scholarly journals Radioterapia intraoperatoria de electrones en cáncer de mama. Experiencia en Venezuela.

2021 ◽  
Vol 81 (03) ◽  
pp. 248-255
Author(s):  
Javier Soteldo-Clavier ◽  
Manuel Escalante-Reinozo ◽  
Desirée Bermúdez-Morantes
Keyword(s):  
Radiation Therapy ◽  
Ductal Carcinoma ◽  
Cáncer De Mama ◽  
Electron Radiation ◽  
Luminal B ◽  
Tumor Bed ◽  
Key Words Breast ◽  
Breast Cancer Radiotherapy ◽  
The Mean ◽  
The Right

Objective: To evaluate the evolution of patients treated with intraoperative electron radiotherapy by Group J Soteldo, in Hospital de Clínicas Caracas. Methods: Descriptive observational study. We included 18 patients treated with intraoperative electron radiation therapy between April 2017 and July 2018. Medical records were reviewed to study the evolution, patients who had not returned in the last six months were contacted by telephone. Intraoperative electron radiation therapy was applied during the same surgical act, at a dose of 21 Gy, after the tumor was removed from the affected breast, at the level of the tumor bed. Results: The mean age was 54.5 years, the mean tumor size was 2.48 cm. Twelve patients had cancer in the right breast (66.7%) and six in the left (33.3%). Nine cases (50%) were Luminal B; 15 patients had infiltrating ductal carcinoma (83.3%), 13 (72.2%) had a negative axilla. Six patients (33.3%) underwent axillary dissection up to the third level and 12 (66.7%) had a sentinel node. Five patients (27.8%) received a single dose of intraoperative electron radiation therapy and 13 (72.2%) received booster doses. No patient has had a relapse of the disease or serious adverse effects associated with radiation therapy. Conclusion: The use of intraoperative electron radiation therapy was an effective and well tolerated treatment in this group of patients. It is not a commonly used treatment in Venezuela. Key words: Breast cancer, Radiotherapy, Electrons.

scholarly journals Ultrasound-Guided Core-Needle Biopsy of Suspicious Breast Lesions

2020 ◽  
Vol 5 (2) ◽  
pp. 48-55
Author(s):  
Kincső-Zsófia Lőrincz ◽  
Zsuzsánna Pap ◽  
Simona Lileana Mocan ◽  
Csanád-Endre Lőrincz ◽  
Beáta-Ágota Baróti
Keyword(s):  
Core Needle Biopsy ◽  
Needle Biopsy ◽  
Breast Imaging ◽  
Ductal Carcinoma ◽  
Screening Program ◽  
Core Needle ◽  
Luminal B ◽  
Triple Assessment ◽  
Mean Size ◽  
The Mean

AbstractBackground: Breast cancer is the female cancer with the highest mortality. While early detection is a public health priority in Western European countries, a screening program in our country has yet to be implemented. The best diagnostic accuracy is achieved through the use of triple assessment: clinical examination, imaging, and core-needle biopsy where indicated. Prognosis is influenced by clinical, histological, and biological factors, and therapy is most effective when individually tailored.Aim of the study: To analyze the clinical, histological, and immunohistochemical characteristics of the biopsied nodules and summarize our experience from the last three years.Material and Methods: We retrospectively analyzed data from 137 patients who underwent core-needle biopsy between 2017 and 2019. Imaging score was assigned based on ultrasound examination or mammography. Clinical and pathological parameters were recorded, followed by statistical processing of the data.Results: The mean age of the patients was 58 ± 14 years, lesions had a mean size of 22.83 ± 14.10 mm. Most nodules (n = 63, 47.01%) were located in the upper-outer quadrant, and bilateral presence was found in 4 (3.08%) cases. We found a significant positive correlation between lesion size and the patients’ age (Spearman r = 0.356; 95% CI 0.186, 0.506; p = 0.000). The malignancy rates within the Breast Imaging Reporting and Data System (BI-RADS) categories were as follows: 0% for „4a”, 31.58% for „4b”, 71.42% for „4c”, and 97.72% for „5”. Most malignancies (n = 73, 78.35%) were represented by invasive ductal carcinoma of no special type, 58.43% (n = 52) were grade 2, 89.13% (n = 82) were estrogen receptor positive, and Luminal B-like type was the most common (n = 63, 78.75%).Conclusions: The mean size of tumors was larger than the average size at discovery described in the literature. In our region, age and tumor size are positively correlated. Preoperative histological results may indicate the reliability of the imaging risk stratification system. Most cases can benefit from adjuvant endocrine therapy.

scholarly journals Finding an Alternative for the Surgical Clips-based Delineation of Tumor Bed Boost Volume for Radiotherapy after Breast Conserving Surgery: A Prospective Comparative Study

2021 ◽  
Vol 5 (4) ◽  
pp. 303-306
Author(s):  
Mrutyunjayarao Muvvala ◽  
Pragna Sagar Rapole ◽  
Gunaseelan Karunanithi ◽  
Vijayaprabhu Neelakandan ◽  
Kadambari Dharanipragada
Keyword(s):  
Breast Tissue ◽  
Ductal Carcinoma ◽  
Standard Technique ◽  
Breast Conserving Surgery ◽  
The Other ◽  
Surgical Clips ◽  
Tumor Bed ◽  
Prospective Comparative Study ◽  
The Mean ◽  
Good Concordance

Background: Radiotherapy after breast conserving surgery includes irradiation of whole breast and regional lymphatic areas which is followed by a boost to the tumor bed. Several different techniques have been proposed for delineation of tumor bed for boost. The purpose of the study was to identify the best method for localizing the tumor bed. Methods: 21 patients with histologically proven stage I and II infiltating ductal carcinoma of breast who underwent breast conserving surgery were included in the study. We delineated the boost volumes using five different techniques viz., patients’ self-localization, surgeon’s localization, pre-op CT based, scar-based and surgical clips based. The surgical clips-based volume is taken as a standard volume and the other volumes were compared with it. The outcome measures studied were the mean overlap volumes, the mean volume of surgical clips based volume missed by the other PTVs, the mean volumes of breast tissue outside the clips based PTV that could have been irradiated by the other PTVs. Results: None of the PTV volumes had good concordance with the surgical clips-based volume (PTV1). The best volume overlap was with patient’s self-localization (PTV3) albeit only being 34%. The scar-based localization volume had the least overlap with PTV1 (23%). The patients’ self-localization volume (PTV3) had the highest amount of breast tissue included outside PTV1 (64cc) and preop CT based volume (PTV4) included the least (42cc). Conclusion: Delineation of boost volume using surgical clips augmented by the simulation CT should be the standard technique for boost bed irradiation. 

scholarly journals Prone versus supine free-breathing for right-sided whole breast radiotherapy

2022 ◽  
Vol 12 (1) ◽  
Author(s):  
Odile Fargier-Bochaton ◽  
Xinzhuo Wang ◽  
Giovanna Dipasquale ◽  
Mohamed Laouiti ◽  
Melpomeni Kountouri ◽  
...  
Keyword(s):  
Free Breathing ◽  
September 11 ◽  
Breast Cancer Patients ◽  
Lung Dose ◽  
Breast Radiotherapy ◽  
Tumor Bed ◽  
Whole Breast Radiotherapy ◽  
The Mean ◽  
The Right ◽  
Robust Linear Regression

AbstractProne setup has been advocated to improve organ sparing in whole breast radiotherapy without impairing breast coverage. We evaluate the dosimetric advantage of prone setup for the right breast and look for predictors of the gain. Right breast cancer patients treated in 2010–2013 who had a dual supine and prone planning were retrospectively identified. A penalty score was computed from the mean absolute dose deviation to heart, lungs, breasts, and tumor bed for each patient's supine and prone plan. Dosimetric advantage of prone was assessed by the reduction of penalty score from supine to prone. The effect of patients' characteristics on the reduction of penalty was analyzed using robust linear regression. A total of 146 patients with right breast dual plans were identified. Prone compared to supine reduced the penalty score in 119 patients (81.5%). Lung doses were reduced by 70.8%, from 4.8 Gy supine to 1.4 Gy prone. Among patient's characteristics, the only significant predictors were the breast volumes, but no cutoff could identify when prone would be less advantageous than supine. Prone was associated with a dosimetric advantage in most patients. It sets a benchmark of achievable lung dose reduction.Trial registration: ClinicalTrials.gov NCT02237469, HUGProne, September 11, 2014, retrospectively registered.

scholarly journals Early Invasive Cancer and Partial Intraoperative Electron Radiation Therapy of the Breast: Experience of the Jules Bordet Institute

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
C. Philippson ◽  
S. Simon ◽  
C. Vandekerkhove ◽  
D. Hertens ◽  
I. Veys ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Ductal Carcinoma ◽  
Early Stage ◽  
Selection Process ◽  
Tumour Size ◽  
Clinical Results ◽  
Lymph Node Involvement ◽  
Electron Radiation ◽  
Recurrence Rates

Objectives. The aim of this prospective phase II study is to evaluate the treatment of early-stage breast cancer (T1 N0) with intraoperative electron radiation therapy (IOERT) in terms of local control, early complications, and cosmesis.Patients and Methods. From February 2010 to February 2012, 200 patients underwent partial IOERT of the breast. Inclusion criteria were unifocal invasive ductal carcinoma, age ≥40 years, histological tumour size ≤20 mm, and no lymph node involvement. A 21 Gy dose was prescribed over the 90% isodose line in the tumour bed. Median follow-up is 23.3 months (7–37).Results. Acute toxicity was not frequent (Grade 1: 4.5%, Grade 2: 1%). The cosmetic result was considered to be very good or good in 92.5%. One ipsi lateral out-quadrant recurrence at 18 months was observed. The crude and actuarial local recurrence rates after median follow-up were 0.5% and 0.9%, respectively.Conclusion. The preoperative diagnostic work-up must be comprehensive and the selection process must be rigorous for this therapeutic approach reserved for small ductal unifocal cancers. After a 23.3-month median follow-up time, the clinical results of IOERT for selected patients are encouraging for the locoregional recurrence and the toxicity rates. The satisfaction of our patients in terms of quality of life was extremely high.

DMSA-scintigraphy in paediatrics: Is the evaluation of the geometric mean necessary for the calculation of the differential renal function?

2001 ◽  
Vol 40 (04) ◽  
pp. 107-110 ◽  
Author(s):  
B. Roßmüller ◽  
S. Alalp ◽  
S. Fischer ◽  
S. Dresel ◽  
K. Hahn ◽  
...  
Keyword(s):  
Renal Function ◽  
Geometric Mean ◽  
Region Of Interest ◽  
Posterior View ◽  
Renal Abnormality ◽  
Anterior View ◽  
Differential Renal Function ◽  
The Mean ◽  
The Right ◽  
To Receive

SummaryFor assessment of differential renal function (PF) by means of static renal scintigraphy with Tc-99m-dimer-captosuccinic acid (DMSA) the calculation of the geometric mean of counts from the anterior and posterior view is recommended. Aim of this retrospective study was to find out, if the anterior view is necessary to receive an accurate differential renal function by calculating the geometric mean compared to calculating PF using the counts of the posterior view only. Methods: 164 DMSA-scans of 151 children (86 f, 65 m) aged 16 d to 16 a (4.7 ± 3.9 a) were reviewed. The scans were performed using a dual head gamma camera (Picker Prism 2000 XP, low energy ultra high resolution collimator, matrix 256 x 256,300 kcts/view, Zoom: 1.6-2.0). Background corrected values from both kidneys anterior and posterior were obtained. Using region of interest technique PF was calculated using the counts of the dorsal view and compared with the calculated geometric mean [SQR(Ctsdors x Ctsventr]. Results: The differential function of the right kidney was significantly less when compared to the calculation of the geometric mean (p<0.01). The mean difference between the PFgeom and the PFdors was 1.5 ± 1.4%. A difference > 5% (5.0-9.5%) was obtained in only 6/164 scans (3.7%). Three of 6 patients presented with an underestimated PFdors due to dystopic kidneys on the left side in 2 patients and on the right side in one patient. The other 3 patients with a difference >5% did not show any renal abnormality. Conclusion: The calculation of the PF from the posterior view only will give an underestimated value of the right kidney compared to the calculation of the geometric mean. This effect is not relevant for the calculation of the differntial renal function in orthotopic kidneys, so that in these cases the anterior view is not necesssary. However, geometric mean calculation to obtain reliable values for differential renal function should be applied in cases with an obvious anatomical abnormality.

Successful radiation therapy for primary cutaneous follicle center lymphoma

2019 ◽  
Vol 8 (2) ◽  
Author(s):  
Takashi Matsushita ◽  
Tomoyasu Kumano ◽  
Kazuhiko Takehara
Keyword(s):  
Radiation Therapy ◽  
Skin Biopsy ◽  
B Cell ◽  
B Cell Lymphomas ◽  
Solitary Lesion ◽  
Lower Jaw ◽  
First Choice ◽  
The Right

Primary cutaneous follicle center lymphoma (PCFCL) accounts for the majority of primary cutaneous B-cell lymphomas. We report a 60-year-old womanwith PCFCL. She had a red nodule (25 × 25 mm) on the right side of the lower jaw. She was diagnosed with PCFCL by skin biopsy. And then, she was treated with radiation therapy (total 30.6 Gy), which completely eliminated the nodule. Our case suggests that radiation therapy may be a first choice for PCFCL patients with a solitary lesion or localized lesions.    

Therapeutic Effects of Hab Shabyar on Open-Angle Glaucoma: A Double-Blinded, Randomized, Placebo-Controlled Trial

2019 ◽  
Vol 8 ◽  
pp. 1218
Author(s):  
Ebrahim Khalil BaniHabib ◽  
Ali Mostafai ◽  
Seyyed Mohammad Bagher Fazljou ◽  
Ghadir Mohammdi
Keyword(s):  
Placebo Group ◽  
Intraocular Pressure ◽  
Open Angle Glaucoma ◽  
Controlled Trial ◽  
Intervention Group ◽  
Therapeutic Effects ◽  
Open Angle ◽  
The Mean ◽  
The Right ◽  
Double Blinded

Background: Open-angle glaucoma (OAG) is one of the leading causes of blindness worldwide. This study evaluates the therapeutic effects of hab shabyar in patients with open-angle glaucoma. Materials and Methods: In this clinical randomized controlled trial, 50 patients with OAG were randomized into two groups. The intervention group was received a drop of timolol plus 500 mg of hab shabyar every 12 hours. The placebo group was received a drop of timolol every 12 hours plus 500 mg of wheat germ as a placebo. The intraocular pressure in patients with OAG was measured in each group and compared at before the intervention (t1), one month (t2), and two months (t3) after the intervention. Results: The mean decrease in intraocular pressure for the right eye at three times in the intervention group was statistically significant, but the mean decrease in the placebo group was not significant. Similar results were obtained for the left eye at t1 when compared to t3. The patients in the intervention group expressed more satisfaction than the patients in the placebo group (P≤0.001). Conclusion: Our study demonstrated that consumption of timolol plus hab shabyar instead of consuming of timolol alone was probably more effective for reducing intraocular pressure in patients with OAG.[GMJ.2019;In press:e1218]

Flow cytometric identification and isolation of hypertrophic type II pneumocytes after partial pneumonectomy

1989 ◽  
Vol 257 (3) ◽  
pp. C528-C536 ◽  
Author(s):  
B. D. Uhal ◽  
S. R. Rannels ◽  
D. E. Rannels
Keyword(s):  
Gradient Centrifugation ◽  
Type Ii Cells ◽  
Type Ii ◽  
Acridine Orange Staining ◽  
Flow Cytometric ◽  
Percoll Density Gradient Centrifugation ◽  
Type Ii Pneumocytes ◽  
The Mean ◽  
Cellular Dna ◽  
The Right

Type II pneumocytes were isolated by either Percoll density gradient centrifugation or by immunoglobulin G (IgG) panning from the lungs of normal rats and the right lung of rats subjected to left pneumonectomy. Cells were studied at 7- (pnx-7) and 15- (pnx-15) days postoperative, times during and after, respectively, rapid compensatory growth of the right lung. Acridine orange staining permitted resolution of type II cells from contaminants on the basis of high red fluorescence (greater than 590 nm). Simultaneous measurement of forward-angle light scatter (FALS) suggested a shift of pnx-7 cells toward greater size, which was reversed in pnx-15 cells. By Percoll gradient isolation, approximately 15% of pnx-7 cells analyzed were above the mean FALS of control cells. In contrast, approximately 30% of the pnx-7 cells isolated by IgG panning were above the mean FALS of corresponding control cells. Biochemical analyses of pnx-7 cells separated by cell sorting into "high FALS" and "low FALS" subgroups revealed that high FALS type II cells contained 50% more protein (P less than 0.05) and 140% more RNA (P less than 0.01) than low FALS cells, with no significant change in cellular DNA content. These data are consistent with previous studies of type II cells isolated from the lungs of pneumonectomized animals and confirm the presence of hypertrophic cells in these preparations. They provide a foundation from which to design further flow cytometric studies of the role of hypertrophic type II pneumocytes in compensatory lung growth.

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