 13.3% of the cases.Histologically, the bone biopsy performed in 64 patients made it possible to specify the histological type (carcinoma, adenocarcinoma) in 64% of the cases and to lead to primary cancer in 57.8%. A non-radio-guided percutaneous bone biopsy was performed in 44 patients (68.75%) including 41 osteo-medullary biopsy in iliac crest (BOM) and 3 in the sternum, a bone biopsy directed under scanner in 16 cases (25%) and a surgical bone biopsy in 4 cases.The BOM was positive in 21 cases (51.2%) showing a poorly or moderately differentiated adenocarcinoma or carcinoma. It allowed referral to a primitive in 20 cases: a prostatic origin in 11 cases, a pulmonary origin in 5 cases, a digestive origin in 2 cases, a mammary origin in one case and a neuroblastoma in one case.Conclusion:Thanks to improved sampling and immunohistochemistry techniques, the precise histological type and location of the primary tumor could be identified, there by improving the quality of care for patients with increased life expectancy.Disclosure of Interests:None declared

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