Platelet-Rich Fibrin in Combination with Local Antibiotics Optimizes Wound Healing After Deep Sternal Wound Problems and Prevents Reinfection

2021 ◽  
Vol 39 ◽  
Author(s):  
Ralf-Uwe Kuehnel ◽  
◽  
Filip Schroeter ◽  
Torsten Mueller ◽  
Roya Ostovar ◽  
...  
Keyword(s):  
Wound Healing ◽  
Growth Factors ◽  
Wound Closure ◽  
Positive Impact ◽  
Vacuum Therapy ◽  
Site Infection ◽  
Local Antibiotics ◽  
Persistent Problem ◽  
Platelet Rich Fibrin ◽  
Secondary Wound Closure

Objective: Disturbed wound healing is a significant problem in patients after cardiac surgery. Problems with deep sternal wound healing are rare, but can be quite difficult to treat. Furthermore, the therapy is highly expensive and consumes many of the patient’s personal resources. Another major obstacle in this patient group is reinfection after secondary wound closure. We examined how to prevent early reinfection through the use of growth factors in combination with local antibiotics. Methods: Our study included 232 patients with a deep sternal wound healing problem. After initial vacuum therapy, we planned secondary wound closure. During wound closure, we used only platelet-rich fibrin in a PRF group (109 patients). In another group (123 patients), we covered the wounds intraoperatively with a combination of PRF and local antibiotics (PRF CoDelivery). All patients were observed for 30 days for signs of early surgical site infection. Results: After 30 days, 22 patients (20.2%) in the PRF group showed a persistent problem with wound healing with or without reinfection. In contrast, only 12 patients (9.8%) in the PRF CoDelivery group had this problem (p=0.023 PRF vs. PRF CoDelivery). Conclusion: The combination of growth factors and antibiotics was associated with a significantly reduced incidence of early reinfection and thus can be expected to have a positive impact on wound healing in complicated scenarios. Furthermore, the combination of PRF and local antibiotics was easy to use. Further studies are needed to verify these initial findings.

Principles of wound healing and growth factor considerations

1993 ◽  
Vol 83 (4) ◽  
pp. 223-227 ◽  
Author(s):  
SJ Skokan ◽  
RH Davis
Keyword(s):  
Wound Healing ◽  
Growth Factors ◽  
Growth Factor ◽  
Wound Repair ◽  
Wound Closure ◽  
Cellular Proliferation ◽  
Positive Influence ◽  
Surgical Wounds ◽  
And Migration ◽  
Proliferation And Migration

This review examines some of the important principles in wound repair and significant considerations for the use of growth factors. Moisture provides a positive influence on the mechanical and hormonal aspects of wounds. Atraumatic closure of surgical wounds and postoperative care and the types of wound closure are discussed. Cellular proliferation and migration in wounds are central features regarding growth factors.

scholarly journals Clinical Application of Platelet-Rich Fibrin in Pediatric Dentistry

2021 ◽  
Author(s):  
Sowndarya Gunasekaran ◽  
Soundarya Sakthivel ◽  
Shanthala B. M. ◽  
George Babu ◽  
Vidhya Vijayan
Keyword(s):  
Wound Healing ◽  
Growth Factors ◽  
Clinical Application ◽  
Pediatric Dentistry ◽  
Simple Process ◽  
Platelet Rich Fibrin ◽  
Promote Wound Healing ◽  
Fibrin Matrix ◽  
Tissue Healing ◽  
Insight Into

AbstractPlatelet-rich fibrin (PRF) is a fibrin matrix in which platelet cytokines, growth factors, and cells are trapped and may be released after a certain time and that can serve as a resorbable membrane. It can be obtained from blood with the help of a simple process. PRF is basically a concentrate of growth factors that promote wound healing and regeneration, which is used in various disciplines of dentistry to repair various lesions and regenerate dental and oral tissues. Although the use of PRF is well-documented, its use in pediatric dentistry remains unexplored, due to its restrictions and on account of the fact that it is a blood-derived product. PRF has been used globally to enhance tissue healing. This article provides an insight into the use of PRF in pediatric dentistry, its benefits, limitations, and recommendations.

scholarly journals Platelet-Rich Fibrin as a Biofuel for Tissue Regeneration

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Sujeet Vinayak Khiste ◽  
Ritam Naik Tari
Keyword(s):  
Wound Healing ◽  
Growth Factors ◽  
Clinical Application ◽  
Platelet Rich Plasma ◽  
Healing Process ◽  
Vital Role ◽  
Wound Healing Process ◽  
Platelet Rich Fibrin ◽  
Fibrin Network ◽  
New Material

Wound healing is a staged process which involves the activity of leukocytes and platelets. For this process to work efficiently, the platelets play a vital role. The growth factors present in platelets are important to guide the regenerating cells to the area of healing. Platelet-rich-fibrin (PRF) is one such material that holds on to these growth factors enmeshed in the fibrin network resulting in their sustained release over a period of time that can accelerate the wound healing process. With this knowledge, research has been carried out for a past few years for the clinical application of PRF. Various platelet concentrates have been studied including the platelet-rich-plasma (PRP). However, the short duration of cytokine release and its poor mechanical properties have resulted in the search of a new material with adequate properties for clinical application and ease of preparation. PRF has found a place in the regenerative field owing to its advantages over PRP. This review focuses on the properties and various applications of PRF in the clinical practice.

scholarly journals SURGICAL MANAGEMENT OF A LARGE PERIAPICAL LESION USING TRICALCIUM SILICATE CEMENT AND PLATELET RICH FIBRIN FOLLOWED BY WALKING BLEACH OF DISCOLOURED TOOTH– A CASE REPORT WITH 2 YEAR FOLLOWUP

2021 ◽  
pp. 1-2
Author(s):  
Shilpi Tiwari ◽  
Vaibhav Krishna Singh
Keyword(s):  
Wound Healing ◽  
Case Report ◽  
Growth Factors ◽  
Gold Standard ◽  
Surgical Intervention ◽  
Tricalcium Silicate ◽  
Mechanical Support ◽  
Periapical Lesion ◽  
Standard Material ◽  
Platelet Rich Fibrin

The most common approach to treat the cases of periapical lesion is an orthograde endodontic treatment, however lesions which are unable to heal nonsurgically needs a surgical intervention. MTA is considered as a gold standard material in root end filling, however it has shown several disadvantages, hence Biodentin was introduced to overcome these disadvantages of MTA. PRF is a way to accelerate and enhance the body’s natural wound healing mechanisms as it provides the mechanical support and various growth factors which are necessary for the neoangiogenesis, vascularization and survival of the graft.

Comparison of the ficus for the wound healing activity in various species

2020 ◽  
Vol 10 (4) ◽  
pp. 67-70
Author(s):  
Mothilal K ◽  
Akila CR ◽  
Mahender K ◽  
Chaitanya Kumar K ◽  
Ravi D
Keyword(s):  
Wound Healing ◽  
Wound Closure ◽  
Subcutaneous Tissue ◽  
Significant Activity ◽  
Herbal Extracts ◽  
Standard Drug ◽  
Excision Wound ◽  
Injuries And Wounds ◽  
Skin Conditions ◽  
Wound Healing Activity

Injuries and wounds are any sorts of damage to the skin or subcutaneous tissue. Usually, any wounds of such sorts are self-healed. Sometimes, there may be a delay in healing, and that delay is caused due to the functional delays in various processes of wound healing. All the Ficus plants show similar activities like the antioxidant, anti-inflammatory and wound healing properties 7including skin conditions like ulcers and rheumatism. The anthelmintic property and immunomodulatory are also seen. The herbal extracts of the same family of Ficus in different plants were investigated for the wound healing activity in the excision wound method, and the extracts showed significant activity compared to the drug. All the extracts showed a better healing ability, but the extract of FBO-100 showed the highest activity followed by FMO followed by FHO and finally the FRO. Overall, the activity of the extract ointment was comparable and was significant compared to the standard drug ointment. The wound closure of the extract ointment treated groups were better and were completed in 12 days, and the activity was more than 96%. The herbal extracts of the same family of Ficus in different plants were investigated for the wound healing activity in the excision wound method, and the extracts showed significant activity compared to the drug. The plants of microcarpa, benghalensis, religiosa and hispida are compared for the activity, and the order showed for the activity was FBO>FMO>FHO>FRO.

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