Effect of hydro-alcoholic root extract of Plumbago zeylanica l alone and its combination with aqueous leaf extract of Camellia sinensis on haloperidol induced parkinsonism in wistar rats

Background: Plants are important source of chemical substances with therapeutic effects. Although, the promising potentials for good number of medicinal plants are being established, there exists in developing countries where people resort to herbal plants without proper awareness of the associated risks particularly in event of excessive or chronic use. Hence, the need to evaluate the histological and biochemical effects of aqueous leaf extract of Cadaba farinosa used traditionally for treatments of gastrointestinal parasites, cancer and diabetes in North-Eastern Nigeria. To evaluate the histological and biochemical effects of aqueous leaf extract of Cadaba farinosa on liver of adult Wistar rats.Methods: Twelve adult Wistar rats of both sexes were used and divided into four groups of three rats each. Group 1 served as control. Aqueous leaf extract were orally administered for 28 days at doses of 100, 200 and 300mg/kg respectively. Biochemical and histological analysis were performed.Results: This study showed significantly elevated levels of aspartate transaminase, alkaline phosphatase and alanine transaminase in animals treated with Cadaba farinosa (especially the highest dose 300mg/kg) compared to negative control. Elevated liver enzymes were corroborated by histopathological changes of liver exhibiting ballooning degenerations and steatohepatitis.Conclusions: Cadaba farinosa causes hepatic injury. Hence, further work needs to be done to ascertain whether reducing the dose of Cadaba farinosa would ameliorate this effect. Authors speculate that injury to multiple organelles including fat droplets and endoplasmic reticulum contribute to this characteristic finding.

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Reproductive Function Evaluation in Female Wistar Rats Treated with Aqueous leaf Extract of Cissusaralioides

Biosciences Biotechnology Research Asia ◽

10.13005/bbra/2804 ◽

2019 ◽

Vol 16 (04) ◽

pp. 857-864

Author(s):

Bartholomew Chukwuebuka Nwogueze ◽

Anthony Emeka Ojieh ◽

Richard Nduka Ossai ◽

ChidinmaNwanneamaka Eke

Keyword(s):

Wistar Rats ◽

Leaf Extract ◽

Reproductive Function ◽

Function Evaluation ◽

Eastern Region ◽

Body Weight Reduction ◽

Therapeutic Benefits ◽

The Family ◽

Female Wistar Rats ◽

Aqueous Leaf Extract

ABSTRACT: Background: Medicinal plants are increasingly getting recognition. Cissus aralioides is a lofty climber belonging to the family of Vitaceae and widely distributed in South-Eastern region of Nigeria. Varied therapeutic benefits as well as well health harming effects have been reported about the plant. This study evaluated the effects of aqueous extract of Cissus aralioides leaf on reproductive functions in female Wistar rats.Methods: 72 adult female Wistar rats weighing between 110-180/g were used for the study. The animals were randomly grouped into 6 groups of twelve rats each (n=12). Groups 1 and 2 served as control while groups 3 to 6 were the experimental groups and were administered (100/mg, 200/mg, 300/mg and 500/mg)/kg of the extract respectively for 4 weeks. At the end of the experiment, blood samples were collected and centrifuged to obtain the serum for biochemical analysis for Follicle Stimulating Hormone (FSH), Estrogen and Luteinizing Hormone (LH). Data were analyzed using the SPSS package and expressed as mean± SEM and ANOVA.Results: There was significant body weight reduction across groups administered with the extract. Also, there were significant decrease in estrogen level in groups that received 300/mg/kg and 500/mg/kg when compared with the control groups, a similar decrease was not observed with LH and FSH across the groups.Conclusion: Observations from this study shows that aqueous leaf extract of Cissus aralioides decreases circulating levels of estrogen in female Wistar rats.

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