scholarly journals Surgical management of central giant cell granuloma of mandible and prosthetic rehabilitation in a nine year girl: A case report

2021 ◽  
Vol 2 (3) ◽  
pp. 158-165
Author(s):  
Mallayya C. Hiremath ◽  
SK Srinath ◽  
Nihal R Kothari
Keyword(s):  
Giant Cell ◽  
Osteolytic Lesion ◽  
Giant Cells ◽  
Cortical Plate ◽  
Giant Cell Granuloma ◽  
Partial Denture ◽  
Central Giant Cell Granuloma ◽  
One Year ◽  
And Function

Central giant cell granuloma (CGCG) is an uncommon, benign, idiopathic, osteolytic lesion of jaws, histologically characterized by multinucleated giant cells distributed in fibrovascular connective tissue stroma. Accurate diagnosis of the lesion is essential for the successful management and the prognosis of this locally destructive lesion. In this paper, a rare case of large destructive CGCG involving anterior region of mandible, causing expansion of labial cortical plate and mobility of teeth in a nine-year girl is presented. It was treated successfully by enucleation and curettage with satisfactory preservation of the continuity of mandible. Nine months post operatively, the child was rehabilitated with a temporary partial denture to improve esthetics, phonetics and function. One year clinical and radiographic follow up showed new bone formation and no evidence of recurrence.

Management of recurrent central giant cell granuloma of mandible using intralesional corticosteroid with long-term follow-up

2020 ◽  
Vol 13 (9) ◽  
pp. e237200
Author(s):  
Kumar Nilesh ◽  
Anuj Dadhich ◽  
Rahul Patil
Keyword(s):  
Giant Cell ◽  
Osteolytic Lesion ◽  
Giant Cell Granuloma ◽  
Central Giant Cell Granuloma ◽  
Intralesional Corticosteroid ◽  
Ablative Surgery ◽  
Long Term Follow Up ◽  
Intralesional Injections

Central giant cell granuloma (CGCG) is an expansile osteolytic lesion of the jawbone. Conventional treatment of CGCG is surgical and vary from simple curettage to more aggressive resection of the jaw. However, surgical management is associated with drawbacks including requirement of hospitalisation and general anaesthesia, damage to vital anatomic structures and continuity defect of the mandible requiring reconstruction surgery. Use of intralesional injections of corticosteroid for the management of CGCG have been inconsistently used as an alternative non-surgical method of management of CGCG with varying success. While the use of such conservative modality over ablative surgery can significantly reduce postoperative morbidity, follow-up of such cases for a long period is important to study the possible recurrence. This paper reports successful treatment of a recurrent CGCG of posterior mandible by intralesional administration of triamcinolone acetonide in a 27-year old female patient, with long-term follow-up of 10 years.

scholarly journals Central giant-cell granuloma located in the mandibular symphyseal region of a child

2018 ◽  
Vol 24 (2) ◽  
pp. 53-56
Author(s):  
Aurélien Bonolis ◽  
Edouard Euvrard ◽  
Christophe Meyer ◽  
Aurélien Louvrier
Keyword(s):  
Giant Cell ◽  
Postoperative Period ◽  
Clinical Presentation ◽  
Osteolytic Lesion ◽  
Giant Cell Granuloma ◽  
Central Giant Cell Granuloma ◽  
Mandibular Tumor ◽  
Dental Lesions ◽  
Delay In Treatment

Introduction: Central giant-cell granuloma (CGCG) is a rare mandibular tumor. The originality of this case lies in its clinical presentation, with a delay in treatment despite a significant aesthetic impact. Observation: An 8-year-old boy whose chin had been swelling for three (3) months was referred to have a consultation. The medical imaging examination revealed a well-defined osteolytic lesion of about 3 cm and round in shape. The lesion was surgically treated by enucleation. The anatomopathological examination provided evidence of a CGCG. Conclusion: Postoperative period was aesthetically acceptable, there were no nervous or dental lesions and no relapse at the 6-month follow-up.

Cellular cannibalism in giant cells of central giant cell granuloma of jaw bones and giant cell tumors of long bones

2016 ◽  
Vol 8 (2) ◽  
pp. e12214 ◽  
Author(s):  
Gargi S. Sarode ◽  
Sachin C. Sarode ◽  
Shailesh Gawande ◽  
Snehal Patil ◽  
Rahul Anand ◽  
...  
Keyword(s):  
Giant Cell ◽  
Giant Cells ◽  
Long Bones ◽  
Giant Cell Granuloma ◽  
Giant Cell Tumors ◽  
Central Giant Cell Granuloma ◽  
Jaw Bones

scholarly journals Central Giant Cell Granuloma of Posterior Maxilla: First Expression of Primary Hyperparathyroidism

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Deepanshu Gulati ◽  
Vishal Bansal ◽  
Prajesh Dubey ◽  
Sanjay Pandey ◽  
Abhinav Agrawal
Keyword(s):  
Primary Hyperparathyroidism ◽  
Giant Cell ◽  
Elevated Serum ◽  
Cortical Plate ◽  
Radiographic Examination ◽  
Surgical Removal ◽  
Giant Cell Granuloma ◽  
Central Giant Cell Granuloma ◽  
Posterior Maxilla ◽  
Patient Reported

A case of 19-year-old male patient reported with the chief complaint of slowly growing diffuse painless swelling over the right part of the face from last 6 months. Intraoral examination revealed a swelling on right side of palate in relation to molar region with buccal cortical plate expansion. Radiographic examination (orthopantograph and 3DCT) showed large multilocular radiolucency in right maxilla with generalized loss of lamina dura. Incisional biopsy was done and specimen was sent for histopathological examination which showed multinucleated giant cells containing 15–30 nuclei. Based on clinical, radiological, and histopathological findings provisional diagnosis of central giant cell granuloma was made. Blood tests after histopathology demonstrated elevated serum calcium level and alkaline phosphatase level. Immunoassay of parathyroid hormone (PTH) level was found to be highly elevated. Radiographic examination of long bones like humerus and femur, mandible, and skull was also done which showed osteoclastic lesions. Considering the clinical, radiographic, histopathological, and blood investigation findings, final diagnosis of brown tumour of maxilla was made. The patient underwent partial parathyroidectomy under general anaesthesia to control primary hyperparathyroidism. Surgical removal of the bony lesion was done by curettage. The patient has been followed up for 1 year with no postoperative complications and the lesion healed uneventfully.

scholarly journals Central giant cell granuloma of the maxilla: a case re-port

2017 ◽  
Vol 5 (2) ◽  
pp. 145
Author(s):  
Najwa Alchalabi ◽  
Hayder Salih ◽  
Ahmed Merza
Keyword(s):  
Giant Cell ◽  
Unusual Case ◽  
Clinical Presentation ◽  
Benign Lesion ◽  
Giant Cell Granuloma ◽  
Case Presentation ◽  
Central Giant Cell Granuloma ◽  
First Choice ◽  
Bone Cortex

Introduction: Central giant-cell is a benign lesion that predominantly involves the bone of the mandible and maxilla with a wide variation of its behavior. Surgery usually is the first choice in treatment of central giant cell granuloma.Case Report: In this case report we present a 29 years-old female with well define swelling on left maxilla. Diagnosis through incisional biopsy showed a central giant cell granuloma. Surgery with curettage was our treatment option with a follow up( 2 years ), No recurrence was reported.Discussion: Information on the maxillary central giant cell granuloma in published studies is insufficient. So here we present our case as unusual case presentation. Differential diagnosis of this case included osteosarcoma (parosteal type) since the tumor clinical presentation in periosteous tissue adjacent to the bone cortex and showed rapid growth. We chose the conventional surgical treatment by simple surgical curettage by mid-face degloving approach to avoid any facial scaring.

scholarly journals A rare coexistence of central giant cell granuloma and parathyroid adenoma: Case report

2021 ◽  
Vol 6 (2) ◽  
pp. 155-158
Author(s):  
Rohini Sebastian ◽  
Meethu Rappai
Keyword(s):  
Case Report ◽  
Connective Tissue ◽  
Parathyroid Adenoma ◽  
Giant Cell ◽  
Stromal Cells ◽  
Giant Cells ◽  
Giant Cell Granuloma ◽  
Multinucleated Giant Cells ◽  
Central Giant Cell Granuloma ◽  
Bony Lesion

Central giant cell granuloma is a reparative bony lesion characterised by abundant multinucleated giant cells within a sea of spindle shaped mesenchymal stromal cells. Giant cells are scattered throughout the fibrovascular connective tissue stroma containing hemorrhage. Its coexistence with parathyroid adenoma is very rare. Brown tumour is a close differential in this scenario. Herein we present the case of a central giant cell granuloma of maxilla and parathyroid adenoma diagnosed almost during the same time in a 58 years old male.

scholarly journals A UNIQUE CASE REPORT OF AGGRESSIVE CENTRAL GIANT CELL GRANULOMA OF THE MANDIBLE TREATED WITH CONSERVATIVE SURGICAL ENUCLEATION WITH LONG TERM FOLLOW-UP

2019 ◽  
Author(s):  
Gourab Das ◽  
Bharat Shukla ◽  
Dhritiman Pathak ◽  
Abhishek Singh ◽  
Shailesh Kumar
Keyword(s):  
Giant Cell ◽  
Giant Cells ◽  
Giant Cell Granuloma ◽  
Central Giant Cell Granuloma ◽  
Woven Bone ◽  
Long Term Follow Up ◽  
Benign Tumours ◽  
Bone Trabeculae ◽  
Surgical Aspects

Central Giant Cell Granuloma (CGCG) is an intrabony lesion showing cellular fibrosis with numerous foci of haemorrhage, woven bone trabeculae and multinucleated giant cells. It is more commonly found in the mandible than maxilla. Among all benign tumours of jaw, it accounts for less than 7%. According to the reports, in approximately 48% cases, it is diagnosed in the first two decades of life and in almost 60% cases, before 30 years of age. This paper presents a case of CGCG involving the mandibular left anterior region of a female patient with clinical, radiological, histopathological and surgical aspects of the lesion. Key Words- Central Giant Cell Granuloma (CGCG), CONSERVATIVE SURGICAL ENUCLEATION

scholarly journals Central Giant Cell Granuloma

2019 ◽  
Vol 2 (1) ◽  
pp. 01-04
Author(s):  
Nilotpol Kashyap ◽  
Manisha Upadhyay ◽  
Rupam Tripathi ◽  
Pallavi Pawar ◽  
Ranjeet Kumar Prasad Sah ◽  
...  
Keyword(s):  
Giant Cell ◽  
Fibrous Tissue ◽  
Giant Cells ◽  
World Health ◽  
Giant Cell Granuloma ◽  
Central Giant Cell Granuloma ◽  
Bony Lesion ◽  
Benign Tumours ◽  
Health Organization ◽  
Intraosseous Lesion

Central giant cell granuloma (central giant cell granuloma) is an uncommon benign bony lesion that occurs in the mandible and maxilla and accounts for approximately 7% of all benign tumours of the jaws [1]. The World Health Organization (WHO) has defined central giant cell granuloma as an intraosseous lesion consisting of cellular fibrous tissue that contains multiple foci of haemorrhage, aggregations of multinucleated giant cells and occasional trabeculae of woven bone [2]. Central giant cell granuloma occurs predominantly in children or young adults, with approximately 75%of cases presenting before 30 years of age although presentation can occur at any age [3]. Females are affected more frequently than males, with a ratio of 2:1

Central Giant Cell Granuloma: A Narrative Review of Radiological Features and Differential Diagnosis

2020 ◽  
Vol 3 (2) ◽  
pp. 01-05
Author(s):  
Cinzia Casu
Keyword(s):  
Giant Cell ◽  
Fibrous Tissue ◽  
Giant Cells ◽  
Giant Cell Granuloma ◽  
Genetic Syndromes ◽  
Radiographic Appearance ◽  
Central Giant Cell Granuloma ◽  
Jaw Bones ◽  
Aneurysmal Bone Cysts ◽  
Intraosseous Lesion

The Central Giant Cell Granuloma is an uncommon lesion, accounting less than 7% of all benign jaw lesions. In 1953, Jaffe was the first to describe these lesions as a giant cell reparative granuloma of the jaw bones, and in 1971, thanks to Pindborg and Kramer, it was included in the current nomenclature. The aetiology of CGCG is unknown, there is also a peripheral type that some authors consider the most common in maxillary bones. WHO defines CGCG as an intraosseous lesion consisting of cellular fibrous tissue that contains multiple foci of hemorrhage, aggregations of multinucleated giant cells, and some trabeculae of woven bone. The radiographic appearance of CGCGs is not pathognomonic. CGCGs should be differentiated from other lesions of the jaws such as Brown’s tumour of hyperparathyroidism, fibrous dysplasia, aneurysmal bone cysts, giant cell tumours, fibro-osseous lesions, and other malignancies that arise in the jaw bones. Furthermore, it needs to be differentiated even from some genetic syndromes, such as Cherubism, type 1-neurofibromatosis and Noonan’s syndrome. The aim of this study is to focus on radiographic features of CGCG in order to achieve an appropriate tool for diagnosis.

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