scholarly journals Outcome of stroke patients on clopidogrel plus proton-pump inhibitors: a single-center cohort study

2019 ◽  
Vol 39 (2) ◽  
pp. 82-86
Author(s):  
Rahaf A. Alghamdi ◽  
Sina Marzoughi ◽  
Muath S. Alghamdi ◽  
Aisha Alghamdi ◽  
Mohammed Almekhlafi
Keyword(s):  
Cohort Study ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Single Center ◽  
Stroke Patients

scholarly journals The costly case of proton-pump inhibitors: a single-center experience

2020 ◽  
Vol 13 ◽  
pp. 263177452091936
Author(s):  
Vishnu Charan Suresh Kumar ◽  
Venkata Suresh Patthipatti ◽  
Kishore Kumar Mani ◽  
Abbinaya Elangovan ◽  
Lawrence Goldstein
Keyword(s):  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Single Center ◽  
Single Center Experience

Observational cohort study: safety outcomes in children using proton pump inhibitors or histamine-2 receptor antagonists

2017 ◽  
Vol 34 (4) ◽  
pp. 577-583 ◽  
Author(s):  
Eline Houben ◽  
Saga Johansson ◽  
Péter Nagy ◽  
Fernie J. A. Penning-van Beest ◽  
Ernst J. Kuipers ◽  
...  
Keyword(s):  
Cohort Study ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Observational Cohort Study ◽  
Receptor Antagonists ◽  
Safety Outcomes ◽  
Observational Cohort

Characteristics of children and adolescents first prescribed proton pump inhibitors or histamine-2-receptor antagonists: an observational cohort study

2017 ◽  
Vol 33 (12) ◽  
pp. 2251-2259
Author(s):  
Ana Ruigómez ◽  
Leanne M. A. Kool-Houweling ◽  
Luis A. García Rodríguez ◽  
Fernie J. A. Penning-van Beest ◽  
Ron M. C. Herings
Keyword(s):  
Cohort Study ◽  
Children And Adolescents ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Observational Cohort Study ◽  
Receptor Antagonists ◽  
Observational Cohort

Implementation of Global Strategies to Prevent Hospital-Onset Clostridium difficile Infection: Targeting Proton Pump Inhibitors and Probiotics

2017 ◽  
Vol 51 (10) ◽  
pp. 848-854 ◽  
Author(s):  
Paul O. Lewis ◽  
Timothy S. Lundberg ◽  
Jennifer L. Tharp ◽  
Clay W. Runnels
Keyword(s):  
Cohort Study ◽  
Clostridium Difficile ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Clostridium Difficile Infection ◽  
Retrospective Cohort ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
Order Sets ◽  
Global Strategies

Background: Proton pump inhibitors (PPIs) have been identified as a significant risk factor for the development of Clostridium difficile infection (CDI). Probiotics given concurrently with antibiotics have been shown to have a moderate impact on preventing CDI. Objective: To evaluate the effectiveness of hospital-wide interventions designed to reduce PPI use and increase probiotics and whether these interventions were associated with a change in the incidence of hospital onset (HO)-CDI. Methods: This retrospective cohort study compared 2 fiscal years: July 2013 to June 2014 (FY14) and July 2014 to June 2015 (FY15). In July of FY15, global educational initiatives were launched targeting PPIs. Additionally, a HO-CDI prevention bundle was added to antibiotic-containing order sets targeting probiotics. Overall PPI use, probiotic use, and incidence of HO-CDI were recorded and compared for each cohort. Charts were also reviewed for patients who developed HO-CDI for the presence and appropriateness of a PPI and presence of probiotics. Results: The interventions resulted in a decrease in PPI use by 14% or 96 doses/1000 patient days (TPD; P = 0.0002) and a reduction in IV PPI use by 31% or 71 doses/TPD ( P = 0.0008). Probiotic use increased by 130% or 126 doses/TPD ( P = 0.0006). The incidence of HO-CDI decreased by 20% or 0.1 cases/TPD ( P = 0.04). Conclusions: A collaborative, multifaceted educational initiative directed at highlighting the risks associated with PPI use was effective in reducing PPI prescribing. The implementation of a probiotic bundle added to antibiotic order sets was effective in increasing probiotic use. These interventions were associated with a decrease in incidence of HO-CDI.

Incidence and predictors of left atrium thrombus in acute ischemic stroke patients without atrial fibrillation: a single center cohort study

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
T Cinar ◽  
M.I Hayiroglu ◽  
V Cicek ◽  
S Asal ◽  
M.M Atmaca ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Cohort Study ◽  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Left Atrium ◽  
Characteristic Curve ◽  
Multivariate Logistic Regression Analysis ◽  
Single Center ◽  
Stroke Patients ◽  
Previous Diagnosis

Abstract Introduction The present study aimed to determine independent predictors of left atrial thrombus (LAT) in acute ischemic stroke patients without atrial fibrillation (AF) using transesophageal echocardiography (TEE). Material and methods In this single center, retrospective cohort study, we enrolled 149 consecutive acute ischemic stroke patients. All of the patients underwent TEE examination to detect LAT within 10 days following admission. Multivariate logistic regression analysis was performed to assess independent predictors of LAT. Results Among all cases, 14 patients (9.3%) had a diagnosis of LAT on TEE examination. In a multivariate analysis; a previous diagnosis of cerebrovascular accident, elevated mean platelet volume (MPV), low left ventricle ejection fraction (EF) and a reduced left atrium appendix (LAA) peak emptying velocity were independent predictors of LAT. The area of MPV under the receiver operating characteristic curve analysis was 0.70 (95% CI: 0.57–0.83; p=0.011). With the optimal cut-off value of 9.45, MPV had a sensitivity of 71.4% and a specificity of 63% to predict LAT. Conclusion Patients with low ventricle EF and elevated MPV should undergo further TEE examination for the possibility of cardio-embolic source. In addition, this research may provide novel information with respect to the applicability of MPV to predict LAT in acute ischemic stroke patients without AF. Figure 1 Funding Acknowledgement Type of funding source: None

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