Isabel Galina is a researcher at the Instituto de Investigaciones Bibliográficas, a research institute for bibliographic studies at the National Autonomous University of Mexico, UNAM. The university is also home to the Biblioteca Nacional, Mexico’s national library. Isabel Galina discusses the emergence of digital humanities and her views on how DH works within this particular structure and related issues to do with understanding national bibliographical collections in the digital age, in particular regarding e-legal deposit and digital preservation. She discusses the difficulties in identifying, selecting, and incorporating born-digital materials. In the interview, Isabel Galina also describes how she got involved in DH, the creation of the Red de Humanidades Digitales (RedHD), and other DH developments in Mexico and Latin America. Finally, the conversation examines university and government support for DH as well as a look at DH works in Mexico in collaboration with other countries, and in particular hosting the international Digital Humanities conference in Mexico City in 2018.