acute and sub-acute toxicity studies of aqueous leaf extract of launaea taraxacifolia (willd.) in wistar rats

2021 ◽  
Vol 12 (1) ◽  
pp. 95
Author(s):  
Millicent Umaru ◽  
Kabiru Abubakar ◽  
Gabriel Uyaiabasi ◽  
Giaze Tijjani ◽  
Yusuf Alkali ◽  
...  
Keyword(s):  
Acute Toxicity ◽  
Wistar Rats ◽  
Leaf Extract ◽  
Toxicity Studies ◽  
Aqueous Leaf Extract

scholarly journals Acute and Sub-acute Toxicity Profile of Aqueous Leaf Extract of Nymphaea lotus Linn (Nymphaeaceae) in Wistar Rats

2015 ◽  
Vol 14 (7) ◽  
pp. 1231 ◽  
Author(s):  
OJ Sharaibi ◽  
OT Ogundipe ◽  
OA Magbagbeola ◽  
MI Kazeem ◽  
AJ Afolayan
Keyword(s):  
Acute Toxicity ◽  
Wistar Rats ◽  
Leaf Extract ◽  
Toxicity Profile ◽  
Aqueous Leaf Extract

scholarly journals Acute toxicity studies of aqueous leaf extract of Phyllanthus niruri

2011 ◽  
Vol 4 (4) ◽  
pp. 206-210 ◽  
Author(s):  
George Asare ◽  
Phyllis Addo ◽  
Kwasi Bugyei ◽  
Ben Gyan ◽  
Samuel Adjei ◽  
...  
Keyword(s):  
Acute Toxicity ◽  
Leaf Extract ◽  
Female Rats ◽  
Full Blood Count ◽  
Control Group ◽  
High Dose ◽  
Oral Gavage ◽  
Phyllanthus Niruri ◽  
Toxicity Studies ◽  
Aqueous Leaf Extract

Acute toxicity studies of aqueous leaf extract ofPhyllanthus niruriPhyllanthus niruriis a plant with medicinal properties. It is often used to treat mild malaria and the elimination of renal stones. However, studies on its toxicity are scarce. The study was carried out to determine if the aqueous leaf extract ofP. niruriadministered to female Sprague-Dawley rats would illicit evidence of toxicity. Fifteen female rats weighing 150-200 g were divided into 3 groups. Rats in Group 1 were given a single low dose (LD) of 2 000 mg/kg b.w. of the extract by oral gavage within 24 hrs. Rats in Group 2 were given a single high dose (HD) of 5 000 mg/kg b.w. of the extract by oral gavage within 24 hrs. Rats in Group 3 were not given any extract but drinking water and served as the control group (C). All the rats were observed for signs of toxidromes for 14 days. On the 15thday, all the rats were sacrificed. Body organs were harvested for macroscopic examination. Urine and blood samples were drawn and analyzed. Hematological tests performed included full blood count and hemoglobin. Biochemical examinations included bilirubin, alanine aminotransferase (ALT), aspartate aminotransferase (AST), total protein, albumin, globulin, alkaline phosphatse (ALP), γ-glutamyltranspeptidase (GGT), urea, and creatinine. The results of the three groups were not significantly different. Examination of the various body organs did not show any abnormality. Thus no toxicity was observed at the levels administered. The LD50of the aqueous extract is > 5 000 mg/kg. b.w.

scholarly journals Toxicity Studies of Striga hermonthica (Delile) Benth Leaf Extract in Rats

2020 ◽  
Vol 2 (2) ◽  
pp. 7-18
Author(s):  
M. M. Onakpa
Keyword(s):  
Acute Toxicity ◽  
Wistar Rats ◽  
Leaf Extract ◽  
Negative Control ◽  
Striga Hermonthica ◽  
Oral Toxicity ◽  
Toxicity Studies ◽  
Group I ◽  
Significant Difference ◽  
Male Wistar Rats

Striga hermonthica is a ubiquitous hemi-parasitic plant commonly known as witch-weed and is used in West Africa as a traditional herbal medicine for the treatment of an array of diseases. In this study, methanol leaf extract of S. hermonthica was used to investigate the acute and sub-acute toxicity effects in male Wistar rats. In the acute toxicity studies, Wistar rats were divided into six groups comprising of negative control and extract treated groups (250, 500, 1000, 1500 and 2000 mg/kg of extract orally). The rats were observed for 72 hours while in the sub-acute oral toxicity studies, the rats were divided into 4 groups consisting of 5 rats per group. The extract was administered orally at doses of 25, 50 and 100 mg/kg daily for 28 days to groups II, III and IV respectively while group I (negative control) received 2 ml of distilled water. The dose of 2000 mg/kg did not cause any mortality or signs of toxicity in the treated rats during the acute and subacute toxicity studies did not show any treatment-related abnormalities in the hematological (RBC, Hb, WBC, Lymphocytes) and biochemical (AST, ALT, ALP, TB, Glucose, HDL, LDL, Total protein, Albumin) parameters while the liver revealed lesions in the histopathology studies, there were no treatment-related lesions observed in the heart, lungs, pancreas and kidney whereas, the weight of rats did not show significant difference (p > 0.05) between the control and the treated groups. The study showed that S. hermonthica caused hepatotoxicity and could be potentially harmful for use. A more comprehensive research is recommended to investigate on its safe use and mode of action.

scholarly journals Chronic Toxicity Studies of Aqueous Leaf Extract of Voacanga africana in Wistar Rats

2016 ◽  
Vol 19 (4) ◽  
pp. 639
Author(s):  
Igbe Ighodaro ◽  
Silvanus Innih ◽  
Stephen Vincent Ogedengbe ◽  
Lucy Amamina
Keyword(s):  
Wistar Rats ◽  
Leaf Extract ◽  
Chronic Toxicity ◽  
Toxicity Studies ◽  
Aqueous Leaf Extract

scholarly journals Acute and Subchronic Toxicity Studies of Aqueous Extract of Desmodium adscendens (Sw) DC

2017 ◽  
Vol 22 (4) ◽  
pp. 753-759 ◽  
Author(s):  
Osbourne Quaye ◽  
Precious Cramer ◽  
Mark Ofosuhene ◽  
Laud K. N. Okine ◽  
Alexander K. Nyarko
Keyword(s):  
Body Weight ◽  
Drug Interaction ◽  
Acute Toxicity ◽  
Plant Extract ◽  
Wistar Rats ◽  
Leaf Extract ◽  
Lethal Dose ◽  
Subchronic Toxicity ◽  
Toxicity Studies ◽  
Toxicity Effects

Extracts of Desmodium adscendens (Sw) DC are used for the treatment of various diseases but limited toxicological evaluations have been done on the medicinal plant. This study investigates toxicity effects of the leave extract of D adscendens, and the possibility of drug-drug interaction of the plant extract when co-administered with other drugs. Oral administrations of leaf extract of D adscendens to white Wistar rats in an acute toxicity studies allowed the estimation of an LD50 (median lethal dose) value of 1122 mg/kg body weight. In a subchronic toxicity studies, the plant extract caused a decrease in zoxazolamine paralysis time and prevented thiopentone from causing sleep in test animals compared to controls. Overall, the results are consistent with the plant extract being safe at the doses administered in humans. However, the induction of the CYP enzymes is an indication of a possible drug interaction when the plant extract is co-administered with other drugs.

scholarly journals Antidiabetic activity and acute toxicity evaluation of aqueous leaf extract of Vernonia amygdalina

2014 ◽  
Vol 13 (50) ◽  
pp. 4586-4593 ◽  
Author(s):  
A. Momoh M. ◽  
O. Adedokun M. ◽  
T. Mora A. ◽  
A. Agboke A.
Keyword(s):  
Acute Toxicity ◽  
Leaf Extract ◽  
Antidiabetic Activity ◽  
Vernonia Amygdalina ◽  
Toxicity Evaluation ◽  
Aqueous Leaf Extract
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