scholarly journals CHARACTERISTICS OF WHITE MATTER HYPOINTENSITY IN NORMAL COGNITIVE VIETNAMESE ADULTS USING MRI

2021 ◽  
Vol 506 (1-2) ◽  
Author(s):  
Tong Quoc Dong ◽  
Vu Khac Quy ◽  
Le Gia Vinh ◽  
Tran Hai Anh ◽  
Nguyen Le Chien
Keyword(s):  
Growth Rate ◽  
Cognitive Impairment ◽  
White Matter ◽  
Magnetic Resonance ◽  
Middle Age ◽  
Magnetic Resonance Images ◽  
Regression Analyses ◽  
Volume Characteristics ◽  
Parkinson Diseases ◽  
Cerebral Degeneration

Objectives: access the white-matter hypointensity (WMHypo) volume characteristics in relationships with age. Methods: Analysing for volumes of cerebral WMHypo volumes from cranial magnetic resonance images taken from 455 normal cognitive Vietnamese subjects (males 47,03%), and ranging in age from 17 to 87 years. Results: The volumes of WMHypo were increasing with age in both male (p< 0,001) and female (p < 0,001). And regression analyses indicated that WMHypo volume increasing in cubic manners that relatively stable with age under 40-50 y.o then sharply increase from 60s. Conclusion: White matter hypointensity had appeared since youth and boosted from middle age, since any cognitive impairment could be detected as in elders, and and its growth rate coexists with atrophy in the cerebral degeneration process such as Alzheimer and Parkinson diseases.

scholarly journals Altered Homotopic Functional Connectivity Within White Matter in the Early Stages of Alzheimer’s Disease

2021 ◽  
Vol 15 ◽  
Author(s):  
Pan Wang ◽  
Zedong Wang ◽  
Jianlin Wang ◽  
Yuan Jiang ◽  
Hong Zhang ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
White Matter ◽  
Magnetic Resonance ◽  
Functional Connectivity ◽  
Parietal Lobe ◽  
Neurodegenerative Disorder ◽  
Magnetic Resonance Images ◽  
Support Vector

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder with memory loss and cognitive impairment. The white matter (WM) BOLD signal has recently been shown to provide an important role in understanding the intrinsic cerebral activity. Although the altered homotopic functional connectivity within gray matter (GM-HFC) has been examined in AD, the abnormal HFC to WM remains unknown. The present study sought to identify changes in the WM-HFC and anatomic characteristics by combining functional magnetic resonance imaging with diffusion tensor imaging (DTI). Resting-state and DTI magnetic resonance images were collected from the OASIS-3 dataset and consisted of 53 mild cognitive impairment (MCI) patients, 90 very MCI (VMCI), and 100 normal cognitive (NC) subjects. Voxel-mirrored HFC was adopted to examine whether WM-HFC was disrupted in VMCI and MCI participants. Moreover, the DTI technique was used to investigate whether specific alterations of WM-HFC were associated with anatomic characteristics. Support vector machine analyses were used to identify the MCI and VMCI participants using the abnormal WM-HFC as the features. Compared with NC, MCI, and VMCI participants showed significantly decreased GM-HFC in the middle occipital gyrus and inferior parietal gyrus and decreased WM-HFC in the bilateral middle occipital and parietal lobe-WM. In addition, specific WM-functional network alteration for the bilateral sub-lobar-WM was found in MCI subjects. MCI subjects showed abnormal anatomic characteristics for bilateral sub-lobar and parietal lobe-WM. Results of GM-HFC mainly showed common neuroimaging features for VMCI and MCI subjects, whereas analysis of WM-HFC showed specific clinical neuromarkers and effectively compensated for the lack of GM-HFC to distinguish NC, VMCI, and MCI subjects.

The use of combined T2-weighted and FLAIR synthetic magnetic resonance images to improve white matter region contrast: a feasibility study

2019 ◽  
Vol 12 (1) ◽  
pp. 118-125 ◽  
Author(s):  
Yasuhiro Fujiwara ◽  
Yumi Inoue ◽  
Masayuki Kanamoto ◽  
Shota Ishida ◽  
Toshiki Adachi ◽  
...  
Keyword(s):  
White Matter ◽  
Magnetic Resonance ◽  
Feasibility Study ◽  
Magnetic Resonance Images ◽  
White Matter Region ◽  
Region Contrast

scholarly journals Incidental White Matter Lesions Identified on Magnetic Resonance Images of Normal Japanese Individuals

1994 ◽  
Vol 34 (5) ◽  
pp. 286-290 ◽  
Author(s):  
Hirofumi OYAMA ◽  
Yoshihisa KIDA ◽  
Takayuki TANAKA ◽  
Takanori IWAKOSHI ◽  
Masahiro NIWA ◽  
...  
Keyword(s):  
White Matter ◽  
Magnetic Resonance ◽  
White Matter Lesions ◽  
Magnetic Resonance Images ◽  
Normal Japanese

scholarly journals Cerebral White Matter Hyperintensities in T2 Weighted Magnetic Resonance Images of Elderly Patients- Correlation with their Mental Status

2021 ◽  
Vol 4 (1) ◽  
pp. 26-31
Author(s):  
Niraj Regmi ◽  
Abu Saleh Mohiuddin ◽  
Abu Taher ◽  
Mahfuz Ara Ferdousi
Keyword(s):  
White Matter ◽  
Magnetic Resonance ◽  
Elderly Patients ◽  
Mental Status ◽  
Negative Correlation ◽  
White Matter Hyperintensities ◽  
Mmse Score ◽  
Significant Negative Correlation ◽  
Magnetic Resonance Images ◽  
Elderly Subjects

Background: White matter hyperintensities (WMH), focal and/or diffuse areas of hyperintense signals on T2 weighted magnetic resonance imaging (MRI), are the most common incidental finding in elderly patients. However, their clinical significance is usually overlooked. We aimed to find out the correlation between the degree of cerebral WMH in MRI with the mental status of elderly patients, assessed by Mini-Mental Status Examination (MMSE) score. Methods: This cross-sectional study was conducted for two years on eighty eligible elderly patients (> 60 years) referred to the Department of Radiology and Imaging for MRI of the brain. Demographic variables like age and sex, MMSE score, and MRI variables like location and number of WMHs were studied. The Pearson’s correlation coefficient was used to calculate the correlation between the extent of periventricular WMHs and MMSE score. Results: A significant negative correlation (r = -0.78; p < 0.001) was found between decreased MMSE and the extent of periventricular WMH. A significant negative correlation was also found when periventricular hyperintensities were evaluated individually for frontal caps (r = -0.68; p < 0.0001), band opacities (r = -0.55; p<0.0001) and occipital cap (r = -0.59; p < 0.0001). However, subcortical WMH was not significantly corelated with MMSE score (r = +0.018, p = 0.0897). Conclusion: A significant negative correlation exists between the extent of periventricular WMH seen at brain MRI with cognitive decline in elderly subjects. However, no such correlation exists between subcortical WMH and mental status.

Abstract P349: Neuroprotective Effects of L-Carnitine on Vascular Dementia in Hemodialysis Patients

Stroke ◽  
2021 ◽  
Vol 52 (Suppl_1) ◽  
Author(s):  
Yuji Ueno ◽  
Takao Urabe ◽  
Nobutaka Hattori
Keyword(s):  
Magnetic Resonance Imaging ◽  
Cognitive Impairment ◽  
White Matter ◽  
Magnetic Resonance ◽  
Diffusion Magnetic Resonance Imaging ◽  
Hemodialysis Patients ◽  
Resonance Imaging ◽  
Short Term ◽  
Microstructural Damage

Background and purpose: L-carnitine alleviated oxidative stress and white matter lesions in an experimental study. Cognitive decline is not uncommon in hemodialysis patients, the pathogenesis of which has not been elucidated. Methods: Using novel diffusion magnetic resonance imaging techniques, white matter microstructural changes and cognitive decline in hemodialysis patients, and the effects of l-carnitine on such disorders were investigated. Fourteen hemodialysis patients underwent diffusion tensor imaging, diffusion kurtosis imaging, neurite orientation dispersion and density imaging, and laboratory and neuropsychological tests, which were compared between two groups based on the duration of l-carnitine treatment: (1) no or short-term l-carnitine treatment; and (2) long-term l-carnitine treatment. Ten age and sex-matched controls were enrolled. Results: On neuropsychological testing, the majority of hemodialysis patients were categorized as having mild cognitive impairment. Seven patients were classified into the no or short-term l-carnitine treatment and long-term l-carnitine treatment groups. Compared to controls, microstructural disorders of white matter were widely detected in no or short-term l-carnitine treatment on diffusion magnetic resonance imaging. An autopsy study from the no or short-term l-carnitine treatment group showed rarefaction of myelinated fibers in white matter. In long-term l-carnitine treatment, microstructural damage on diffusion magnetic resonance imaging was alleviated along with lower levels of high-sensitivity C-reactive protein ( P <0.001) and substantial increases of carnitine levels ( P <0.001). The long-term l-carnitine treatment group showed better achievement in Trail Making Test-A ( P =0.017), which was correlated with amelioration of disorders in bilateral anterior thalamic radiations, the left cingulum in the cingulate gyrus, the right superior longitudinal fasciculus, and the forceps major ( P <0.05). Conclusion: Novel diffusion magnetic resonance imaging tractography detected abnormalities of white matter tracts in hemodialysis patients. Long-term treatment with l-carnitine alleviated white matter microstructural damage and cognitive impairment.

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