scholarly journals Turmeric Powder as a Natural Heavy Metal Chelating Agent: Surface Characterisation

2017 ◽  
Vol 60 (1) ◽  
pp. 1-8
Author(s):  
Amtul Qayoom ◽  
Syed Arif Kazmi ◽  
Saeeda Nadir Ali
Keyword(s):  
Binding Sites ◽  
Chelating Agent ◽  
Spectroscopic Studies ◽  
Surface Characterisation ◽  
Energy Dispersion Spectroscopy ◽  
Oh Groups ◽  
Potentiometric Titrations ◽  
Metal Chelating ◽  
Infra Red ◽  
Titration Data

The present study was conducted to investigate surface properties of turmeric in order to evaluateits detoxification potential and ability to sequester toxic metals ions. Scanning Electron Microscopy (SEM),Energy Dispersion Spectroscopy (EDS), Infra-Red (IR) spectroscopy and potentiometric titrations wereemployed for characterisation of the surface of turmeric powder. Spectroscopic studies revealed that thesurface of turmeric powder was porous mainly composed of polymeric -OH , -NH , -CH2 , -COO and-OH groups of polysaccharides. From potentiometric titrations and modelling of batch titration data, it wasfound that surface of the turmeric contains at least four binding sites with pKa values 3.56 (pK1), 4.83(pK2), 7.68 (pK3) and 10.4 (pK4). Turmeric powder contains highest concentration of amino and hydroxylgroups for the pK4 values i.e., 0.55 mmol/ g. The total binding sites concentration for turmeric powderwas 1.2 mmol/ g.

Antidotes — inappropriate timely availability

2000 ◽  
Vol 19 (9) ◽  
pp. 485-488 ◽  
Author(s):  
M A Higgins ◽  
R Evans
Keyword(s):  
Heavy Metal ◽  
Chelating Agent ◽  
The South ◽  
Chemical Safety ◽  
Metal Chelating ◽  
South West ◽  
Accident And Emergency ◽  
Cyanide Antidote ◽  
International Programme ◽  
Timely Fashion

The aim of this study was to determine the availability of antidotes to poisons in Wales and the South West of England. A stocklist of antidotes that are available to accident and emergency departments was requested and was compared with recommendations from the International Programme on Chemical Safety (IPCS). Chief pharmacists were invited to complete a short questionnaire regarding knowledge of existing guidelines. Thirty-four of 43 centres replied (response rate 77%). No department held all 36 antidotes (mean 13, range 7-33). All departments held antidotes that were frequently used. Ninety-one percent of departments held one cyanide antidote. Eighty-eight percent held one heavy metal chelating agent. The remaining antidotes were variably stocked. New agents such as 4-methylpyrazole, hydroxocobalamin and the heavy metal chelating agents DMSA and DMPS were infrequently held. Twenty of 34 chief pharmacists were unfamiliar with existing UK guidelines. A trend exists whereby larger departments stocked more antidotes. Some antidotes to poisons are not available in a timely fashion in Wales and the South West of England. There is a lack of awareness of existing guidelines. New recommendations relevant to clinical need and local practice should ideally be developed.

Modification of cisplatin toxicity with diethyldithiocarbamate.

1990 ◽  
Vol 8 (9) ◽  
pp. 1585-1590 ◽  
Author(s):  
J M Berry ◽  
C Jacobs ◽  
B Sikic ◽  
J Halsey ◽  
R F Borch
Keyword(s):  
Heavy Metal ◽  
Platelet Count ◽  
Chelating Agent ◽  
Cranial Irradiation ◽  
Limiting Factor ◽  
Preclinical Studies ◽  
Dose Escalation Study ◽  
Metal Chelating ◽  
Wbc Count ◽  
Local Burning

Diethyldithiocarbamate (DDTC), a heavy metal-chelating agent, has been shown to decrease cisplatin (CP) toxicity in preclinical studies. This phase I dose-escalation study was undertaken to investigate DDTC as a chemoprotector in patients with advanced cancer. Thirty-five courses of CP in doses ranging from 120 to 160 mg/m2 were given intravenous (IV) bolus to 19 patients. DDTC at 4 g/m2 was infused over 1 hour, starting 45 minutes after CP. There was minimal nephrotoxicity with a mean creatine clearance of 99 mL/min +/- 4 pretreatment and 86 mL/min +/- 4 on day 21. Two courses were associated with a WBC count less than 2,000/mm3 and one course with a platelet count of 15,000/mm3. Two patients had grade 2 neurotoxicity. Hearing loss occurred in 11 patients: five greater than or equal to 20 dB, five greater than or equal to 40 dB, and one greater than or equal to 60 dB. All patients who received cranial irradiation had ototoxicity compared with 43% of those without radiation (P less than .05). All patients experienced toxicity during the DDTC infusion, including hypertension, flushing, diaphoresis, agitation, and local burning. We conclude that DDTC can protect against CP nephrotoxicity at doses up to 160 mg/m2. Ototoxicity became the dose-limiting factor.

Alloying the near Surface Layer of Stainless Steel with Rare Earth Elements (REE) Using High Intensity Pulsed Plasma Beams (HIPPB)

2012 ◽  
Vol 186 ◽  
pp. 292-295 ◽  
Author(s):  
Bożena Sartowska ◽  
Jerzy Piekoszewski ◽  
Lech Waliś ◽  
Marek Barlak ◽  
Irene Calliari ◽  
...  
Keyword(s):  
Stainless Steel ◽  
Surface Layer ◽  
High Intensity ◽  
Austenitic Stainless Steels ◽  
Pulsed Plasma ◽  
Surface Characterisation ◽  
Energy Dispersion Spectroscopy ◽  
Temperature Oxidation ◽  
Near Surface ◽  
316L Austenitic Stainless Steel

Addition of some active elements such as yttrium, cerium, lanthanum and other rare earths elements (REE) to austenitic stainless steels helps to improve their high temperature oxidation resistance and tribological properties. The high intensity plasma pulses were used to introduce Ce and La into AISI 316L austenitic stainless steel. The plasma pulses contained both ions/atoms of Ce-La and those of the working gas. The pulse energy densities were sufficient to melt the near surface layer of the steel and introduce those elements into the surface layer. Scanning electron microscopy (SEM) as well as energy dispersion spectroscopy (EDS) was used during each one part of surface characterisation. Obtained results allowed us to make decision about directions of modified material successive investigations.

scholarly journals Evaluation of the Biodistribution of Serinolamide-Derivatized C60 Fullerene

Nanomaterials ◽  
2020 ◽  
Vol 10 (1) ◽  
pp. 143 ◽  
Author(s):  
Nicholas G. Zaibaq ◽  
Alyssa C. Pollard ◽  
Michael J. Collins ◽  
Federica Pisaneschi ◽  
Mark D. Pagel ◽  
...  
Keyword(s):  
Carbon Nanoparticles ◽  
Chelating Agent ◽  
Water Soluble ◽  
Emission Tomography ◽  
C60 Fullerene ◽  
Fullerene Cage ◽  
Metal Chelating ◽  
In Vivo Biodistribution ◽  
Positron Emission

Carbon nanoparticles have consistently been of great interest in medicine. However, there are currently no clinical materials based on carbon nanoparticles, due to inconsistent biodistribution and excretion data. In this work, we have synthesized a novel C60 derivative with a metal chelating agent (1,4,7-Triazacyclononane-1,4,7-triacetic acid; NOTA) covalently bound to the C60 cage and radiolabeled with copper-64 (t1/2 = 12.7 h). Biodistribution of the material was assessed in vivo using positron emission tomography (PET). Bingel-Hirsch chemistry was employed to functionalize the fullerene cage with highly water-soluble serinolamide groups allowing this new C60 conjugate to clear quickly from mice almost exclusively through the kidneys. Comparing the present results to the larger context of reports of biocompatible fullerene derivatives, this work offers an important evaluation of the in vivo biodistribution, using experimental evidence to establish functionalization guidelines for future C60-based biomedical platforms.

Spectroscopic studies of vanadium biosorption on different types of carbohydrate biomass

2013 ◽  
Vol 91 (3) ◽  
pp. 186-195 ◽  
Author(s):  
Jousy García ◽  
Juan Carlos González ◽  
María Inés Frascaroli ◽  
Silvia García ◽  
Patricia Blanes ◽  
...  
Keyword(s):  
Metal Ion ◽  
Orange Peel ◽  
Spectroscopic Studies ◽  
Visible Range ◽  
Water Molecules ◽  
Main Process ◽  
Paramagnetic Resonance ◽  
Oh Groups ◽  
Surface Level ◽  
Different Types

The biosorption potential of different types of carbohydrate biomass is investigated to evaluate their application to purify water contaminated by vanadium in environmentally relevant oxidation states (VIV and VV). Spectroscopic studies were done by electron paramagnetic resonance (EPR), vanadium nuclear magnetic resonance (51V NMR), circular dichroism (CD), and electronic absorption in the visible range (vis). Both d-galacturonic and d-glucuronic acids are major components of plant cellular wall polysaccharides. The interaction of VIV with the model ligands d-galacturonic and d-glucuronic acids showed that complexation starts at low pH values (pH 3) and that carboxylate and sugar–OH groups, as well as water molecules, are involved in the coordination. At pH > 4.5, coordination promotes the sugar–OH deprotonation and new species form with the ligand chelating the metal ion via oxygen atoms of carboxylate and of adjacent sugar–O− donors. The studies with pectin and citric acid show the ability of both compounds to partially reduce VV to VIV in solution and the EPR parameters suggest coordination of carboxylate, sugar–OH, and water molecules. The interaction of VV with biomass from different sources shows that grapefruit, orange peel, and plane tree fruit are the most suitable candidates for the biosorption of vanadium. Studies with VV and grapefruit (or the grainless stalk of corn) indicate that the reduction takes place at the “surface” of the solid. EPR studies on the interaction of VIV with different carbohydrate biomass show their ability to complex high amounts of VIV. We propose that the biosorption mechanism, when the biomass is in contact with VV species, involves sorption, reduction, and retention at the surface level of VIV coordinated by oxygen donors of the biomass. When the interaction starts with VIV, the main process just involves the uptake of the metal ion at the surface level.

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