scholarly journals Histopathological examination of thyroid specimens - a single center study from Peshawar, Khyber Pakhtunkhwa

2020 ◽  
Vol 6 (1) ◽  
pp. 20-22
Author(s):  
Salman Khan ◽  
Muhammad Khizar Hayat ◽  
Omer Nasim ◽  
Muhammad Shah Fahad
Keyword(s):  
Papillary Carcinoma ◽  
Multinodular Goiter ◽  
Histopathological Examination ◽  
Follicular Adenoma ◽  
Nodular Goiter ◽  
Medullary Carcinoma ◽  
Medical Institute ◽  
Cross Sectional ◽  
Surgical Specimen ◽  
Neoplastic Lesions

Introduction: Thyroid gland enlargement is a surgical problem that affects about a third of the world's adults. Thyroid enlargement is best diagnosed by histopathology of surgical specimen and can also give a clue about different pattern of diseases that include simple goiter, multinodular goiter, thyroiditis, adenoma, and last but not the least, carcinoma. Objective: To determine presentation of thyroid lesions based on their histopathology in patients presenting to Rehman Medical Institute (RMI), Peshawar from August 2018 to July 2019. Materials & Methods: This was a descriptive cross-sectional study, inclusive of all thyroid specimens, irrespective of age and gender, received in the Department of Pathology, Rehman Medical Institute (RMI), Peshawar, from August 2018 to July 2019.  Data were retrieved and analyzed for descriptive statistics in MS Excel. Results: A total of 64 samples were collected; 56(87.5%) were non-neoplastic lesions while 08(12.5%) were neoplastic. 40(71%) multi nodular goiters, 11(19.64%) simple nodular goiter, 01(1.7%) case of Hashimoto’s thyroiditis, among neoplastic 04(50%) were found to be papillary carcinoma and 02(25%) each were follicular and medullary carcinoma. Female to male ratio was 5:3 or 1.67:1 in neoplastic lesions. Conclusion: The most common cause of goiter was multinodular goiter. Among the neoplastic lesions, follicular adenoma was the commonest, while papillary carcinoma was the most common malignant lesions. Keywords: Multinodular goiter, follicular adenoma, Papillary carcinoma, Fine needle aspiration cytology.

scholarly journals Frequency & pattern of malignancy in solitary thyroid nodule

1970 ◽  
Vol 15 (1) ◽  
pp. 1-5
Author(s):  
Md Rafiqul Islam ◽  
AFM Ekramuddaula ◽  
MS Alam ◽  
MS Kabir ◽  
Md Delwar Hossain ◽  
...  
Keyword(s):  
Thyroid Nodule ◽  
Papillary Carcinoma ◽  
Histopathological Examination ◽  
Malignant Lesion ◽  
Medullary Carcinoma ◽  
College Hospital ◽  
Frequency Pattern ◽  
Cross Sectional ◽  
Female Ratio ◽  
Solitary Thyroid Nodule

This cross sectional study done in the department of Banghabandhu Sheikh Mujib Medical University and Dhaka Medical College Hospital during the period of July 2005 to October 2007 to determine frequency & pattern of malignancy in solitary thyroid nodule. For this study, 118 patients who were diagnosed as a case of malignancy in solitary thyroid nodule by detailed history, clinical examination, thyroid hormone assay, ultrasonogram, thyroid scan, FNAC and histopathological examination, were collected. In this study majority of the patients were within 21-40 years of age. Frequency of solitary thyroid nodule is more in female with male female ratio 1: 2.11 Majority of the nodules were firm (72.03%), others were hard (16.95%) and cystic (11.02%). Malignant lesion was more common in hard nodule (70%). Most of the nodules were cold (66.10%) among them 25.6% cases were malignant, followed by warm (30.5%) and hot (3.3%). No malignancy was found in hot nodule. FNAC showed colloid nodule (44%), cellular follicular lesion (29.66%), papillary carcinoma (12.7%), colloid degeneration (4.2%) and medullary carcinoma (1.6%) Out of 118 patients, histopathologically non malignant were 96 (81.35%) and malignant were 22(18.65%). Among malignant cases, 16 (72.72%) cases were papillary carcinoma, 4 (18.18%) cases were follicular carcinoma and 2(9.1%) cases were medullary carcinoma. Key words: Solitary thyroid nodule, FNAC, Papillary carcinoma, Follicular carcinomaDOI: 10.3329/bjo.v15i1.4303 Bangladesh J of Otorhinolaryngology 2009; 15(1): 1-5

scholarly journals Morphological Spectrum of Lesions Seen in Thyroidectomy Specimens At A Tertiary Care Institute

Esculapio ◽  
2020 ◽  
Vol 16 (03, july 2020-Septmber 2020) ◽  
Author(s):  
Iram Nadeem ◽  
Samra Sameen ◽  
Sahar Iqbal ◽  
Tazeen Anis
Keyword(s):  
Papillary Carcinoma ◽  
Tertiary Care ◽  
Follicular Adenoma ◽  
Follicular Carcinoma ◽  
Medullary Carcinoma ◽  
Anaplastic Carcinoma ◽  
Cell Adenoma ◽  
Care Institute ◽  
Hyalinizing Trabecular Tumor ◽  
Neoplastic Lesions

Objective: To determine the morphological spectrum of thyroid lesions encountered in thyroidectomy specimens at a tertiary care institute. Methods: It was a retrospective study conducted in Pathology Department, Allama Iqbal Medical College, Lahore. A retrospective manual collection of data was done from record registers, for the years 2012 & 2013. Results: A total of 307 cases were retrieved with age range of 16-70 years. Amongst them, 47 were males and 260 were females. Non neoplastic conditions outnumbered the neoplastic lesions as 229(75%) cases were of colloid goiter. Hashimoto thyroiditis was present in 12(3.9%) specimens and associated hyperplastic changes were seen in 15(4.9%) cases. There were 19(6.2%) cases of papillary carcinoma, 3(0.9%) cases of follicular carcinoma, 3(0.9%) cases of medullary carcinoma, 1(0.3 %) case of insular carcinoma and 2(0.6%) anaplastic carcinoma. Papillary microcarcinoma was seen in 4(1.3 %) cases and medullary microcarcinoma in 1(0.3%) case. Follicular adenoma comprised 29(9.4%) cases and Hurthle cell adenoma 3(0.9%) cases. Study data also showed 1(0.3%) rare case of hyalinizing trabecular tumor. Conclusion: Non neoplastic thyroid diseases are more common as compared to neoplastic lesions. Papillary carcinoma is most common thyroid malignancy encountered in our setting. Key Words: Thyroidectomy, Colloid goiter, papillary carcinoma

scholarly journals Diagnostic Value of CK19, HBME-1 and TROP2 Biomarkers in Identification of Different Types of Thyroid Follicular Neoplasms

2021 ◽  
Author(s):  
Shohreh Vojuhi ◽  
Masoud Mohebbi ◽  
Zohreh Mousavi ◽  
Mohammadali Yaghoubi ◽  
Reza Ziaolhagh
Keyword(s):  
Positive Predictive Value ◽  
Papillary Carcinoma ◽  
Predictive Value ◽  
Thyroid Nodules ◽  
Follicular Adenoma ◽  
Thyroid Neoplasms ◽  
Diagnostic Value ◽  
Cross Sectional ◽  
Predictive Values ◽  
Different Types

Thyroid malignancies are found in 7% to 15% of all thyroid nodules. Immunohistochemical markers, including CK19, HBME-1and TROP2, have shown an effective role in identifying these malignancies. Hence, due to the lack of appropriate diagnostic tests for the identification of thyroid neoplasms, in this study, we aimed to determine the diagnostic value of these biomarkers in the identification of different types of follicular thyroid neoplasms. In this cross-sectional study, paraffin-embedded tissue blocks from the surgical resection of patients with thyroid nodules, referring to Imam Reza and Razavi Hospitals of Mashhad in 2017, were studied. Sensitivity, specificity, and positive and negative predictive values of these biomarkers for the identification of different types of follicular thyroid neoplasms were also studied. 129 patients with a mean age of 44.65±12.59 years participated in this study, of whom 101 (78.29%) were women. The most common type of follicular thyroid neoplasm was papillary carcinoma (60.47%). The highest sensitivity (94.87%) and positive predictive value (68.51%) in the detection of follicular neoplasms was observed by CK19 in papillary carcinoma. The sensitivity and positive predictive value of TROP2 in the detection of papillary neoplasms was 93.58% and 75.25%, respectively. In addition, HBME-1 had the highest specificity (72.54 %) and positive predictive value (81.57%) in identifying this neoplasm. The results of this study showed that CK19, HBME-1, and TROP2 had high diagnostic value in the detection of papillary thyroid neoplasms. Although these biomarkers had low diagnostic value in identifying follicular adenoma and carcinoma, given the high negative predictive value, they can be considered as powerful markers in identifying negative cases.

scholarly journals Spectrum of histopathological lesions in the fallopian tubes

2013 ◽  
Vol 3 (5) ◽  
pp. 356-360 ◽  
Author(s):  
S Gon ◽  
A Basu ◽  
B Majumdar ◽  
TK Das ◽  
M Sengupta ◽  
...  
Keyword(s):  
Genital Tract ◽  
Histopathological Examination ◽  
Female Genital Tract ◽  
Secondary Malignancies ◽  
Fallopian Tubes ◽  
Serial Sections ◽  
Pathology Laboratory ◽  
Surgical Specimen ◽  
Neoplastic Lesions ◽  
Female Genital

Background: Fallopian tubes are common surgical specimen in the pathology laboratory; still there is a lack of data to describe the frequency of various histological fi ndings. The aim and objectives of this study was to describe the various histopathological fi ndings of fallopian tubes. Materials and Methods: Two thousand fi ve hundred and seventy fi ve cases where fallopian tubes were removed either separately or along with other female genital tract organs were studied retrospectively and their histopathological fi ndings documented. Results: Ectopic pregnancy comprised maximum number of cases closely followed by salpingitis. Primary neoplastic lesions were rare as compared to secondary malignancies. Serial sections of fallopian tube and sections from representative areas are essential for a pathologist so that the diagnosis of these pathological entities is not missed. Conclusion: Though the fallopian tubes remain unremarkable in majority of the surgical pathological specimens, it must be subjected for histopathological examination to demonstrate the pathological lesions. Journal of Pathology of Nepal (2013) Vol. 3, No.1, Issue 5, 356-360 DOI: http://dx.doi.org/10.3126/jpn.v3i5.7858

scholarly journals Ultrasonographic Evaluation of Solitary Thyroid Nodule with Histopathological Comparison

2020 ◽  
Vol 25 (2) ◽  
pp. 76-84
Author(s):  
Samia Quadir ◽  
Sabiha Quadir ◽  
Md Momin Uddin ◽  
Kazi Shameemus Salam ◽  
Mohammad Sazzad Hossain ◽  
...  
Keyword(s):  
Thyroid Nodule ◽  
Follicular Adenoma ◽  
Nodular Goiter ◽  
Cross Sectional Study ◽  
The Body ◽  
Histopathological Diagnosis ◽  
Sectional Study ◽  
Diagnostic Modality ◽  
Cross Sectional ◽  
Solitary Thyroid Nodule

Background: Thyroid gland is the largest gland of the body which secretes thyroid hormones named T3 & T4. Incidence of solitary thyroid nodule is common in Bangladesh. Objectives: To validate the ultrasonography evaluation of solitary thyroid nodule comparing with histopathological diagnosis. Methodology: This cross sectional study enrolled 75 patients of age range between 14 to 72 years during July 2016 to June 2018 and the study was carried out in the department of Radiology & Imaging of Ultrasonography evaluation was finally compared with histopathological diagnosis which was considered as gold standard. Results: Among 75 patients are included in this study the age ranged between 14 to 72 years. Majority of the patients 37 (49.3%) were found between 31 to 40 years. 65 (86.3%) were female & 10 (13.3%) were male. All patients were presents with thyroid swelling. In USG findings Microcalcifications were present 9 (12%) in benign & 5(6.7%) in malignant cases. Presence of Halo were in all benign cases 14 (18.7%). Comet tail sign were in 5 (6.7%) in benign & 3 (4%) in malignant cases. Histological nodular goiter were 57 (76%), Follicular adenoma 8 (10.7%), Thyroditis 5 (6.7%) and Papillary carcinoma 4 (5.3%), Follicular Carcinoma 1 (1.3%). Conclusion: This cross sectional study was carried out with an aim to determine the usefulness of ultrasonogram diagnosis of solitary thyroid nodule compared with histopathology findings. As the validity test results are higher, it can be concluded that the ultrasonogram is a useful diagnostic modality in the evaluation of solitary thyroid nodule. Bangladesh J Otorhinolaryngol; October 2019; 25(2): 76-84

scholarly journals Prevalence of iodine deficiency among multinodular goiter patients: a South Indian study

2017 ◽  
Vol 4 (2) ◽  
pp. 680 ◽  
Author(s):  
Nishad Kerakada ◽  
Ganesh Manikantan ◽  
Meer M. Chisthi
Keyword(s):  
Iodine Deficiency ◽  
Multinodular Goiter ◽  
Control Cell ◽  
Nodular Goiter ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
South Indian ◽  
Number Of Patients ◽  
High Prevalence ◽  
The Government

Background: Mass iodization of table salt was introduced by the Government of India to treat as well as prevent iodine deficiency problems including goitres. However, even after so many years of introduction of iodized salt, the number of patients reporting with multi nodular goiter to the hospitals in Kerala seems to be high. The coastal districts of Trivandrum and Kollam report especially high prevalence of goitres and subsequently thyroidectomies. The aim of this study was to find the prevalence of iodine deficiency among patients with multi nodular goiter in South Kerala.Methods: This was a cross sectional study of 300 patients admitted with multinodular goitre in the general surgical wards of Government Medical College Trivandrum, Kerala, India. From June 2013 to June 2014, these patients were evaluated clinically and with the investigatory facilities available at this institution. Their urine spot iodine excretion levels were measured at the laboratory of state iodine deficiency control cell, Trivandrum, Kerala, India.Results: Out of the 300 cases, 6 patients were found to have mild iodine deficiency. Mean iodine level was normal at 170 microgram per decilitre. The prevalence of iodine deficiency in multinodular goiter cases studied was found to be 2%.Conclusions: The high prevalence of multinodular goiter cases in Kerala cannot be sited per se as due to iodine deficiency as only 2% of the total number of cases studied had low urine iodine levels. This raises a question whether the salt iodization programme needs to be re-analyzed and possibly re-structured for the state of Kerala.

scholarly journals A study to determine the incidence of carcinoma of the thyroid gland in patients treated for multinodular goiter

2019 ◽  
Vol 6 (9) ◽  
pp. 3289
Author(s):  
Vikram Yogish ◽  
Challa Teja ◽  
Himanshi Grover
Keyword(s):  
Thyroid Gland ◽  
Multinodular Goiter ◽  
Tamil Nadu ◽  
Complete Blood Count ◽  
Histopathological Examination ◽  
Nodular Goiter ◽  
Needle Aspiration ◽  
Thyroid Function Tests ◽  
College Hospital ◽  
Detailed History

Background: In the population today, the presence of multi nodular goiter (MNG) is found in quite a few people and this may be due to various reasons. The patients should be thoroughly evaluated and a detailed history must be collected. Surgical treatment is offered to patients for various reasons. The objective of this research article is, to determine the incidence and the type of carcinoma of the thyroid gland in patients treated for multinodular goiter.Methods: A total of 105 patients who had multinodular goiter were studied. The study was carried out at SRM Medical College Hospital and Research Center, Kattankulathur, Tamil Nadu, India, from March 2016 to February 2019, for a period of three years. A detailed history was obtained and a thorough clinical evaluation was done. Investigations such as, complete blood count, thyroid function tests, ultrasound of the neck, and fine needle aspiration cytology were done. The patients then underwent total thyroidectomy and the operated specimens were subjected to histopathological examination (HPE). Out of the total of 105 patients that were studied, 21 patients were found to have carcinoma of the thyroid gland. The statistics were analysed using SPSS package 16.0.Results: From the results it was seen that papillary carcinoma of the thyroid gland was most commonly found in the operated specimens. The findings were compared with other studies.Conclusions: In patients with multinodulargoiter, a thorough evaluation and a detailed histopathological examination of the operated specimens must be done.

scholarly journals Malignancy in Clinically Non-toxic Multinodular Goiter

2021 ◽  
Vol 10 (1-2) ◽  
pp. 84-88
Author(s):  
Mohd Shahjahan Ali ◽  
Md Habibullah Sarkar ◽  
Syeda Momena Hossain
Keyword(s):  
Total Thyroidectomy ◽  
Multinodular Goiter ◽  
Histopathological Examination ◽  
Follicular Adenoma ◽  
Cervical Lymphadenopathy ◽  
Follicular Carcinoma ◽  
Chronic Thyroiditis ◽  
College Hospital ◽  
Toxic Multinodular Goiter ◽  
Thyroid Swelling

Objective: Goiter is a common form of thyroid swelling among population living in areas of iodine deficiency. Of the goiters, non-toxic multinodular goiter (MNG) is the most common and benign form of thyroid disease. However, studies have shown that long-standing MNGs may harbour malignancy. The present study was, therefore, undertaken to ascertain the prevalence of malignancy in clinically diagnosed non-toxic MNGs. Methods: This cross-sectional study was conducted in the Department of Surgery (all four-units) and ENT Department, Rajshahi Medical College Hospital, Rajshahi from July 2007 to June 2008 on 100 patients of clinically non-toxic MNG who underwent thyroid surgery. Biopsy materials were taken from the excised nodules and were sent for histopathological examination to see what proportion of them harboured malignancy. Result: The findings of the study showed that 40% of patients were 30-40 years old with mean age of the patients being 35.5 ± 10.1 (range: 14-75) years. Majority (87%) of the patients was female. Half of the patients with non-toxic MNGs had a history of thyroid swelling for 1-5 years and the rest half for > 5 years with median duration of illness being 5.5 years (range: 1-30 years). Of the 100 patients 4% had stridor and 6% dyspnoea; dysphagia and cervical lymphadenopathy each was 6%. Nearly 60% of the patients had goiter of size 15 sq-cm or below. Sub-total thyroidectomy was the most common operation performed (33%) followed by right hemi-thyroidectomy (24%), near total thyroidectomy (20%), left hemi-thyroidectomy (18%) and total thyroidectomy (5%). Histopathological examination of resected specimens revealed that 15% of the MNGs had malignancy with papillary to follicular carcinoma ratio being 4:1. Histopathological typing showed that 79% was simple MNGs, 4% follicular adenoma, 12% papillary carcinoma, 3% follicular carcinoma and 2% chronic thyroiditis. Neither age nor sex was found to be associated with presence of malignancies in MNGs (p = 0.865 and p = 0.647 respectively). The goiter-size was also not associated with presence of malignancies (p = 0.691). However, the mean duration of thyroid swelling in patients who had malignancy was much higher (8.5 years) than that in patients who did not haveany malignancy (5.7 years) (p = 0.024). Conclusion: The study concluded that a small proportion of long-standing non-toxic MNGs may turn into malignancy. Therefore, routine operative treatment without confirming that the cases are malignant does not seem to be justified. Ibrahim Card Med J 2020; 10 (1&2): 84-88

scholarly journals Histopathological Spectrum of Non-Neoplastic and Neoplastic Lesions of Thyroid: A Descriptive Cross-sectional Study

2020 ◽  
Vol 58 (231) ◽  
Author(s):  
Dilasma Ghartimagar ◽  
Arnab Ghosh ◽  
Manish Kiran Shrestha ◽  
Sushma Thapa ◽  
Om Prakash Talwar
Keyword(s):  
Thyroid Gland ◽  
Papillary Carcinoma ◽  
Follicular Carcinoma ◽  
Cross Sectional Study ◽  
Anaplastic Carcinoma ◽  
Sectional Study ◽  
Cross Sectional ◽  
Female Ratio ◽  
Neoplastic Lesions ◽  
Thyroid Lesions

Introduction: Thyroid gland lesions are the most common endocrine disorders encountered globally. Diseases of the thyroid gland present with either an alteration of hormone secretion or as an enlargement of the thyroid gland. The objective of the study is to find the frequency of different thyroid lesions. Methods: A descriptive cross-sectional study was conducted at Manipal Teaching Hospital, Pokhara from Jan 2005 to Jan 2020. Ethical approval was taken from the Institutional Review Committee (Ref: 330). Patients who had undergone thyroidectomy procedures for both non-neoplastic and neoplastic thyroid lesions were enrolled. Convenient sampling was done. IBM Statistical Package for Social Sciences version 21 and Microsoft Excel were used. Results: Out of 345 thyroidectomy specimens, 246 (71.3%) cases of non-neoplastic lesions, and 99 (28.69%) cases of neoplastic lesions were present. There were 54 males and 291 females with a male to female ratio of 1:5.4. The age ranged from 9 to 76 years with a mean age of 43.67 years. In non-neoplastic lesions, the predominant lesion was the colloid goiter with 205 (83.33%) cases followed by Grave’s disease and lymphocytic thyroiditis with 14 (5.69%) cases each. In neoplastic lesions, papillary carcinoma was the commonest lesion with 56 (56.56%) cases followed by follicular carcinoma with 14 (14.14%) cases and follicular adenoma with 13 (13.13%) cases. There were also 9 (9.09%) cases of anaplastic carcinoma in neoplastic lesions. Conclusions: Colloid goiter and papillary carcinoma was the most commonly encountered non-neoplastic and neoplastic lesion with a female predominance. Rare tumors like anaplastic carcinoma, papillary carcinoma, and follicular carcinoma with anaplastic transformation were also encountered.

scholarly journals Incident of Thyroid Carcinomas and Other Pathologies with Age Correlation in Patients Presented with Palpable Thyroid Masses Undergoing Thyroidectomies

2021 ◽  
Vol 15 (1) ◽  
pp. 77-81
Author(s):  
Mahwish Niaz ◽  
Keyword(s):  
Papillary Carcinoma ◽  
Multinodular Goiter ◽  
Follicular Adenoma ◽  
Anaplastic Carcinoma ◽  
Cell Adenoma ◽  
Thyroid Carcinomas ◽  
Hürthle Cell ◽  
Poorly Differentiated Carcinoma ◽  
Poorly Differentiated ◽  
Age Range

Background: Thyroid cancer is the leading cause of death both in developing and developed countries. Patients present with enlarged thyroid. Radiology shows hot and cold nodules. Thyroidectomy or lobectomy is done to rule out malignancy. Objective: To determine the incidence of thyroid carcinomas and other pathologies in thyroidectomy specimen of different age group patients presenting with clinically enlarged thyroid. Study Design: Cross-sectional study. Settings: Department of Histopathology, Foundation University Medical College (FUMC), Islamabad and Department of surgery, Fauji Foundation Hospital (FFH), Rawalpindi Pakistan. Duration: from Jan 2012 to March 2019. Methodology: All the thyroidectomies specimens send from Surgery department of FFH to Histopathology Department of FUMC during study period and fulfilling the pre-set criteria were included in the study. All the data and results were analyzed using SPSS version 17.0. Results: Out of 500 total patients, 89% (n=445) were diagnosed as having multinodular goiter, 2.6% (n=13) thyroiditis, 2.2% (n=11) follicular adenoma, 0.8% (n=4) Hurthle cell adenoma, 0.2%(n=1) hyalinizing trabacular adenoma and thyroid carcinomas. The carcinomas comprised 2.6%(n=13) papillary carcinoma, 0.8%(n=4) poorly differentiated carcinoma,0.8%(n=4) anaplastic carcinoma,0.6%(n=3) medullary carcinoma and 0.4%(n=2) follicular carcinoma. In 445 patients of multinodular goiter 158 patients were in the age range of 41-50 years, in 13 cases of thyroiditis 7 were in the age range of 31-40 years, in 11 cases of follicular adenoma 4 patients were in the age range of 31-40 years, in 4 cases of hurthle cell adenoma 3 patients were in the age range of 41-50 years, in 13 cases of papillary thyroid carcinoma 5 patients were in the age range of 31-40 years, in 4 cases of poorly differentiated carcinoma 2 patients were in the age range of 41-50 years and in 4 cases of anaplastic carcinoma 2 patients were in the age range of 61-70 years. Conclusion: The study concluded that thyroid carcinomas collectively constituted 5.20% of the study cases. Papillary carcinoma was the most frequent malignant neoplasm constituting 2.6 % and occurring mostly in the age range of 31-40 years, while anaplastic carcinoma comprised of 0.8% of malignant lesions occurring in the age range of 61-70 years. The most frequent cause of thyroid enlargement was multinodular goiter (89%) with majority of the patients in the age range of 41-50 years.

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