scholarly journals ASSESSMENT OF THE FREQUENCY OF DIFFERENT PATTERNS OF CLINICAL PRESENTATION OF CHILDREN PRESENTING WITH CONGENITAL ADRENAL HYPERPLASIA

2021 ◽  
Vol 31 (04) ◽  
pp. 178-181
Author(s):  
Habib Ullah ◽  
Fayiza Manzoor Ahmad ◽  
Sumaira Hmaid ◽  
Noor ul Ain Mehak ◽  
Assiya Afzal ◽  
...  
Keyword(s):  
Congenital Adrenal Hyperplasia ◽  
Clinical Presentation ◽  
Local Population ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Adrenal Hyperplasia ◽  
Cross Sectional ◽  
Cousin Marriage ◽  
Salt Depletion ◽  
The Mean

Objective: To assess the frequency of different patterns of presentation of children presenting with congenital adrenal hyperplasia. Methodology:It was a cross sectional study conducted at the department of Pediatric, Fatima Memorial Hospital, Lahore, from19-12-2017 to 19-06-2018.92 infants who met the selectin criteria were recruited for the study. Then blood sample was obtained and if serum sodium <135mEq/L, then salt depletion was labeled. Then, infants underwent genital examination for assessment of genital virilization. All data is entered is specially designed Performa and analyzed in SPSS. Results: The mean age of patients was 6.52±3.56months. There were 49 (53.26%) male while 43 (46.74%) female infants. The mean weight of patients was 5.59±1.44kg. There were 21 (22.83%) cases of consanguineous marriage while 71 (77.17%) were other than cousin marriage. There were 63 (68.48%) had salt depletion while in 29 (31.52%) did not had salt depletion. There were 39 (42.39%) had genital virilization while in 53 (57.61%) did not had genital virilization. Conclusion: Thus the frequency of patterns (salt depletion and genital virilization) of Congenital adrenal hyperplasia are high in local population.

A Multicenter Cross-Sectional Study of Malaysian Females With Congenital Adrenal Hyperplasia: Their Body Image and Their Perspectives on Feminizing Surgery

2020 ◽  
Vol 33 (5) ◽  
pp. 477-483
Author(s):  
Ani Amelia Zainuddin ◽  
Sonia Regina Grover ◽  
Chong Hong Soon ◽  
Nur Azurah Abdul Ghani ◽  
Zaleha Abdullah Mahdy ◽  
...  
Keyword(s):  
Body Image ◽  
Congenital Adrenal Hyperplasia ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Adrenal Hyperplasia ◽  
Cross Sectional

Classical congenital adrenal hyperplasia due to 21-hydroxylase deficiency: a cross-sectional study of factors involved in bone mineral density

2003 ◽  
Vol 21 (6) ◽  
pp. 396-401 ◽  
Author(s):  
Patr�cia Oliveira de Almeida Freire ◽  
Sofia Helena Valente de Lemos-Marini ◽  
Andr�a Trevas Maciel-Guerra ◽  
Andr� Moreno Morcillo ◽  
Maria Tereza Matias Baptista ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Congenital Adrenal Hyperplasia ◽  
Bone Mineral ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Adrenal Hyperplasia ◽  
Mineral Density ◽  
Hydroxylase Deficiency ◽  
Cross Sectional ◽  
21 Hydroxylase Deficiency

scholarly journals Influence of hormones on the immunotolerogenic molecule HLA-G: a cross-sectional study in patients with congenital adrenal hyperplasia

2019 ◽  
Vol 181 (5) ◽  
pp. 481-488 ◽  
Author(s):  
Lee S Nguyen ◽  
Nathalie Rouas-Freiss ◽  
Christian Funck-Brentano ◽  
Monique Leban ◽  
Edgardo D Carosella ◽  
...  
Keyword(s):  
Congenital Adrenal Hyperplasia ◽  
Critical Role ◽  
Renin Angiotensin System ◽  
Cross Sectional Study ◽  
Healthy Controls ◽  
Sectional Study ◽  
Adrenal Hyperplasia ◽  
Cross Sectional ◽  
Adequate Model ◽  
Soluble Hla

Background HLA-G is an immune checkpoint molecule, naturally expressed during pregnancy, playing a critical role in the tolerance of the fetal semi-allograft from the maternal immune system. While HLA-G expression levels are associated with progesterone, the influence of other hormones is still unclear. Congenital adrenal hyperplasia (CAH) represents an adequate model to study the hormonal influence on biomarkers as it leads to impaired cortisol biosynthesis and increased progesterone and androgens production due to 21-hydroxylase enzyme deficiency. Methods In a cross-sectional study of CAH patients matched on sex and age with healthy control, the association between circulating levels of soluble HLA-G and hormones was assessed by use of non-parametric analyses tests. Multivariable linear regressions were performed on normalized data. Results Overall, 83 CAH patients and 69 healthy controls were included. Among CAH patients, all were under glucocorticoid and 52 (62.6%) were under mineralocorticoid supplementation. Compared to controls, CAH patients had increased HLA-G levels (15 vs 8 ng/mL, P = 0.02). In controls, HLA-G level was independently associated with progesterone and estradiol (β = 0.44 (0.35–1.27) and −0.44 (−0.94, −0.26) respectively, both P values = 0.001). In CAH patients, HLA-G level was independently associated with mineralocorticoid supplementation dosage (β = 0.25 (0.04–0.41), P = 0.001) and estradiol (β = −0.22 (−0.57, −0.02), P < 0.001). Conclusion CAH patients had higher HLA-G levels than healthy controls. HLA-G level was positively associated with progesterone and corticosteroid supplementation, and negatively with estradiol. The association between mineralocorticoid, renin and HLA-G levels may suggest a role of the renin-angiotensin system in the expression of soluble HLA-G.

Severity of Virilization Is Associated with Cosmetic Appearance and Sexual Function in Women with Congenital Adrenal Hyperplasia: A Cross‐Sectional Study

2013 ◽  
Vol 10 (3) ◽  
pp. 866-875 ◽  
Author(s):  
Yvonne G. van der Zwan ◽  
Eefje H.C.C. Janssen ◽  
Nina Callens ◽  
Katja P. Wolffenbuttel ◽  
Peggy T. Cohen‐Kettenis ◽  
...  
Keyword(s):  
Sexual Function ◽  
Congenital Adrenal Hyperplasia ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Adrenal Hyperplasia ◽  
Cross Sectional ◽  
Cosmetic Appearance

scholarly journals ANKLE AND MIDFOOT FRACTURES;

2017 ◽  
Vol 24 (11) ◽  
pp. 1680-1684
Author(s):  
Mohammad Shabir ◽  
Shahid Iqbal ◽  
Muhammad Inam ◽  
Arif Shehzad ◽  
Ihsanullah -
Keyword(s):  
Study Design ◽  
Local Population ◽  
Research Work ◽  
Cross Sectional Study ◽  
Age Group ◽  
Sectional Study ◽  
Cross Sectional ◽  
X Ray ◽  
Foot Fracture ◽  
The Mean

Objectives: To determine the diagnostic accuracy of Ottawa rule in ankle andmidfoot fracture keeping x-ray as gold standard. Study Design: Descriptive study. Setting:Department of Orthopedics, Lady Reading Hospital Peshawar. Period: June 2014 to May 2016.Materials and Methods: Through a Cross Sectional Study Design, a total of 175 patientspresenting with suspicion of ankle/mid foot fracture were selected in a consecutive mannerfrom the OPD and subjected to detection of fracture through Ottawa Ankle Rule followed byX-ray to confirm the diagnosis of fracture. Results: The mean age group of patients in ourstudy was 36.1+10.4 years. There were 85.7% males and 14.3% were females. The sensitivityanalysis shows OAR has a sensitivity of 81.2% and specificity 61.9%., positive predictive valueof the OAR is 79.1% and negative predictive value is 65.0% keeping X-ray as a gold standard.Conclusion: The overall sensitivity and specificity of the OAR lies within an acceptable rangein our local population however, we still recommend further research work over it beforerecommendations as a routine screening test for the fracture of ankle or mid foot.

Comparison of Heffner Criteria and Light Criteria in Differentiating Exudative and Transudative Pleural Effusion

2020 ◽  
Vol 22 (3) ◽  
pp. 141-145
Author(s):  
Krishna Chandra Devkota ◽  
S Hamal ◽  
PP Panta
Keyword(s):  
Pleural Effusion ◽  
Cross Sectional Study ◽  
Pleural Space ◽  
Sectional Study ◽  
Inclusion Criteria ◽  
Cross Sectional ◽  
Medical College ◽  
The Common ◽  
The Mean ◽  
Exudative Pleural Effusion

Pleural effusion is present when there is >15ml of fluid is accumulated in the pleural space. It can be divided into two types; exudative and transudative pleural effusion. Tuberculosis and parapneumonic effusion are the common cause of exudative pleural effusion whereas heart failure accounts for most of the cases of transudative pleural effusion. This study was a hospital based cross sectional study performed at Nepal Medical College during the period of January 2016-December 2016. A total of 50 patients who fulfilled the inclusion criteria were enrolled. Pleural effusion was confirmed by clinical examination and radiology. After confirmation of pleural effusion, pleural fluid was aspirated and was analysed for protein, LDH, cholesterol. The Heffner criteria was compared with Light criteria to classify exudative or transudative pleural effusion. Among 50 patients, 30 were male and 20 were female. The mean age of patient was 45.4±21.85 years. The sensitivity and specificity of using Light criteria to detect the two type of pleural effusion was 100% and 90.9%, whereas using Heffner criteria was 94.87%, 100% respectively(P<0.01). There are variety of causes for development of pleural effusion and no one criteria is definite to differentiate between exudative or transudative effusion. In this study Light criteria was more sensitive whereas Heffner criteria was more specific to classify exudative pleural effusion. Hence a combination of criteria might be useful in case where there is difficulty to identify the cause of pleural effusion.

Effect of Medialization of the Trochlear Groove and Lateralization of the Tibial Tubercle on TT-TG Distance: A Cross-sectional Study of Dysplastic and Nondysplastic Knees

2021 ◽  
pp. 036354652098781
Author(s):  
Mathias Paiva ◽  
Lars Blønd ◽  
Per Hölmich ◽  
Kristoffer Weisskirchner Barfod
Keyword(s):  
Trochlear Dysplasia ◽  
Cross Sectional Study ◽  
Magnetic Resonance Images ◽  
Tibial Tubercle ◽  
Control Group ◽  
Trochlear Groove ◽  
Sectional Study ◽  
Cross Sectional ◽  
Mean Values ◽  
The Mean

Background: Tibial tubercle–trochlear groove (TT-TG) distance is often used as a measure of lateralization of the TT and is important for surgical planning. Purpose: To investigate if increased TT-TG distance measured on axial magnetic resonance images is due to lateralization of the TT or medialization of the TG. Study Design: Cross-sectional study; Level of evidence, 3. Methods: A total of 84 knees (28 normal [NK], 28 with trochlear dysplasia [TD], and 28 with patellar dislocation without TD [PD]) were examined. The medial border of the posterior cruciate ligament (PCL) was chosen as the central anatomic landmark. The distance from the TT to PCL (TT-PCL) was measured to examine the lateralization of the TT. The distance from the TG to the PCL (TG-PCL) was measured to examine the medialization of the TG. Between-group differences were investigated by use of 1-way analysis of variance. Results: The mean values for TT-TG distance were 8.7 ± 3.6 mm for NK, 12.1 ± 6.0 mm for PD, and 16.7 ± 4.3 mm in the TD group ( P < .01). The mean values for TT-PCL distance were 18.5 ± 3.6 mm for NK, 18.5 ± 4.5 mm for PD, and 21.2 ± 4.2 mm in the TD group ( P = .03). The mean values for TG-PCL distance were 9.6 ± 3.0 mm for NK, 7.1 ± 3.4 mm for PD, and 5.1 ± 3.3 mm in the dysplastic group ( P < .01). Conclusion: The present results indicate that increased TT-TG distance is due to medialization of the TG and not lateralization of the TT. Knees with TD had increased TT-TG distance compared with the knees of the control group and the knees with PD. The TT-PCL distance did not differ significantly between groups, whereas the TG-PCL distance declined with increased TT-TG.

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