Comparison of Ex-vivo Perfused and Non-perfused Porcine Liver Ablations using Uncooled Microwave Applicators

Author(s):  
Mattia Dimitri ◽  
Fabio Staderini ◽  
Sara Aquino ◽  
Lucrezia Mazzantini ◽  
Andrea Corvi ◽  
...  
2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Jens Ziegle ◽  
Alfredo Illanes ◽  
Axel Boese ◽  
Michael Friebe

AbstractDuring thermal ablation in a target tissue the information about temperature is crucial for decision making of successful therapy. An observable temporal and spatial temperature propagation would give a visual feedback of irreversible cell damage of the target tissue. Potential temperature features in ultrasound (US) B-Mode image sequences during radiofrequency (RF) ablation in ex-vivo porcine liver were found and analysed. These features could help to detect the transition between reversible and irreversible damage of the ablated target tissue. Experimental RF ablations of ex-vivo porcine liver were imaged with US B-Mode imaging and image sequences were recorded. Temperature was simultaneously measured within the liver tissue around a bipolar RF needle electrode. In the B-Mode images, regions of interest (ROIs) around the centre of the measurement spots were analysed in post-processing using average gray-level (AVGL) compared against temperature. The pole of maximum energy level in the time-frequency domain of the AVGL changes was investigated in relation to the measured temperatures. Frequency shifts of the pole were observed which could be related to transitions between the states of tissue damage.


2010 ◽  
Vol 21 (10) ◽  
pp. 1573-1578 ◽  
Author(s):  
Joseph L. Farnam ◽  
Benjamin C. Smith ◽  
Brandon R. Johnson ◽  
Rodolfo Estrada ◽  
Theresa L. Edelman ◽  
...  

2020 ◽  
Vol 11 (1) ◽  
pp. 87-95
Author(s):  
Guanming Zhu ◽  
Liang Zhou ◽  
Shilong Wang ◽  
Pengjie Lin ◽  
Jing Guo ◽  
...  

AbstractIt is a common challenge for the surgeon to detect pathological tissues and determine the resection margin during a minimally invasive surgery. In this study, we present a drop-in sensor probe based on the electrical bioimpedance spectroscopic technology, which can be grasped by a laparoscopic forceps and controlled by the surgeon to inspect suspicious tissue area conveniently. The probe is designed with an optimized electrode and a suitable shape specifically for Minimally Invasive Surgery (MIS). Subsequently, a series of ex vivo experiments are carried out with porcine liver tissue for feasibility validation. During the experiments, impedance measured at frequencies from 1 kHz to 2 MHz are collected on both normal tissues and water soaked tissue. In addition, classifiers based on discriminant analysis are developed. The result of the experiment indicate that the sensor probe can be used to measure the impedance of the tissue easily and the developed tissue classifier achieved accuracy of 80% and 100% respectively.


2017 ◽  
Vol 32 (2) ◽  
pp. 743-750 ◽  
Author(s):  
Wenyan Liu ◽  
Xinglong Zheng ◽  
Rongqian Wu ◽  
Yinbin Jin ◽  
Shu Kong ◽  
...  

2018 ◽  
Vol 44 (2) ◽  
pp. E13 ◽  
Author(s):  
Goutam Ghoshal ◽  
Lucy Gee ◽  
Tamas Heffter ◽  
Emery Williams ◽  
Corinne Bromfield ◽  
...  

OBJECTIVEMinimally invasive procedures may allow surgeons to avoid conventional open surgical procedures for certain neurological disorders. This paper describes the iterative process for development of a catheter-based ultrasound thermal therapy applicator.METHODSUsing an ultrasound applicator with an array of longitudinally stacked and angularly sectored tubular transducers within a catheter, the authors conducted experimental studies in porcine liver, in vivo and ex vivo, in order to characterize the device performance and lesion patterns. In addition, they applied the technique in a rodent model of Parkinson’s disease to investigate the feasibility of its application in brain.RESULTSThermal lesions with multiple shapes and sizes were readily achieved in porcine liver. The feasibility of catheter-based focused ultrasound in the treatment of brain conditions was demonstrated in a rodent model of Parkinson’s disease.CONCLUSIONSThe authors show proof of principle of a catheter-based ultrasound system that can create lesions with concurrent thermode-based measurements.


1993 ◽  
Vol 17 (1) ◽  
pp. 3-9 ◽  
Author(s):  
B. Mets ◽  
C. Rose-Innes ◽  
Z. Lotz ◽  
R. Hickman ◽  
D. Chalton
Keyword(s):  
Ex Vivo ◽  

2017 ◽  
Vol 28 (5) ◽  
pp. 732-739 ◽  
Author(s):  
Pulathis N. Siriwardana ◽  
Saurabh Singh ◽  
Edward W. Johnston ◽  
Jennifer Watkins ◽  
Steve Bandula ◽  
...  

2013 ◽  
Vol 16 (4) ◽  
pp. 475-482 ◽  
Author(s):  
Ahmed Alzaraa ◽  
Dhya Al-Leswas ◽  
Wen Yuan Chung ◽  
Gianpiero Gravante ◽  
Morgan Bruno ◽  
...  

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