scholarly journals Prevention and Treatment of Potentially Problematic Acute Wounds to Achieve Full Recovery by Using Platelet-Rich Plasma: Research Results

2020 ◽  
Vol 13 (2) ◽  
pp. 127-133
Author(s):  
Tsvetan V. Sokolov
Keyword(s):  
Conventional Treatment ◽  
Platelet Rich Plasma ◽  
Preventive Treatment ◽  
Skin Wounds ◽  
Surgical Wound ◽  
Wound Debridement ◽  
Prevention And Treatment ◽  
Patients At Risk ◽  
Plasma Research ◽  
Experimental Group

Summary The study presents the outcomes from platelet-rich plasma (PRP) application in treating acute and potentially problematic skin wounds from 2009 to 2016. Fifty-six hospitalized patients with acute skin wounds were divided into two groups: an experimental group of 30 patients treated with platelet-rich plasma and 26 controls with similar wounds, treated by conventional methods. After platelet-rich plasma treatment of 30 acute and potentially problematic wounds in the Experimental Group patients, 29 (96.7%) of the wounds healed for 16 weeks on average. After applying conventional treatment with surgical wound debridement, of the 26 acute, potentially problematic wounds in the controls, only 2 (7.6%) healed. Since acute and potentially problematic wounds are very likely to become chronic and difficult to heal, we recommend PRP application as a preventive treatment in patients at risk.

scholarly journals TREATMENT OF PROBLEMATIC SKIN WOUNDS BASED ON THE PLATELET-RICH PLASMA METHOD. OUR OWN ALGORITHMS FOR APPLICATION

2020 ◽  
Vol 26 (4) ◽  
pp. 3436-3442
Author(s):  
Tsvetan Sokolov ◽  
◽  
Anelya Manukova ◽  
Vihar Kovachev ◽  
Mancho Kovachev ◽  
...  
Keyword(s):  
Platelet Rich Plasma ◽  
Skin Wounds ◽  
Plasma Method ◽  
Normal Life ◽  
Complicated Skin ◽  
Prevention And Treatment ◽  
Skin Healing

OBJECTIVE: The objective of this paper is to present the application of our own algorithms for prevention and treatment of problematic skin wounds (PSW) by using the platelet-rich plasma (PRP) based on the first study on PRP application carried out in Bulgaria. MATERIAL AND METHODS: The study was carried out at the Clinic of Orthopedics and Traumatology, UMBAL Kanev Ruse, for a period of 84 months - from February 2009 to September 2016. A total of 83 patients with PSW have been treated with platelet-rich plasma. Scores introduced by Cancela AM are used for the assessment of the respective wound. Each of these scores is used for assessing specific wound parameters. RESULTS: Our own algorithms for prevention and treatment of PSW by PRP increase the percentage of successfully cured wounds. Prevention algorithm of applying PRP ensures that a high percentage of acute skin wounds will not turn into PSW. The proposed algorithms for prevention and treatment of PSW by applying PRP are an effective and safe way to reduce the uncured complicated skin wounds and ensure the subsequent normal life of patients. They also ensure more predictable skin healing. CONCLUSION: Our own algorithms for prevention and treatment of PSW by PRP increase the percentage of successfully cured wounds. The proposed algorithms for prevention and treatment of PSW by applying PRP are an effective and safe way to reduce the uncured complicated skin wounds and ensure the subsequent normal life of patients.

scholarly journals RESEARCH OF MEDICAL FACTORS AND REASONS FOR HEALING FAILURE OF PROBLEMATIC SKIN WOUNDS TREATED WITH PLATELET–RICH PLASMA

2020 ◽  
Vol 26 (4) ◽  
pp. 3463-3468
Author(s):  
Tsvetan Sokolov ◽  
◽  
Aneliya Manukova ◽  
Keyword(s):  
Social Sciences ◽  
Platelet Rich Plasma ◽  
Treatment Algorithm ◽  
Physiological Saline ◽  
Treatment Method ◽  
Fibrin Clot ◽  
Control Group ◽  
Skin Wounds ◽  
The Social ◽  
Experimental Group

OBJECTIVE: To present our problematic skin wounds cases treated with PRP application of that has not responded to the treatment method. MATERIAL AND METHODS: Out of a total of 154 hospitalized patients with complex skin wounds 83 have been treated with platelet-rich plasma, comprising the Experimental group (EG), and 71 patients with comparable wounds have been treated by utilizing traditional techniques for the respective pathology, comprising the Control Group (CG). Ratings introduced by Cancela AM are used for the evaluation of the respective wound. Statistical analyzes have been performed by using the software SPSS (Statistical Package for the Social Sciences). All cases were treated in a procedure, which includes activated platelet-rich plasma. The treatment algorithm we used is as follows: first, there is surgical treatment and debridement of the wound. Activated plasma is used to infiltrate the wound edges and the fibrin clot is used to fill the wound itself. A sterile dressing soaked with physiological saline is applied. The treatment is repeated on a weekly basis until the wound problem is resolved in full. RESULTS: The results of our research indicate that 77 (92.78%) of patients enjoy a full recovery, while 6 (7.22%) of patients have no positive wound healing outcome (unhealed wound). CONCLUSION: Theoretical and clinical studies prove that the PRP method is a reliable, rational, and modern option for PSW treatment. It should not be seen as the only one and universal.

Rising patients" adherence to CVD preventive treatment via medical and psychological counseling using remote technologies

2021 ◽  
Vol 28 (Supplement_1) ◽  
Author(s):  
OV Kopylova ◽  
NA Sirota ◽  
VM Yaltonsky
Keyword(s):  
Risk Factors ◽  
Medical Treatment ◽  
Healthy Lifestyle ◽  
Preventive Treatment ◽  
Control Group ◽  
Psychological Counselling ◽  
Funding Sources ◽  
Item Questionnaire ◽  
Experimental Group ◽  
Funding Acknowledgements

Abstract Funding Acknowledgements Type of funding sources: None. Introduction Low adherence to healthy lifestyle and CVD preventive medical treatment is a seriouse problem in lowering of CVD morbidity and mortality. Using modern medical, psychological and remote technologies may help to increase patients" adherence. Purpose To study the efficacy of medical and psychological counselling using remote technologies in rising patients" adherence to CVD preventive treatment. Methods The study included 140 patients with risk factors for cardiovascular disease (RF CVD), who were divided into two comparable groups: group of medical and psychological counselling with the use of remote technologies (n = 70) and group of control (n = 70).  The study lastet 12 months. Level of adherence was measured via standard Morisky-Green"s 4-item questionnaire as well as via additional questionnaire developed by authors for this study. Results Comparative analysis of the level of adherence in the two groups did not reveal statistically significant differences at baseline. After 12 months, the experimental group showed a statistically significant increase in adherence to preventive treatment compared with the control group (р=0,001) Conclusion(s) Medical and psychological counselling using remote technologies is an effective method for rising patients" adherence to CVD preventive medical treatment

scholarly journals Systematic Review: Adipose-Derived Mesenchymal Stem Cells, Platelet-Rich Plasma and Biomaterials as New Regenerative Strategies in Chronic Skin Wounds and Soft Tissue Defects

2021 ◽  
Vol 22 (4) ◽  
pp. 1538 ◽  
Author(s):  
Pietro Gentile ◽  
Simone Garcovich
Keyword(s):  
Systematic Review ◽  
Stem Cells ◽  
Wound Healing ◽  
Soft Tissue ◽  
Chronic Wounds ◽  
Platelet Rich Plasma ◽  
Skin Wounds ◽  
Soft Tissue Defects ◽  
Chronic Skin ◽  
Tissue Defects

The number of clinical trials evaluating adipose-derived mesenchymal stem cells (AD-MSCs), platelet-rich plasma (PRP), and biomaterials efficacy in regenerative plastic surgery has exponentially increased during the last ten years. AD-MSCs are easily accessible from various fat depots and show intrinsic plasticity in giving rise to cell types involved in wound healing and angiogenesis. AD-MSCs have been used in the treatment of soft tissue defects and chronic wounds, employed in conjunction with a fat grafting technique or with dermal substitute scaffolds and platelet-rich plasma. In this systematic review, an overview of the current knowledge on this topic has been provided, based on existing studies and the authors’ experience. A multistep search of the PubMed, MEDLINE, Embase, PreMEDLINE, Ebase, CINAHL, PsycINFO, Clinicaltrials.gov, Scopus database, and Cochrane databases has been performed to identify papers on AD-MSCs, PRP, and biomaterials used in soft tissue defects and chronic wounds. Of the 2136 articles initially identified, 422 articles focusing on regenerative strategies in wound healing were selected and, consequently, only 278 articles apparently related to AD-MSC, PRP, and biomaterials were initially assessed for eligibility. Of these, 85 articles were excluded as pre-clinical, experimental, and in vitro studies. For the above-mentioned reasons, 193 articles were selected; of this amount, 121 letters, expert opinions, commentary, and editorials were removed. The remaining 72 articles, strictly regarding the use of AD-MSCs, PRP, and biomaterials in chronic skin wounds and soft tissue defects, were analyzed. The studies included had to match predetermined criteria according to the patients, intervention, comparator, outcomes, and study design (PICOS) approach. The information analyzed highlights the safety and efficacy of AD-MSCs, PRP, and biomaterials on soft tissue defects and chronic wounds, without major side effects.

Trajectories of Frailty in the five years Prior to Death Among US Veterans Born 1927-1934

2021 ◽  
Author(s):  
Rachel E Ward ◽  
Ariela R Orkaby ◽  
Clark Dumontier ◽  
Brian Charest ◽  
Chelsea E Henderson ◽  
...  
Keyword(s):  
Medical Record ◽  
Claims Data ◽  
Treatment Strategies ◽  
Compression Of Morbidity ◽  
Age At Death ◽  
Prevention And Treatment ◽  
Insurance Claims Data ◽  
Patients At Risk ◽  
Us Veterans ◽  
Future Work

Abstract Background Electronic frailty indices (eFIs) are increasingly used to identify patients at risk for morbidity and mortality. Whether eFIs capture the spectrum of frailty change, including decline, stability, and improvement is unknown. Methods In a nationwide retrospective birth-cohort of US Veterans, a validated eFI, including 31 health deficits, was calculated annually using medical record and insurance claims data (2002-2012). K-means clustering was used to assign patients into frailty trajectories measured five years prior to death. Results There were 214,250 Veterans born between 1927-1934 (mean (SD) age at death = 79.4 (2.8) years, 99.2% male, 90.3% white) with an annual eFI in the five years before death. Nine frailty trajectories were identified. Those starting at non-frail or pre-frail had two stable trajectories (non-frail to pre-frail, n=29,786 and stable pre-frail, n=28,499) and two rapidly increasing trajectories (pre-frail to moderately frail, n=28,244 and pre-frail to severely frail, n=22,596). Those who were mildly frail at baseline included one gradually increasing trajectory (mildly to moderately frail, n=33,806) and one rapidly increasing trajectory (mildly to severely frail, n=15,253). Trajectories that started at moderately or severely frail included two gradually increasing trajectories (moderately to severely frail, n=27,662 and progressing severely frail, n=14,478) and one recovering trajectory (moderately frail to mildly frail, n=13,926). Conclusions Nine frailty trajectories, including one recovering trajectory, were identified in this cohort of older US Veterans. Future work is needed to understand whether prevention and treatment strategies can improve frailty trajectories and contribute to compression of morbidity towards the end of life.

scholarly journals Macroscopic and histomorphometric evaluation of different healing stages of skin wounds in horses treated with leukocyte-poor platelet-rich plasma

2017 ◽  
Vol 11 (2) ◽  
pp. 111-123
Author(s):  
Maria Souza ◽  
José Pinto ◽  
Mary Varaschin ◽  
José Moreira ◽  
Thayne Silva ◽  
...  
Keyword(s):  
Platelet Rich Plasma ◽  
Skin Wounds

scholarly journals Evaluation of platelet-rich plasma gel as an angiogenesis-inducing agent in canineadvancement skin flaps

2020 ◽  
Vol 40 (6) ◽  
pp. 474-478
Author(s):  
Grazielle A.S. Aleixo ◽  
Maria C.O.C. Coelho ◽  
Telga L.A. Almeida ◽  
Márcia F. Pereira ◽  
Miriam N. Teixeira ◽  
...  
Keyword(s):  
Blood Vessel ◽  
Skin Color ◽  
Platelet Rich Plasma ◽  
Skin Flap ◽  
Skin Flaps ◽  
Experimental Conditions ◽  
Significant Difference ◽  
Experimental Group ◽  
Prp Gel ◽  
Made In

ABSTRACT: This work aimed to evaluate the effect of platelet-rich plasma (PRP) on advancement skin flaps in dogs regarding improvement of vascularization, with focus on increasing its viable area, since there are reports that it is a potential angiogenesis stimulator. The experimental group was composed of eight adult bitches, in which two advancement skin flaps were made in the ventral abdominal region. No product was applied in the control flap (CF), while PRP was used in the contralateral flap, called treated flap (TF). The areas were clinically evaluated every two days until the 7th postoperative day regarding skin color and presence of necrosis. At 10 days, both flaps were removed and submitted to histological examination and blood vessel morphometry. The vessels counted in each group were statistically analyzed by the F-test at 1% probability. Results showed no significant difference in macroscopic changes in the wound, or CF and TF vascularization, thus suggesting that PRP gel did not improve advancement skin flap angiogenesis in bitches under the experimental conditions in which this research was developed.

scholarly journals Effect of mobilization on ankle mobility and balance performance in diabetic patients

Biomedicine ◽  
2020 ◽  
Vol 39 (2) ◽  
pp. 305-309
Author(s):  
Albin Jerome ◽  
Karthikeyan Jeyabalan ◽  
Hoe Kean Keong ◽  
Gaurai Gharote
Keyword(s):  
Range Of Motion ◽  
Conventional Treatment ◽  
Plantar Flexion ◽  
Joint Mobility ◽  
Functional Reach ◽  
Significant Difference ◽  
Functional Reach Test ◽  
Diabetic Population ◽  
Experimental Group ◽  
Ankle Plantar Flexion

Introduction and Aim: Diabetic Cheiroarthropathy is defined as the condition of restriction joint mobility due to pseudo-sclerodermatous hand, the fibrosis of the elastin connective tissues over the skin. It limits joint mobility especially around Tibia fibular mobility that are interrelated with the flexibility of ankle motion that results in the balance disorder in diabetic population. The aim of the study was to determine the effects of the tibia fibular mobilization technique on ankle joint in diabetes mellitus patients. Materials and Methods: 60 diabetic subjects were randomly assigned into experimental group and control, in which experimental group received Tibia fibular mobilization technique and conventional treatment whereas control group received only conventional treatment 1 time a week for 3 weeks. Results: There is no significant difference in Ankle dorsi flexion range of motion in both extremities but there is significant difference in ankle plantar flexion range of motion in both extremities and functional reach test in both extremities. Conclusion: There is a significant difference in the ankle plantar flexion range of motion and functional reach test, Hence, mobilization of Tibiofibular joint will be beneficial in improving the ankle range of motion and balance factor in the diabetic population.  

scholarly journals Challenge of diagnosing pyoderma gangrenosum after caesarean section

2019 ◽  
Vol 12 (7) ◽  
pp. e230315 ◽  
Author(s):  
Philipp Foessleitner ◽  
Ulrike Just ◽  
Herbert Kiss ◽  
Alex Farr
Keyword(s):  
Caesarean Section ◽  
Wound Infection ◽  
Pyoderma Gangrenosum ◽  
Rare Complication ◽  
Surgical Wound Infection ◽  
Interdisciplinary Treatment ◽  
High Dose ◽  
Surgical Wound ◽  
Wound Debridement ◽  
Rare Diagnosis

Pyoderma gangrenosum is a neutrophilic skin disease that leads to extensive, painful, necrotic ulcerations, particularly at surgical sites. As obstetric cases with pyoderma gangrenosum are rare and, therefore, often misdiagnosed initially, it is important to raise awareness about this rare complication. Here, we describe a patient who presented with pyoderma gangrenosum at the surgical site 4 days after undergoing a caesarean section. The erythema was initially misdiagnosed as wound infection, and the patient, who was experiencing pain, underwent antibiotic treatment and surgical wound debridement. When the wound was unresponsive to these treatments, a dermatologist was consulted who suspected pyoderma gangrenosum and began a high-dose corticosteroids therapy, which led to a fulminant improvement of the local wound. In conclusion, the rare diagnosis of pyoderma gangrenosum should be considered in the differential diagnosis of a suspected surgical wound infection. Early interdisciplinary treatment is essential to avoid further complications.

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