The investigation of the calcium metabolism changes in rheumatic mitral valve patients

2021 ◽  
Author(s):  
Aziz Inan Celik ◽  
Resit Coskun ◽  
Muhammet Bugra Karaaslan ◽  
Tahir Bezgin ◽  
Suleyman Karakoyun ◽  
...  
Keyword(s):  
Vitamin D ◽  
Mitral Valve ◽  
Clinical Laboratory ◽  
Multivariate Logistic Regression Analysis ◽  
Multivariate Logistic Regression ◽  
Mitral Valve Area ◽  
Vitamin D Levels ◽  
Echocardiographic Parameters ◽  
The Relationship ◽  
Valve Area

Objectives: Rheumatic mitral valve disease (RMVD) is associated with autoimmune heart valve injury. Parathyroid hormone (PTH) and vitamin D are two essential molecules that have effects on the immune system. In this study, we aimed to evaluate the relationship between PTH and vitamin D in patients with RMVD. Patients and Methods: We investigated 81 patients with RMVD and 75 healthy subjects. According to Wilkins score, baseline clinical, laboratory, and echocardiographic parameters were recorded, and all RMVD patients were analyzed. Multivariate logistic regression analysis was performed between the groups. Results: Vitamin D levels were significantly low in the RMVD group. Patients were stratified according to Wilkins score [Wilkins score < 7 (n:50) vs. Wilkins score 7 (n:31)]. Age, BMI, and PTH were significantly higher, and mitral valve area was significantly lower in Wilkins score 7 patients. In multivariate analysis, age (OR: 1.052; 95% CI 1.005-1.100, p=0.028) and PTH (OR: 1.017; 95% CI 1.000-1.033, p=0.047) were found to be independent predictors of high Wilkins score. Conclusion: This study showed that vitamin D levels were low in patients with RMVD. According to the Wilkins score, PTH levels were significantly high in patients with high Wilkins score. The contrary changes in PTH and vitamin D levels may trigger inflammation and be responsible for valve damage.

scholarly journals Hubungan Antara kadar Vitamin D dengan HbA1c pada Pasien Diabetes Mellitus Tipe 2 di Laboratorium Klinik Thamrin Medan Tahun 2019

2020 ◽  
Vol 2 (1) ◽  
pp. 8-12
Author(s):  
Desi Novita ◽  
Meida Nugrahalia ◽  
Ida Fauziah
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Vitamin D ◽  
Type 2 Diabetes Mellitus ◽  
Clinical Laboratory ◽  
Glucose Binding ◽  
Vitamin D Levels ◽  
Sugar Levels ◽  
The Relationship

Vitamin D as an immunomodulator play an important role in controlling glycemic levels and reducing the risk of diabetes. HbA1c as a substance formed from glucose binding with hemoglobin which has a good relationship with average blood sugar levels of fasting, daily and 3 months. This research was conducted to determine the relationship between vitamin D levels and HbA1c in patients with type 2 diabetes mellitus. This research used descriptive methods and the research samples were all patients who suffer from type 2 diabetes mellitus in the clinical laboratory of Thamrin Medan. Data were obtained by checking vitamin D and HbA1c levels in patients blood serum. The number of samples in this research were 47 people. The results of this research indicate that there is a very weak relationship between vitamin D levels and HbA1c, with r = 0,225 and R = 5,1%, therefore, it was clearly presented that effect of vitamin D on HbA1c is 5,1%.

scholarly journals Correlation between Mitral Valve Area and Right Ventricle Function based on TAPSE (Tricuspid Annular Plane Systolic Excursion) Parameter in Mitral Stenosis Patient

2018 ◽  
Vol 4 (2) ◽  
pp. 73
Author(s):  
Hashina Zulfa ◽  
Erika Maharani ◽  
Hasanah Mumpuni
Keyword(s):  
Mitral Valve ◽  
Right Ventricle ◽  
Mitral Stenosis ◽  
Right Ventricle Function ◽  
Mitral Valve Area ◽  
Spearman Correlation Test ◽  
The Mean ◽  
The Relationship ◽  
Ventricle Function ◽  
Valve Area

Background: Mitral stenosis is the most common mitral valve disease found in Indonesia. Mechanical obstruction of blood flow from left atrium to left ventricle is compensated by pressure elevation in the left atrium and pulmonary circulation. It leads to right ventricle dysfunction which can be scored using TAPSE (Tricuspid Annular Plane Systolic Excursion) Parameter.Aim: The goal of this study is to assess the relationship between mitral valve area and right ventricle function based on TAPSE parameter in mitral stenosis patient.Methods: This study was conducted in Dr. Sardjito Hospital from May until July 2017. This was a part of mitral stenosis registry study. The parameter used was planimetry mitral valve area and TAPSE from echocardiography. The relationship between mitral valve area and TAPSE score we reanalyzed using Spearman correlation test in SPSS software.Results: The total sample included in this study was 132 people, consisted of thirty-eight (28.79%) males and ninety-four (71.21%) females. The range of the subjects’age was 18 68 year oldand the mean was 43.31±11.13 year old. The body mass index median was 21.24 (14.24–35.38) kg/m2. The subjects were dominated by severe degree mitral stenosis patients, those were ninety-three (70.45%) people, followed by moderate degree patients, those were thirty-two (24.24%) people, and mild degree patients, those were seven (5.30%) people. Twenty-eight (21.21%) people had isolated mitral stenosis. The mitral valve area median was 0.8 (0.27–1.90) cm2. The TAPSE score range was 6–30 mm and the mean was 17.48±4.58 mm. The result from Spearman correlation test showed that the relationship strength between mitral valve area and TAPSE score were very weak (r=0.167) with significant p-value (p=0.028).Conclusion: There is a statistically significant positive relationship with very weak strength between mitral valve area and TAPSE score as a right ventricle function parameter in mitral stenosis patients (r = 0.167, p = 0.028).

scholarly journals Mid-term (up to 12 years) clinical and echocardiographic outcomes of percutaneous transvenous mitral commissurotomy in patients with rheumatic mitral stenosis

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yahya Dadjo ◽  
Maryam Moshkani Farahani ◽  
Reza Nowshad ◽  
Mohsen Sadeghi Ghahrodi ◽  
Alireza Moaref ◽  
...  
Keyword(s):  
Mitral Valve ◽  
Mitral Stenosis ◽  
Protective Factor ◽  
Cardiac Events ◽  
Mitral Valve Area ◽  
Adverse Cardiac Events ◽  
Percutaneous Transvenous Mitral Commissurotomy ◽  
Mitral Commissurotomy ◽  
Valve Area

Abstract Background Rheumatic heart disease (RHD) is still a concerning issue in developing countries. Among delayed RHD presentations, rheumatic mitral valve stenosis (MS) remains a prevalent finding. Percutaneous transvenous mitral commissurotomy (PTMC) is the intervention of choice for severe mitral stenosis (MS). We aimed to assess the mid-term outcome of PTMC in patients with immediate success. Methods In this retrospective cohort study, out of 220 patients who had undergone successful PTMC between 2006 and 2018, the clinical course of 186 patients could be successfully followed. Cardiac-related death, undergoing a second PTMC or mitral valve replacement (MVR) were considered adverse cardiac events for the purpose of this study. In order to find significant factors related to adverse cardiac outcomes, peri-procedural data for the studied patients were collected.The patients were also contacted to find out their current clinical status and whether they had continued secondary antibiotic prophylaxis regimen or not. Those who had not suffered from the adverse cardiac events were additionally asked to undergo echocardiographic imaging, in order to assess the prevalence of mitral valve restenosis, defined as mitral valve area (MVA) < 1.5 cm2 and loss of ≥ 50% of initial area gain. Results During the mean follow-up time of 5.69 ± 3.24 years, 31 patients (16.6% of patients) had suffered from adverse cardiac events. Atrial fibrillation rhythm (p = 0.003, HR = 3.659), Wilkins echocardiographic score > 8 (p = 0.028, HR = 2.320) and higher pre-procedural systolic pulmonary arterial pressure (p = 0.021, HR = 1.031) were three independent predictors of adverse events and immediate post-PTMC mitral valve area (IMVA) ≥ 2 cm2 (p < 0.001, HR = 0.06) was the significant predictor of event-free outcome. Additionally, follow-up echocardiographic imaging detected mitral restenosis in 44 patients (23.6% of all patients). The only statistically significant protective factor against restenosis was again IMVA ≥ 2 cm2 (p = 0.001, OR = 0.240). Conclusion The mid-term results of PTMC are multifactorial and may be influenced by heterogeneous peri-procedural determinants. IMVA had a great impact on the long-term success of this procedure. Continuing secondary antibiotic prophylaxis was not a protective factor against adverse cardiac events in this study. (clinicaltrial.gov registration: NCT04112108).

scholarly journals The relationship between 25(OH) vitamin D levels and COVID-19 onset and disease course in Spanish patients

2021 ◽  
pp. 105928
Author(s):  
Manuel Diaz-Curiel ◽  
Alfonso Cabello ◽  
Rosa Arboiro-Pinel ◽  
Luis Mansur ◽  
Sarah Heili-Frades ◽  
...  
Keyword(s):  
Vitamin D ◽  
Disease Course ◽  
Vitamin D Levels ◽  
25 Oh Vitamin D ◽  
The Relationship

Two-dimensional-Wilkins and real-time transesophageal three-dimensional scoring systems: Which one is preferred to mitral valve morphological assessment?

2021 ◽  
pp. 021849232110304
Author(s):  
Mehrnoush Toufan ◽  
Zahra Jabbary ◽  
Naser Khezerlou aghdam
Keyword(s):  
Mitral Valve ◽  
Transthoracic Echocardiography ◽  
Scoring System ◽  
Three Dimensional ◽  
Scoring Systems ◽  
Two Dimensional ◽  
Mitral Valve Area ◽  
2D And 3D ◽  
Morphological Assessment ◽  
Valve Area

Background To quantify valvular morphological assessment, some two-dimensional (2D) and three-dimensional (3D) scoring systems have been developed to target the patients for balloon mitral valvuloplasty; however, each scoring system has some potential limitations. To achieve the best scoring system with the most features and the least restrictions, it is necessary to check the degree of overlap of these systems. Also the factors related to the accuracy of these systems should be studied. We aimed to determine the correlation between the 2D Wilkins and real-time transesophageal three-dimensional (RT3D-TEE) scoring systems. Methods This cross-sectional study was performed on 156 patients with moderate to severe mitral stenosis who were candidates for percutaneous balloon valvuloplasty. To morphologic assessment of mitral valve, patients were examined by 2D-transthoracic echocardiography and RT3D-TEE techniques on the same day. Results A strong association was found between total Wilkins and total RT3D-TEE scores (r = 0.809, p < 0.001). The mean mitral valve area assessed by the 2D and 3D was 1.07 ± 0.25 and 1.03 ± 0.26, respectively, indicating a mean difference of 0.037 cm2 (p = 0.001). We found a strong correlation between the values of mitral valve area assessed by 2D and 3D techniques (r = 0.846, p < 0.001). Conclusion There is a high correlation between the two scoring systems in terms of evaluating dominant morphological features. Partially, mitral valve area overestimation in the 2D-transthoracic echocardiography and its inability to assess commissural involvement as well as its dependence on patient age were exceptions in this study.

scholarly journals Prevalence of vitamin D level in the serum of patients living in Erbil city, Iraq, referred to private clinical laboratory and effect of age and sex on it

2018 ◽  
Vol 91 (1) ◽  
Author(s):  
Rabar M. Abdulrahman ◽  
Balen Muhsin Abdul Rahman
Keyword(s):  
Vitamin D ◽  
Clinical Laboratory ◽  
Mediterranean Country ◽  
Hydroxyvitamin D ◽  
Vitamin D Levels ◽  
Study Population ◽  
25 Hydroxyvitamin D ◽  
Country People ◽  
Effect Of Age ◽  
Age And Sex

This retrospective study aimed to determine the levels of 25- hydroxyvitamin D [25-(OH) D] in the individuals that have been referred to two laboratories (Bio Lab and King Lab) and to around 50 private side laboratories that use both Bio Lab and King Lab as a referral lab for their tests, in Erbil city, Iraq. Then show the range of deficiency and its relation with sunlight exposure, sex and age. Out of the total number of cases (N=10823), large percentage (nearly 78%) referred to both clinical laboratory based in Erbil city were found to have a deficiency in vitamin D levels, which means they had 25-(OH) D levels lower than 20 μg/L. This study found the percentage of vitamin D level in the serum of groups insufficient, deficient, adequate, optimal; intoxication were 52.8, 24.1, 11, 12 and 0.2% respectively. When the records have been compared according to gender, the results suggested that there was no difference between male and female within the study population (P>0.05), while there was difference in the grouped ages (P<0.05). Our results indicate that although Erbil is located in a Mediterranean country, people living there should periodically check their 25-(OH) D levels, in order to get appropriate supplements of vitamin D, which eventually prevents secondary chronic disease due to vitamin D deficiency.

Two-dimensional transesophageal echocardiographic determination of mitral valve area in adults with mitral stenosis

1994 ◽  
Vol 127 (5) ◽  
pp. 1348-1353 ◽  
Author(s):  
Marcus F Stoddard ◽  
Charles R Prince ◽  
Nasar M Ammash ◽  
John L Goad
Keyword(s):  
Mitral Valve ◽  
Mitral Stenosis ◽  
Two Dimensional ◽  
Mitral Valve Area ◽  
Valve Area

Closed Mitral Valvotomy for Mitral Stenosis in Mirror Image Dextrocardia

1995 ◽  
Vol 3 (2) ◽  
pp. 75-77 ◽  
Author(s):  
Gutti Ramasubrahmanyam ◽  
Dronamraju Dilip ◽  
Pirovam Venkat Ramnarayan ◽  
Raju Subramaniam Iyer ◽  
Kothapalle Venugopal Naidu
Keyword(s):  
Mitral Valve ◽  
Surgical Approach ◽  
Mitral Stenosis ◽  
Mirror Image ◽  
Abnormal Position ◽  
Mitral Valve Area ◽  
Anterolateral Thoracotomy ◽  
Mitral Valvotomy ◽  
Valve Area

A 22-year-old female with mirror image dextrocardia and rheumatic valvular mitral stenosis underwent closed mitral valvotomy using a Tubb's dilator with good results. Despite abnormal position of situs, the surgical approach was simple through right anterolateral thoracotomy, and the operator's hands were mirror image to that of levocardia valvotomy in certain steps. Preoperative mitral valve area was 0.8 cm2, and peak and mean diastolic gradients were 21 and 15 mmHg respectively. Postoperatively, valve area improved to 2.16 cm2, and peak and mean diastolic gradients were 8 and 3.1 mmHg, respectively.

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