scholarly journals TREATMENT OF PROBLEMATIC SKIN WOUNDS BASED ON THE PLATELET-RICH PLASMA METHOD. OUR OWN ALGORITHMS FOR APPLICATION

2020 ◽  
Vol 26 (4) ◽  
pp. 3436-3442
Author(s):  
Tsvetan Sokolov ◽  
◽  
Anelya Manukova ◽  
Vihar Kovachev ◽  
Mancho Kovachev ◽  
...  
Keyword(s):  
Platelet Rich Plasma ◽  
Skin Wounds ◽  
Plasma Method ◽  
Normal Life ◽  
Complicated Skin ◽  
Prevention And Treatment ◽  
Skin Healing

OBJECTIVE: The objective of this paper is to present the application of our own algorithms for prevention and treatment of problematic skin wounds (PSW) by using the platelet-rich plasma (PRP) based on the first study on PRP application carried out in Bulgaria. MATERIAL AND METHODS: The study was carried out at the Clinic of Orthopedics and Traumatology, UMBAL Kanev Ruse, for a period of 84 months - from February 2009 to September 2016. A total of 83 patients with PSW have been treated with platelet-rich plasma. Scores introduced by Cancela AM are used for the assessment of the respective wound. Each of these scores is used for assessing specific wound parameters. RESULTS: Our own algorithms for prevention and treatment of PSW by PRP increase the percentage of successfully cured wounds. Prevention algorithm of applying PRP ensures that a high percentage of acute skin wounds will not turn into PSW. The proposed algorithms for prevention and treatment of PSW by applying PRP are an effective and safe way to reduce the uncured complicated skin wounds and ensure the subsequent normal life of patients. They also ensure more predictable skin healing. CONCLUSION: Our own algorithms for prevention and treatment of PSW by PRP increase the percentage of successfully cured wounds. The proposed algorithms for prevention and treatment of PSW by applying PRP are an effective and safe way to reduce the uncured complicated skin wounds and ensure the subsequent normal life of patients.

scholarly journals Prevention and Treatment of Potentially Problematic Acute Wounds to Achieve Full Recovery by Using Platelet-Rich Plasma: Research Results

2020 ◽  
Vol 13 (2) ◽  
pp. 127-133
Author(s):  
Tsvetan V. Sokolov
Keyword(s):  
Conventional Treatment ◽  
Platelet Rich Plasma ◽  
Preventive Treatment ◽  
Skin Wounds ◽  
Surgical Wound ◽  
Wound Debridement ◽  
Prevention And Treatment ◽  
Patients At Risk ◽  
Plasma Research ◽  
Experimental Group

Summary The study presents the outcomes from platelet-rich plasma (PRP) application in treating acute and potentially problematic skin wounds from 2009 to 2016. Fifty-six hospitalized patients with acute skin wounds were divided into two groups: an experimental group of 30 patients treated with platelet-rich plasma and 26 controls with similar wounds, treated by conventional methods. After platelet-rich plasma treatment of 30 acute and potentially problematic wounds in the Experimental Group patients, 29 (96.7%) of the wounds healed for 16 weeks on average. After applying conventional treatment with surgical wound debridement, of the 26 acute, potentially problematic wounds in the controls, only 2 (7.6%) healed. Since acute and potentially problematic wounds are very likely to become chronic and difficult to heal, we recommend PRP application as a preventive treatment in patients at risk.

scholarly journals Systematic Review: Adipose-Derived Mesenchymal Stem Cells, Platelet-Rich Plasma and Biomaterials as New Regenerative Strategies in Chronic Skin Wounds and Soft Tissue Defects

2021 ◽  
Vol 22 (4) ◽  
pp. 1538 ◽  
Author(s):  
Pietro Gentile ◽  
Simone Garcovich
Keyword(s):  
Systematic Review ◽  
Stem Cells ◽  
Wound Healing ◽  
Soft Tissue ◽  
Chronic Wounds ◽  
Platelet Rich Plasma ◽  
Skin Wounds ◽  
Soft Tissue Defects ◽  
Chronic Skin ◽  
Tissue Defects

The number of clinical trials evaluating adipose-derived mesenchymal stem cells (AD-MSCs), platelet-rich plasma (PRP), and biomaterials efficacy in regenerative plastic surgery has exponentially increased during the last ten years. AD-MSCs are easily accessible from various fat depots and show intrinsic plasticity in giving rise to cell types involved in wound healing and angiogenesis. AD-MSCs have been used in the treatment of soft tissue defects and chronic wounds, employed in conjunction with a fat grafting technique or with dermal substitute scaffolds and platelet-rich plasma. In this systematic review, an overview of the current knowledge on this topic has been provided, based on existing studies and the authors’ experience. A multistep search of the PubMed, MEDLINE, Embase, PreMEDLINE, Ebase, CINAHL, PsycINFO, Clinicaltrials.gov, Scopus database, and Cochrane databases has been performed to identify papers on AD-MSCs, PRP, and biomaterials used in soft tissue defects and chronic wounds. Of the 2136 articles initially identified, 422 articles focusing on regenerative strategies in wound healing were selected and, consequently, only 278 articles apparently related to AD-MSC, PRP, and biomaterials were initially assessed for eligibility. Of these, 85 articles were excluded as pre-clinical, experimental, and in vitro studies. For the above-mentioned reasons, 193 articles were selected; of this amount, 121 letters, expert opinions, commentary, and editorials were removed. The remaining 72 articles, strictly regarding the use of AD-MSCs, PRP, and biomaterials in chronic skin wounds and soft tissue defects, were analyzed. The studies included had to match predetermined criteria according to the patients, intervention, comparator, outcomes, and study design (PICOS) approach. The information analyzed highlights the safety and efficacy of AD-MSCs, PRP, and biomaterials on soft tissue defects and chronic wounds, without major side effects.

scholarly journals Macroscopic and histomorphometric evaluation of different healing stages of skin wounds in horses treated with leukocyte-poor platelet-rich plasma

2017 ◽  
Vol 11 (2) ◽  
pp. 111-123
Author(s):  
Maria Souza ◽  
José Pinto ◽  
Mary Varaschin ◽  
José Moreira ◽  
Thayne Silva ◽  
...  
Keyword(s):  
Platelet Rich Plasma ◽  
Skin Wounds

Eight-hour versus 24-h whole-blood hold before preparation of platelet concentrates by the platelet-rich plasma method

2014 ◽  
Vol 39 (4) ◽  
pp. 195
Author(s):  
GhadaM El-Gohary ◽  
AzzaS El-Danasoury ◽  
MahiraI El-Mogy ◽  
Amal Farouk ◽  
GhadaS Neseem
Keyword(s):  
Whole Blood ◽  
Platelet Rich Plasma ◽  
Platelet Concentrates ◽  
Plasma Method

scholarly journals New Treatment Strategy for a Delayed Skin Necrosis Related to a Calcaneal Fracture

2017 ◽  
Vol 11 (1) ◽  
pp. 1568-1576 ◽  
Author(s):  
Konstantinos C. Xarchas ◽  
George Kyriakopoulos ◽  
Maria Vlachou ◽  
Katerina Manta
Keyword(s):  
Treatment Strategy ◽  
Skin Necrosis ◽  
Platelet Rich Plasma ◽  
Calcaneal Fracture ◽  
Treatment Modalities ◽  
Vacuum Assisted Closure ◽  
Avulsion Fractures ◽  
Novel Treatment ◽  
New Treatment ◽  
Skin Healing

In calcaneal avulsion fractures, skin necrosis as a result of pressure from the underlying fragment is a fairly common and serious complication. In spite of proper treatment, skin healing complication may occur. We report a calcaneal fracture case complicated by skin necrosis and managed with a novel treatment strategy including application of Platelet Rich Plasma (PRP) and Vacuum Assisted Closure (VAC). This is the first application of combined PRP and VAC treatment in a calcaneal fracture complicated by skin necrosis and was accompanied with very favorable outcomes while avoiding other more complex treatment modalities.

Pooled Platelet Concentrates Prepared by the Platelet-Rich-Plasma Method and Filtered with Three Different Filters and Stored for 8 Days

Vox Sanguinis ◽  
1995 ◽  
Vol 68 (2) ◽  
pp. 82-89 ◽  
Author(s):  
M.N. Boomgaard ◽  
C.W.N. Gouwerok ◽  
C.H. Palfenier ◽  
I.E. Pankalla-Blandeau ◽  
H.A. Veldman ◽  
...  
Keyword(s):  
Platelet Rich Plasma ◽  
Platelet Concentrates ◽  
Plasma Method

Pooled Platelet Concentrates Prepared by the Platelet-Rich-Plasma Method and Filtered with Three Different Filters and Stored for 8 Days

Vox Sanguinis ◽  
1995 ◽  
Vol 68 (2) ◽  
pp. 82-89 ◽  
Author(s):  
M. N. Boomgaard ◽  
C. W.N. Gouwerok ◽  
C.H. Palfenier ◽  
I.E. Pankalla-Blandeau ◽  
H.A. Veldman ◽  
...  
Keyword(s):  
Platelet Rich Plasma ◽  
Platelet Concentrates ◽  
Plasma Method

scholarly journals FEATURES OF SKIN WOUNDS HEALING UNDER CHRONIC HYPERGLYCEMIA AND IMPROVEMENT OF THEIR TREATMENT METHODS

2021 ◽  
Vol 74 (5) ◽  
pp. 1174-1179
Author(s):  
Olena S. Maksymova ◽  
Svitlana M. German ◽  
Pavlo O. Moskalenko ◽  
Viktoriia O. Yasenok ◽  
Olena M. Gortynska ◽  
...  
Keyword(s):  
Connective Tissue ◽  
Vascular Remodeling ◽  
Platelet Rich Plasma ◽  
Skin Wounds ◽  
Pathological Changes ◽  
Skin Injuries ◽  
Laboratory Rats ◽  
Chronic Hyperglycemia ◽  
Autologous Platelet Rich Plasma ◽  
Autologous Platelet

The aim: The work was aimed to study the histological, morphometric and planimetric features of skin regeneration in mature rats with chronic hyperglycemia under the influence of platelet-rich plasma. Materials and methods: 60 mature white laboratory rats were used. The animals were divided into three groups (I – control with mechanical skin injuries; II – rats with chronic hyperglycemia and modeled mechanical skin injuries; III – animals with the chronic hyperglycemia and modeled mechanical skin injuries which were injected with the platelet-rich plasma). The samples were studied using light microscopy.Statistical data processing was performed using SPSS-17. Results: On the 21st day, the epithelialization of control mature rats wound was almost complete. The epithelium contained all layers without pathological changes. The new dermis has been reorganized into papillary and reticular layers. On the 21st day, the wound of rats with chronic hyperglycemia was not completely covered with the epidermis. The connective tissue of the dermis was disorganized. On the 21st day, the wound epithelialization was also more complete in mature rats with chronic hyperglycemia received platelet-rich plasma compared to the rats with chronic hyperglycemia. The dermis contained a large number of blood vessels with normal, full-blooded lumens. Conclusions: The chronic hyperglycemia leads to disruption of epithelialization processes, angiogenesis, a delay in the reorganization of dermis connective tissue, and vascular remodeling. The injections of autologous platelet-rich plasma promote faster angiogenesis, reduce inflammation, and accelerate wound epithelialization.

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