scholarly journals The role of immune mediators in pathogenesis of hepatitis B virus infection

Biomedicine ◽  
2021 ◽  
Vol 41 (4) ◽  
pp. 752-755
Author(s):  
Hana Abdul-Qader Khuder
Keyword(s):  
Hepatitis B Virus ◽  
Virus Infection ◽  
Hepatitis B ◽  
Clinical Symptoms ◽  
Acute Infection ◽  
Elisa Test ◽  
Hbv Infection ◽  
B Virus ◽  
Life Threatening ◽  
Healthy Control

Introduction and Aim: Viral hepatitis, is considered a major cause of cirrhosis and liver transplantation, both of which are life-threatening conditions. In comparison to Hepatitis C virus infection, Hepatitis B virus (HBV) infection has a lower rate of chronicity. The purpose of this study is to assess the immunological particles CD2 and CD4, as well as the cytokines IL-10, in HBV-infected patients. Materials and Methods: Between April and June 2021, a case-control study was conducted on 180 female subjects with a mean age of 35 years who visited a private clinic in Mosul city. A (10 ml) sample of blood was collected from each subject by routine venipuncture technique, and the blood sample was centrifuged at 3,000 rpm for 10 minutes to separate the plasma, which was used for further investigations. The ELISA test was used to determine the sizes of cytokines in the serum (R&D Systems). A microplate reader was used to limit absorbance in copies (Beckman Coulter). The last concentration was measured in pg/ml.   Results: The findings of this study revealed that (15%) of cases had clinical symptoms of HBV, while (70%) of cases were asymptomatic, and (5%) of cases progressed to chronic liver disease. In compared to healthy control groups, HBV patients had highly significant variations in mean CD 2 and CD 4 expression (p<0.0001). Conclusion: During the acute phase of hepatitis, the immune system successfully fights off the infection; however, differences in immune responses to different viruses may explain the tendency for acute infection to resolve rather than develop to chronic infection. Hepatitis viruses employ a variety of tactics to evade human immunity. To fully comprehend the complicated interplay between immunological mediators and HBV infection, more research is needed.

High prevalence of occult hepatitis C virus infection in patients with chronic hepatitis B virus infection

2013 ◽  
Vol 62 (8) ◽  
pp. 1235-1238 ◽  
Author(s):  
Inmaculada Castillo ◽  
Javier Bartolomé ◽  
Juan Antonio Quiroga ◽  
Vicente Carreño
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Hepatitis B Virus ◽  
Virus Infection ◽  
Hepatitis B ◽  
Hcv Infection ◽  
Hbv Infection ◽  
Chronic Hepatitis B Virus ◽  
B Virus

Hepatitis C virus (HCV) infection in the absence of detectable antibodies against HCV and of viral RNA in serum is called occult HCV infection. Its prevalence and clinical significance in chronic hepatitis B virus (HBV) infection is unknown. HCV RNA was tested for in the liver samples of 52 patients with chronic HBV infection and 21 (40 %) of them were positive for viral RNA (occult HCV infection). Liver fibrosis was found more frequently and the fibrosis score was significantly higher in patients with occult HCV than in negative ones, suggesting that occult HCV infection may have an impact on the clinical course of HBV infection.

scholarly journals Paternal hepatitis B virus infection with different clinical courses between siblings

2021 ◽  
Author(s):  
Yoshiaki Sasaki ◽  
Hiroki Kajino
Keyword(s):  
Hepatitis B Virus ◽  
Virus Infection ◽  
Hepatitis B ◽  
Family Members ◽  
Hbv Infection ◽  
Hepatitis B Virus Infection ◽  
Hbv Vaccination ◽  
B Virus

No countermeasures have been established against horizontal infection in non-vaccinated children. We reported about siblings with different clinical courses of HBV paternal infection. To eradicate HBV, we should encourage HBV vaccination of all children and HBV infection screening of fathers and other family members.

scholarly journals Prevalence of Hepatitis B among Food Vendors in Wurukum Market, Makurdi Benue State

2018 ◽  
pp. 1-5
Author(s):  
V. U. Obisike ◽  
C. M. Uke ◽  
E. U. Amuta
Keyword(s):  
Risk Factors ◽  
Liver Disease ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Age Groups ◽  
Hbv Infection ◽  
Test Strips ◽  
Significant Difference ◽  
B Virus ◽  
Life Threatening

Hepatitis B is a life threatening infectious liver disease caused by hepatitis B virus (HBV). The aim of this study was to determine the prevalence of HBV among food vendors in Wurukum, a highly commercial section of metropolitan Makurdi in Benue State. The test was carried out with the use of an immunochromatographic  micropoint HBsAg test strips and a HBsAg  buffer screen for the virus. Out of the 250 non-vaccinated food vendors sampled, 27(10.8%) had HBV infection, with more in males (21.7%) than in females (6.6%). No significant difference (p>0.05) was found among age groups in spite of the observed highest prevalence of 14.3% among the 20-29 year olds. Therefore, the need for routine screening cannot be overemphasized in spite of known risk factors among food vendors.

Polyarteritis Nodosa Following Vaccination Against Hepatitis B Virus with Lower-Extremity Manifestations: A Case Report

2019 ◽  
Vol 109 (3) ◽  
pp. 241-245
Author(s):  
Daniel R. Wright ◽  
Jenni M. Davis ◽  
Karl Robstad ◽  
Melissa D. Shah ◽  
Michael C. Keller ◽  
...  
Keyword(s):  
Case Report ◽  
Hepatitis B Virus ◽  
Virus Infection ◽  
Hepatitis B ◽  
Polyarteritis Nodosa ◽  
Peripheral Nerves ◽  
Hepatitis B Virus Infection ◽  
Multiple Organs ◽  
B Virus ◽  
Life Threatening

Polyarteritis nodosa is a progressive, often life-threatening, vasculitis affecting multiple organs, including the skin and peripheral nerves. We report a patient presenting with systemic features of the disease and with characteristic lesions in the feet 3 weeks after vaccination against hepatitis B virus infection.

Hepatitis B Virus Infection in Health Care Workers in Albania: a Country still Highly Endemic for HBV Infection

Infection ◽  
2007 ◽  
Vol 35 (2) ◽  
pp. 94-97 ◽  
Author(s):  
L. A. Kondili ◽  
D. Ulqinaku ◽  
M. Hajdini ◽  
M. Basho ◽  
P. Chionne ◽  
...  
Keyword(s):  
Health Care ◽  
Hepatitis B Virus ◽  
Virus Infection ◽  
Hepatitis B ◽  
Health Care Workers ◽  
Hbv Infection ◽  
Hepatitis B Virus Infection ◽  
Care Workers ◽  
B Virus

scholarly journals Prevalence and Knowledge of Hepatitis B Virus Infection among Pregnant Women in the Ningo-Prampram District, Ghana

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Precious Kwablah Kwadzokpui ◽  
Elliot Elikplim Akorsu ◽  
Albert Abaka-Yawson ◽  
Solomon Sosu Quarshie ◽  
Stephen Adomako Amankwah ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Virus Infection ◽  
Hepatitis B ◽  
Antenatal Care ◽  
Pregnant Women ◽  
Health Facility ◽  
Hbv Infection ◽  
Hepatitis B Virus Infection ◽  
B Virus ◽  
Study Participants

Background. Hepatitis B virus (HBV) infection has been suggested to play a role in various adverse birth outcomes. The study determined the prevalence as well as knowledge of hepatitis B virus infection among pregnant women in the Ningo-Prampram District of the Greater Accra Region of Ghana. Materials and Methods. A cross-sectional study using simple random sampling technique was used to recruit 213 pregnant women receiving antenatal care in three different health facilities (Prampram Polyclinic (PPC), Dangme Community Hospital (DCH), and Old Ningo Health Center (ONHC)) in the Ningo-Prampram District of Ghana from November 2018 to January 2019. A semi-structured questionnaire was used to collect data which included participants’ HBsAg test results, sociodemographic and gynaecological characteristics, and their level of knowledge on HBV infection. Knowledge of the participants on HBV infection was classified as either excellent, good, or poor based on their cumulative percentage scores from the questionnaire according to Al Rubaish system of classification. Results. Overall low-intermediate prevalence of HBV infection was 3.3%; however, PPC recorded the highest prevalence of 4.0% while DCH and ONHC recorded 2.82% and 2.50%, respectively. Statistically significant association was observed between HBV infection and the health facility. Majority (77.40%) of the study participants had poor knowledge on HBV infection while only 14 (6.57%) had excellent knowledge on HBV. Regarding excellent knowledge, 8 (11.0%) among the participants were demonstrated by the majority of those who received antenatal care from DCH. Generally, knowledge on HBV and the infection was poor among the study participants. Knowledge on HBV infection was found to be associated with residential status (p=0.006), educational level (p<0.001), occupation (p<0.001), and gestational period (p<0.001). Participant’s knowledge was also significantly associated with the health facility (p=0.027). Conclusion. HBV infection among pregnant women is prevalent in the Ningo-Prampram District even though the prevalence is not very high. The majority of pregnant women in the Ningo-Prampram District inadequate knowledge on HBV infection and it mode of transmission. Intensive public health education on the HBV infection is required in the district to help prevent and manage future transmissions as well as inform the population about the negative side effects of the virus and the need to prevent it by way of vaccination.

scholarly journals Effect of concurrent acute infection with hepatitis C virus on acute hepatitis B virus infection.

BMJ ◽  
1993 ◽  
Vol 307 (6912) ◽  
pp. 1095-1097 ◽  
Author(s):  
L T Mimms ◽  
J W Mosley ◽  
F B Hollinger ◽  
R D Aach ◽  
C E Stevens ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Hepatitis B Virus ◽  
Virus Infection ◽  
Hepatitis B ◽  
Acute Hepatitis ◽  
Acute Infection ◽  
Hepatitis B Virus Infection ◽  
B Virus ◽  
Acute Hepatitis B
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