The Relationship of Clinicopathological Findings and PDGFR-β Expression With Tumor Recurrence in Gastrointestinal Stromal Tumors

GROβ(CXCL2) is a chemokine produced by endotoxin-treated macrophages that mediates inflammation and tumor development. However, little is known about GROβexpression in gastrointestinal stromal tumors (GIST) or the relationship between GROβexpression and clinical attributes of GIST. GROβexpression was examined via immunohistochemical staining of 173 GIST samples using tissue microarray. The relationship between GROβexpression and relevant patient and tumor characteristics was assessed, using chi-square tests. Univariate and multivariate analysis was carried out using the Cox regression method. High GROβcytoplasm staining was detected in 56 (32.4%) specimens; high GROβnuclear staining was detected in 64 (37.0%) specimens. High GROβcytoplasm staining was significantly associated with patients’ age (P=0.043) and tumor location (P=0.014), while high GROβnucleus staining was significantly associated with mitotic index (P=0.034), tumor location (P=0.049), and AFIP-Miettinen risk classification (P=0.048). Kaplan-Meier survival curves showed GIST patients with low GROβcytoplasm expression (P=0.023) and mitotic index < 6 per 50 HPFs (P=0.026) to have a more favorable prognosis. These findings indicate that GROβexpression correlates with malignant GIST phenotypes and could be an unfavorable prognostic marker in patients with GIST.

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Synchronous Occurrence of Ileal Stromal Tumor (GIST) and Colonic Adenocarcinoma: A Case Report/ Синхроно Јавување На Илеален Стромален Тумор (Гист) И Аденокарцином На Колон – Приказ На Случај

PRILOZI ◽

10.1515/prilozi-2015-0049 ◽

2015 ◽

Vol 36 (1) ◽

pp. 219-223

Author(s):

Elizabeta Trajkovska ◽

Vesna Janevska ◽

Liljana Spasevska ◽

Vlado Janevski ◽

Julija Zhivadinovik ◽

...

Keyword(s):

Case Report ◽

Gastrointestinal Stromal Tumors ◽

Spindle Cell ◽

Tnm Classification ◽

Colonic Adenocarcinoma ◽

Mesenchymal Tumors ◽

Gastrointestinal Malignancies ◽

Stromal Tumors ◽

Low Malignant Potential ◽

The Relationship

Abstract Introduction: Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the digestive tract. There is an increasing number of literature reports on synchronous occurrence of gastrointestinal stromal tumors and another malignancy of distinct etiology and evolution. The most reported cases include gastric synchronous occurrence of gastrointestinal stromal tumors and adenocarcinoma and gastric gastrointestinal stromal tumors and colonic adenocarcinoma. Case report: We present a case of a 77-old female, with synchronous cecal moderately differentiated adenocarcinoma in Stage IIA according to the TNM classification and ileal spindle cell type GIST with low malignant potential, positive for c-Kit, CD34, vimentin, Actin, and negative for S100. Conclusion: The synchronous occurrence of small bowel gastrointestinal stromal tumors and other primary gastrointestinal malignancies has been rarely reported. There is a need of further investigations to identify the relationship between gastrointestinal stromal tumors and colorectal cancers.

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Microscopically Positive Margins for Primary Gastrointestinal Stromal Tumors: Analysis of Risk Factors and Tumor Recurrence

Journal of the American College of Surgeons ◽

10.1016/j.jamcollsurg.2012.05.008 ◽

2012 ◽

Vol 215 (1) ◽

pp. 53-59 ◽

Cited By ~ 71

Author(s):

Martin D. McCarter ◽

Cristina R. Antonescu ◽

Karla V. Ballman ◽

Robert G. Maki ◽

Peter W.T. Pisters ◽

...

Keyword(s):

Risk Factors ◽

Gastrointestinal Stromal Tumors ◽

Tumor Recurrence ◽

Positive Margins ◽

Stromal Tumors

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Protein expression of cancer testis antigens predicts tumor recurrence and treatment response to imatinib in gastrointestinal stromal tumors

International Journal of Cancer ◽

10.1002/ijc.25836 ◽

2011 ◽

Vol 128 (12) ◽

pp. 2947-2952 ◽

Cited By ~ 22

Author(s):

Daniel Perez ◽

Fabian Hauswirth ◽

Dirk Jäger ◽

Urs Metzger ◽

Eleftherios Pierre Samartzis ◽

...

Keyword(s):

Protein Expression ◽

Treatment Response ◽

Gastrointestinal Stromal Tumors ◽

Tumor Recurrence ◽

Stromal Tumors ◽

Cancer Testis Antigens ◽

Cancer Testis

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Prediction of Tumor Recurrence in Patients with Non-Gastric Gastrointestinal Stromal Tumors Following Resection according to the Modified National Institutes of Health Criteria

Intestinal Research ◽

10.5217/ir.2014.12.3.229 ◽

2014 ◽

Vol 12 (3) ◽

pp. 229 ◽

Cited By ~ 3

Author(s):

Seung Hyeon Jang ◽

Ji Eun Kwon ◽

Jee Hyun Kim ◽

June Young Lee ◽

Sang Gyun Kim ◽

...

Keyword(s):

Gastrointestinal Stromal Tumors ◽

Tumor Recurrence ◽

National Institutes Of Health ◽

Stromal Tumors

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Computed tomography imaging characteristics of synchronous gastrointestinal stromal tumors in patients with gastric cancer and correlation with clinicopathological findings

Molecular and Clinical Oncology ◽

10.3892/mco.2015.621 ◽

2015 ◽

Vol 3 (6) ◽

pp. 1311-1314 ◽

Cited By ~ 3

Author(s):

ZHENSHAN SHI ◽

QIAN ZHUANG

Keyword(s):

Gastric Cancer ◽

Computed Tomography ◽

Gastrointestinal Stromal Tumors ◽

Computed Tomography Imaging ◽

Tomography Imaging ◽

Stromal Tumors ◽

Imaging Characteristics ◽

Clinicopathological Findings

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Outcome and prognostic factors of primary gastrointestinal stromal tumours following complete surgical resection

International Surgery Journal ◽

10.18203/2349-2902.isj20194401 ◽

2019 ◽

Vol 6 (10) ◽

pp. 3513

Author(s):

Mohamed Ebrahim El Dahshan ◽

Mohamed Ali Mless ◽

Nehal Mohamed Elmashad ◽

Hossam Ramadan Moussa ◽

Ahmed Atia Darwish

Keyword(s):

Prognostic Factors ◽

Mitotic Index ◽

Survival Data ◽

Gastrointestinal Stromal Tumors ◽

Tumor Recurrence ◽

Surgical Excision ◽

University Hospital ◽

Definitive Treatment ◽

Resection Margins ◽

Stromal Tumors

Background: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms. Surgical excision is the definitive treatment for primary localized GISTs. Targeted therapy represented by tyrosine kinase inhibitors has clearly improved the survival rates in patients with GISTs. The aim of this study was to identify prognostic factors influencing tumor recurrence and survival after curative resection of primary GISTs.Methods: This study was conducted on thirty seven patients with localized primary GIST who were operated on in the Department of General Surgery. Then completed adjuvant therapy in the medical Oncology Department, Faculty of Medicine; Tanta University Hospital, from March 2016 to August 2017. All patients’ data, clinical presentations, radiological and endoscopic data, surgical procedures, complications, and survival data were collected, reviewed and analyzed.Results: The mean age of the studied cases was 53.62 years. 14 patients were males and 23 patients were females. Eleven patients had performance status 2. Abdominal pain was the most common complaint. 4 patients presented with acute intestinal obstruction. Ileum was the most common site (14 cases) followed by stomach (13 cases). We reported four cases of extra-gastrointestinal stromal tumors (EGISTs). According to the mitotic index in studied cases; sixteen patients had mitotic count ˃5/50 HPF. Surgical excision was done in all cases with histopathologically negative resection margins. Thirty three cases showed good complete response without local recurrence or distant metastasis.Conclusions:Performance status of patients, tumor size and mitotic index were independent prognostic predictors for tumor recurrence or metastasis.

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