THE ACTIVITY OF TRANSMEMBRANE OXYGEN TRANSPORT AND PHYSICAL AND CHEMICAL PROPERTIES OF ERYTHROCYTE MEMBRANES IN PATIENTS WITH DIABETIC FOOT
The problem of the pathogenesis of diabetic foot being a complication of diabetes mellitus has been very topical up to now. The supply of oxygen to tissues is one of the key issues of the pathogenesis of diabetic foot. The aim of the work was to study the physical and chemical properties of erythrocyte membranes and activity of oxygen transfer in patients with diabetic foot. It has been found that the activity of oxygen release from erythrocytes is the most significant among the studied parameters in detection of patients with diabetic foot and healthy people. Patients with diabetic foot are divided into two groups in terms of physical and chemical properties of erythrocyte membranes and the activity of oxygen release. The first group of patients with diabetic foot is different from healthy people by the activity of oxygen release and micropolarity, microviscosity of annular lipid pool. The second group of patients with diabetic foot differs from healthy people by micropolarity of annular lipid pool (with 2 concentrations of pyrene), microviscosity of total lipid pool and the activity of oxygen release.