Unstructured Group Support Enhances Compliance to Pharmacological Treatment by Improving Social Cognition in Patients with Bipolar Disorder: A Pilot fMRI Study

Background: Mood disorders are often associated with persistent cognitive impairments. However, pro-cognitive treatments are essentially lacking. This is partially because of poor insight into the neurocircuitry abnormalities underlying these deficits and their change with illness progression. Aims: This functional magnetic resonance imaging (fMRI) study investigates the neuronal underpinnings of cognitive impairments and neuronal change after mood episodes in remitted patients with bipolar disorder (BD) using a hippocampus-based picture encoding paradigm. Methods: Remitted patients with BD ( n=153) and healthy controls ( n=52) were assessed with neuropsychological tests and underwent fMRI while performing a strategic picture encoding task. A subgroup of patients ( n=43) were rescanned after 16 months. We conducted data-driven hierarchical cluster analysis of patients’ neuropsychological data and compared encoding-related neuronal activity between the resulting neurocognitive subgroups. For patients with follow-up data, effects of mood episodes were assessed by comparing encoding-related neuronal activity change in BD patients with and without episode(s). Results: Two neurocognitive subgroups were revealed: 91 patients displayed cognitive impairments while 62 patients were cognitively normal. No neuronal activity differences were observed between neurocognitive subgroups within the dorsal cognitive control network or hippocampus. However, exploratory whole-brain analysis revealed lower activity within a small region of middle temporal gyrus in impaired patients, which significantly correlated with poorer neuropsychological performance. No changes were observed in encoding-related neuronal activity or picture recall accuracy with the occurrence of mood episode(s) during the follow-up period. Conclusion: Memory encoding fMRI paradigms may not capture the neuronal underpinnings of cognitive impairment or effects of mood episodes.

Download Full-text

Cannabis Use in Affectively Stable Patients With Bipolar Disorder: Effects on Social Cognition, Emotional Processing, and Social Function

Biological Psychiatry ◽

10.1016/j.biopsych.2021.02.151 ◽

2021 ◽

Vol 89 (9) ◽

pp. S54

Author(s):

Katherine Burdick ◽

Caitlin Millett

Keyword(s):

Bipolar Disorder ◽

Social Cognition ◽

Emotional Processing ◽

Social Function ◽

Cannabis Use ◽

Disorder Effects

Download Full-text

Abnormal transitions of dynamic functional connectivity states in bipolar disorder: A whole-brain resting-state fMRI study

Journal of Affective Disorders ◽

10.1016/j.jad.2021.04.005 ◽

2021 ◽

Author(s):

Mengjiao Du ◽

Li Zhang ◽

Linling Li ◽

Erni Ji ◽

Xue Han ◽

...

Keyword(s):

Bipolar Disorder ◽

Functional Connectivity ◽

Resting State ◽

Resting State Fmri ◽

Dynamic Functional Connectivity ◽

Whole Brain ◽

Fmri Study

Download Full-text

The hippocampus and encoding of neutral and aversive stimuli in patients with bipolar disorder: an fMRI study

NeuroImage ◽

10.1016/s1053-8119(09)70436-7 ◽

2009 ◽

Vol 47 ◽

pp. S72

Author(s):

MK Otnæss ◽

J Jensen ◽

Ø Gadmar ◽

A Server ◽

PH Nakstad ◽

...

Keyword(s):

Bipolar Disorder ◽

Aversive Stimuli ◽

Fmri Study

Download Full-text

Brain structural correlates of executive and social cognition profiles in behavioral variant frontotemporal dementia and elderly bipolar disorder

Neuropsychologia ◽

10.1016/j.neuropsychologia.2017.02.012 ◽

2019 ◽

Vol 126 ◽

pp. 159-169 ◽

Cited By ~ 22

Author(s):

Sandra Baez ◽

Clara Pinasco ◽

María Roca ◽

Jesica Ferrari ◽

Blas Couto ◽

...

Keyword(s):

Bipolar Disorder ◽

Social Cognition ◽

Frontotemporal Dementia ◽

Behavioral Variant Frontotemporal Dementia

Download Full-text

Social Cognition, Language, and Social Behavior in 7-Year-Old Children at Familial High-Risk of Developing Schizophrenia or Bipolar Disorder: The Danish High Risk and Resilience Study VIA 7—A Population-Based Cohort Study

Schizophrenia Bulletin ◽

10.1093/schbul/sbz001 ◽

2019 ◽

Vol 45 (6) ◽

pp. 1218-1230 ◽

Cited By ~ 4

Author(s):

Camilla Jerlang Christiani ◽

Jens R M Jepsen ◽

Anne Thorup ◽

Nicoline Hemager ◽

Ditte Ellersgaard ◽

...

Keyword(s):

Bipolar Disorder ◽

Social Cognition ◽

Social Behavior ◽

High Risk ◽

Social Functioning ◽

Population Based ◽

Social Responsiveness ◽

Developmental Phase ◽

Bonferroni Correction ◽

Familial High Risk

Abstract Objective To characterize social cognition, language, and social behavior as potentially shared vulnerability markers in children at familial high-risk of schizophrenia (FHR-SZ) and bipolar disorder (FHR-BP). Methods The Danish High-Risk and Resilience Study VIA7 is a multisite population-based cohort of 522 7-year-old children extracted from the Danish registries. The population-based controls were matched to the FHR-SZ children on age, sex, and municipality. The FHR-BP group followed same inclusion criteria. Data were collected blinded to familial high-risk status. Outcomes were social cognition, language, and social behavior. Results The analysis included 202 FHR-SZ children (girls: 46%), 120 FHR-BP children (girls: 46.7%), and 200 controls (girls: 46.5%). FHR-SZ children displayed significant deficits in language (receptive: d = −0.27, P = .006; pragmatic: d = −0.51, P < .001), social responsiveness (d = −0.54, P < .001), and adaptive social functioning (d = −0.47, P < .001) compared to controls after Bonferroni correction. Compared to FHR-BP children, FHR-SZ children performed significantly poorer on adaptive social functioning (d = −0.29, P = .007) after Bonferroni correction. FHR-BP and FHR-SZ children showed no significant social cognitive impairments compared to controls after Bonferroni correction. Conclusion Language, social responsiveness, and adaptive social functioning deficits seem associated with FHR-SZ but not FHR-BP in this developmental phase. The pattern of results suggests adaptive social functioning impairments may not be shared between FHR-BP and FHR-SZ in this developmental phase and thus not reflective of the shared risk factors for schizophrenia and bipolar disorder.

Download Full-text