Abdominal emergency - Acute promyelocytic leukaemia presenting as a corpus luteal cyst

2021 ◽  
Vol 2 (2) ◽  
Author(s):  
Brinderjeet Kaur ◽  
◽  
Fayyaz S ◽  
Keyword(s):  
Corpus Luteum ◽  
Acute Promyelocytic Leukaemia ◽  
Ovarian Tissue ◽  
Promyelocytic Leukaemia ◽  
Singular Case ◽  
Disseminated Intravascular Coagulopathy ◽  
Abdominal Emergency ◽  
Child Bearing ◽  
Intravascular Coagulopathy ◽  
Life Threatening

Acute promyelocytic leukaemia (APML) is known to present with disseminated intravascular coagulopathy (DIC) but as a Corpus luteal cyst hemorrhage however, it is rarely seen at presentation. This case is the first to describe a patient with APML who presented with ruptured corpus luteum without ovarian tissue infiltration with blasts, leading to hemoperitoneum posing as life threatening acute abdominal emergency in a woman belonging to child bearing age. The case is a singular case where APL has presented in such a rare manner.

scholarly journals Life-Threatening Intrapulmonary Hemorrhage due to Vancomycin-Induced Thrombocytopenia: A Case Report

2020 ◽  
Vol 2020 ◽  
pp. 1-3
Author(s):  
Haneen Abdalhadi ◽  
Yazan Fahmawi ◽  
Abhijin Das ◽  
Brian Fouty
Keyword(s):  
Atypical Hemolytic Uremic Syndrome ◽  
Kidney Injury ◽  
Ventilator Associated Pneumonia ◽  
Disseminated Intravascular Coagulopathy ◽  
Heparin Induced Thrombocytopenia ◽  
Platelet Antibodies ◽  
Intravascular Coagulopathy ◽  
Life Threatening ◽  
Uremic Syndrome ◽  
Life Threatening Complication

Thrombocytopenia is a rare and sometimes life-threatening complication of Vancomycin. A 52-year-old male patient with acute kidney injury was treated with Vancomycin for ventilator-associated pneumonia. Three days later, his platelets decreased from 172×109/L to 3×109/L over a 36-hour period. The patient developed significant intrapulmonary bleeding leading to profound hypoxemia. Workup was negative for thrombotic thrombocytopenic purpura, disseminated intravascular coagulopathy, atypical hemolytic uremic syndrome, heparin-induced thrombocytopenia, and autoimmune diseases. All recently started medications were discontinued, and the patient was started empirically on methylprednisolone and intravenous immunoglobulin. The patient’s platelets increased, and his airway bleeding stopped within 48 hours; his platelet count returned to normal by 18 days. Vancomycin-dependent anti-platelet antibodies were identified in the patient’s serum by flow cytometry. Thrombocytopenia is an underrecognized complication of Vancomycin that can lead to life-threating bleeding. Stopping Vancomycin may be sufficient to reverse the thrombocytopenia in patients with normal renal function, but more aggressive measures such as steroids, IVIG, and dialysis may be required to stop bleeding and reverse thrombocytopenia in patients with underlying kidney injury who cannot effectively excrete Vancomycin.

scholarly journals Disseminated Intravascular Coagulopathy following Induced Second Trimester Curettage Abortion

2011 ◽  
Vol 2011 ◽  
pp. 1-2
Author(s):  
Paulami Guha
Keyword(s):  
Recovery Period ◽  
Uneventful Recovery ◽  
Second Trimester ◽  
Trimester Abortion ◽  
Disseminated Intravascular Coagulopathy ◽  
Threatening Condition ◽  
Intravascular Coagulopathy ◽  
Life Threatening ◽  
Second Trimester Abortion ◽  
Packed Rbcs

Background. This is a case of 18-year-old adolescent girl admitted with profuse vaginal bleeding following induced second trimester curettage abortion at 13 weeks of gestation. Case. Her transvaginal sonogram detected retained products of conceptus, and her blood reports revealed a full blown picture of DIC. Dilatation and evacuation was done after initial resuscitation with packed RBCs and platelet concentrates. She had an uneventful recovery period. Conclusion. DIC is an extremely life-threatening condition which can occur as a very infrequent complication of second trimester abortion.

Life-threatening hepatic toxicity caused by all-trans-retinoic acid in a patient with acute promyelocytic leukaemia

2008 ◽  
Vol 16 (2) ◽  
pp. 191-195 ◽  
Author(s):  
KEISUKE SHIBATA ◽  
YOSHINORI SHIMAMOTO ◽  
SADATOSHI ISHIBASHI ◽  
HIDEKI TOMINAGA ◽  
KENJI SUGA ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Acute Promyelocytic Leukaemia ◽  
Promyelocytic Leukaemia ◽  
Hepatic Toxicity ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid ◽  
Life Threatening

scholarly journals Cyclophosphamide and varicella zoster virus induced disseminated intravascular coagulopathy with fatal outcome

2017 ◽  
Vol 3 (2) ◽  
pp. 303
Author(s):  
A. S. Salunke ◽  
V. A. Belgaumkar ◽  
R. B. Chavan ◽  
S. S. Tharewal
Keyword(s):  
Varicella Zoster Virus ◽  
Fatal Outcome ◽  
Pemphigus Vulgaris ◽  
Paediatric Population ◽  
Varicella Zoster Virus Infection ◽  
Virus Infections ◽  
Disseminated Intravascular Coagulopathy ◽  
Varicella Zoster ◽  
Intravascular Coagulopathy ◽  
Life Threatening

<p>Varicella is usually a mild self-limiting disease, commonly occurring in paediatric population. However, in adults and in specific groups of patients, such as those who are immunosuppressed, varicella virus infections can be fulminant and life threatening. We are hereby reporting two cases of Pemphigus vulgaris on cyclophosphamide therapy, who succumbed due to disseminated intravascular coagulopathy (DIC) after varicella zoster virus infection. </p>

scholarly journals Concealed abruptio-placenta and disseminated intravascular coagulopathy: a near fatal management experience in a peripheral center

2018 ◽  
Vol 5 (10) ◽  
pp. 3430
Author(s):  
Manoj Kumar Sharma
Keyword(s):  
Interesting Case ◽  
Premature Rupture Of Membranes ◽  
Fatal Complication ◽  
Disseminated Intravascular Coagulopathy ◽  
Operative Care ◽  
Life Saving ◽  
Intravascular Coagulopathy ◽  
Life Threatening ◽  
Abruptio Placenta ◽  
Management Experience

Disseminated Intravascular Coagulopathy (DIC) is a fatal complication. In pregnant mothers concealed abruptio placenta though less commonly occurring but more dangerous is a compounding factor for development of DIC. Ascending uterine infection in premature rupture of membranes and PIH are also compounding factors in causing DIC. However, the outcome is not very positive in majority of the cases. While managing such cases in peripheral setting, it is most pertinent to keep in mind the possibility of rapid deterioration of clinical condition of such patients, which might progress to fatality. Therefore, timely institution of resuscitative and supportive measures in such labile patient is of utmost necessity while delivering peri and post-operative care. The interesting case report discussed in this patient also was of life threatening severity but timely institution of whole blood transfusion, FFP and fluid support was immensely helpful in saving the patient in peripheral setup despite her undergoing three consecutive life saving surgeries and a peri-operative cardiac arrest.

scholarly journals Extrapulmonary Manifestations of COVID-19: A Call to Extra Vigilance and Tribute to Dr Li Wenliang

2020 ◽  
Vol 1 (1) ◽  
pp. xi-xiv ◽  
Author(s):  
AM Onoja ◽  
GTA Jombo ◽  
AT Onoja ◽  
AI Nwannadi ◽  
IH Aba
Keyword(s):  
Degradation Products ◽  
Clinical Manifestations ◽  
Fulminant Myocarditis ◽  
Severe Thrombocytopenia ◽  
Disseminated Intravascular Coagulopathy ◽  
Course Of Disease ◽  
Fibrin Degradation Products ◽  
Intravascular Coagulopathy ◽  
Life Threatening ◽  
D Dimer

COVID-19 pandemic has covered all continents and virtually all countries of the world infecting millions of people with several hundred thousands of death. It was first brought to the attention of a Chinese ophthalmologist Dr Li Wenliang. The disease which was first believed to be solely associated with the lungs and respiratory system has now shown that the spectrum of organ involvement of the disease is much larger than earlier believed.  While lung and pulmonary features still account for a much larger presentation of the disease, other clinical manifestations such as  fulminant myocarditis, arteriovenous thromboembolism, disseminated intravascular coagulopathy, intracerebral haemorrhage, diarrhea, hypoxic encephalopathy, septicaemia and detection of SARS-CoV-2 particles in stool, saliva and semen of infected individuals are also becoming less infrequent. Haematologic manifestations of hypercoagulable blood are commonly reported among hospitalized COVID‐19 patients.  An elevated  D‐Dimer, that is rising  in the course of disease may signifies disease deterioration. Prolonged PT and aPTT and increased fibrin degradation products with severe thrombocytopenia have been associated with life-threatening disseminated intravascular coagulation (DIC). Physicians should therefore be on a watch out for these features in the management of patients and be ready to spot out other new surprises by the disease. This should be through deepening of curiosity by health personnel in the assessment and management of patients to spot out early surprises of COVID-19 to strengthen the sustenance of the ongoing control of the pandemic

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